Clinical trials: C.Surgical Procedure
Delirium, C.Surgical Procedure; Cardiac
Dexmedetomidine and Delirium in Patients After Cardiac Surgery
Postoperative delirium (POD) is a frequently occurring complication after cardiac surgery. Its occurrence is associated with worse outcomes of patients, including increased morbidity, prolonged hospital stay, increased medical…
- Conditions
- Delirium, C.Surgical Procedure; Cardiac, Postoperative Complications
- Trial name
- NCT02267538
- Testing
- dexmedetomidine hydrochloride for injection, 0.9% sodium chloride for injection
- Where
- China
- Volunteers
- 285 people
- Sponsor
- Peking University First Hospital
C.Surgical Procedure; Cardiac
Prospective Trial of Tranexamic Acid in Cardiac Surgery
Tranexamic acid, an antifibrinolytic drug, is wildly used in cardiac surgeries to decrease perioperative bleeding and allogenic transfusion. But the optimum dose of tranexamic acid is still unknown.
- Trial name
- NCT01998438
- Testing
- Tranexamic Acid
- Where
- China
- Volunteers
- 955 people
- Sponsor
- Hongwen Ji
C.Surgical Procedure; Cardiac
Hemodynamic Monitoring, Positive Inotropic and Vasoactive Drugs During Cardiac Surgery (EMOA)
Describe the proportion of patients who underwent cardiac surgery in France and benefiting from a monitoring cardiac output, describe the use of positive inotropic and vasoactive agents for cardiac surgery patients operated (type…
- Trial name
- EMOA (NCT02571920)
- Where
- France
- Volunteers
- 3,099 people
- Sponsor
- University Hospital, Caen
C.Surgical Procedure; Cardiac
High-risk Patients in Cardiac Surgery Procedures: HiriSCORE
Over time there is a need to improve old and develop new risk models. Overall the assessment of mortality risk in cardiac surgery is performed with the use of preoperative risk models.
- Trial name
- HiriSCORE (NCT02560285)
- Where
- Brazil
- Volunteers
- 3,000 people
- Sponsor
- University of Sao Paulo General Hospital
C.Surgical Procedure; Cardiac
Ketamine Pharmacokinetics in Children Having Heart Surgery
What are the pharmacokinetics of ketamine in infants and children requiring ketamine for induction of anesthesia for cardiac surgery that requires CPB? Specific Aim 1: To determine the pharmacokinetic parameters of a single…
- Trial name
- NCT00598195
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Arkansas Children's Hospital Research Institute
C.Surgical Procedure; Digestive System
Caffeinated Gum to Prevent Post-Operative Ileus: A Prospective, Randomized, Placebo-controlled Trial
This is a randomized, three-arm, double-blind, placebo-controlled, Phase III clinical trial of caffeinated gum and sugar-less gum in adult patients after an abdominal procedure.
- Trial name
- NCT02250924
- Testing
- Caffeine, Gum, wear silicone bracelet
- Where
- United States
- Sponsor
- The Guthrie Clinic
C.Surgical Procedure; Cardiac, Delirium
Decreasing the Incidence of Delirium After Cardiac Surgery
In critically ill surgical patients, delirium (confusion and disorientation) is extremely common and is associated with longer hospital length of stay, mortality, cost, and long term cognitive impairment.
- Trial name
- NCT02119806
- Testing
- Benzodiazepine, Fentanyl, Propofol
- Where
- United States
- Sponsor
- University of California, Los Angeles
Blood Coagulation Disorders, C.Surgical Procedure; Cardiac
Blood Cell Adhesion to Arterial Filters During Cardiac Surgery
Cardiopulmonary bypass (CPB) is a unique clinical scenario that results in widespread activation of the hemostatic system. Conventional CPB interferes with normal hemostasis by diluting hemostatic cells and proteins, through…
- Trial name
- NCT03882593
- Testing
- Analysis of arterial filters after CPB
- Where
- Brazil
- Volunteers
- 28 people
- Sponsor
- Instituto do Coracao
C.Surgical Procedure; Cardiac
PWV for Cardiovascular Complication After Cardiac Surgery
Arterial stiffness has been suggested as an independent risk factor for the development of coronary artery disease and stroke. Pulse wave velocity (PWV) is an noninvasive established index to quantify arterial stiffness.
- Trial name
- NCT02014012
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
C.Surgical Procedure; Disruption of Wound, Suture
Use of Stratafix Symmetric™ to Prevent Incisional Hernia in Gastrointestinal and Abdominal Surgery
Comparing the use of Stratafix Symmetric™ sutures to standard laparotomy closure sutures.
- Trial name
- STRATA-G (NCT06063577)
- Testing
- Stratafix suture, Standard of care suture
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- West Michigan Cancer Center
Atrial Fibrillation, Atrial Flutter
Detection of Atrial Fibrillation After Cardiac Surgery
The aim of the SEARCH-AF trial is to evaluate a novel diagnostic tool for detecting post-operative atrial fibrillation or flutter (POAF/AFL) in cardiac surgical subjects during the early, sub-acute post-operative period.
