Clinical trials: C Section
Postpartum Hemorrhage
Carbetocin at Elective Cesarean Delivery Part 3
Post-partum hemorrhage (PPH) is a major cause of maternal death worldwide. Oxytocin is the most common uterotonic drug used to prevent and treat PPH in North America, however, there are some limitations to its use.
- Trial name
- NCT01651130
- Testing
- Carbetocin
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Myomectomy
Myomectomy During Cesarean Section
Cesarean Myomectomy, safety and effect on uterine cavity.
- Trial name
- NCT03095014
- Testing
- Cesarean Myomectomy, Cesarean section
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Cesarean Delivery Affecting Newborn, Obesity, Childhood
Vaginal Microbiome Seeding and Health Outcomes in Cesarean-delivered Neonates.
Neonates delivered by scheduled Cesarean Section will be randomized to receive vaginal seeding (exposing the infant to Mother's vaginal flora) or sham.
- Conditions
- Cesarean Delivery Affecting Newborn, Obesity, Childhood, Intestinal Microbiome, Microbiota
- Trial name
- NCT03298334
- Testing
- Vaginal Seeding, No Vaginal Seeding
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Drug Usage
Gabapentin as Adjunctive Treatment for Postoperative Pain Control
The specific aims of this research study are to use 600 mg gabapentin as an adjunctive treatment for acute postoperative pain control in order to reduce postoperative opiate consumption and improve postoperative pain control.
- Trial name
- NCT02490345
- Testing
- gabapentin
- Where
- 2 sites in United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Indiana University
Pain, Obesity
Effect of Body Mass Index on the Dose of Intrathecal Hyperbaric Bupivacaine for Elective Cesarean Section
Combined spinal - epidural (CSE) anesthesia is a well established technique used for elective Cesarean section. As its name suggests, it combines two anesthesia techniques - spinal and epidural.
- Trial name
- NCT00403663
- Testing
- bupivacaine 0.75% with fentanyl and morphine
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Multimodal Analgesia, Cesarean Section
TAP Using Dexmedetomidine and Ropivacaine for Cesarean Section Analgesia
To evaluate the effect of dexmedetomidine as an adjuvant of ropivacaine in the TAP block on cesarean section parturients under multimodal analgesia, optimize the multimodal analgesia program for cesarean section, and guide…
- Trial name
- NCT05700045
- Testing
- Dexmedetomidine
- Where
- 2 sites in China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Surgical Site Infection
The Mepilex Cesarean Delivery Trial / MEPIDEL
The goal of this clinical trial is to learn whether a silver-containing foam dressing (Mepilex Border Post-Op Ag) works as well as the standard dressing in preventing surgical site infection after cesarean delivery.
- Trial name
- MEPIDEL (NCT07914569)
- Testing
- Mepilex Border Post-Op Ag, Standard Postoperative Dressing
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Anesthesia, Spinal
Intrathecal Dexmedetomidine With Bupivacaine for Spinal Anesthesia in Cesarean Section
A Randomized, Controlled, Double blind study aiming to evaluate the analgesic potentials and side effect profile of different dose levels of Dexmedetomidine added to subarachnoid bupivacaine in full-term pregnant women undergoing…
- Trial name
- NCT02365857
- Testing
- Dexmedetomidine & Bupivacaine., Bupivacaine Only.
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pain
Multimodal Pain Management for Cesarean Delivery
Opioid use and abuse has become a major medical problem in the United States. Over prescription of opioid medications is a major contributor to this growing problem.
- Trial name
- NCT02922985
- Testing
- Intravenous acetominophen, Ketorolac, intramuscular, Bupivacaine, subcutaneous
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Labor Pain, Post-cesarean Delivery
Mu-Opioid Receptor Genetic Polymorphism and Intrathecal Analgesia
Pharmacogenetics has allowed clinicians to identify associations between an individual's genetic profile and his/her response to drugs.
