Clinical trials: CFD
Healthy
Study of a Single Dose of Danicopan in Healthy Participants
This was a single ascending dose, randomized, double-blind study assessing the safety, tolerability, pharmacokinetics, and pharmacodynamics of danicopan in healthy participants.
- Trial name
- NCT04889677
- Testing
- Danicopan
- Where
- New Zealand
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Alexion Pharmaceuticals, Inc.
Healthy
Drug-Drug Interaction (DDI) Study of ALXN2050 in Healthy Adult Participants
This study will evaluate the potential drug interactions between ALXN2050 and cyclosporine (Part 1), between ALXN2050 and tacrolimus (Part 2), and between ALXN2050 and mycophenolate mofetil (MMF) (Part 3).
- Trial name
- NCT05202145
- Testing
- ALXN2050, Cyclosporine, Tacrolimus
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Alexion Pharmaceuticals, Inc.
Endometriosis, Complement System
Endometriosis and Complement System
Endometriosis is a chronic gynecological condition affecting nearly 10% of women of reproductive age. A definitive diagnosis of endometriosis requires laparoscopy.
- Conditions
- Endometriosis, Complement System, Alternative Complement Pathway
- Trial name
- NCT06495151
- Testing
- Mannose-binding lectin-associated serine protease-3 (MASP-3) Level, Adipsin Level, Properdin Level
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Healthy
A Study of the Effects of Food and Age on Danicopan
This will be an open-label, 2-part study. Part 1 will be a randomized, 2-sequence, 2-period crossover, food-effect study in healthy young adult participants.
- Trial name
- NCT04551599
- Testing
- Danicopan
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Alexion Pharmaceuticals, Inc.