Clinical trials: CAN
Critically Ill Patients Who Are Not Allowed to Eat Orally But Can Initiate Enteral Nutrition Within 48 Hours of ICU
Association of Biomarkers and Gastric Antral Motility Index With Feeding Intolerance in Critically Ill Patients
When the subjects are admitted to the department, the researchers will monitor potential biomarkers of gastrointestinal injury before administering enteral nutrition (a small amount of blood is drawn, serum is separated by…
- Trial name
- NCT07178626
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 160 people
- Sponsor
- The First Hospital of Jilin University
To Evaluate the Efficacy of Fruquintinib and Pirfenidone in Combination With Anti-PD-1 Antibody in Colorectal Carcinoma, To Evaluate Whether Pirfenidone Can Reshape the Tumor Microenvironment in Colorectal Cancer
Fruquintinib and Pirfenidone in Combination With Anti-PD-1 Antibody in Advanced or Metastatic pMMR/MSS Colorectal Carcinoma
The purpose of this study is to evaluate the efficacy and safety of fruquintinib and pirfenidone in combination with anti-PD-1 antibody in patients with standard treatment failure of advanced or metastatic pMMR/MSS colorectal…
- Conditions
- To Evaluate the Efficacy of Fruquintinib and Pirfenidone in Combination With Anti-PD-1 Antibody in Colorectal Carcinoma, To Evaluate Whether Pirfenidone Can Reshape the Tumor Microenvironment in Colorectal Cancer, Combination of Fruquintinib and Anti-PD-1 Antibody Was Reported to Improve Patient Prognosis in Colorectal Cancer
- Trial name
- NCT06484153
- Testing
- Pirfenidone, Fruquintinib, Pembrolizumab
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Coronary Heart Disease, Diabetes
The Effect of Autonomic Neuropathy Status on the Endpoint Events in Diabetes Patients With Coronary Heart Disease and Sleep Apnea.
Background: diabetes combined with cardiac autonomic neuropathy (CAN) can denervate the heart, which may prevent patients with sleep apnea syndrome from bradycardia in the early stage, and directly show an increased risk of…
- Conditions
- Coronary Heart Disease, Diabetes, Sleep Apnea Syndrome, Cardiovascular Autonomic Neuropathy (CAN)
- Trial name
- NCT07723222
- Testing
- The total score of Ewing test (i.e. cardiovascular autonomic reflex test and heart rate variability) was ≥1, which was divided into cardiac autonomic neuropathy group (CAN grou
- Volunteers
- 326 people
- Sponsor
- Xiangtan Central Hospital
Typical Development, Typically Developing Children Ages 3 to 6
Assessment of Language Comprehension and Learning in Children Attending Child Psychiatry Services (TICOALA-SOINS)
Language is central to children's cognitive, emotional, and social development, and language difficulties are a frequent reason for consultation in child psychiatry, often co-occurring with psychiatric disorders.
- Conditions
- Typical Development, Typically Developing Children Ages 3 to 6, Typical Preschoolers Who Can Not Zipper, Children
- Trial name
- TICOALA-SOINS (NCT07283458)
- Testing
- TICOALA
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Acute Rejection (AR) of Transplanted Kidney, Chronic Allograft Nephropathy (CAN)
Proteogenomic Monitoring and Assessment of Kidney Transplant Recipients
Chronic Allograft Nephropathy (CAN)/Interstitial fibrosis and Tubular Atrophy (IFTA) is responsible for most kidney transplant failures. CAN/IFTA on a 3 month kidney biopsy strongly predicts graft survival long term.
