Clinical trials: COPD
COPD (Chronic Obstructive Pulmonary Disease)
Photon-counting CT in Chest Imaging
Purpose and objective: This project aims to evaluate photon-counting computed tomography (PCCT) quantitative accuracy using COPDGene subjects.
- Trial name
- NCT07031336
- Testing
- Photon-counting CT, Energy-integrating CT
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Chronic Obstructive Airway Disease
Cardiac Hemodynamics in Overlap Syndrome (COPD With Obstructive Sleep Apnea)
Patients with both sleep apnea and COPD have overlap syndrome, but their optimal management is not known. We plan to conduct a randomized trial of of bi-level PAP vs.
- Trial name
- NCT01261377
- Testing
- Bi-level positive airway pressure (BPAP), Oxygen, CPAP
- Where
- 2 sites in United States
- Sponsor
- Brigham and Women's Hospital
COPD
Does Muscle Wasting Always Mean Muscle Weakness? A Prevalence Study in COPD
Peripheral muscle mass and strength are relevant indicators of COPD survival. Current guidelines recommend to assess muscle strength only in muscle wasted patients.
- Trial name
- M2W (NCT02080936)
- Where
- France
- Volunteers
- 138 people
- Sponsor
- 5 Santé
Chronic Obstructive Pulmonary Disease
Transdiaphragmatic Pressure and Neural Respiratory Drive Measured During Inspiratory Muscle Training in COPD
Inspiratory muscle training（IMT）was an rehabilitation therapy for stable patients with chronic obstructive pulmonary disease(COPD).
- Trial name
- NCT03017300
- Testing
- Threshold IMT®, PFLEX®
- Volunteers
- 12 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Post Operative Complication, Pulmonary, Lung Cancer
Efficacy of Nebulized Pulmicort Respules in Primary Lung Cancer Patients With COPD
To test the hypothesis that nebulized Pulmicort Respules could reduce post operation pulmonary complication incidence in primary lung cancer patients with COPD.
- Conditions
- Post Operative Complication, Pulmonary, Lung Cancer, COPD
- Trial name
- NCT02504801
- Testing
- Budesonide
- Volunteers
- 73 people
- Sponsor
- Xiuyi Zhi
Chronic Obstructive Pulmonary Disease
Long Term Evaluation of Activity Levels Post Pulmonary Rehabilitation
Sustained improvement after pulmonary rehabilitation in activity levels as measured by an activity armband. Pulmonary rehabilitation is utilized to improve exercise capacity, quality of life and prognosis for patients who suffer…
- Trial name
- NCT01530412
- Testing
- Pulmonary Rehabilitation
- Where
- Ireland
- Volunteers
- 65 people
- Sponsor
- Beaumont Hospital
Chronic Obstructive Lung Disease
Treatment of Chronic Obstructive Pulmonary Disease (COPD) With Iodinated Activated Charcoal
The purpose of this study s to determine whether treatment with Iodinated Active Charcoal can improve lung function and physical capacity in patients with chronic obstructive lung disorders.
- Trial name
- NCT01404000
- Testing
- Iodinated Active Charcoal (IodoCarb)
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- PharmaLundensis AB
Chronic Obstructive Pulmonary Disease, Bronchitis
Efficacy Safety Study of Arformoterol/Tiotropium Combination Versus Either Therapy Alone in Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to evaluate and compare the efficacy of arformoterol twice a day and tiotropium once a day (dosed sequentially) versus tiotropium once a day alone in subjects with Chronic Obstructive Pulmonary…
- Conditions
- Chronic Obstructive Pulmonary Disease, Bronchitis, Emphysema
- Trial name
- NCT00424528
- Testing
- Arformoterol Tartrate Inhalation Solution, Tiotropium, Arformoterol and Tiotropium
- Where
- 28 sites in United States
- Volunteers
- 235 people
- Sponsor
- Sumitomo Pharma America, Inc.
Study is Being Conducted in Healthy Volunteers
A Study to Assess How Much Drug Reaches the Blood When Given From Symbicort pMDI With Spacer Compared to That of Symbicort pMDI Without Spacer in Healthy Volunteers
This study will be conducted to establish the relative bioavailability of budesonide and formoterol delivered via Symbicort pressurized metered-dose inhaler (pMDI) with and without a spacer device.
- Trial name
- NCT02934607
- Testing
- Symbicort pMDI with spacer device, Symbicort pMDI without spacer device
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Pulmonary Disease, Chronic Obstructive
Trial to Determine Effective Aspirin Dose in COPD
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States. Current treatments for COPD focus on inhaler therapies that do not address manifestations of the disease on other organ…
- Trial name
- NCT05265299
- Testing
- Aspirin 81mg, Aspirin 162 mg, Aspirin 325mg
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Johns Hopkins University
Chronic Obstructive Pulmonary Disease
Effect of Tiotropium on Inflammation and Exacerbations in COPD
Patients with COPD experience exacerbations that are a major cause of morbidity. Exacerbations are associated with increased airway and systemic inflammation and those experiencing frequent exacerbations demonstrate increased…
- Trial name
- NCT00405236
- Testing
- tiotropium
- Where
- United Kingdom
- Volunteers
- 220 people
- Sponsor
- Royal Free and University College Medical School
Chronic Obstructive Pulmonary Disease (COPD), Blood Flow Restriction Training (BFRT)
Effects Of Low-Load Blood Flow Restriction Training Of The Upper Extremity In Patients With Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is characterized by persistent airflow limitation, progressive dyspnea, and peripheral muscle dysfunction, significantly impairing functional capacity and quality of life.
- Trial name
- NCT07469111
- Testing
- Low-Load Blood Flow Restriction Training (LL-BFRT) + Aerobic Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Inonu University
Malnutrition, Pulmonary Disease, Chronic Obstructive
Nutritional Supplementation in Adults With Chronic Respiratory Disease
The purpose of this study is to determine whether nutritional support with a complete formula is effective to improve malnutrition and respiratory function in patients with chronic pulmonary disease compared to the standard…
- Conditions
- Malnutrition, Pulmonary Disease, Chronic Obstructive, Other Pulmonary Disease, Chronic Obstructive
- Trial name
- OFOS (NCT02102009)
- Testing
- Complete enteral formula, Dietary Advise
- Where
- Peru
- Volunteers
- 99 people
- Sponsor
- Laboratorios Ordesa
Chronic Obstructive Pulmonary Disease (COPD)
Comparison of Indacaterol With That of Placebo in 'Maintenance naïve' Patients With COPD Using Blinded Tiotropium as Active Control
This study will compare the efficacy of indacaterol versus placebo (i.e., rescue medication only) and tiotropium in patients with Chronic Obstructive Pulmonary Disease (COPD) who have not received maintenance COPD medication for…
- Trial name
- INITIATE (NCT01715311)
- Testing
- Indacaterol, Tiotropium
- Sponsor
- Novartis Pharmaceuticals
COPD (Chronic Obstructive Pulmonary Disease)
Comparison of Clinical Parameters in Chronic Obstructive Pulmonary Disease Patients and Healthy Individuals
The investigators think that the functions of core stabilization muscles are different in chronic obstructive pulmonary disease (COPD) patients than in healthy individuals.
- Trial name
- NCT06677671
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Chronic Obstructive Pulmonary Disease, Hypogonadism
Association Between Testosterone Levels and COPD Severity
The Aims of the study are estimate the association between the severity of COPD and free testosterone level and the prevalence of hypogonadism in adult men with stable COPD
- Trial name
- COPDTESTO (NCT02824809)
- Where
- Argentina
- Volunteers
- 150 people
- Sponsor
- Hospital Italiano de Buenos Aires
COPD, Hypercapnic Respiratory Failure
Efficacy of High-intensity NPPV and Low-intensity NPPV in Patients With Chronic Hypercapnic COPD
High-intensity noninvasive positive pressure ventilation (NPPV), which can well improve the gas exchange and reduce the work of breathing of patients, is a new strategy targeted at maximally reducing arterial carbon dioxide.
- Trial name
- NPPV;COPD (NCT03238014)
- Testing
- Noninvasive positive pressure ventilation
- Where
- China
- Volunteers
- 14 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Chronic Obstructive Pulmonary Disease (COPD)
A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease
This Phase IIb dose-ranging study will evaluate the efficacy and safety of 2 different doses of AZD6793 compared with placebo tablets in participants with moderate to very severe chronic obstructive pulmonary disease.
- Trial name
- PRESTO (NCT07082738)
- Testing
- AZD6793
- Where
- 367 sites in United States, Argentina and 22 more
- Volunteers
- 987 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
Illness Expectations in COPD
This study investigates the impact of expectations on individuals with Chronic Obstructive Pulmonary Disease (COPD) and aims to develop and validate a novel tool to assess these expectations.
- Trial name
- ASPECTO-BPCO (NCT06509308)
- Testing
- Psychological Questionnaires
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
COPD, Sympathetic Nervous System Diseases
Sympathetic Nerve Activity Predictors in Patients With Chronic Obstructive Pulmonary Disease
The project will be pursued in our respiratory, autonomic nervous system physiology laboratory (Respiratory, autonomic nervous system physiology laboratory, Department of Pneumology and Intensive Care Medicine, RWTH Aachen…
- Conditions
- COPD, Sympathetic Nervous System Diseases, Catecholamine; Overproduction
- Trial name
- SNAP-COPD (NCT04849806)
- Testing
- Assessments of the sympathetic nerve activity axis, OSA severity, Determination of PH and right HF severity
- Where
- Germany
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University