Clinical trials: CIN
ASC-US, Human Papilloma Virus
Can B12 and Folate Levels Predict HPV Penetration in Patients With ASCUS?
Non-classified atypical squamous cells (ASCUS) is the most common abnormal cervical cytology (%39). The risk of cervical intraepithelial neoplasia 2-3 is 5% and the risk of carcinoma is around 0.1% after diagnosis.
- Trial name
- NCT03903952
- Testing
- Vitamin B12 and folate
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Educational Problems, Cervix, Dysplasia
Colposcopy Education Using Operant Learning
Images will be collected during routine colposcopy and paired with their pathology results to be used for resident education
- Trial name
- Colpo (NCT04340011)
- Testing
- Colposcopy
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Cervical Dysplasia, Vulvar Dysplasia
OCT-AF Imaging of Pre-cancers of Vulva and Cervix
The multimodal imaging technology, OCT-AFI, will be used to image sites on the cervix, the endocervical canal and vulva. The imaging probe is small enough, it can be inserted into the endocervical canal for imaging.
- Conditions
- Cervical Dysplasia, Vulvar Dysplasia, Precancerous Lesions, Vulvar Cancer
- Trial name
- NCT03285841
- Testing
- OCT-AFI
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- British Columbia Cancer Agency
Cervical Cancer Screening
Comparing Effectiveness of Physician-assisted Versus Self-assisted Pap Smear Collection
This purpose of this research study is to determine the effectiveness of the Personal Pap Smear Device™ to collect adequate cervical cell samples for cytology examination when compared with the Rover Cervex-Brush…
- Trial name
- NCT06229275
- Testing
- Pap smear collection using the Personal Pap Smear (PPS) Device, Active Comparator: Pap smear collection using the Rovers Cervex-Brush
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Morehouse School of Medicine
Cervical Intraepithelial Neoplasia
Management of Cervical Intraepithelial Neoplasia Grade 2
The aim of this study was to compare two management options for CIN 2. This randomized clinical trial performed between 2003 and 2006.
- Trial name
- CIN2 (NCT00733109)
- Testing
- Excision of the lesion, Follow-up for spontaneous regression of the lesion
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Universidade Cidade de Sao Paulo
Cervical Intraepithelial Neoplasia, Cervical Cancer
The Development of a "Mother/Child, Screen, Treat and Vaccinate Program" in Manchay and Iquitos, Peru
This project will use a community based participatory research orientation to develop a model for large scale "campaign" preventive healthcare interventions.
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Cancer, Cervical Neoplasm, Cervical Dysplasia
- Trial name
- PERCAPS (NCT01338051)
- Testing
- Gardasil
- Where
- 2 sites in Peru
- Volunteers
- 642 people, healthy volunteers welcome
- Sponsor
- Preventive Oncology International, Inc.
Human Papilloma Virus Infection, Human Papilloma Virus Integration
Diagnostic Cervical Conization for Persistent Infection or Integration of HPV
For the patients with cervical persistent infection or integration of HPV, we has designed a program to perform cervical conization for certain patients to earlier and better diagnose and cure the diseases of HPV infection and…
- Conditions
- Human Papilloma Virus Infection, Human Papilloma Virus Integration, Cervical Intraepithelial Neoplasia, Cervical Cancer
- Trial name
- NCT05510830
- Testing
- diagnostic cervical conization
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Tongji Hospital
Contrast-Induced Nephropathy, Coronary Angiography
Effect of Continuing vs. Discontinuing ACE Inhibitors on Renal Function After Coronary Angiography
This clinical trial evaluates whether continuing or withholding ACE inhibitors (specifically Ramipril) before coronary angiography affects the risk of contrast-induced nephropathy (CIN).
- Conditions
- Contrast-Induced Nephropathy, Coronary Angiography, Acute Kidney Injury
- Trial name
- ACEI-RF (NCT07184918)
- Testing
- Continuing Ramipril, Withholding Ramipril
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Tanta University
Cervical Cancer, Cervical Intraepithelial Neoplasia (CIN)
Epidemiological Factors and Optimization of Conservative Approaches to Precancerous Lesions of Female Reproductive Organs
The primary aim of this study is to develop a recommended clinical practice guideline for managing women with HPV HR (high-risk human papillomavirus) positivity and cervical lesions.
- Conditions
- Cervical Cancer, Cervical Intraepithelial Neoplasia (CIN), Risk Factors, Conservative Management
- Trial name
- NCT06967740
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- Nikola Janovska
Nephropathy
Efficacy of Statins In Prevention of CIN
To determine if statin therapy plus intravenous normal saline, in patients with chronic renal insufficiency undergoing angiography, is superior to placebo plus intravenous normal saline therapy in the prevention of CIN.
- Trial name
- SCIN (NCT01071993)
- Testing
- atorvastatin
- Where
- 2 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Contrast-induced Nephropathy Following Percutaneous Intervention (CIN)
Efficacy and Safety of a Beet-Derived Inorganic Nitrate-Based Food Product for the Prevention of Contrast-Induced Nephropathy in High-Risk Patients Undergoing Percutaneous Coronary Intervention
Contrast-induced nephropathy (CIN) is a common complication in high-risk patients undergoing percutaneous coronary intervention (PCI) due to exposure to iodinated contrast agents.