- Conditions
- Acute Rejection (AR) of Transplanted Kidney, Chronic Allograft Nephropathy (CAN), Interstitial Fibrosis (IF), Tubular Atrophy (TA)
- Trial name
- Mini-Kidney (NCT01531257)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Northwestern University
Acute Kidney Injury (AKI), Coronary Artery Bypass Graft (CABG)
Effect of Cardiovascular Autonomic Neuropathy on AKI and Outcomes in Isolated CABG Surgery
This study aims to investigate the effects of Cardiovascular Autonomic Neuropathy (CAN) on Acute Kidney Injury (AKI) and clinical outcomes in patients undergoing isolated Coronary Artery Bypass Graft (CABG) surgery requiring…
- Conditions
- Acute Kidney Injury (AKI), Coronary Artery Bypass Graft (CABG), Cardiovascular Autonomic Neuropathy (CAN), Postoperative Outcomes
- Trial name
- CAN-AKI-CABG (NCT07254468)
- Where
- Turkey (Türkiye)
- Volunteers
- 912 people
- Sponsor
- Akdeniz University
To Understand Whether Increasing the Willingness to Exercise Can Improve Rehabilitation Outcomes (Upper Limb Motor Activation), for Patient With Stroke
Voice-Induced Motor Intention to Enhance Upper Limb Rehabilitation Efficacy of Exoskeleton Robots for Stroke Patients
This study aims to investigate whether combining "motor imagery" (the mental visualization of movement) with robotic exoskeleton therapy can improve upper limb recovery in stroke patients.
- Trial name
- NCT07398131
- Testing
- single-joint robot (Active Voice-Controlled Mode), single-joint robot (Passive Mode)
- Volunteers
- 32 people
- Sponsor
- Taipei Hospital, Ministry of Health and Welfare
To Explore Whether the Application of Intelligent Hypertension Management System Can Effectively Reduce Blood Pressure in Hypertensive Patients
Intelligent Hypertension Intervention Study
To explore whether the application of intelligent hypertension management system can effectively reduce blood pressure in hypertensive patients. A total of 320 eligible subjects will be recruited and randomization to two groups.
- Trial name
- NCT05526300
- Testing
- Intelligent Hypertension Management System, The standard care
- Where
- 3 sites in China
- Volunteers
- 320 people
- Sponsor
- Shanghai Tong Ren Hospital
Patients With Uterine Fibroids Receiving HIFUA Treatment ,and Can Undergo Regular Follow-up
The Clinical Application of Ultramicro-flow Technique in the Treatment of Benign Uterine Tumors With High-intensity Focused Ultrasound
High intensity focused ultrasound ablation (HIFUA) is a new non-invasive treatment method for uterine tumors. Traditionally, nuclear magnetic resonance imaging (NMRI), also known as magnetic resonance imaging (MRI), is used as…
- Trial name
- NCT06435663
- Testing
- Different methods of efficacy evaluation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
This is a Pilot Study Which Aims to Assess the Validity and Applicability of Lateral Flow Assays (LFAs) Which Can be Used as a Point of Care Test for COVID-19, Covid19
The LAVA (Lateral Flow Antigen Validation and Applicability) Study for COVID-19
This is a pilot study which aims to assess the validity and applicability of lateral flow assays (LFAs) which can be used as a point of care test for COVID-19.
- Trial name
- LAVA (NCT04629157)
- Testing
- Innova Lateral Flow Device
- Where
- 2 sites in United Kingdom
- Volunteers
- 400 people
- Sponsor
- Alder Hey Children's NHS Foundation Trust
Volunteers Who Can do Moderate Physical Activity
Effects of Eccentric Pedaling at Different Rates on Neuromuscular Function
The recent appearance of ergocycles that can be used for eccentric pedaling (Cyclus type) has aroused a growing interest in the field of rehabilitation.
- Trial name
- Exo-Mode 3 (NCT04886115)
- Testing
- Neuromuscular evaluation, Assessment of aerobic capacity, muscle architecture and habituation to the eccentric pedaling task, Pedaling at 15 rpm
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Determine the Number of Anatomical Sites at Which Successful Thermoacoustic Fat Measurements Can be Made From Five Acquisitions Using the FLIP ITA Device, Determine the Correlation of Fat Measures Obtained by the FLIP Device and Those Obtained From Quantitative MRI
Fatty Liver Imaging Project
This study is being done to test the FLIP device, a novel device developed and manufactured by Endra Life Sciences, located in Ann Arbor, Michigan.
