Clinical trials: CAD
Coronary Artery Disease (CAD), Ischemic Heart Disease
Coroflex® ISAR NEO PMCF Study
International, Multicenter, prospective, non-randomized, post-market clinical follow-up (PMCF) study to confirm and support the clinical safety and performance of Coroflex® ISAR NEO coronary stent system to meet EU Medical Device…
- Trial name
- rEPIC07 (NCT05698732)
- Testing
- Coroflex® ISAR NEO coronary stent system
- Where
- 26 sites in France, Spain and 1 more
- Volunteers
- 3,000 people
- Sponsor
- Fundación EPIC
Percutaneous Coronary Intervention (PCI), Coronary Arterial Disease (CAD)
Medipixel XA-Assisted PCI in Coronary Artery Disease
This prospective, multicenter, single-arm, interventional study evaluates the effectiveness and safety of Medipixel XA-Assisted Percutaneous Coronary Intervention (MPXA-PCI) in patients with coronary artery disease (CAD).
- Trial name
- MAP I (NCT06985693)
- Testing
- Medipixel XA-Assisted Percutaneous Coronary Intervention
- Where
- 6 sites in South Korea
- Volunteers
- 830 people
- Sponsor
- CHA University
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))
Barriers Limiting OCT Penetration in Clinical Practice
The updated guidelines from the European Society of Cardiology (ESC) for chronic coronary syndrome (CCS) have upgraded the use of IVUS and OCT to a class IA recommendation for complex PCI, based on evidence showing a reduction in…
- Trial name
- OCT2ACT (NCT07193693)
- Where
- 2 sites in Italy
- Volunteers
- 1,189 people
- Sponsor
- Consorzio Futuro in Ricerca
Coronary Arterial Disease (CAD), de Novo Lesions in Native Coronary Arteries
AGENT DCB STANCE: Safety and Effectiveness Study of AGENT Drug-Coated Balloon Compared to Standard of Care Percutaneous Coronary Intervention (PCI) Treatment for de Novo Coronary Lesions
AGENT DCB STANCE is a prospective, multicenter, open-label, 1:1 randomized controlled study designed to assess the safety and effectiveness of a treatment strategy with the AGENT Drug-Coated Balloon compared to standard of care…
- Trial name
- NCT06959524
- Testing
- Drug Eluting Balloon, Drug eluting stent, Plain old balloon angioplasty
- Where
- 71 sites in United States, Australia and 7 more
- Volunteers
- 1,616 people
- Sponsor
- Boston Scientific Corporation
Enamel Hypoplasia, Molar-Incisor Hypomineralization (MIH)
Clinical Comparison of CAD/CAM Nanohybrid Composite and Hybrid Ceramic Overlays in Children With Molar-Incisor Hypomineralisation
This clinical study was conducted to compare two different dental materials used in the treatment of children who have a condition called molar-incisor hypomineralization (MIH).
- Conditions
- Enamel Hypoplasia, Molar-Incisor Hypomineralization (MIH), Restoration of Permanent Molars Affected by MIH With CAD/CAM Blocks
- Trial name
- NCT06987448
- Testing
- Semi-direct onlay restoration using CAD/CAM hybrid composite block, Semi-direct onlay restoration using CAD/CAM hybrid ceramic block
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Alp Akça
Angina (Stable), Coronary Artery Disease(CAD)
Study of Lesion-Specific Invasive Haemodynamic Angina Thresholds
ORBITA-SOLAR is an invasive physiological cardiac catheterisation study that aims to determine whether different coronary stenoses have different angina thresholds.