- Conditions
- Atrial Fibrillation, Atrial Flutter, C.Surgical Procedure; Cardiac, Arrhythmias, Cardiac
- Trial name
- SEARCH-AF (NCT02793895)
- Testing
- Medtronic SEEQ™ mobile cardiac telemetry system, Usual Care, CardioSTAT (Icentia Inc.) cardiac rhythm monitoring device
- Where
- 10 sites in Canada
- Volunteers
- 336 people
- Sponsor
- Unity Health Toronto
Systemic Inflammatory Response Syndrome, C.Surgical Procedure; Cardiac
Studying Complement Inhibition in Complex Cardiac Surgery
The trial enrolls patients undergoing a complex cardiac surgery. The primary goal of the trial is to evaluate the pharmacodynamic dose response relationship of the monoclonal antibody IFX-1 in these patients.
- Trial name
- CARDIAC (NCT02866825)
- Testing
- IFX-1
- Where
- 10 sites in Germany
- Volunteers
- 116 people
- Sponsor
- InflaRx GmbH
C.Surgical Procedure; Cardiac, Right-Sided Heart Failure
Evaluation of Monitoring TECHNOlogies in the PERI-OPerative Care of Cardiac Surgical Patients
The purpose of this prospective observational cohort study is to evaluate multimodal monitoring technologies in the perioperative care of cardiac surgical patients.
- Conditions
- C.Surgical Procedure; Cardiac, Right-Sided Heart Failure, Acute Kidney Injury, Respiratory Insufficiency
- Trial name
- TechnoPeriOp (NCT02658006)
- Testing
- Cardiac surgery
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Montreal Heart Institute
C.Surgical Procedure; Digestive System, Symptomatic Disorders of the Gastrointestinal Tract
An International, Multicentric, Prospective, Observational Study to Evaluate Monosyn® Suture Material for Anastomoses in the Gastrointestinal Tract
The aim of this non-interventional study is to evaluate the efficacy of a monofilament, mid-term absorbable suture material (Monosyn®) for anastomosis performed in the gastrointestinal tract using the frequency of anastomosis…
- Conditions
- C.Surgical Procedure; Digestive System, Symptomatic Disorders of the Gastrointestinal Tract, Gastric Anastomosis (Site), Gastrointestinal Neoplasms
- Trial name
- PROMEGAT (NCT02080702)
- Testing
- Monosyn
- Where
- 5 sites in Malaysia, Philippines and 2 more
- Volunteers
- 106 people
- Sponsor
- Aesculap AG
C.Surgical Procedure; Cardiac
Albumin in Cardiac Surgery
Colloid solutions are widely used for volume replacement therapy because of their high oncotic pressure, which could reduce interstitial fluid shifting.
- Trial name
- ALBICS (NCT02560519)
- Testing
- Albumin solution, Ringers acetate solution
- Where
- Finland
- Volunteers
- 1,386 people
- Sponsor
- Helsinki University Central Hospital
C.Surgical Procedure; Gastrointestinal
Triple Therapy for Postoperative Nausea and Vomiting in Laparoscopic Gastrointestinal Surgery
Postoperative nausea and vomiting (PONV) are common in patients, especially in patients at high risk. PONV may result in prolonged hospital stay and threaten patients' life.
- Trial name
- NCT04853147
- Testing
- palonosetron, dexamethasone, and fosaprepitant dissolved in 0.9% NaCl, palonosetron, dexamethasone, and 0.9% NaCl
- Where
- China
- Volunteers
- 1,154 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
C.Surgical Procedure, Cardiac
Steroids and Microcirculation In Cardiac Surgery
Cardiac surgery is sometimes associated with organ dysfunction of variable severity (renal insufficiency, cognitive decline, arrhythmias, ARDS).
- Trial name
- SICS (NCT02798068)
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Erasme University Hospital
C.Surgical Procedure; Cardiac, Blood Coagulation Disorders
Effects of Prophylactic Desmopressin on Blood Coagulation Parameters in Heart Valve Surgery
The purpose of this study is evaluate the effect of prophylactic desmopressin on blood coagulation parameters and postoperative bleeding in patients undergoing valve cardiac surgery with cardiopulmonary bypass.
- Trial name
- NCT03343418
- Testing
- Desmopressin
- Where
- Brazil
- Volunteers
- 108 people
- Sponsor
- Instituto do Coracao
C.Surgical Procedure; Dehiscence, Cesarean Section
Zip Incision Approximation vs. Suture for C-Section
The study will evaluate the ZipLine Medical Surgical Skin Closure device (Zip)versus sutures when utilized for skin layer closure during wound closure of Cesarean Section Procedure.
- Trial name
- ZIPS-C (NCT02915952)
- Testing
- Zip Surgical Skin Closure Device, Conventional Sutures
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ZipLine Medical Inc.
C.Surgical Procedure; Cardiac, Haemorrhage.
Safety and Performance of 032-11 Haemostat in Cardiac and Thoracic Aortic Surgery
The effectiveness objective of this study is to evaluate whether 032-11 is non-inferior to Floseal as an adjunct to achieving haemostasis during surgical procedures involving cardiac and aortic thoracic surgery.
- Trial name
- NCT01879475
- Testing
- 032-11, Floseal (R)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Medtrade