Clinical trials: CD - Crohn's Disease
Crohn's Disease, Ulcerative Colitis
Safety of Accelerated Infliximab Infusions in Patients With Inflammatory Bowel Disease (IBD)
This study aims to test the hypothesis that the accelerated infusion of infliximab is not inferior to the conventional 2 hour infusion with respect to the frequency of infusion reaction.
- Trial name
- NCT01346826
- Testing
- Standard 2 hours-infusion, Accelerated 1 hour-infusion, Accelerated 30 minutes-infusion
- Where
- South Korea
- Volunteers
- 145 people
- Sponsor
- Asan Medical Center
Crohn Disease
Extracorporeal Photopheresis of Patients With Crohn's Disease Using 5-aminolevulinic Acid
In the clinical trial the investigators will assess efficacy, safety and tolerability after single and multiple doses of 3 millimolar 5 aminolevulinic acid (Gliolan®) in combination with blue-light (405 nanometer) photopheresis…
- Trial name
- NCT04164849
- Testing
- 5-aminolevulinic acid, Blue light photopheresis, Transfusion
- Where
- Norway
- Volunteers
- 7 people
- Sponsor
- University Hospital, Akershus
Crohn's Disease
Intra-erythrocyte Dexamethasone Versus Placebo in Patients With Steroid-dependent Crohn's Disease
Primary objective: Assessment of the efficacy of EryDex vs PLACEBO in maintaining patients with steroid-dependent Crohn's disease in clinical remission throughout 12 months without oral steroids. Secondary objectives: 1.
- Trial name
- Crodex (NCT01277289)
- Testing
- Dexamethasone
- Where
- 8 sites in Italy, Romania and 1 more
- Volunteers
- 51 people
- Sponsor
- Quince Therapeutics S.p.A.
Crohn Disease
Post-Operative Crohn's Disease Outcome in Children
Objectives: To examine the effect of prophylaxis therapy on clinical and endoscopic disease recurrence in children with Crohn's Disease (CD) following ileo-cecal resection.
- Trial name
- POPCORN (NCT03681652)
- Testing
- Azathioprine, Anti-TNF Drug
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Schneider Children's Medical Center, Israel
Crohn's Disease
High Dose Oral 4-Aminosalicylic Acid (PASER®) to Control Acute Flares of Mild to Moderate Crohn's Disease
The purpose of this 4 week study is to determine whether PASER®, an approved delayed-release oral formulation of 4-aminosalicylic acid, in doses of 4 grams three times daily for 2 weeks followed by 4 grams twice daily for 2…
- Trial name
- NCT00417690
- Testing
- 4-Aminosalicylic acid
- Where
- 5 sites in United States, Israel
- Volunteers
- 54 people
- Sponsor
- Jacobus Pharmaceutical
Crohn Disease
Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease
This study will compare two current first-line treatments for childhood Crohn's Disease, steroids versus a liquid diet, and determine the effects of these treatments on bone health, quality of life and treatment efficacy.
- Trial name
- NCT00609752
- Testing
- prednisolone, Alicalm (polymeric liquid formula)
- Where
- 6 sites in United Kingdom
- Volunteers
- 80 people
- Sponsor
- University Hospital Birmingham
Crohn's Disease
A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease
The main aim of this study is to learn whether vedolizumab and upadacitinib given together (also called dual targeted therapy or DTT) reduces bowel inflammation and ulcers in the bowel compared to vedolizumab only (also called…
- Trial name
- VICTRIVA (NCT06227910)
- Testing
- Vedolizumab, Upadacitinib
- Where
- 138 sites in United States, Austria and 24 more
- Volunteers
- 396 people
- Sponsor
- Takeda
Crohn's Disease (CD)
A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Crohn's Disease (CD)
Vedolizumab is a medicine that helps to reduce inflammation and pain in the digestive system. In this study, children and teenagers with moderate to severe Crohn's disease will be treated with vedolizumab.
- Trial name
- NCT04779320
- Testing
- Vedolizumab IV
- Where
- 96 sites in United States, Australia and 16 more
- Volunteers
- 120 people
- Sponsor
- Takeda
Crohn's Disease, IBD
Open-label Extension Study of Brazikumab in Crohn's Disease
The purpose of Study D5271C00002 (Legacy #3150-303-008) is to permit participants in D5271C00001 (Legacy #3150-301-008) to receive open-label brazikumab in Study D5271C00002 (Legacy #3150-303-008).
- Trial name
- INTREPID OLE (NCT03961815)
- Testing
- Brazikumab Induction Dose, Brazikumab Maintenance Dose
- Where
- 15 sites in United States, Germany and 3 more
- Volunteers
- 18 people
- Sponsor
- AstraZeneca
Crohn Disease
Description of Perianal Lesions in a Cohort of Crohn's Disease Patients
The perianal lesions (LAP) specific for Crohn's disease have been reported in 1938, six years after the first cases of luminal disease.
- Trial name
- LAPCROHN (NCT02899013)
- Testing
- No intervention
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Crohn Disease
Distant Management of Crohn's Disease by Smartphones is Feasible and Effective Additionally it Reduces the Costs
Evaluation of the feasibility, acceptability, patient satisfaction and economic benefits of smartphone video-based telehealth in the management of Crohn's disease patients
- Trial name
- NCT04754620
- Testing
- real time online video visit
- Where
- Turkey (Türkiye)
- Volunteers
- 139 people
- Sponsor
- Kocaeli University
Crohn's Disease
Study Investigating Tailored Treatment With Infliximab for Active Crohn's Disease
To investigate whether sustained trough levels of IFX can be achieved using IFX (Infliximab) trough level measurements and adjustment of dosing based upon these levels by means of two different standardized algorithms in…
- Trial name
- TAILORIX (NCT01442025)
- Testing
- Infliximab
- Where
- 12 sites in France
- Volunteers
- 121 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Crohn Disease, Crohn Disease of Small Intestine
Efficacy and Safety of Bowel Preparation for Patency Capsule in CD Patients Who Previously Failed Patency Capsule
The goal of this observational study is to evaluate the success rate of a second bowel preparation protocol for patency capsule (PC) in Crohn Disease (CD) patients who failed to pass an initial protocol PC on a previous attempt.
- Trial name
- NCT06515171
- Where
- Israel
- Volunteers
- 400 people
- Sponsor
- Shmuel Kivity, MD
Crohn's Disease
Transplantation of Bone Marrow Mesenchymal Stem Cell in Crohn's Disease
This study is a prospective, randomized, parallel, phase 1 trial to assess the safety and feasibility of the transplantation of bone marrow derived mesenchymal stem cells (MSCs) in fistulizing Crohn's disease.
- Trial name
- NCT01874015
- Testing
- mesenchymal cell transplantation, mesenchymal cell and fibroblast injection
- Where
- Iran
- Volunteers
- 10 people
- Sponsor
- Royan Institute
Moderate to Severe Crohn's Disease
Rapidity of Response to Adalimumab Treatment in Patients With Crohn´s Disease
The purpose of this study is to evaluate the rapidity of onset of clinical response to adalimumab therapy in patients with luminal Crohn's disease.
- Trial name
- RAPIDA (NCT02148718)
- Testing
- adalimumab
- Volunteers
- 100 people
- Sponsor
- AbbVie
Inflammatory Bowel Diseases
Effects of Prednisolone and Infliximab on the Regulation of Urea Synthesis in Active Inflammatory Bowel Disease
Loss of total mass of muscles (catabolism) is a serious clinical problem in patients with active inflammatory bowel disease (IBD).
- Trial name
- NCT00955123
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- University of Aarhus
IBD (Inflammatory Bowel Disease), Crohn Disease (CD)
FAPi-PET Imaging of in Vivo Fibrosis in Inflammatory Bowel Disease Patients
Our main objective is to evaluate the feasibility of 68Ga-FAPi PET/CT in detecting intestinal fibrosis in patients with IBD. To this end, we will determine 68Ga-FAPi uptake in IBD in relation to cellular FAP expression in…
- Conditions
- IBD (Inflammatory Bowel Disease), Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- PIMAFI (NCT06604260)
- Testing
- 68Ga-FAPi-46
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Dalia Lartey
Flammatory Bowel Disease, Crohn's Disease
Early Postoperative Recurrence in Crohn's Disease: Predictors of Research Targeting the Constitutional Mutation of IRGM
Crohn's disease is a disease of complex etiology, multifactorial and still poorly understood. This disease, due to its morbidity and mortality, poses a significant public health problem in France.
- Trial name
- NCT01663142
- Where
- 4 sites in France
- Volunteers
- 230 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Crohn Disease (CD), Crohn Disease
Cranberry and Gut Health in Crohn's Disease
This study is investigating whether a cranberry-based dietary supplement, rich in polyphenols and fiber, can enhance gut health in individuals with Crohn's disease.
- Trial name
- NCT07170462
- Testing
- Cranberry powder
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Ana Maldonado-Contreras
Crohn's Disease
Detecting Postoperative Recurrence in Crohn's Disease
Up to ¾ of patients who have been diagnosed with Crohn's disease (CD) will have to undergo bowel resection during their lifetime despite modern medical therapies.
- Trial name
- NCT00886327
- Testing
- Colonic capsule endoscopy
- Where
- 4 sites in Germany
- Volunteers
- 70 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
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