Clinical trials: CD - Crohn's Disease
Crohn Disease
Advanced Non-Invasive Diagnostics in Inflammatory Bowel Disease
The purpose of this study is to determine whether Non-invasive endoscopic procedures (pillcam colon capsule endoscopy, PCCE) and non-ionizing radiological modalities (MR enterocolonography, MREC and ultrasound, US) - offer a…
- Trial name
- ANDI (NCT03134586)
- Testing
- Diagnostic imaging
- Where
- 3 sites in Denmark
- Volunteers
- 153 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Inflammatory Bowel Disease, Crohn's Disease
Efficacy and Safety of Upadacitinib in Inflammatory Bowel Disease
Inflammatory Bowel Disease (IBD), which encompasses ulcerative Colitis (UC) and Crohn's Disease (CD), has seen significant improvements in patient outcomes with biologic treatments.
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- EaseUpIBD (NCT06780683)
- Testing
- Upadacitinib
- Where
- 6 sites in China
- Volunteers
- 174 people
- Sponsor
- Xiang Gao
Ulcerative Colitis, Crohn's Colitis
Chromoendoscopy for Dysplasia Detection in Chronic Inflammatory Bowel Disease
Patients with longstanding ulcerative colitis or crohn's disease in the large bowel have an increased risk of developing cancer.
- Trial name
- NCT01505842
- Testing
- Colonoscopy with Indigo-Carmine chromoendoscopy, Conventional white-light colonoscopy
- Where
- Sweden
- Volunteers
- 304 people
- Sponsor
- Karolinska University Hospital
IBS, Ulcerative Colitis, Active
Visceral Sensitivity in IBD (Irritable Bowel Disease) and IBS (Irritable Bowel Syndrome)
Aim: More insight in pathogenesis of IBS and IBD. Samples are collected in context of an European research project.
- Conditions
- IBS, Ulcerative Colitis, Active, Ulcerative Colitis, Remission (3a: With IBS Symptoms, 3b: Without IBS Symptoms), Healthy Controls
- Trial name
- NCT02421705
- Testing
- Sample collection
- Where
- Belgium
- Volunteers
- 99,999,999 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Crohn Disease, Fistula
An Open Label, Prospective, One Arm, Feasibility, Study for The Use of Halevy Kit for the Treatment of Perianal Fistulas in Patients With Crohn's Disease
Today, there is no available equipment specifically designed for the procedure of instillation of fibrin glue for the repair of perianal fistulae.
- Trial name
- NCT00653094
- Testing
- Halevy kit
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- ResQ Medical Ltd
Crohn's Disease
The Effect of Adalimumab on the Bone Microstructure in Crohn's Disease (CD) Patients
The investigators will study the effect of Adalimumab on the bone microstructure. Trial with medicinal product
- Trial name
- NCT01012570
- Testing
- Application of Adalimumab
- Where
- Switzerland
- Volunteers
- 34 people
- Sponsor
- Gerhard Rogler
Crohn Disease, Intestinal Tuberculosis
Validation of Scoring Systems for Differentiating Intestinal Tuberculosis from Crohn's Disease
Differentiating CD from intestinal tuberculosis (ITB) is difficult due to the low sensitivities of currently available diagnostic tests.
- Conditions
- Crohn Disease, Intestinal Tuberculosis, Differential Diagnosis
- Trial name
- NCT06629194
- Testing
- interferon gamma releasing assay (IGRA)
- Where
- 2 sites in Thailand
- Volunteers
- 84 people
- Sponsor
- Mahidol University
Crohn's Disease, Inflammatory Bowel Disease
A Comparison of Ultrasound Guided Transversus Abdominis Plane Nerve Block Techniques
Postoperative pain can pose significant challenges in the postoperative recovery of patients undergoing major colorectal surgery. Traditionally, opioids have played an important role in treating postoperative pain.
- Conditions
- Crohn's Disease, Inflammatory Bowel Disease, Postoperative Pain
- Trial name
- NCT02538679
- Testing
- US TAP Bupivacaine/Epinephrine, Lap TAP Bupivacaine/Epinephrine
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Crohn Disease
Telephone-based Motivational Interviewing for Smoking Cessation in Crohn's Disease Patients
Quitting smoking unequivocally improves the course of Crohn's disease (EC), and therefore, it should be one of the main therapeutic targets in the treatment of this disease.