- Trial name
- BEET-CIN (NCT06984406)
- Testing
- Beet-Derived Inorganic Nitrate-Based Food Product
- Where
- Russia
- Volunteers
- 88 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Cervical Dysplasia
Large Loop Excision of the Transformation Zone During Follicular Vs. Luteal Phase of the Menstrual Cycle (LLETZ-MC)
Cervical cancer is one of the most common cancers in women and one of the leading causes of death in women worldwide. Pre-cancerous lesions (dysplasias) are detected by the preventive smear test at the gynecologist and can thus…
- Trial name
- LLETZ-MC (NCT05391243)
- Testing
- LLETZ
- Where
- Germany
- Volunteers
- 152 people
- Sponsor
- Ruhr University of Bochum
Cervical Intraepithelial Neoplasia, Papillomavirus Infections
Hexaminolevulinate Photodynamic Therapy (HAL-PDT) With Deferred Surgery Versus Surgery for High-grade Squamous Intraepithelial Lesions (HSIL)
High-grade squamous intraepithelial lesions (HSIL), encompassing cervical intraepithelial neoplasia grade 2 (CIN2) with p16 positivity and grade 3 (CIN3), are precancerous conditions that require effective intervention.
- Trial name
- Aurora (NCT07669363)
- Testing
- Loop Electrosurgical Excision Procedure (LEEP) or Cold Knife Conization (CKC), HAL 5% with illumination
- Where
- 28 sites in China
- Volunteers
- 230 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Cervical Intraepithelial Neoplasia
Clinical Evaluation of Polarized Light Assisted Colposcopy
This is a prospective study to compare unpolarized (conventional) to polarized light colposcopy. Subjects will be asked to participate in the study when they arrive for their prescheduled colposcopic examination.
- Trial name
- NCT01349621
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Augusta University
Cervical Intraepithelial Neoplasia, Cervical Cancer
Efficacy and Immunogenicity Study of Recombinant Human Papillomavirus Bivalent（Type 16/18 ）Vaccine
This is a Phase III clinical trial of the novel recombinant HPV 16/18 bivalent vaccine manufactured by Xiamen Innovax Biotech CO., LTD.
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Cancer, Vaginal Intraepithelial Neoplasia, Vulvar Intraepithelial Neoplasia
- Trial name
- NCT01735006
- Testing
- HPV Vaccine, HEV vaccine
- Where
- China
- Volunteers
- 7,372 people, healthy volunteers welcome
- Sponsor
- Xiamen University
Cervical Dysplasia
Correlation Between Colposcopist Findings and Digital Cervicography Employing Gynescope System
Correlation between colposcopist findings and digital cervicography employing Gynescope system
- Trial name
- NCT03840187
- Testing
- Digital cervicography
- Where
- Israel
- Volunteers
- 29 people
- Sponsor
- Barzilai Medical Center
Cervical Dysplasia
Smoking Cessation in Women With Gynecological Conditions
This feasibility study will compare two smoking cessation methods, traditional nicotine replacement therapy and Electronic Nicotine Delivery Systems (electronic cigarettes) in patients with gynecological conditions.
- Trial name
- NCT01989923
- Testing
- Nicotine Replacement Therapy, Electronic Cigarettes
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Stage 0 Cervical Cancer, High-grade Squamous Intraepithelial Lesion
S0212 Celecoxib in Treating Patients With High-Grade Squamous Intraepithelial Lesions of the Cervix
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of cancer. Celecoxib may be effective in preventing cervical cancer.
- Trial name
- NCT00072540
- Testing
- celecoxib, anti-cytokine therapy, antiangiogenesis therapy
- Sponsor
- SWOG Cancer Research Network
Neoplasia of the Uterine Cervix, Cancer Prevention
HRME: Screening for Cervical Cancer and Its Precursors in Low-Resource Settings
A new mobile diagnostic and treatment unit is being developed by BCH to address the loss-to follow-up associated with the mobile screening program and demonstrate POC diagnosis by HRME.
- Conditions
- Neoplasia of the Uterine Cervix, Cancer Prevention, Cervical Intraepithelial Neoplasia
- Trial name
- HRME-UH2 (NCT02494310)
- Testing
- High-Resolution Microendoscopy Imaging
- Volunteers
- 200 people
- Sponsor
- Barretos Cancer Hospital
Uterine Cervical Cancer, Cervical Intraepithelial Neoplasia
A Multicenter Randomized Controlled Study of Photoelectric Detection in Cervical Cancer Screening
The main purpose of this study is to verify the accuracy of the fluorescence photoelectric cervical lesion image detector relative to the pathological gold standard and the detection rate of CIN 2 +, as well as the significance…
- Conditions
- Uterine Cervical Cancer, Cervical Intraepithelial Neoplasia, High Grade Squamous Intraepithelial Lesions, Low Grade Squamous Intraepithelial Lesions
- Trial name
- NCT06491888
- Testing
- Detection of Cervical Lesions by Fluorescence Photoelectric Image
- Where
- China
- Volunteers
- 4,200 people
- Sponsor
- Lei Li