Clinical trials: CONTROL Condition
Elevated LDL-Cholesterol (LDL-C)
Trial to Evaluate Safety and Tolerability of ALN-PCS02 in Subjects With Elevated LDL-Cholesterol (LDL-C)
The purpose of this study is to determine the safety, tolerability, pharmacokinetics and pharmacodynamics of a single dose of ALN-PCS02 in subjects with Elevated LDL-Cholesterol (LDL-C).
- Trial name
- NCT01437059
- Testing
- ALN-PCS02, Sterile Normal Saline (0.9% NaCl)
- Where
- 2 sites in United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Alnylam Pharmaceuticals
Malaria, Dengue
Clinical Evaluation of Insect Repellent and Insecticide Treated Nets in Lao PDR
Rural communities involved in agriculture are often at highest risk of insect-borne diseases in Southeast (SE) Asia. Skin-applied insect repellents may prove a useful means of reducing mosquito-borne diseases for those people…
- Conditions
- Malaria, Dengue, Japanese Encephalitis
- Trial name
- NCT00938379
- Testing
- 20% deet insect repellent
- Where
- Laos
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Schizophrenia, Schizoaffective Disorder
Decision-Making in Schizophrenia: A Combined Neuroimaging and Experience Sampling Study
The goal of this clinical trial is to learn if attention and ways of thinking impact decision-making and brain processes related to decision-making in people with schizophrenia or schizoaffective disorder relative to people…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Control Subjects
- Trial name
- NCT06745479
- Testing
- Positive Emotion Upregulation
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Hyperlipemia
A Single and Multiple Ascending Doses Study to Evaluate the Safety, Tolerability and Pharmacokinetics of RBD7022
This is a randomized, single blind, placebo controlled, single center phase I study to evaluate the safety, tolerability, pharmacokinetics, and preliminary pharmacodynamics of single and multiple ascending doses of subcutaneously…
- Trial name
- NCT05912296
- Testing
- RBD7022
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Suzhou Ribo Life Science Co. Ltd.
Labor Pain, Induced; Birth
Intracervical Balloon Placement With Nitrous Oxide Administration
This randomized controlled trial aims to compare the effectiveness of nitrous oxide versus oxygen in facilitating the successful placement of a Foley balloon catheter for cervical ripening and induction of labor.
- Trial name
- NCT06498908
- Testing
- Nitrous oxide, Oxygen
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Jefferson Drapkin
Colorectal Cancer
RCT of Air Insufflation Versus Water Infusion Colonoscopy
Compared with the conventional (air) method, patients examined by the study (water) method have lower pain scores and require less medication but have similar cecal intubation rate and willingness to repeat future colonoscopy.
- Trial name
- NCT00785889
- Testing
- water infusion colonoscopy
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- East Bay Institute for Research and Education
Healthy
Next-Day Residual Effects of Gabapentin, Diphenhydramine and Triazolam on Simulated Driving Performance in Normal Volunteers
This study will examine the next-day residual effects of a nighttime dose of gabapentin 250 mg, diphenhydramine citrate 76 mg and triazolam 0.5 mg compared to placebo and each other on simulated driving performance in normal…
- Trial name
- NCT01888497
- Testing
- Gabapentin, Diphenhydramine citrate, Triazolam
- Where
- 4 sites in United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Anterior Knee Pain Syndrome
Lumbar Thrust-mobilization Effects on Hip Strength and Anterior Knee Pain
The purpose of this study is to investigate changes in lateral hip muscle strength as well as self-reported pain during the performance of three functional tests in patients with anterior knee pain following a lumbopelvic…
- Trial name
- NCT04119310
- Testing
- Lumbar-thrust mobilization
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Messiah College
Mild Cognitive Impairment
Exploratory Trial in Healthy Adults With Mild Cognitive Impairment,16-week Intervention With Mitocholine™
To evaluate the effect of 16-weeks consumption of Mitocholine on Executive Function and Homocysteine levels in a population experiencing Mild Cognitive Impairment.
- Trial name
- NCT05690724
- Where
- Ireland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mitocholine Ltd
Cough
First-in-Human Study to Investigate the Safety and Tolerability and Pharmacokinetics of HS-10383
This is a first-in-human study that will investigate the safety, tolerability and pharmacokinetics of ascending single doses of HS-10383 using a randomized, double blind, placebo controlled, single center study design.
- Trial name
- NCT05429723
- Testing
- HS-10383
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.
Prader-Willi Syndrome
Study of Emotion and Cognition Abilities of Children With PWS and Proposition of an Innovative Remediation
The present project project is divided in two parts. The primary aim of the part 1 of this study is to evaluate emotional control abilities of children with Prader-Willi syndrome (PWS) aged from 9 to 15 years and to study…
- Trial name
- PRACOM1 (NCT04526379)
- Testing
- Questionnaires, t-VNS
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Rumination, Cognitive Avoidance
The Effectiveness of Dialectical Behavior Therapy on Rumination and Cognitive Avoidance in Teachers
This randomized controlled trial evaluated the effectiveness of Dialectical Behavior Therapy (DBT) skills training in reducing rumination and cognitive avoidance among middle-school teachers in Isfahan, Iran.
- Trial name
- NCT07650617
- Testing
- Dialectical Behavior Therapy Skills Training
- Where
- Iran
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Emotional Problem, Behavior Problem
Enhancement of Emotion Regulation Skills in Adolescents
For the current study, a prevention program is developed and applied to enhance the emotion regulation skills of adolescents. Before and after the application of the prevention program, all participants will be assessed for their…
- Trial name
- NCT04001140
- Testing
- Enhancement of emotion regulation skills
- Where
- Cyprus
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Cyprus
Neuromuscular Block, Residual
Diaphragm Function After Reversal of Rocuronium-induced Neuromuscular Blockade With Sugammadex or Neostigmine in Children
This study is to evaluate the recovery of diaphragm function and atelectasis after reversal of neuromuscular blockade with Neostigmine and Sugammadex using lung ultrasound and diaphragm ultrasound for children aged 2 to 7 who are…
- Trial name
- NCT05724550
- Testing
- Sugammadex, Neostigmine
- Where
- South Korea
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Prediabetic State, Substrate Oxidation
Effects of 2 Weeks Treatment With Dapagliflozin in Subjects With an Impaired Glucose Homeostasis on Nocturnal Substrate Oxidation
The purpose of this study is to investigate the effect of 2 weeks dapagliflozin treatment in individuals with a disrupted glucose homeostasis on the switch between carbohydrate and lipid oxidation during the night
- Trial name
- MaasFlex (NCT03721874)
- Testing
- Dapagliflozin 10mg
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Obesity
Role of Dopamine Transporter in Glucose Control
Healthy subjects will be enrolled in this study. Each subject will be scanned twice with F18-FP-CIT PET which is commercially available. F18-FP-CIT reflects dopamine transporter availability of striatum.
- Trial name
- NCT03466697
- Testing
- Glucose injection/Normal saline injection
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Hypoxia, Endoscopy
Nasal Continuous Positive Airway Pressure Versus Standard Care During Procedural Sedation for Gastrointestinal Endoscopy
This study is a randomized controlled trial comparing oxygen delivery by nasal mask with continuous positive airway pressure versus standard care (nasal cannula or standard facemask) during propofol-based sedation for…
- Conditions
- Hypoxia, Endoscopy, Anesthesia Morbidity
- Trial name
- NCT03369197
- Testing
- Nasal Mask, Control: Nasal Cannula
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Postoperative Pain
Administration of Pre-Operative Gabapentin to Patients Undergoing Laparoscopy
The purpose of this study is to prospectively determine the influence of immediate pre-operative gabapentin administration on acute postoperative pain.
- Trial name
- Gabapentin (NCT02359110)
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Pain
Local Continuous Wound Infusion of Anesthetics in the Management of Post-operative Pain After Total Hip Arthroplasty.
The combination of subarachnoid anaesthesia (SAB) and continuous local wound infiltration (LCWI) with a consistent amount of local anaesthetics could prevent central sensitization through an additive or synergistic effect because…
- Trial name
- NCT02728310
- Testing
- Levobupivacaine, Saline
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- San Salvatore Hospital of L'Aquila
Mental Health, Mindfulness
Perspective on Thoughts and Feelings as a Predictor of Psychological Well-being in Daily Life, in a Community Sample
This project examines the psychological construct of decentering - a mindfulness-related construct marked by an observer perspective on one's ongoing mental processes.
- Trial name
- NCT03336710
- Where
- United States
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
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