Clinical trials: CLBP - Chronic Low Back Pain
Low Back Pain, Osteoarthritis
Long-term Open-Label Safety Study to Evaluate EN3409
The purpose of the long-terms study is to evaluate the safety, tolerability, and analgesic efficacy of EN3409 in subjects with moderate to severe chronic pain requiring continuous around-the-clock opioid analgesia for an extended…
- Conditions
- Low Back Pain, Osteoarthritis, Neuropathic Pain
- Trial name
- NCT01755546
- Testing
- EN3409
- Where
- 57 sites in United States
- Volunteers
- 304 people
- Sponsor
- BioDelivery Sciences International
Chronic Low Back Pain, Fear of Pain
The VIGOR Study - Virtual Immersive Gaming to Optimize Recovery in Low Back Pain
This study will measure the effects of interactive, whole-body video games on movement behavior in people with chronic low back pain.
- Conditions
- Chronic Low Back Pain, Fear of Pain, Fear of Injury
- Trial name
- VIGOR (NCT03463824)
- Testing
- Experimental Group 1, Experimental Group 2
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Virginia Commonwealth University
Chronic Low Back Pain
Management of Chronic Low Back Pain in Older Adults Using Auricular Point Acupressure
Almost one-third (30%) of persons 60 years and older suffer from cLBP and cause a significant negative impact on individuals and society in the U.S.
- Trial name
- NCT03589703
- Testing
- Target ear points related to chronic low back pain (T-APA), Non-Target ear Points not related to chronic low back pain (NT-APA), Enhanced Educational Control Group (CG-2)
- Where
- 2 sites in United States
- Volunteers
- 272 people
- Sponsor
- The University of Texas Health Science Center, Houston
Chronic Low Back Pain
Transcranial Alternating Current Stimulation in Back Pain- Pilot Sudy
Chronic pain is a severe disabling problem within society, affecting 25-30% of the United States population.. Transcranial alternating current stimulation (tACS) has the potential to provide a treatment option that is safe…
- Trial name
- BPS (NCT03243084)
- Testing
- XCSITE100 Stimulator tACS
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of North Carolina, Chapel Hill
Chronic Low-back Pain
Persica 002 Phase 1b PP353 vs Placebo in the Treatment of Low Back Pain
A Phase 1b study to investigate the efficacy of PP353 compared to placebo in the treatment of chronic low back pain associated with bone oedema.
- Trial name
- NCT04238676
- Testing
- PP353
- Where
- 10 sites in Denmark, New Zealand and 2 more
- Volunteers
- 43 people
- Sponsor
- Persica Pharmaceuticals Ltd
Low Back Pain
Efficacy and Safety of Hydrocodone Bitartrate Extended-Release Tablets for Moderate to Severe Chronic Low Back Pain
The primary objective of this study is to evaluate the efficacy of hydrocodone bitartrate extended-release tablets at doses of 30 to 90 mg every 12 hours compared with placebo in alleviating moderate to severe pain in patients…
- Trial name
- NCT01789970
- Testing
- Hydrocodone ER
- Where
- 87 sites in United States
- Volunteers
- 625 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Low Back Pain
The McKenzie Method Versus Manipulation for Patients With Chronic Low Back Pain
Introduction: The McKenzie method as well as spinal manipulation is commonly used for the treatment of low back pain throughout the western world.
- Trial name
- NCT00939107
- Testing
- spinal manipulation, McKenzie exercises
- Where
- Denmark
- Volunteers
- 350 people
- Sponsor
- Back and Rehabilitation Center, Copenhagen
Low Back Pain
Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® Disc Augmentation System: A Pilot Study
The purpose of this study is to assess the safety of the Biostat Disc Augmentation System for the treatment of chronic low-back (lumbar) pain due to symptomatic internal disc disruptions (IDD) and to obtain preliminary efficacy…
- Trial name
- NCT00693784
- Testing
- Biostat® Disc Augmentation System
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- Spinal Restoration, Inc.
Chronic Low-back Pain
ReActiv8 Stimulation Therapy vs Optimal Medical Management: A Randomized Evaluation
This study is a prospective, randomized study comparing ReActiv8 Therapy to Optimal Medical Management (OMM).
- Trial name
- RESTORE (NCT04803214)
- Testing
- ReActiv8
- Where
- 28 sites in United States
- Volunteers
- 203 people
- Sponsor
- Mainstay Medical
Low Back Pain
Long Term Safety and Efficacy Study of Tanezumab in Japanese Adult Subjects With Chronic Low Back Pain
This study will investigate the long-term safety and efficacy of a fixed dose of tanezumab 5 mg and 10 mg administered subcutaneously (SC) seven times at 8 week intervals.
- Trial name
- TANGO (NCT02725411)
- Testing
- Celecoxib, Tanezumab 5 mg, Tanezumab 10 mg
- Where
- 55 sites in Japan
- Volunteers
- 277 people
- Sponsor
- Pfizer
Low Back Pain
Selecting Effective Combinations of Treatment for Low Back Pain
Back pain is the #1 contributor to disability in the United States (US), and second only to hearing problems as a reason for new Veteran disability compensation.
