Clinical trials: COPD, completed
Copd, Heart Failure
Effect of Dual Bronchodilation With Umeclidinium/Vilanterol on Patients With COPD, Hyperinflation and Heart Failure
Double-blind, randomized, two-period crossover, placebo-controlled, single-center study, to determine the effect of umeclidinium/vilanterol 55/22 μg compared with placebo on the increase in left systolic chamber function during…
- Trial name
- CHHEF (NCT04522596)
- Testing
- Umeclidinium/vilanterol
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Luis Puente Maestu
COPD Exacerbation, Pulmonary Rehabilitation
Virtual Reality in COPD Exacerbation
In addition to conventional pulmonary rehabilitation, virtual reality will be applied during the hospitalization period of individuals hospitalized for COPD exacerbation.
- Trial name
- NCT05687396
- Testing
- virtual reality, conventional pulmonary rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Pamukkale University
Chronic Obstructive Pulmonary Disease (COPD)
Sensorimotor Function in COPD
The aim of this study was to investigate the level of sensorimotor function impairment according to disease stage in individuals with Chronic Obstructive Pulmonary Disease (COPD) and to determine whether functional differences…
- Trial name
- NCT07825636
- Where
- Turkey (Türkiye)
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Alanya Alaaddin Keykubat University
COPD Acute Exacerbation
Rademikibart Add-on Treatment of an Acute COPD Exacerbation (Seabreeze STAT COPD)
This is a Phase 2, multicenter study in adult participants with an acute COPD exacerbation and type 2 inflammation
- Trial name
- NCT06940154
- Testing
- Rademikibart in prefilled syringe
- Where
- 52 sites in United States, Argentina and 4 more
- Volunteers
- 159 people
- Sponsor
- Connect Biopharm LLC
COPD
Effect of Rehabilitation at Moderate Altitude on Airway Resistance Measured With Forced Oscillation Technique in COPD-patients
Airway resistance will be measured using the forced oscillation technique (FOT). The parameters Rrs, Xrs, and ∆Xrs will be compared before and after a pulmonary rehabilitation cycle at moderate altitude.
- Trial name
- NCT07063563
- Testing
- ambiant air, Oxygen
- Where
- 2 sites in Kyrgyzstan, Switzerland
- Volunteers
- 52 people
- Sponsor
- Eastern Switzerland University of Applied Sciences
COPD (Chronic Obstructive Pulmonary Disease)
Effect of Rehabilitation on the Respiratory Signal in Patients With COPD and Exercise-Induced Desaturation
The aim is to study the effect of SSOT during a 3-week in-patient pulmonary rehabilitation programme. Further aim is to analyse exercise endurance, distinguishing between those exercising whilst breathing air at 760m "normoxia"…
- Trial name
- NCT07107828
- Testing
- Ambient air, Oxygen, Altitude
- Where
- Kyrgyzstan
- Volunteers
- 52 people
- Sponsor
- Eastern Switzerland University of Applied Sciences
COPD
Oxygen Therapy During Exercise Training in Inpatient Rehabilitation in Chronic Lung Disease- Does it Matter?
The aim of the current study is the effect of SSOT during a 3-weeks inpatient pulmonary rehabilitation program. Further aim is to analyze exercise endurance, distinguishing between those exercising whilst breathing air at 760m…
- Trial name
- NCT07044843
- Testing
- Oxygen, Standard ambiant air will be breathed during endurance training.
- Where
- 2 sites in Kyrgyzstan, Switzerland
- Volunteers
- 54 people
- Sponsor
- Eastern Switzerland University of Applied Sciences
COPD Exacerbation, Hypoxia
Automated Oxygen Delivery by O2matic to Patients Admitted With an Exacerbation in COPD
The aim of the study is to examine if automated oxygen delivery with O2matic is better than manually controlled oxygen therapy for patients admitted to hospital with an exacerbation in Chronic Obstructive Pulmonary Disease…
- Conditions
- COPD Exacerbation, Hypoxia, Hyperoxia, Respiratory Failure
- Trial name
- O2MATIC (NCT03464695)
- Testing
- O2matic
- Where
- 2 sites in Denmark
- Volunteers
- 20 people
- Sponsor
- Hvidovre University Hospital
COPD
A Phase I Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics for a Single Dose of HRS-9821 Powder for Inhalation and Inhalation Suspension Administered in Healthy Subjects and Multiple Doses in Patients With COPD.
The aim of this study was to evaluate the safety and tolerability of HRS-9821 Powder for Inhalation and inhalation suspension administered in a single dose in healthy individuals and multiple doses in patients with COPD
- Trial name
- NCT07116915
- Testing
- HRS-9821 Powder for Inhalation/HRS-9821 inhalation suspension, Moxifloxacin Hydrochloride Tablets
- Where
- China
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Guangdong Hengrui Pharmaceutical Co., Ltd
COPD, Chronic Obstructive Pulmonary Disease
GOLD 0 - DLCO 1: A Look Beyond the Obstruction. Is Spirometry Enough for COPD (Chronic Obstructive Pulmonary Disease) Screening?
This is a multicenter observational prospective study in smokers or ex-smokers with cumulative exposure ≥ 10 a / p (years / pack) with respiratory symptoms and presenting a normal spirometry.