- Conditions
- Determine the Number of Anatomical Sites at Which Successful Thermoacoustic Fat Measurements Can be Made From Five Acquisitions Using the FLIP ITA Device, Determine the Correlation of Fat Measures Obtained by the FLIP Device and Those Obtained From Quantitative MRI, Provide Insight Into the Sensitivity of Thermoacoustic Liver Fat Assessment With the Aim of Detecting Fat Content in Liver at 15% or Less, by Volume
- Trial name
- FLIP (NCT03757832)
- Testing
- Liver Imaging
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aaron Fenster
Explore Whether lncRNA-ElNAT1 in Urine Exosomes Can be Used as a New Target for Preoperative Diagnosis of Lymph Node Metastasis
A Prospective, Multicenter Cohort Study of Urinary Exosome lncRNAs for Preoperative Diagnosis of Lymphatic Metastasis in Patients With Bladder Cancer
Bladder cancer is one of the most frequent malignant tumors of the urinary system in China, seriously threatening the life safety of patients.
- Trial name
- NCT05270174
- Testing
- no intervention
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Preoperative Ultrasound Assessment of the Upper Airway Can Predict Difficult Laryngscopy in Obese at Emergency Operations
Ultrasonography in Predicting Difficult Intubation in Obese Emergency Surgical Patients
Validity of ultrasonography in predicting difficult laryngoscopy and confirming endotracheal intubation in obese emergency surgical patients
- Trial name
- NCT05109221
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 1 people
- Sponsor
- Minia University
Anyone Who Meets the Eligibility Criteria Can Use the Software
Validation of the Performance of the COBOX Solution for Measuring Heart Rate and Respiratory Rate
Quantiq.io "COBOX" is a software as a medical device. It relies on remote photoplethysmography, allowing for the remote measurement of a patient's physiological parameters from a healthcare professional's or patient's device…
- Trial name
- COBOX (NCT05528042)
- Testing
- Heart rate and respiratory rate measurement
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- Quantiq.io
Can BFR Cycling Augment Strength and VO2peak
BFR Training on a Bike to Augment RC Strength, Leg Strength, and VO2 Peak
This study will investigate if subjects who bike at 40% of heart rate reserve (HRR) with blood flow restriction (BFR) applied to bilateral thighs for 10 minutes (at 80% limb occlusion pressure) will experience greater gains in 10…
- Trial name
- NCT05344391
- Testing
- BFR cycling, Cycling without BFR
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- George Fox University
Can the Geriatric Questionnaires Predict Adverse Effects in Geriatric Breast Cancer Patients Treated With Cyclin-dependent Kinase 4 and 6 Inhibitors
Evaluation of Geriatric Questionnaires to Predict Toxicities of CDK 4/6 Inhibitors in Older Breast Cancer Patients?
CDK 4/6 inhibitors (palbociclib, ribociclib) have taken their place in our practice recently with their clinical benefits in the treatment of hormone-positive and HER2 negative metastatic breast cancer.
- Trial name
- NCT05051956
- Testing
- Palbociclib 125mg and Ribociclib 600 mg
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Namik Kemal University
Diabetic Neuropathies, Distal Peripheral Sensory Neuropathy
Diabetic Neuropathy Screening Study 1.1 + Substudy 1.2-1.3-1.4
The overall objective of this project is to describe the prevalence of and risk factors to diabetic neuropathy in a representative cohort of diabetes patients and to investigate pathophysiological conditions in those patients…
- Conditions
- Diabetic Neuropathies, Distal Peripheral Sensory Neuropathy, Diabetic Foot, Foot Deformities
- Trial name
- DANES (NCT05043636)
- Testing
- Vagus, HeartsTrends, Sudoscan
- Where
- Denmark
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Can Blood Flow Restriction Therapy Augments Strength Gains in the Rotator Cuff, Muscle Weakness
Can Blood Flow Restriction Therapy Improve Strength and Cross-Sectional Area for Shoulder External Rotators Better Than Exercise Alone?
This 8-week study will investigate whether the application of blood flow restriction (BFR) therapy augments rotator cuff strength in untrained individuals. This is a RCT with subjects randomized to a BFR or non-BFR group.
- Trial name
- NCT04596020
- Testing
- Blood Flow Restriction Group (exercise with blood flow restriction using a Delfi unit)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- George Fox University
To Demonstrate That a New Sensor System Can Register Fetal ECG and Distinguish it From Maternal ECG
Fetal Monitoring by Transabdominal Electrocardiogram Recording
Fetal monitoring by transabdominal electrocardiogram recording
- Trial name
- ELAINE (NCT04574739)
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern