Clinical trials: CHILD Syndrome
Vascular Diseases, Vascular Malformation
A New Approach in Laser Surgery Using the Regenerative Solution in Children Diagnosed With Vascular Pathology
Laser treatment (LT) is the first-line treatment for Vascular Pathology. However even when LT is based on the selective photothermolysis it causes the first-degree burns.
- Conditions
- Vascular Diseases, Vascular Malformation, Capillary Malformation-Arteriovenous Malformation, Port-Wine Stain
- Trial name
- DOUBLE-SKIN (NCT04999618)
- Testing
- Haemoblock
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Center for Vascular Pathology, Moscow
Overweight, Obesity
Correlation of Irisin and Adipokine Levels With Body Mass Index and Risk Factors for Metabolic Syndrome in Hispanic Children
Childhood obesity is one of the most serious global public health challenges of the 21st century (Daniels et al., 2009). Mexico has the highest prevalence of obesity, (Secretaría de Salud, 2009); 34.4% of children and 35% of…
- Conditions
- Overweight, Obesity, Thinness
- Trial name
- NCT02320110
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Instituto Tecnologico y de Estudios Superiores de Monterey
Down Syndrome
Swiss Ball Versus Frenkel Exercises Effects in Down Syndrome
Down syndrome (or trisomy 21) is the most common genetic cause of intellectual disability, occurring in an estimated 1 in 800 births worldwide.
- Trial name
- NCT06732713
- Testing
- Swiss Ball, Frenkel exercise
- Where
- Pakistan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Neurofibromatosis Type 1
A Randomized Placebo-Controlled Study of Lovastatin in Children With Neurofibromatosis Type 1
The specific aim of this study is to determine whether Lovastatin ™ significantly improves visual spatial learning and/or sustained attention in children with NF1.
- Trial name
- STARS (NCT00853580)
- Testing
- Lovastatin ™
- Where
- 12 sites in United States, Australia
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
PTSD, Traumatic Brain Injury
Psychological Treatment for Children Suffering From Post Traumatic Stress Symptoms and Mild Traumatic Brain Injury
The purpose of this study is to determine whether Prolonged Exposure Therapy (PE)is effective in the treatment of post-traumatic stress symptoms in children and adolescents with mild traumatic brain injury (m-TBI) due to motor…
- Conditions
- PTSD, Traumatic Brain Injury, Post Concussive Syndrome
- Trial name
- TBI (NCT01315379)
- Testing
- Prolonged Exposure Therapy
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Rabin Medical Center
Down Syndrome
Effect Of Pilates On Postural Control And Balance In Children With Down's Syndrome
Down's syndrome (DS) is a genetic condition characterized by the presence of an extra chromosome 21, leading to various clinical symptoms.
- Trial name
- NCT05969873
- Testing
- Pilates exercise, Balance training
- Where
- Pakistan
- Volunteers
- 22 people
- Sponsor
- Riphah International University
Community-Acquired Infections
Community Acquired Bacteremic Syndromes in Young Nigerian Children
To define the etiologic agents of community acquired bacteremic syndromes (defined as septicemia, bacteremia, pneumonia and/or meningitis) in a malaria endemic setting.
- Trial name
- CABSYNC (NCT02946775)
- Where
- Nigeria
- Volunteers
- 29,146 people
- Sponsor
- University of Nebraska
Sleep Disordered Breathing (SDB), Endothelial Dysfunction
Sleep Disordered Breathing in Children: Inflammation and Oxidative Stress
The purpose of the study is to measure markers of inflammatory and oxidative stress known to be associated with cardiovascular morbidity in snoring children.
- Trial name
- NCT02040701
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Frequently Relapsing Nephrotic Syndrome, Steroid-Dependent Nephrotic Syndrome
Randomized Trial Evaluating Mycophenolate Mofetil in Children With Nephrotic Syndrome After Rituximab Treatment
The aim of this study is to evaluate the efficacy and safety of maintenance Mycophenolate Mofetil following single course of Rituximab in maintaining remission over 12 months among Children with frequently-relapsing or…
- Trial name
- NCT04531865
- Testing
- Rituximab, Mycophenolate Mofetil
- Where
- 4 sites in China
- Sponsor
- Children's Hospital of Fudan University
Nephrotic Syndrome
Ofatumumab Versus Rituximab in Children With Steroid and Calcineurin Inhibitor Dependent Idiopathic Nephrotic Syndrome
Open-label, two-parallel-arm, controlled randomized clinical trial testing the superiority of Ofatumumab over Rituximab in maintaining steroid- and calcineurin-inhibitor-free disease remission in SD-INS.
- Trial name
- NCT02394119
- Testing
- Ofatumumab, Rituximab
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Istituto Giannina Gaslini
Autism Spectrum Disorder, Asperger Syndrome
Milnacipran in Autism and the Functional Locus Coeruleus and Noradrenergic Model of Autism
Autism Spectrum Disorders (ASD) include Autistic disorder, Asperger's syndrome and Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS). These are developmental disorders beginning prior to three years of age.
- Conditions
- Autism Spectrum Disorder, Asperger Syndrome, Aspergers Syndrome
- Trial name
- NCT01337700
- Testing
- Milnacipran
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Montefiore Medical Center
Peritoneal Neoplasms, Retroperitoneal Neoplasms
Continuous Hyperthermic Peritoneal Perfusion (CHPP) With Cisplatin for Children With Peritoneal Cancer
There has been no successful treatment of diffuse peritoneal metastasis or carcinomatosis, in childhood tumors. Once this advanced stage of disease is evident, survival is measured in weeks.
- Conditions
- Peritoneal Neoplasms, Retroperitoneal Neoplasms, Gastrointestinal Neoplasms, Adenocarcinoma
- Trial name
- NCT00436657
- Testing
- CHPP of Cisplatin, Abdominal Surgery
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- M.D. Anderson Cancer Center
Down Syndrome
Exercise Intensity for Down Syndrome Children
The current study aimed to determine the appropriate exercise intensity for the rehabilitation of children with down syndrome.
- Trial name
- NCT05271201
- Testing
- treadmill exercise (mild), treadmill exercise (moderate)
- Where
- Saudi Arabia
- Volunteers
- 34 people
- Sponsor
- Taif University
Low Vision in Children
Biofeedback in Idiopathic Infantile Nystagmus Syndrome
Active eye movement control training, an old and still most prevalent intervention in low vision rehabilitation (LVR) was never used in nystagmus clinically.
- Trial name
- NCT04142307
- Testing
- Biofeedback Training
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- Monica Daibert Nido
Sleep, Sleep Apnea Syndromes
Identification of Sleep-Disordered Breathing in Children
The purpose of this research is to study and improve the methods used to detect childhood breathing problems during sleep that can affect daytime behavior at home and school.
- Conditions
- Sleep, Sleep Apnea Syndromes, Sleep Disordered Breathing
- Trial name
- NCT00233194
- Testing
- Observational follow-up study of adenotonsillectomy
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Obstructive Sleep Apnea of Child
Factors Correlated With Obstructive Sleep Apnea in Children and Adolescents
Obstructive Sleep Apnea (OSA) is a severe condition of sleep respiratory disorders. It is characterized by partial (hypopnea) or total (apnea) obstruction of the upper airways, negatively affecting the general and oral health of…
- Trial name
- NCT04328402
- Testing
- Polysomnography
- Where
- Brazil
- Volunteers
- 187 people
- Sponsor
- Federal University of Pelotas
Dental Caries in Children, Pit and Fissure Sealant
Progression of Active Microcavitated Carious Lesions on Primary Molar Occlusal Surfaces
Objective: To verify the progression of active microcavitated carious lesions on occlusal surfaces of primary molars after the orientation of the brushing technique associated with fluoride dentifrice compared to resin sealant…
- Conditions
- Dental Caries in Children, Pit and Fissure Sealant, Toothbrushing
- Trial name
- NCT04127357
- Testing
- 1450 ppm fluoride toothpaste brushing x Resin sealing (FluroShield, Dentsply, Brazil).
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Faculty Sao Leopoldo Mandic Campinas
HIV/AIDS Treatment, HIV Infections
Lopinavir/Ritonavir (Kaletra) PK in Children
The objective of this study is to compare the pharmacokinetics of lopinavir tablets administered to pediatric patients as either whole or crushed tablets.
- Trial name
- NCT00810108
- Testing
- lopinavir/ritonavir (Kaletra®) tablets
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Epilepsy, Epilepsy in Children
XEN496 (Ezogabine) in Children With KCNQ2 Developmental and Epileptic Encephalopathy
To investigate the potential antiseizure effects of adjunctive XEN496 (ezogabine) compared with placebo in children with KCNQ2 Developmental and Epileptic Encephalopathy (KCNQ2-DEE).
- Conditions
- Epilepsy, Epilepsy in Children, Epilepsy; Seizure, Disease
- Trial name
- EPIK (NCT04639310)
- Testing
- XEN496
- Where
- 20 sites in United States, Australia and 3 more
- Volunteers
- 8 people
- Sponsor
- Xenon Pharmaceuticals Inc.
Septic Shock
Diagnostic Study of Adrenal Cortical Function in Children With Septic Shock
OBJECTIVES: I. Examine adrenal cortical function and the incidence of adrenal dysfunction in children with septic shock. II. Examine the mortality, length of stay in the PICU, and incidence of multiorgan failure in children with…
- Trial name
- NCT00005890
- Testing
- corticotropin
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- National Center for Research Resources (NCRR)
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