Clinical trials: CD - Crohn's Disease
Chronic Pain, Crohn Disease
Group ACT for CD Pain- a Feasibility Study
Pain is a common symptom of inflammatory bowel disease (IBD) and has a significant impact on patient quality of life. Pain will frequently be the presenting complaint and is experienced throughout the disease course.
- Trial name
- NCT05418062
- Testing
- Acceptance and commitment therapy (ACT)
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- King's College London
Crohn Disease, Intestinal Tuberculosis
MRI Differentiating Gut TB and Crohn's
It is clinically challenging to differentiate Crohn's disease from gut tuberculosis especially in regions endemic of tuberculosis infection.
- Trial name
- NCT03096379
- Testing
- Magnetic resonance imaging
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The University of Hong Kong
Crohn Disease
EXL01 in the Maintenance of Steroid-induced Clinical Response/Remission in Participants With Mild to Moderate Crohn's Disease
A Phase 1, 2-part, multicentre study to evaluate the safety and preliminary efficacy of the oral administration of EXL01 in the maintenance of corticosteroid-induced clinical response/remission in participants with mild to…
- Trial name
- MAINTAIN (NCT05542355)
- Testing
- EXL01, SoC corticosteroid - Induction Period, SoC corticosteroid - Tapering
- Where
- 5 sites in Belgium, Poland
- Volunteers
- 8 people
- Sponsor
- Exeliom Biosciences
Crohn's Disease
Green Tea in Crohn's Disease
The purpose of this study is to assess whether green tea or coffee influence the course and life quality of patients with mild to moderately active Crohn's disease.
- Trial name
- NCT01231217
- Testing
- Green tea (Camellia sinensis), Coffee
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- University Hospital Heidelberg
Crohn Disease, Genetic Predisposition
The Biologic Onset of Crohn's Disease: A Screening Study in First Degree Relatives
Pursuing very early diagnosis is standard of care for several diseases including colon cancer, diabetes and liver disease where an early and aggressive diagnostic and therapeutic approach has been shown to change their natural…
- Conditions
- Crohn Disease, Genetic Predisposition, IBD
- Trial name
- NCT03291743
- Testing
- Capsule endoscopy
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
Safety Issues, Efficacy
Is Local Injection of Mesenchymal Stem Cells After Endoscopic Dilation Safe and Does it Improve the Outcome of Intestinal Stricture in Patients With Crohn's Disease?
This is an exploratory phase II study, to evaluate the impact of these Mesenchymal Stem Cells (MSCs) on strictures in Crohn's disease patients with symptomatic intestinal stricture eligible to endoscopic dilatation.
- Trial name
- NCT06317818
- Testing
- Mesenchymal Stem Cells
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
Ulcerative Colitis, Pediatric, Inflammatory Bowel Diseases
COMPARE - Pediatric Inflammatory Bowel Disease (PIBD)
The purpose of the study is to compare the clinical effectiveness and safety of newer inflammatory bowel disease (IBD) medications in anti-tumor necrosis factor (TNF) refractory patients with pediatric IBD (PIBD).
- Conditions
- Ulcerative Colitis, Pediatric, Inflammatory Bowel Diseases, Crohn Disease
- Trial name
- COMPARE (NCT07198113)
- Where
- 4 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- University of North Carolina, Chapel Hill
Ulcerative Colitis, Crohn's Disease
Predicting Medication Response for Autoimmune Disease
Coral is conducting a large study comparing and predicting the relative effectiveness of different medications for autoimmune patients.
- Conditions
- Ulcerative Colitis, Crohn's Disease, Psoriasis, Rheumatoid Arthritis
- Trial name
- REEF (NCT04995783)
- Testing
- Coral FRS test
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Coral Genomics, Inc.
Crohn Disease (CD)
Virtual hIStology of Crohn's Disease Ex-vivo Resected Anatomical Lesions
Crohn's disease is a chronic, incurable inflammatory bowel disease with an unpredictable course, characterized by alternating remission and inflammatory flares.
- Trial name
- VISCERAL (NCT07413653)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
Crohn's Disease
High Dose Vitamin D3 in Crohn's Disease
This is a randomized, double-blind placebo-controlled trial of high dose vitamin D3 at 10,000 International Units (IU) daily compared to low dose at 1000 IU daily in patients with Crohn's disease in remission.
