Clinical trials: CBD, open to volunteers
Alcohol Addiction, Alcoholism
A Trial to Investigate the Effects of Cannabidiol Plus Naltrexone on Alcohol Craving in Patients With Alcohol Dependence
Alcohol addiction (AD) is a chronic relapsing disorder with currently limited pharmacological treatment options. Alcohol craving, a hallmark symptom of AD that drives relapse in patients, is only insufficiently treated by…
- Trial name
- ICONICplus (NCT06845124)
- Testing
- Cannabidiol capsules, Naltrexone (drug)
- Where
- 2 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Alzheimer Disease, Dementia
Effects of THC-Free CBD Oil on Agitation in Patients With Alzheimer's Disease
This is a randomized, double-blinded, placebo-controlled, crossover trial that aims to 1) determine the efficacy of THC-free cannabidiol (CBD oil) in reducing the severity of agitation among participants and 2) determine whether…
- Conditions
- Alzheimer Disease, Dementia, Major Neurocognitive Disorder With Aggressive Behavior
- Trial name
- NCT04436081
- Testing
- THC-free CBD Oil
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Eastern Virginia Medical School
Carpal Tunnel Syndrome
Topical Cannabidiol for Treating Carpal Tunnel Syndrome
The Purpose of this study is to assess the safety and efficacy of Cannabidiol on treatment of Carpal Tunnel Syndrome.
- Trial name
- NCT06108349
- Testing
- Cannabidiol
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Lennox-Gastaut Syndrome (LGS), Dravet Syndrome (DS)
CBD Delivery with the A-Synaptic GT4 Transdermal Delivery System in with Dravet Syndrome And/or Lennox-Gastaut Syndrome
This study is a preliminary open-label, single-arm Phase II investigation into the safety and efficacy of transdermal cannabidiol (CBD) delivered using GT4 skin bream technology in individuals diagnosed with Dravet and/or…
- Trial name
- NCT06738732
- Testing
- CBD: GT4 Transdermal Delivery System
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Alexander Rotenberg
PTSD
Safety and Efficacy of Cannabidiol (CBD) for Symptoms of PTSD in Adults
Post-traumatic stress disorder (PTSD) is a psychiatric disorder than may develop following a traumatic event including serious incidents, natural or human-caused disasters, violence, death of a loved one, receipt of traumatic…
- Trial name
- NCT05269459
- Testing
- Cannabidiol Administered as Nantheia ATL5
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Nebraska
Refractory Epilepsy in Children, Refractory Epilepsy
Cannabidiol as add-on Therapy for Children With Refractory Epilepsy (CBD-uN1que), a High-quality Individualized Approach: a Series of N-of-1 Trials
The goal of this clinical trial is to learn if cannabidiol ("CBD-oil") works to treat severe epilepsy in children. It will also learn about the safety of cannabidiol.
- Conditions
- Refractory Epilepsy in Children, Refractory Epilepsy, Epilepsy
- Trial name
- CBD-uN1que (NCT07668856)
- Testing
- Cannabidiol (CBD) oral solution
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- UMC Utrecht
Calcular Obstructive Jaundice
*Effect of Prophylactic CBD Stenting Versus Non Stenting on Recurrence of CBD Stones in Patients Awaiting Cholecystectomy*
Primary objective: Compare recurrence rates of CBD stones in stented versus non-stented patients. Secondary objectives: Identify predictors of stone recurrence. Assess the incidence and risk factors for post-ERCP complications.
- Trial name
- NCT07084493
- Testing
- CBD stent either a 7-Fr and 7 cm or a 10-Fr and 7-cm OR double-pigtail stent, biliary stent
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Assiut University
Parkinson Disease
Clinical Trial with Cannabidiol (Kanbis®) for Parkinson Disease Symptoms
Parkinson disease (PD) is a chronic, progressive neurodegenerative disorder characterized by clinical motor and non-motor symptoms. Knowing the potential benefits has led to the use of cannabis as an alternative therapy.
- Trial name
- CBD-EP-2 (NCT06629389)
- Testing
- Cannabidiol 100 mg/ml, cannabidiol 300 mg/ml, Cannabidiol 400 mg/ml
- Where
- Argentina
- Volunteers
- 88 people
- Sponsor
- Laboratorio Elea Phoenix S.A.
Tobacco Use, Tobacco Smoking
Oral Cannabidiol for Tobacco Cessation
Cannabidiol is a compound found in cannabis plants that is well tolerated, has low abuse liability, and might be an effective medication to promote tobacco cessation.