- Conditions
- Angina (Stable), Coronary Artery Disease(CAD), Ischaemic Heart Disease (IHD)
- Trial name
- ORBITA-SOLAR (NCT07386418)
- Testing
- Percutaneous coronary intervention (PCI), Measurement of the angina threshold
- Where
- 7 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- Imperial College London
Acute Coronary Syndromes (ACS), Coronary Artery Disease (CAD)
Fexuprazan for Prevention of Upper Gastrointestinal Bleeding in High Bleeding Risk Patients Receiving Dual Antiplatelet Therapy
This study evaluates whether fexuprazan is effective in preventing upper gastrointestinal bleeding and related upper gastrointestinal clinical events in high bleeding risk patients who require dual antiplatelet therapy after…
- Trial name
- SAINT-FEXUDAPT (NCT07479056)
- Testing
- Fexuprazan 40mg, Lansoprazole 30mg
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- SUK MIN SEO
Elderly, Coronary Arterial Disease (CAD)
GOT VOICE GROUP SINGING
Unlike traditional physical exercise, the impact of singing on cardiovascular health has not been extensively studied. Endothelial dysfunction predicts cardiovascular events, and physical exercise improves vascular endothelial…
- Trial name
- GOT VOICE (NCT07881692)
- Testing
- In-Person Group Singing, instructional sing-along video series, Weekly health education
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Medical College of Wisconsin
Coronary Arterial Disease (CAD), Vulnerable Coronary Plaques
Effectiveness of Interventional Therapy for Non-Flow-Limiting Vulnerable Plaques
The aim of this clinical trial is to explore the optimal preventative treatment strategy for non-flow-limiting vulnerable plaques.
- Conditions
- Coronary Arterial Disease (CAD), Vulnerable Coronary Plaques, Thin-cap fIbroatheroma, Acute Coronary Syndromes (ACS)
- Trial name
- NCT06855537
- Testing
- PCI strategy, OMT strategy
- Where
- China
- Volunteers
- 2,190 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Disease (CAD), Menopause
Serum Endogenous Estrogens, Estrogen Receptors, and Sirtuin-1 and -3 After Resveratrol Supplementation
Atherosclerotic coronary artery disease (CAD) is a leading cause of mortality among postmenopausal women. Resveratrol, a phenolic compound with antioxidant properties, may influence lipid metabolism, endothelial function, and…
- Conditions
- Coronary Artery Disease (CAD), Menopause, Hormones
- Trial name
- RESEARCH (NCT07865377)
- Testing
- Trans-resveratrol, 1000 mg daily for 90 days
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- InCor Heart Institute
Coronary Artery Disease (CAD)
1-Month Versus 6-Month Dual Antiplatelet Therapy After Successful Drug-Coated Balloon-Only Percutaneous Coronary Intervention
This study will compare the clinical outcomes of a 1-month dual antiplatelet therapy (DAPT) strategy with a standard 6-month DAPT strategy in patients undergoing successful drug-coated balloon-only percutaneous coronary…
- Trial name
- ADAPT-DCB (NCT07879430)
- Testing
- 1-Month DAPT, 6-Month DAPT
- Volunteers
- 1,258 people
- Sponsor
- Ulsan University Hospital
CAD/CAM, 3D-printed
Clinical Evaluation of 3D-Printed Resin Versus CAD/CAM-Milled Lithium Disilicate Overlay Restorations
The aim of this study is to clinically evaluate the performance of 3D-printed resin and CAD/CAM lithium disilicate overlay restorations.
- Conditions
- CAD/CAM, 3D-printed, Lithium Disilicate, Overlay Restorations
- Trial name
- NCT07853118
- Testing
- 3D-printed ODYX-CR ceramic-filled resin, CAD/CAM-milled lithium disilicate ceramic
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tanta University
Coronary Arterial Disease (CAD)
The Switching Antiplatelet-9 (SWAP-9) Study
The purpose of this study is to compare the pharmacodynamic effects of ABCD-GENE guided vs. unguided de-escalation strategies among patients on dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI).
- Trial name
- SWAP-9 (NCT06588595)
- Testing
- Prasugrel/Ticagrelor monotherapy or aspirin plus clopidogrel, Aspirin plus clopidogrel
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Florida
Coronary Arterial Disease (CAD), Percutaneous Coronary Intervention (PCI)
Dual Antiplatelet Therapy Escalation From Standard-dose Clopidogrel to Low-Dose Prasugrel in Patients With High Bleeding and Ischemic Risk Undergoing PCI: A Prospective, Randomized Pharmacodynamic Study (TAILOR-BLEED-2)
The primary aim of this study is to investigate the PD effects of switching from standard-dose clopidogrel dose to low-dose prasugrel versus continuing standard-dose clopidogrel in patients at dual-risk (HBR defined as the…
- Trial name
- NCT07025148
- Testing
- Prasugrel, Clopidogrel
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Florida
Aortic Valve Stenosis and Insufficiency, Coronary Artery Disease(CAD)
Assessment of Coronary Artery Disease Before Transcatheter Aortic Valve Replacement: A Randomized, Multicenter, Non-Inferiority Trial
The goal of this clinical trial is to determine whether a non-invasive coronary assessment strategy using photon-counting detector computed tomography (PCD-CT) is non-inferior to invasive coronary angiography (ICA) for evaluating…
- Conditions
- Aortic Valve Stenosis and Insufficiency, Coronary Artery Disease(CAD), Transcatheter Aortic Valve Replacement (TAVR)
- Trial name
- TAVR-CT (NCT07107568)
- Testing
- Standard Invasive Coronary Angiography, PCD-CT-Guided Diagnostic Strategy
- Where
- 2 sites in Austria
- Volunteers
- 700 people
- Sponsor
- Medical University Innsbruck
Coronary Artery Disease (CAD), Stable Angina Pectoris
Identification of Lesion Characteristics in Coronary Plaques Using Multimodality Intravascular Imaging and Novel Photon-counting CT in Stable Angina
Coronary artery disease, caused by the furring up of the heart arteries by atherosclerosis, is a major cause of death in the UK.
- Conditions
- Coronary Artery Disease (CAD), Stable Angina Pectoris, Ischaemic Heart Disease (IHD)
- Trial name
- ILUMINA (NCT07864025)
- Testing
- observational study
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Queen Mary University of London
Coronary Artery Disease (CAD)
Predicting Plaque Growth Using Blood Flow Stress Markers: A Proof-of-Concept Study
Coronary artery disease occurs when fatty deposits (plaques) build up inside the arteries that supply blood to the heart. Some plaques remain stable, while others continue to grow or become more likely to rupture, which can lead…
- Trial name
- POSSEM (NCT07864051)
- Testing
- PCCTA scan, Endothelial cell isolation from peripheral blood sample
- Where
- United Kingdom
- Volunteers
- 270 people
- Sponsor
- Queen Mary University of London
Heart Failure, CAD - Coronary Artery Disease
Risk Stratification of MACE in Heart Failure Patients Who Undergoing CABG
PROFILE-HF is a multicenter, observational, prospective study of the clinical course and outcomes of chronic heart failure (HF) and coronary artery disease (CAD) in patients undergoing coronary artery bypass grafting (CABG).
- Conditions
- Heart Failure, CAD - Coronary Artery Disease, CABG
- Trial name
- PROFILE-HF (NCT07480915)
- Where
- Russia
- Volunteers
- 160 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Acute STEMI, PPCI
On vs Off-hour PPCI in STEMI Patients
ST-elevation myocardial infarction (STEMI) remains a leading cause of morbidity and mortality globally, and timely reperfusion with primary percutaneous coronary intervention (PPCI) is the gold-standard treatment1.
- Conditions
- Acute STEMI, PPCI, Observational Study, Coronary Artery Disease (CAD)
- Trial name
- On vs Off PPCI (NCT07860086)
- Where
- Egypt
- Volunteers
- 450 people
- Sponsor
- Assiut University
CAD - Coronary Artery Disease
EXIT-CVD Project: Evidence Based Exit Strategies for the Cardiovascular Disease Continuum Trough Early Detection, Treatment and Evaluation
This prospective, single-center interventional imaging study aims to evaluate the diagnostic performance of Photon Counting Computed Tomography (PCCT) combined with artificial intelligence-based Quantitative Coronary CT (AI-QCT)…
- Trial name
- EXIT-CVD (NCT07857031)
- Testing
- Photon Counting Computed Tomography (PCCT)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Centro Cardiologico Monzino