- Trial name
- SELECT LBP (NCT03520387)
- Testing
- Lumbar medial branch nerve radiofrequency ablation (LRFA), Simulated LRFA with targeted steroid injections, AcTIVE-CBT
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- VA Office of Research and Development
Low Back Pain
Long Term Safety Study of Tanezumab in Chronic Low Back Pain
The purpose of this study is to investigate the safety and efficacy of tanezumab for chronic low back pain. Patients who were randomized and treated with study medication in a previous chronic low back pain "parent" study will be…
- Trial name
- NCT00924664
- Testing
- Tanezumab 20 mg, Tanezumab 10 mg
- Where
- 149 sites in United States
- Volunteers
- 849 people
- Sponsor
- Pfizer
Chronic Low Back Pain, Chronic Leg Pain
Comparison of the Effects of Two Spinal Cord Stimulation (SCS) Therapies on Subject Reported Pain (BENEFIT-02)
A BIOTRONIK wearable stimulator will be utilized in order to investigate the effects of two study spinal cord stimulation (SCS) therapies on subject reported pain and paresthesia perception observed over 12 days of study…
- Trial name
- NCT03594266
- Testing
- Therapy A spinal cord stimulation parameter set using BIO-RNA system and associated components, Therapy B spinal cord stimulation parameter set using BIO-RNA system and associated components
- Where
- 18 sites in United States
- Volunteers
- 136 people
- Sponsor
- Biotronik, Inc.
Chronic Low Back Pain, Posttraumatic Stress Disorder
Exercise Maintenance in Chronic Pain and PTSD
The primary purpose of the R21 is using an experimental medicine research approach to study whether a chronic, progressive-based exercise program will help Veterans suffering from chronic low back pain (cLBP) and PTSD achieve…
- Trial name
- NCT03644927
- Testing
- Progressive exercise training, Waitlist Control
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Boston University
Chronic Low Back Pain
Placebo In Chronic Back Pain - Double-Blind Randomized Control Trial
This study is designed to examine brain properties for placebo response in chronic back pain patients. The investigators have preliminary data indicating that, in blinded clinical trial studies with neutral instructions regarding…
- Trial name
- NCT02013427
- Testing
- Naproxen, Omeprazole
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Northwestern University
Low Back Pain
RN624 In Adult Patients With Chronic Low Back Pain
The primary objective of this study is to evaluate the analgesic efficacy of RN624 compared with placebo and compared with naproxen in the treatment of adult patients with chronic low back pain.
- Trial name
- NCT00584870
- Testing
- Naproxen, PF-04383119 (RN624)
- Where
- 38 sites in United States
- Volunteers
- 220 people
- Sponsor
- Pfizer
Osteoarthritis, Back Pain
A Study to Compare Oxycodone/Naloxone Prolonged Release Against Codeine/Paracetamol in the Treatment of Moderate to Severe Chronic Low Back Pain or Pain Due to Osteoarthritis
The purpose of this study is to compare oxycodone/naloxone combination tablet and codeine/paracetamol tablets in the treatment of moderate to severe chronic low back pain or pain due to osteoarthritis.
- Trial name
- NCT00784810
- Testing
- Oxycodone/Naloxone, Codeine/Paracetamol
- Where
- United Kingdom
- Volunteers
- 247 people
- Sponsor
- Napp Pharmaceuticals Limited
Chronic Low Back Pain
tDCS for Chronic Low Back Pain
The goal of this study is to investigate the role of central neural pathways in mediating chronic pain. The aim of the study is to test the effect of stimulating brain regions that are part of a network underlying central pain…
- Trial name
- NCT02771990
- Testing
- transcranial direct current stimulation
- Volunteers
- 30 people
- Sponsor
- Providence VA Medical Center
Low Back Pain
Efficacy and Safety of Oxycodone/Naloxone Controlled-release Tablets (OXN) Compared to Placebo in Opioid-experienced Subjects With Moderate to Severe Chronic Low Back Pain
The primary objective of this study is to assess the efficacy and safety of OXN compared to placebo in opioid-experienced subjects with moderate to severe pain due to chronic low back pain who require around-the-clock opioid…
- Trial name
- NCT01358526
- Testing
- Oxycodone/Naloxone Controlled-release
- Where
- 151 sites in United States
- Volunteers
- 1,095 people
- Sponsor
- Purdue Pharma LP
Recurrent Low Back Pain, Persistent Low Back Pain
Chiropractic Maintenance Care of Persistent or Recurrent Low Back Pain
As low back pain is often a recurrent and sometime persistent problem, research into prevention is important. Chiropractors have traditionally treated patients with maintenance care, which means that patients are seen on a…
- Conditions
- Recurrent Low Back Pain, Persistent Low Back Pain, Chronic Low Back Pain
- Trial name
- NCT01539863
- Testing
- maintenance care, Treatment as needed
- Where
- Sweden
- Volunteers
- 328 people
- Sponsor
- Karolinska Institutet