- Conditions
- Tobacco Use, Tobacco Smoking, Tobacco Dependence, Tobacco Use Disorder
- Trial name
- NCT05445804
- Testing
- 300 mg Cannabidiol, 600 mg Cannabidiol
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Autism Spectrum Disorder, Anxiety
Investigating a Marijuana-based Compound as a Treatment for Anxiety in Autistic Adults
The goal of this clinical trial is to learn if drug ABC works to treat severe asthma in adults. It will also learn about the safety of drug ABC.
- Trial name
- NCT06526208
- Testing
- MB-IMP
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Southwest Autism Research & Resource Center
Developmental and Epileptic Encephalopathy (DEE)
A Study to Evaluate the Safety and Efficacy of CBD-OS in Participants With DEE
The efficacy, safety, and tolerability of CBD-OS have been evaluated for the treatment of seizures associated with Lennox-Gastaut syndrome (LGS), Dravet syndrome (DS), and Tuberous sclerosis complex (TSC).
- Trial name
- NCT07723976
- Testing
- CBD-OS
- Volunteers
- 120 people
- Sponsor
- Jazz Pharmaceuticals
Multiple Sclerosis
Cannabis (THC vs. CBD) in Multiple Sclerosis
The goal of this clinical trial is to examine the effect of Cannabis components, THC and CBD, on cognition and bladder symptoms in people with Multiple Sclerosis (MS).
- Trial name
- NCT06261489
- Testing
- THC, CBD
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Early Psychosis
Effects of Cannabidiol (CBD) Versus Placebo as an Adjunct to Treatment in Early Psychosis
This is an outpatient, single center, between-group, double blind, placebo controlled design. Approximately 120 adolescents and adult patients will be randomized to either have their treatment augmented with Cannabidiol Oral…
- Trial name
- NCT04411225
- Testing
- Cannabidiol oral solution
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of California, San Diego
PTSD, Suicidal Thoughts and Behaviors
Cannabis, Neuroinflammation, and Suicidal Ideation: A Supplemental Brain Imaging Study
This study will be the first to use brain imaging to explore how cannabis affects the brain and inflammation in U.S. military veterans with PTSD.
- Conditions
- PTSD, Suicidal Thoughts and Behaviors, PTSD Symptoms, Depressive Symptoms
- Trial name
- CNS (NCT07222306)
- Testing
- 1-(2-[+F]fluoroethyl)-L-tryptophan
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wayne State University
Chemotherapy-Induced Peripheral Neuropathy
CBG/CBD Oil for Chemotherapy-Induced Peripheral Neuropathy
The goal of this clinical trial is to learn if a commercially available cannabigerol (CBG)/cannabidiol (CBD) oil is safe, feasible to use, and can help reduce symptoms of chemotherapy-induced peripheral neuropathy (CIPN) in…
- Trial name
- NCT07016971
- Testing
- CBG/CBD Oil
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Milton S. Hershey Medical Center
Restless Leg Syndrome
Tolerability and Efficacy of CBD Extract for RLS Treatment
This study plans to learn more about the safety and tolerability of high Cannabidiol (CBD) cannabis extract (BRC-002) for use in Idiopathic Restless Legs Syndrome.
- Trial name
- NCT07224932
- Testing
- BRC-002, Placecbo
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Healthy
Naturally Produced Cannabinoids for Neuroprotection From Concussion
The goal of this double-blind, placebo-controlled, cross over study is to learn about the neuroprotective properties of a broad-spectrum cannabinoid formulation in normal healthy adults engaged in elite contact sport competition.
- Trial name
- NCT07715864
- Testing
- Broad spectrum cannabinoid formulation
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Regina
Anxiety and Fear
Cannabidiol Effects on Learning and Anxiety
To examine the extent to which Cannabidiol (CBD) enhances fear conditioning extinction in college undergraduates who show elevated social anxiety.
- Trial name
- NCT05283382
- Testing
- Cannabidiol Oral Product
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Healthy Volunteers
Sustained Release Oral Formulation For Treatment Of Parkinsons Disease
LD/CD (medications to treat Parkinson's disease) will be delivered using an assembly of nested sachets made of permeable material.
- Trial name
- NCT07709741
- Testing
- Formulation A, Formulation B, Formulation C
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Major Depressive Disorder (MDD), Treatment-resistant Depression (TRD)
Cannabidiol Oil for Treatment-Resistant Major Depression
Major depressive disorder is one of the leading causes of disability worldwide, and a substantial proportion of patients do not achieve adequate improvement with conventional antidepressant treatments.
- Trial name
- ANANDA (NCT07696871)
- Testing
- Full-spectrum CBD oil 100 mg/mL
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Universidade do Sul de Santa Catarina