- Trial name
- NCT04225403
- Testing
- Telephone-based motivational interviewing for smoking cessation
- Volunteers
- 144 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Crohn's Disease
Efficacy Study of Targeted, Local Delivery of Drugs to Treat Crohn's Disease
The study is being undertaken to evaluate whether delayed-release medications, designed to begin to open in the lower intestinal tract, the main site of Crohn's Disease, are more effective than standard systemically delivered…
- Trial name
- NCT00287170
- Testing
- Delayed Release 6MP or Calcitriol vs. Purinethol
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Teva GTC
Ulcerative Colitis, Crohn Disease
Evaluation of the Diagnostic Value of microRNAs for Inflammatory Bowel Diseases
The purpose of this study is to assess the diagnostic value of microRNAs in IBD colon (ulcerative colitis or Crohn's disease) in adults as compared to healthy controls (and non-IBD colitis)
- Conditions
- Ulcerative Colitis, Crohn Disease, Healthy, Non-IBD Colitis
- Trial name
- MicroMICI (NCT02020382)
- Testing
- qPCR diagnostic KIT of microRNAS
- Where
- 5 sites in France
- Volunteers
- 325 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Crohn's Disease
A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Crohn's Disease Who Failed Prior Biologic Treatment
The objective of Study M15-991 is to evaluate the efficacy and safety of risankizumab versus placebo during induction therapy in participants with moderately to severely active CD.
- Trial name
- NCT03104413
- Testing
- risankizumab SC, risankizumab IV
- Where
- 403 sites in United States, Argentina and 41 more
- Volunteers
- 618 people
- Sponsor
- AbbVie
Crohn's Disease
A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease
The purpose of this study is to evaluate the clinical efficacy (GALAXI 1), clinical and endoscopic efficacy (GALAXI 2 and GALAXI 3) and safety of guselkumab in participants with Crohn's disease.
- Trial name
- GALAXI (NCT03466411)
- Testing
- Guselkumab Dose 1, Guselkumab Dose 2, Guselkumab Dose 3
- Where
- 579 sites in United States, Australia and 41 more
- Volunteers
- 1,409 people
- Sponsor
- Janssen Research & Development, LLC
Crohn Disease, Ovary Disease
Ovarian Reserve in Crohn's Disease
Crohn's disease reduces fertility by inducing inflammation both directly and in the fallopian tubes and ovaries and indirectly through surgical interventions and tubal adhesions associated with disease treatment.
- Conditions
- Crohn Disease, Ovary Disease, Anti-Mullerian Hormone Deficiency
- Trial name
- NCT03897400
- Testing
- AMH levels in young women with crohn's disease will be considered.
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Crohn Disease (CD)
Kinetics of Transmural Healing in Patients With Crohns Disease Treated With Risankizumab (SKYRIZI®)
Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) that can highly alter patients' quality of life and lead to bowel damage due to its transmural pattern.
- Trial name
- SKYNETICS (NCT07308067)
- Where
- 4 sites in France
- Volunteers
- 109 people
- Sponsor
- University Hospital, Clermont-Ferrand
Crohn Disease
Effectiveness and Safety of Ustekinumab Intensification in Crohn's Disease
The primary purpose of this study is to evaluate the efficacy and safety of intravenous administration at regular intervals of Ustekinumab in participants with loss of response to standard regimen or have evidence of high…
- Trial name
- NCT05705856
- Testing
- Ustekinumab
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Colon Cancer, Diverticulitis
General Surgical Outcomes Quality Improvement Database (UH-SOCRATES)
A database has been established to track the outcomes of all cases performed in the University Hospitals Department of Surgery in an effort to improve quality of surgical performance and case management.
- Conditions
- Colon Cancer, Diverticulitis, Colorectal Polyps, Crohn's Disease
- Trial name
- SOCRATES (NCT00622557)
- Where
- United States
- Volunteers
- 200,000 people
- Sponsor
- University Hospitals Cleveland Medical Center
Ulcerative Colitis, Crohn Disease
Assessment of Nutritional Knowledge in Patients With Inflammatory Bowel Disease
Patients with inflammatory bowel disease (IBD) are increasingly becoming interested in nonpharmacologic approaches to their disease. One of the most frequently asked questions of IBD patients is what they should eat.
- Conditions
- Ulcerative Colitis, Crohn Disease, Nutrition
- Trial name
- NCT04882566
- Testing
- Paleolithic Diet
- Volunteers
- 100 people
- Sponsor
- Assiut University
Crohn's Disease
Role of Capsule Endoscopy in the Evaluation of Mucosal Changes During Treatment of Patients With Active Crohn's Disease
The utility of capsule endoscopy in diagnosing small bowel (SB) Crohn's disease has been demonstrated in a number of studies. Mucosal healing is a good predictor of long term remission.
- Trial name
- CHANCE (NCT02193802)
- Testing
- PillCam® COLON 2 and PillCam Crohn's capsules
- Where
- 11 sites in France, Spain
- Volunteers
- 42 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
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