Clinical trials: CAD
Coronary Artery Disease
Feasibility and Safety Study Comparing REG1 Anticoagulation System With Unfractionated Heparin in Elective PCI
The purpose of this study is to determine if it is feasible and safe to use the REG1 Anticoagulation System instead of unfractionated heparin during percutaneous coronary intervention (PCI) in subjects with coronary artery…
- Trial name
- REVERSAL-PCI (NCT00715455)
- Testing
- REG1, Unfractionated Heparin
- Where
- 6 sites in United States, Argentina
- Volunteers
- 26 people
- Sponsor
- Regado Biosciences, Inc.
Obesity & Overweight, Coronary Heart Disease
Effect of Mazdutide on Coronary Plaque in Patients With Coronary Atherosclerosis and Overweight or Obesity
This multicenter, randomized, double-blind, placebo-controlled trial aims to evaluate the effect of mazdutide, a dual GLP-1/GCG receptor agonist, on coronary plaque progression assessed by coronary computed tomography angiography…
- Trial name
- NCT07657676
- Testing
- Mazdutide
- Where
- China
- Volunteers
- 116 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Disease
2nd International Survey on Interventional Strategies
The study aims to evaluate the decision-making pathways of interventional cardiologists, when assessing patients, presented with stable coronary artery disease.
- Trial name
- NCT04001452
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Coronary Atherosclerosis
Role of Mitophagy in Myeloid Cells During Coronary Atherosclerosis.
Atherosclerosis (deposition of a plaque essentially composed of lipids on the artery walls) is a frequent condition and is a leading cause of death worldwide.
- Trial name
- MITOCARDIA (NCT05708547)
- Testing
- Blood samples, myocardial tissue samples, Data collection
- Where
- France
- Volunteers
- 61 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Gout, Coronary Atheroma
The Correlation Between Sodium Urate (MSU) Deposition and Coronary Atherosclerosis in Patients With Foot Gout
This observational study aims to evaluate the association between sodium urate deposition volume and coronary atherosclerotic plaques in patients with foot gout using dual-energy CT (DECT) and coronary CTA.
- Trial name
- NCT07784049
- Testing
- DECT;CCTA
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Coronary Artery Disease, Percutaneous Coronary Intervention
Clinical and Genetic Characteristics of Coronary Artery Disease in Chinese Young Adults
The aim of this study is to identify genetic loci,or gene variations contributing to the development of coronary artery disease (CAD) in Chinese young adults.
- Trial name
- GRAND (NCT02496858)
- Where
- 38 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Dental Implant, Computer-assisted
Accuracy of Static Computer-assisted Implant Surgery in Distal Free-end Scenarios
Technological advances have influenced the approach to implant treatment. One of the fields presently experiencing rapid development is static computer-assisted guided surgery (sCAIS), which allows transfer of the virtual implant…
- Trial name
- NCT06404385
- Testing
- Static computer-assisted guided surgery with analogic guide, Static computer-assisted guided surgery with CAD-CAM surgical guide
- Where
- Spain
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Type 2 Diabetes, Coronary Artery Disease (CAD)
Evaluating Atherosclerotic Disease Progression in Patients With Diabetes Mellitus
People with type 2 diabetes have a much higher risk of heart disease. One common problem is when the blood vessels that supply the heart become narrowed or blocked by fatty deposits, called plaque.
- Conditions
- Type 2 Diabetes, Coronary Artery Disease (CAD), Atherosclerosis Cardiovascular Disease
- Trial name
- EVOLVE (NCT07237685)
- Where
- 2 sites in Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Frailty
Frailty Assessment in Cardiac Surgery
With increasing life expectancy, cardiac surgical procedures are increasingly being performed in older adults. The biological syndrome of frailty is an aging-associated state with diminished physiological reserve and resistance…
- Trial name
- NCT04191915
- Where
- Turkey (Türkiye)
- Volunteers
- 164 people
- Sponsor
- Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital
Chronic Heart Failure, Coronary Artery Disease
The Influence of Metformin on Chronic Heart Failure Clinical Course in Patients With Prediabetes
It is well known fact, that prediabetes is a predictor of high cardiovascular mortality, increasing the risk of developing such adverse cardiovascular events as myocardial infarction, stroke and sudden cardiac death.
- Conditions
- Chronic Heart Failure, Coronary Artery Disease, PreDiabetes
- Trial name
- NCT04549415
- Testing
- Metformin Hydrochloride, lifestyle modification
- Where
- Kyrgyzstan
- Volunteers
- 97 people
- Sponsor
- National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
Coronary Artery Disease
Optical CoherenCe Tomography-gUided Coronary Intervention in Patients With Complex lesIons: a Randomized Controlled Trial (OCCUPI Trial)
There is no definite conclusive work about the benefit of OCT-guided PCI, which should be determined in complex PCI, assuming better stent optimization by OCT.
