Clinical trials: CD
Crohn Disease
ENTYVIO in Bio-naive Patients With Moderate/Severe Crohn's Disease (CD) in Daily Practice
The purpose of this study is to describe physician-reported clinical effectiveness outcomes, as determined by Harvey-Bradshaw Index (HBI) assessment, in biologic-naive participants with CD over 12 months following treatment…
- Trial name
- EARLY-CD (NCT04349449)
- Where
- 14 sites in Canada
- Sponsor
- Takeda
CD 19+ Acute Leukemia
Pilot Study of T-APCs Following CAR T Cell Immunotherapy for CD19+ Leukemia
Patients with relapsed or refractory CD 19+ leukemia who have achieved remission after CD19 CAR-T cell treatment sometimes relapse because the CD 19 CAR-T cells decrease in number over time.
- Trial name
- NCT03186118
- Testing
- T-cell Antigen Presenting Cells expressing truncated CD19 (T-APC)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Seattle Children's Hospital
Digestive System Disease, Inflammatory Bowel Diseases
Comparative Study of Intestinal Color Ultrasound and Capsule Endoscopy in Monitoring Crohn's Disease
The disease activity index under intestinal color ultrasound was evaluated by SUS-CD, and the disease activity index under capsule endoscopy was evaluated by CECDAI.
- Conditions
- Digestive System Disease, Inflammatory Bowel Diseases, Crohn Disease, Crohn Disease of Small Intestine
- Trial name
- NCT05636657
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Crohn's Disease
An Observational Study to Assess Change in Disease Activity and Adverse Events in Adolescent and Adult Participants With Moderate to Severe Active Crohn's Disease (CD) in Japan
Crohn's disease (CD) is an incurable chronic inflammatory disorder of the gastrointestinal tract. This study will assess how safe and effective upadacitinib is in treating moderately to severely active CD in real world.
- Trial name
- NCT06023030
- Where
- 104 sites in Japan
- Volunteers
- 240 people
- Sponsor
- AbbVie
Crohn Disease
Diet Intervention for Crohn's Disease Patient
The purpose of this study is to determine the effectiveness of a low-fat, high fiber diet (LFD) containing a minimal proportion of fat to improve gastrointestinal symptoms, quality of life and signs of inflammation in blood and…
- Trial name
- NCT04213729
- Testing
- Diet Counseling, CD LFD, Dyadic Psychological Support (DPS)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Miami
CD19+ and CD 22+ B-ALL
Safety and Efficacy of CD19/CD22 Dual Targeted CAR-T Cell Therapy in R/R B-Cell Acute Lymphoblastic Leukemia
This is an open, single-arm, prospective clinical study to evaluate the safety and efficacy of anti CD19 and CD22 CAR-T cell in the treatment of R/R B-ALL.
- Trial name
- NCT05225831
- Testing
- Autologous CD19/CD22 Chimeric Antigen Receptor T-cells, Cyclophosphamide,Fludarabine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Hebei Senlang Biotechnology Inc., Ltd.
Smoking Cessation, Smokeless Tobacco
In-vivo Extraction of Pb, Cd andTSNA From Swedish Snus
In an open label, randomized, two-way cross-over study, 32 male healthy regular snus users will be given repeated doses of four different types of portion snus: "General", "Catch", "Catch Mini" and "Catch Dry Mini".
- Conditions
- Smoking Cessation, Smokeless Tobacco, Harm Reduction
- Trial name
- SMWS03 (NCT01249339)
- Testing
- Buccal Administration of nicotine
- Where
- Sweden
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Contract Research Organization el AB
IBD (Inflammatory Bowel Disease), Crohn Disease (CD)
Individualizing Anti-TNF Therapy in Patients With Inflammatory Bowel Disease
This observational study aims to identify genes that may affect how patients with inflammatory bowel disease respond to anti-TNF treatment and why some patients lose response to treatment over time.
- Conditions
- IBD (Inflammatory Bowel Disease), Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- NCT07644117
- Testing
- This is an observational study with no intervention. Patients will receive anti- TNF therapy as part of their standard care
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Shmuel Kivity, MD
Crohn Disease (CD), Dynamic Prediction Model
Development of a Dynamic Prediction Model for Crohn's Disease-Related Intestinal Surgery Using Longitudinal Indices of Routine Blood Tests: A Single-Center Retrospective Cohort Study
This single-center retrospective cohort study aims to develop and internally validate a dynamic prediction model that uses longitudinal data from routinely collected blood tests to continuously assess the risk of Crohn's disease…
- Trial name
- NCT07644390
- Volunteers
- 500 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Attention Deficit Hyperactivity Disorder
The COMACS Study: A Comparison of Methylphenidates in an Analog Classroom Setting
This study was designed to compare Concerta Extended Release tablets with Metadate CD capsules in children with ADHD who were between 6 and 12 years old.
- Trial name
- NCT00381758
- Testing
- Methylphenidate Extended Release Capsules
- Volunteers
- 184 people
- Sponsor
- UCB Pharma
Malaria
Tolerability and Efficacy of CD+A Compared to AQ+SP for the Treatment of P.Falciparum Malaria in Rwandan Children
In 2005-2006, a clinical trial was carried out to test safety, tolerability and efficacy of the combination chlorproguanil-dapsone+artesunate (CD+A): 800 children aged 12-59 months with uncomplicated P.