- Trial name
- NCT02615288
- Testing
- Vitamin D3
- Volunteers
- 40 people
- Sponsor
- McMaster University
Crohn's Disease
A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease
Crohn's disease (CD) is a long-lasting condition causing inflammation that can affect any part of the gut. The purpose of this study is to evaluate the efficacy and safety of TAK-279 versus placebo in participants with moderately…
- Trial name
- NCT06233461
- Testing
- TAK-279
- Where
- 201 sites in United States, Australia and 23 more
- Volunteers
- 268 people
- Sponsor
- Takeda
Crohn Disease (CD)
Clostridium Butyricum in Stenosing Crohn's Disease
Crohn's disease is a condition of unknown etiology with an immune-mediated pathogenesis. The subgroup of Crohn's disease with a stricturing phenotype represents a particular challenge for clinicians, as currently no effective…
- Trial name
- AUTOCD (NCT07263880)
- Testing
- Clostridum Butyricum Capsule, Trehalose
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- San Giovanni Addolorata Hospital
Crohn Disease (CD)
HB-adMSCs for the Treatment of Crohn's Disease
Methodology: Randomized, double-blind, efficacy and safety study of allogeneic HB-adMSCs vs placebo for the treatment of Crohn's Disease with a 16-week treatment period and a safety and efficacy follow up period for 52 weeks post…
- Trial name
- NCT07077746
- Testing
- HB-adMSCs - Hope Biosciences Adipose Derived Mesenchymal Stem Cells, 0.9% sodium chloride
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Hope Biosciences Research Foundation
Crohn's Disease, Pediatric
Comparison of a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis
The primary purpose of this study is to compare the efficacy of enteral nutrition compared to steroids in inducing remission of active pediatric Crohn's disease.
- Trial name
- NCT00265772
- Testing
- MODULEN IBD (R) (specific Enteral Nutrition), prednisolon
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Hôpital Necker-Enfants Malades
Crohn's Disease
An Active Treatment Study to Induce Clinical Response and/or Remission With GSK1605786A in Subjects With Crohn's Disease
This is a multi-centre, randomised, double-blind, active treatment, parallel group induction study in subjects with moderately-to-severely active Crohn's disease.
- Trial name
- SHIELD-4 (NCT01536418)
- Testing
- GSK1605786A
- Where
- 227 sites in United States, Australia and 29 more
- Volunteers
- 255 people
- Sponsor
- GlaxoSmithKline
Crohn's Disease (CD)
Ultrasound-Guided Versus Standard Margin Selection in Ileocecal Resection of Terminal Ileal CD
This is a Phase II, single-center (Cleveland Clinic), two-arm, randomized, parallel-group superiority trial. The two arms will compare IOUS-guided margin selection against standard macroscopic margin selection in patients…
- Trial name
- SMILE-CD (NCT07680283)
- Testing
- IOUS-guided margin selection
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- The Cleveland Clinic
Crohn's Disease
Comparison of Vedolizumab Treatment to Adalimumab Dose Intensification in Crohn's Disease Patients With Loss of Response or Biomarker Activity to Adalimumab on First Line With Therapeutic Drug Concentration.
A substantial fraction of IBD patients with an initial response to infliximab or adalimumab later experience re-emerging active disease despite ongoing anti-Tumour Necrosis Factor (TNF) agents maintenance therapy.
- Trial name
- VEDIAN (NCT06180382)
- Testing
- Adalimumab, Vedolizumab
- Where
- 12 sites in France
- Volunteers
- 220 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Crohn's Disease
Safety and Immunogenicity of a TNFa Kinoid in Patients With Crohn's Disease
Evaluation of the safety and the immune response induced by active immunization through a TNFa kinoid in patients with Crohn's disease.
- Trial name
- NCT00808262
- Testing
- TNFa Kinoid
- Where
- 6 sites in South Africa, Switzerland
- Volunteers
- 21 people
- Sponsor
- Neovacs
Crohn Disease
A Smartphone Application for Added Psychological Wellbeing in Crohn's Disease
Psychological intervention by COBMINDEX application to reduce psychological stress among CD patients, fatigue and pain and improve the patients' well being, quality-of-life and disease-coping skills, as well as improvement of the…
- Trial name
- COBMINDEX (NCT06221254)
- Testing
- COBMINDEX digital application, Human therapist (Control)
- Where
- 4 sites in Israel
- Volunteers
- 200 people
- Sponsor
- Soroka University Medical Center
Crohn Disease, Ileocolic Resection
CRP Monitoring After ICR in CD Patients
Aim: The aim of this study was to assess the accuracy of the C-reactive protein as an early predictor of intra-abdominal septic complicationss after ileocolic resection for Crohn disease.
- Trial name
- C-ICR-CD (NCT04643496)
- Testing
- Laparoscopic or open Ileocolic resection
- Where
- France
- Volunteers
- 159 people
- Sponsor
- University Hospital, Montpellier
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