- Trial name
- NCT05016466
- Testing
- Standard Care, Standard Care plus oxidative stress study plus inflammation biomarkers study
- Where
- Spain
- Volunteers
- 236 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Bioequivalence Study of Budesonide/Formoterol Inhalation Powder in Healthy Participants
The goal of this study is to learn if a new formulation of Budesonide/Formoterol Inhalation Powder (160μg/4.5μg), manufactured by Shanghai New Huanghe Pharmaceutical Co., Ltd., works the same as the already approved reference…
- Trial name
- BF-BE (NCT07804303)
- Testing
- Budesonide and Formoterol Fumarate Powder for Inhalation (II) (Test), Budesonide and Formoterol Fumarate Powder for Inhalation (II) (Reference)
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shanghai Xin Huanghe Pharmaceutical Co., Ltd.
COPD
Time-based Register and Analysis of COPD Endpoints
The Time-based Register and Analysis of COPD Endpoints (TRACE) study is prospective cohort study aiming at evaluating COPD patients using simple basic tools normally used in the clinic at hand of any physician.
- Trial name
- TRACE (NCT03485690)
- Where
- Spain
- Volunteers
- 1,440 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Noninvasive Ventilation, COPD
Effect of Web-Based Adaptation and Insomnia Severity in Individuals Using Noninvasive Ventilators at Home
Home use of the NIV device, which is used to manage respiratory failure, one of the most disturbing symptoms due to COPD, will continue to increase.
- Trial name
- NCT06343324
- Testing
- Web-based education
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- KTO Karatay University
COPD (Chronic Obstructive Pulmonary Disease)
Validation of Chronic Obstructive Pulmonary Disease (COPD) Algorithm
Under-diagnosis of Chronic Obstructive Pulmonary Disease (COPD) is prevalent, with an estimated 75% of adults suffering from COPD in the US, without clinical recognition.
- Trial name
- COPD (NCT07223749)
- Where
- United States
- Volunteers
- 425 people
- Sponsor
- Wake Forest University Health Sciences
Chronic Obstructive Pulmonary Disease (COPD)
Functional Social Support in COPD Self-Management
This observational study aims to examine how different types of functional social support (emotional/informational, tangible, affectionate, and positive social interaction) predict self-management capacity among individuals with…
- Trial name
- NCT07353034
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Medical University of South Carolina
COPD Patients, Depression in Chronic Obstructive Pulmonary Disease
Effect of Utilizing Virtual Reality With Pulmonary Rehabilitation on Depression in COPD Patients
The goal of this study is to find the effect of utilizing virtual reality with pulmonary rehabilitation on depression in COPD patients.
- Trial name
- NCT07790627
- Testing
- virtual reality with pulmonary rehabilitation, controlled group received pulmonary rehabilitation without utilizing virtual reality
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
COPD Chronic Obstructive Pulmonary Disease, Interstitial Lung Disease
Assessing Functional Capacity in Directly and Remotely Monitored Home-based Settings: A Protocol for a Multinational Validation Study in Individuals With Chronic Respiratory Diseases
The goal of this validation study is to provide further evidence of the metrological properties of the 6-minute stepper test in individuals with chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD).
- Trial name
- 6MST (NCT06447831)
- Where
- 3 sites in Canada, France
- Volunteers
- 89 people
- Sponsor
- Laval University
COPD (Chronic Obstructive Pulmonary Disease), COPD
Dupilumab in Type 2-Inflamed COPD Across the Full Spectrum of Airflow Limitation: An Italian Multicentre Retrospective Cohort Study
This multicentre retrospective cohort study describes lung function and patient-reported outcomes in adults with chronic obstructive pulmonary disease (COPD) and type 2 inflammation who received add-on dupilumab in routine…
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), COPD, Eosinophilia
- Trial name
- DUPICENTRO (NCT07788092)
- Testing
- Dupilumab
- Where
- 6 sites in Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliera di Perugia
COPD (Chronic Obstructive Pulmonary Disease)
Internet-Based Cognitive Behavioral Therapy and Educational Program for People Living With Chronic Obstructive Pulmonary Disease (COPD)
The goal of this clinical trial is to learn if an internet-based cognitive behavioral therapy (CBT) and education program can help improve mental health, disease knowledge, and quality of life in adults with chronic obstructive…
- Trial name
- COPD BALANCE (NCT06891677)
- Testing
- Internet-Based Cognitive Behavioral Therapy (CBT) with ACT and COPD Education
- Where
- Sweden
- Volunteers
- 28 people
- Sponsor
- Jonas Agholme
COPD
Respiratory Therapist-Supported Home Noninvasive Ventilation in Stable Severe COPD Without Hypercapnia
Chronic obstructive pulmonary disease (COPD) can cause persistent breathing problems, reduced exercise capacity, and repeated worsening of symptoms. Noninvasive ventilation (NIV) provides breathing support through a mask.
- Trial name
- COPD (NCT07777497)
- Testing
- BreathePal Bilevel Positive Pressure System (GFM50-MD2201)
- Where
- Taiwan
- Volunteers
- 14 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital