Clinical trials: CHILD Syndrome
HIV Infections
Safety and Efficacy of Zinc Supplementation in HIV-1-Infected Children in South Africa
The goal of the study is to rule out a harmful effect of zinc supplementation in HIV-1-infected children. The null hypothesis is that zinc supplementation will increase plasma HIV RNA levels.
- Trial name
- NCT00138047
- Testing
- zinc supplementation
- Where
- South Africa
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Translocation Down Syndrome, Chromosomal Abnormalities
Prevalence of Translocation Phenotyping in Children With Down Syndrome and Their Parents
This research study will investigate a special type of Down syndrome called translocation Down syndrome. While most children with Down syndrome have an extra copy of chromosome 21, about 3-4% have this extra chromosome material…
- Trial name
- PTP-DS (NCT07175168)
- Testing
- No medical or experimental intervention will be administered
- Volunteers
- 230 people
- Sponsor
- Assiut University
Acute Respiratory Distress Syndrome, Acute Lung Injury
Efficacy and Safety of a Lung Recruitment Protocol in Children With Acute Lung Injury
Lung units which participate in gas exchange are known as 'recruited' lung. Patients with lung injury suffer from a proportion of units which do not participate in gas exchange (i.e.
- Trial name
- Recruitment (NCT00830284)
- Testing
- Recruitment maneuver
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Boston Children's Hospital
Developmental Disability, Chronic Disease
QoL and Stress in Parents of Children With Developmental Disabilities and Chronic Disease
The aim of this cross-sectional study is to investigate the level of stress and quality of life in parents of children with developmental disabilities (Down syndrome, autism spectrum disorder, pervasive developmental disorder…
- Conditions
- Developmental Disability, Chronic Disease, Down Syndrome, Autism Spectrum Disorder
- Trial name
- NCT03602378
- Testing
- salivary cortisol, Holter Medilog AR12 Plus, Polar V800
- Where
- 2 sites in Croatia
- Volunteers
- 592 people, healthy volunteers welcome
- Sponsor
- University of Split, School of Medicine
Clostridium Difficile Infection Recurrence, Ulcerative Colitis (UC)
Real-World Study on Fecal Microbiota Transplantation: Long-Term Effectiveness and Safety Statistics
This is a large-scale observational study aiming to evaluate the long-term effectiveness and safety of Fecal Microbiota Transplantation (FMT).
- Conditions
- Clostridium Difficile Infection Recurrence, Ulcerative Colitis (UC), Crohn Disease (CD), Irritable Bowel Syndrome (IBS)
- Trial name
- NCT07261826
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Chen QiYi
Snoring, Apnea, Obstructive
Dental Appliance to Treat SDB in Children
The clinical hypothesis of this study is that a currently marketed mouthguard may also be able to reduce the symptoms of sleep-disordered breathing in children.
- Conditions
- Snoring, Apnea, Obstructive, Upper Airway Resistance Syndrome, Sleep-Disordered Breathing
- Trial name
- NCT05661747
- Testing
- Vivos Grow/Vivos Way Device
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Vivos BioTechnologies, Inc.
Sepsis, Children, Only
The Impact of Sepsis on Long-term Outcomes in Critical Ill Children With Sepsis
This study is conducted in critically ill children with sepsis with a five years follow-up. We aim to investigate the impact of sepsis on long-term outcomes including growth, neurodevelopment, survival rate, quality of life.
- Trial name
- NCT06323226
- Where
- China
- Volunteers
- 300 people
- Sponsor
- West China Hospital
Kawasaki Disease, Coronary Artery Abnormalities
Statins Study in Children of Acute Kawasaki Disease With Coronary Artery Abnormalities
The goal of this observational study is to learn about the safety and effects of atorvastatin in treatment of Chinese Kawasaki disease (KD) children complicated with coronary artery abnormalities (CAA) in acute phase.
- Trial name
- NCT07530640
- Testing
- atorvastatin of dose level 1, atorvastatin of dose level 2, atorvastatin of dose level 3
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Children's Hospital of Fudan University
MIS-C Associated With COVID-19
Genetic Basis of SARS-CoV-2 Infection-Associated Multisystem Inflammatory Syndrome in Children (MIS-C)
The project aims to investigate the molecular basis of pediatric inflammatory conditions associated with COVID-19 identified by the IDEA network, with the objectives of characterizing their genetic background, pathophysiology…
- Trial name
- MIS-C IDEA (NCT07881068)
- Where
- 3 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Istituto Giannina Gaslini
Long COVID
Consequences of COVID-19 Infection for Child Health and Wellbeing: Protocol for a Prospective, Observational, Longitudinal Study in Children
Prospective follow-up of children with SARS-CoV-2
- Trial name
- NCT05799508
- Where
- Italy
- Volunteers
- 1,200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Down Syndrome
Whole-Body Vibration Versus Gravity Force Stimulation on Postural Stability in Children With Down Syndrome
The purpose of the study is to compare the effect between of whole-body vibration and gravity force stimulation on postural stability in children with Down syndrome.
- Trial name
- NCT05330741
- Testing
- Designed Physical Therapy Program, Whole-Body Vibration, Gravity Force Stimulation
- Volunteers
- 60 people
- Sponsor
- Beni-Suef University
Syphilis, HIV Infections
Spotting Syphilis: A Dual Point-of-Care Syphilis Screening Initiative in a Low-Resource Healthcare Setting
The purpose of this study is to determine if a strategy utilizing the Chembio HIV/syphilis rapid point-of-care (POC) test for diagnosis of HIV and syphilis in pregnant women attending prenatal clinics in Guatemala will increase…
- Trial name
- NCT07498153
- Testing
- Chembio HIV/Syphilis rapid POC test
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- The University of Texas Health Science Center, Houston
Tuberculosis, Human Immunodeficiency Virus
Adequacy of the New Pediatric Isoniazid/Rifampin/Pyrazinamide (HRZ) Tablet
Lack of quality-assured pediatric formulations of the first-line antituberculosis (anti-TB) drugs is barrier to optimized tuberculosis (TB) treatment outcome in children.
- Conditions
- Tuberculosis, Human Immunodeficiency Virus, Coinfection
- Trial name
- NCT03800381
- Testing
- Observational PK study
- Where
- Ghana
- Volunteers
- 92 people
- Sponsor
- University of Florida
15q Duplication Syndrome, CDKL5 Deficiency Disease
A Multicenter, Open-label, Pilot Study of Soticlestat (TAK-935/OV935) in Participants With 15Q Duplication Syndrome (Dup 15q) or Cyclin-Dependent Kinase-Like 5 (CDKL5) Deficiency Disorder (ARCADE STUDY)
The purpose of this study is to investigate the effect of soticlestat on the frequency of motor seizures for participants with Dup15q or CDD during the Maintenance Period.
- Trial name
- NCT03694275
- Testing
- Soticlestat
- Where
- 8 sites in United States
- Volunteers
- 20 people
- Sponsor
- Takeda
Cowden's Disease, Cowden's Syndrome
Double-Blind Trial of Everolimus for Improving Social Abilities in PTEN Germline Mutations
The goal of this study is to examine the safety and treatment effects of everolimus in adults and children with PTEN Hamartoma Tumor Syndrome (PHTS) who experience social difficulties.
- Conditions
- Cowden's Disease, Cowden's Syndrome, Lhermitte-Duclos Disease, Cerebellum Dysplastic Gangliocytoma
- Trial name
- NCT07218575
- Testing
- Everolimus blinded oral capsules
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Boston Children's Hospital
Child Behavior
Parents Resources for Decreasing the Incidence of Change Triggered Temper Outbursts
'PREDICTORS' (Parents Resources for Decreasing the Incidence of Change Triggered Temper Outbursts) aims to evaluate web-based training packages for caregivers of children who show frequent temper outbursts following changes to…
- Trial name
- PREDICTORS (NCT02567357)
- Testing
- Visual Scheduling, signalling change
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Bladder and Bowel Dysfunction
Bladder and Bowel Dysfunction in Children
Background: Bladder and bowel dysfunction (BBD) is characterized by lower urinary tract symptoms accompanied by bowel complaints. BBD is a common condition in childhood.
- Trial name
- NCT05318365
- Testing
- Polyethylene Glycol 3350, Urotherapy
- Where
- 3 sites in Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Obstructive Sleep Disordered Breathing
Characterization of the Tongue in Children With Obstructive Sleep-disordered Breathing
The tongue plays a key role in maintaining upper airway patency during sleep, mainly through the genioglossus, the principal pharyngeal dilator muscle.
- Trial name
- NCT07861230
- Testing
- Cross-sectional assessment
- Where
- Belgium
- Volunteers
- 39 people
- Sponsor
- Université Catholique de Louvain
Neuroblastoma, Opsoclonus-myoclonus
Use of Rituximab in Opsoclonus-Myoclonus in Children With Neuroblastoma
The purpose of this study is to evaluate the feasibility of giving four weekly doses of Rituximab (anti-CD20 antibody) in the treatment of children with refractory neuroblastoma associated opsoclonus-myoclonus.
- Trial name
- NCT00202930
- Testing
- anti-CD20 (Rituximab)
- Volunteers
- 4 people
- Sponsor
- Jean M. Tersak, M.D.
Peroxisome Biogenesis Disorders
Betaine and Peroxisome Biogenesis Disorders
The PBD are a rare group of inherited disorders due to the failure to form functional cellular peroxisomes. Most patients have progressive hearing and visual loss, leading to deafness and blindness, as well as neurological…
- Trial name
- NCT01838941
- Testing
- Betaine
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
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