- Trial name
- NCT00418015
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 293 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Caesarean Section, Pain, Acute
Subarachnoid Block With Ultrasound-Guided Transversalis Fascia Plane Block for Cesarean Section
Postoperative pain management is critical for the fulfillment of the maternal duties. The transversalis fascia plane (TFP) block provides adequate postoperative analgesia in the T12 and L1 dermatomes.
- Trial name
- NCT04172727
- Testing
- Bupivacaine Hcl 0.25% Inj, saline 0.9%
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
Comparing the Effect of Spinal Bupivacaine Versus Spinal Prilocaine on Maternal Blood Pressure in Cesarean Section
one of the most common complications associated with spinal anesthesia is hypotension, which can have adverse effects on both the mother and the fetus.
- Trial name
- NCT06290583
- Testing
- Bupivacaine, Prilocaine
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- South Valley University
Postoperative Pain
Ropivacaine Transversus Abdominis Plane Blocks for Cesarean Section Analgesia
With this research the investigators hope to determine the lowest dose of ropivacaine used in transversus abdominis plane (TAP) blocks that can effectively treat pain in women after cesarean section (c-section).
- Trial name
- TAPROPI (NCT02893423)
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Maimonides Medical Center
Postoperative Pain
Measuring Pain Intensity in Cesarean Patients
Pain intensity is commonly measured in research and clinical settings. Primary objective: To evaluate psychometric properties (validity, reliability, and utility) of 5 pain measurement tools: a verbal 11-point NRS, the FPS-R, a…
- Trial name
- NCT06187688
- Testing
- Questionnaire
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- Prince of Songkla University
Obesity, Complications; Caesarean Section, Wound
Silver Impregnated Dressings to Reduce Wound Complications in Obese Patients at Cesarean Section
Obese patients undergoing cesarean section are at high risk for wound complications, which occur in approximately 20% of patients.
- Trial name
- NCT01528696
- Testing
- Silverlon, Standard Dressing
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Delivery Complication, Cesarean Delivery Affecting Fetus
Time of Oxytocin Initiation at 2nd Stage of Labor and Adverse Outcomes
Early oxytocin administration at the 2nd stage of labor is associated with a higher rate of vaginal delivery, shorter second stage duration, and fewer adverse maternal and neonatal outcomes.
- Trial name
- NCT06181396
- Testing
- Oxytocin
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Postoperative Pain Control
Ultrasound-guided TAP Block Vs Local Wound Infiltration for Analgesia After Cesarean Section.
Adequate pain control after cesarean delivery is a major concern for both parturients and obstetrician, and it usually comprise a combination of systemic and regional techniques.
- Trial name
- NCT04711096
- Testing
- Ultrasound-guided transversus abdominis plane (TAP) block 0.25% bupivacaine.
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Quality of Life, Breastfeeding
Quality of Recovery in Parturients Consumed Preoperative Carbohydrate Fluid for Elective Cesarean Delivery
The establishment of the Enhanced Recovery After Cesarean protocols resulted in to the production of specific care pathways with the aim of optimizing recovery after cesarean delivery (CD) and to reduce the costs to the health…
- Conditions
- Quality of Life, Breastfeeding, Postoperative Pain, Postoperative Nausea
- Trial name
- QoR-10 (NCT05841693)
- Testing
- Carbohydrate
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karamanoğlu Mehmetbey University
Cesarean Delivery
Comparative Mixture of Non-racemic and Racemic Enantiomers of Bupivacaine in Cesarean
The purpose of this study is to determine if the mixture of enantiomers of bupivacaine (bupivacaine S75:R25) dos not represent inferiority efficacy and safety compare to the racemic mixture of enantiomers of bupivacaine…
- Trial name
- NCT01303107
- Testing
- Bupivacaine
- Where
- 2 sites in Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Cristália Produtos Químicos Farmacêuticos Ltda.
Cesarean Section
Bladder Flap Versus Omission of Flap During Cesarean Section of Primiparous Women
Cesarean section is the most common surgical procedure performed on women. Over the years minor variations of each surgical step have been introduced, and cesarean sections are not standardized and many different techniques are…
- Trial name
- NCT02977871
- Testing
- Bladder flap
- Where
- Turkey (Türkiye)
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
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