- Trial name
- NCT00461578
- Testing
- Chlorproguanil-dapsone + artesunate
- Where
- Rwanda
- Volunteers
- 800 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Patients With Histologically Confirmed CD Undergoing Intestinal Resection According to Standard of Care Due to Complicating Disease, Patients With Histologically Confirmed UC Undergoing Intestinal Resection According to Standard of Care Due to Complicating Disease
Spatially Resolved IBD: Spatial Transcriptomics of Inflammatory Bowel Disease (IBD)
The goal of this retrospective observational study is to obtain the spatial resolution of the entire intestinal fibrotic process through the technology STOmics Stereoseq.
- Trial name
- NCT06484738
- Testing
- transcriptomic analysis
- Where
- 2 sites in Italy
- Volunteers
- 16 people
- Sponsor
- IRCCS San Raffaele
Crohn's Disease
Efficacy and Safety of Vedolizumab Subcutaneous (SC) as Maintenance Therapy in Crohn's Disease (CD)
The purpose of this study is to assess the effect of vedolizumab subcutaneous (vedolizumab SC) as maintenance treatment in participants with moderately to severely active CD who achieved clinical response following administration…
- Trial name
- NCT02611817
- Testing
- Vedolizumab SC 108 mg, Vedolizumab IV 300 mg
- Where
- 194 sites in United States, Australia and 28 more
- Volunteers
- 644 people
- Sponsor
- Takeda
Multiple Myeloma
A Phase 1/2a Study of Human Anti-CD 38 Antibody MOR03087 (MOR202) in Relapsed/Refractory Multiple Myeloma
This is an open-label, multicentre, dose escalation study to characterize the safety and preliminary efficacy of the human anti-CD38 antibody MOR03087 (MOR202), in adult subjects with relapsed/refractory multiple myeloma, as…
- Trial name
- NCT01421186
- Testing
- MOR03087 phase 1 dose escalation, MOR03087, Dexamethasone
- Where
- 10 sites in Austria, Germany
- Volunteers
- 91 people
- Sponsor
- MorphoSys AG
Crohn's Disease (CD), Ulcerative Colitis (UC)
Supplementation of Vitamin D3 in Patients With Inflammatory Bowel Diseases and Hypovitaminosis D
This study aims to evaluate the effect of vitamin D3 supplementation on disease activity and quality of life in IBD patients deficient in vitamin D, and also help determine the optimal dose of vitamin D3 for them.
- Trial name
- NCT01877577
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Crohn Disease (CD), Intensification
Optimal Care With Guselkumab in Crohn's Disease / OPTIM Study A Prospective Open Label Interventional, Multicenter Study
Crohn's disease (CD) is a chronic and destructive inflammatory disease of the gastrointestinal tract characterized by phases of relapse and remission.
- Trial name
- OPTIM (NCT07616687)
- Testing
- Guselkumab
- Where
- France
- Volunteers
- 210 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Degenerative Disc Disease
rhBMP-2/CRM/CD HORIZON® Spinal System Pilot Study (2-Level)
The purpose of this study is to evaluate the feasibility of using the investigational implant (rhBMP-2/CRM with the CD HORIZON® Spinal System) as a method of facilitating posterolateral lumbar spinal fusion at two adjacent…
- Trial name
- NCT01491568
- Testing
- rhBMP-2/CRM/CD HORIZON® Spinal System
- Volunteers
- 29 people
- Sponsor
- Medtronic Spinal and Biologics
Crohn's Disease
CUP Certolizumab Pegol (CDP-870) in Adults Suffering From Crohn's Disease (CD)
The objective of this program is to allow treating physicians to supply/continue to supply Certolizumab Pegol (CIMZIA®, CZP) to adults suffering from Crohn's Disease (CD), and who are considered not suitable for treatment…
- Trial name
- COMPAS (NCT03559660)
- Testing
- Certolizumab Pegol
- Sponsor
- UCB Biopharma SRL
Child Behavior, Problem Behavior
Collaborative Problem Solving vs. Positive Solutions for Families in Preschool Parent Groups
The main objectives of this study are to evaluate the feasibility, acceptability, and effects of a CPS parent group on outcomes for a sample of parents of children ages 3 to 5 compared to outcomes after attending a parenting…
- Conditions
- Child Behavior, Problem Behavior, Family Conflict
- Trial name
- NCT02896426
- Testing
- Collaborative Problem Solving, Positive Solutions For Families
- Volunteers
- 22 people
- Sponsor
- Massachusetts General Hospital
Inflammatory Bowel Diseases (IBD), Remission of IBD
VIBRANT-IBD: Brain Effects of Non-Invasive Vagus Nerve Stimulation in IBD Remission
The VIBRANT-IBD study is a pilot, prospective, single-arm feasibility study investigating the effects of non-invasive vagus nerve stimulation (nVNS) in adults with inflammatory bowel disease (IBD) in clinical remission.
- Conditions
- Inflammatory Bowel Diseases (IBD), Remission of IBD, In Adults, Inflammatory Bowel Disease (Crohn's Disease; Ulcerative Colitis)
- Trial name
- VIBRANT-IBD (NCT07636304)
- Testing
- Non-invasive vagus nerve stimulation (nVNS)
- Where
- Poland
- Volunteers
- 15 people
- Sponsor
- University of Gdansk