- Trial name
- NCT03625908
- Testing
- OCT-guided PCI, Angiography-guided PCI
- Where
- South Korea
- Volunteers
- 1,604 people
- Sponsor
- Yonsei University
Coronary Artery Disease, Angina Pectoris
Prevention of Instent Renarrowing With Aggressive Glucose Lowering With Pioglitazone in Diabetic Patients
Patients with diabetes have worse outcomes after percutaneous coronary intervention (PCI) procedures, compared to those patients without diabetes.
- Conditions
- Coronary Artery Disease, Angina Pectoris, Type 2 Diabetes Mellitus, Percutaneous Coronary Intervention
- Trial name
- PPAR-G (NCT00819325)
- Testing
- pioglitazone, oral hypoglycemic agents
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Queen Elizabeth II Health Sciences Centre
Arterial Occlusion, Angina Pectoris
Comparing TR Band to Statseal in Conjunction With TR Band
The primary objectives of this study are to evaluate the performance of StatSeal Advanced used in conjunction with the TR Band (SSA) as compared to the TR Band without SSA (TRB) relative to: the incidence of peri-procedural…
- Conditions
- Arterial Occlusion, Angina Pectoris, Cardiovascular Diseases, Atherosclerosis
- Trial name
- NCT03028025
- Testing
- StatSeal, TR Band
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- VA Long Beach Healthcare System
Dental Implant, Computer
Accuracy of Computer- Guided Implant Surgery in Partially Edentulous Patients.
The dental implant placed freehand with a digital planing is vastly increasing. The accuracy between the planned and the placed implants still not well determined.
- Trial name
- NCT06277076
- Testing
- Computer Implant guided Surgery
- Where
- Lebanon
- Volunteers
- 13 people
- Sponsor
- Saint-Joseph University
Coronary Heart Disease (CHD)
Metoprolol and Trimetazidine for Coronary Heart Disease With Angina
This is a prospective, randomized study to evaluate the effectiveness and safety of combining metoprolol succinate with trimetazidine compared to standard therapy for patients with coronary heart disease (CHD) and angina…
- Trial name
- NCT07074834
- Testing
- Metoprolol Succinate Sustained-Release Tablets, Trimetazidine, Routine Drug Therapy
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Shiyan City Renmin Hospital
Coronary Heart Disease, Atherosclerosis
Fluvastatin AmelIorates aTHerosclerosis Study
The study is designed to assess the effect of statin on atherosclesrosis progression as well as to explore its potential mechanism besides lipid modifying , such as effect on inflammation and vascular calcification.
- Trial name
- FAITH (NCT01681199)
- Testing
- Fluvastatin extended release tablet
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Disease
Hpx•apoB Product as a Biomarker for Coronary Artery Disease
This was a single-center, cross-sectional study designed to investigate a novel composite biomarker, the Hemopexin-Apolipoprotein B (Hpx•apoB) product, for its association with coronary artery disease (CAD).
- Trial name
- NCT07126132
- Testing
- Coronary Angiography, Hpx•apoB Product Measurement
- Where
- China
- Volunteers
- 460 people
- Sponsor
- Shiyan City Renmin Hospital
Cardiovascular Risk Factors, Coronary Disease
Cardiopulmonary Resuscitation (CPR) Dissemination Study Using Nurses and Volunteers
Each year in the United States, 300,000 people suffer from Cardiac Arrest (CA), and of them there is a 90% mortality rate. Out-of-Hospital arrests in particular have a 1-5% survival to hospital discharge.
- Conditions
- Cardiovascular Risk Factors, Coronary Disease, Cardiac Arrest
- Trial name
- NCT01252316
- Testing
- CPR Training using the Family and Friends CPR Anytime VSI Kit, Implementation of an In-Hospital CPR Training Model
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Coronary Arteriosclerosis
Association Between Carotid Plaque Length and Cardiovascular Events
This multicenter study involved 5 hospitals (Changhai Hospital; Yueyang Hospital of Shanghai University of Traditional Chinese Medicine; Gongli Hospital; Putuo Hospital of Shanghai University of Traditional Chinese Medicine; No.
- Trial name
- NCT05159804
- Where
- 5 sites in China
- Volunteers
- 3,637 people
- Sponsor
- Changhai Hospital
Coronary Artery Disease
A Trial of Bare Metal Stent - Cobalt Chromium Versus Stent Coating With Sirolimus
The objective of this study is to evaluate the security issues and efficacy of coronary stenting Cobalt Chrome covered with sirolimus-eluting Cobalt Chrome platform in patients with coronary artery lesion.
- Trial name
- INSPIRON (NCT01093391)
- Testing
- DRUG ELUTING STENT, BARE METAL STENT
- Where
- 4 sites in Brazil
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Scitech Produtos Medicos SA