Clinical trials: COPD Acute Exacerbation
Chronic Obstructive Pulmonary Disease With (Acute) Exacerbation
Comparison of HFNC With NIV in Weaning COPD
High flow nasal cannula (HFNC) has been shown to improve oxygenation and facilitate weaning in hypoxemia patients. Some clinical studies show the benefits of using HFNC in COPD patients, including reducing dead space and work of…
- Trial name
- NCT03458364
- Testing
- High flow nasal cannula, Noninvasive ventilation
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Jie Li
COPD
EMG in COPD - Factor Analysis
Acute exacerbations of COPD contribute to significant morbidity and mortality in the United Kingdom (UK). The ability to assess response to treatment during exacerbations that require hospitalisation would allow clinicians to…
- Trial name
- EMGCOPD (NCT02721199)
- Testing
- Neural Respiratory Drive Automated EMGpara assessment
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Chronic Obstructive Pulmonary Disease
Residential Cleaning of Indoor Air to Protect COPD Patients
This study looks at whether air cleaning devices put in the bedroom and living room of your home could reduce the irritation of your lungs and body that is caused by indoor air pollution.
- Trial name
- CARE (NCT03750292)
- Testing
- HEPAirX air filter, control air filter
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Rochester
Chronic Obstructive Pulmonary Disease
Clinical Trial Assessing the Value of an Antibiotic Protocol Guided by Serum Procalcitonin in Acute Exacerbations of Chronic Obstructive Pulmonary Disease in Intensive Care
Investigators propose to conduct a prospective, randomized, controlled, multicenter assessing the interests of an antibiotic protocol guided by serum procalcitonin (PCT) on morbidity and mortality in patients with chronic…
- Trial name
- BPCTréa (NCT02521636)
- Testing
- Antibiotic therapy randomization, Serum PCT dosage
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Caen
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Safety, PK and PD Relationships of RLS-0071 in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
AECOPD is a major cause of hospital admission and mortality. They contribute to long-term decline in lung function, physical capacity, and quality of life (QoL).
- Trial name
- NCT06175065
- Testing
- RLS-0071
- Where
- 4 sites in United States
- Volunteers
- 24 people
- Sponsor
- ReAlta Life Sciences, Inc.
COPD Exacerbation Acute, Ascaris Lumbricoides Infection
Impact of A. Lumbricoides on Pulmonary Aspergillosis Development
The prevalence of ascariasis in COPD patients with and without concomitant pulmonary aspergillosis and in controls will be determined.
- Conditions
- COPD Exacerbation Acute, Ascaris Lumbricoides Infection, Chronic Pulmonary Aspergillosis
- Trial name
- NCT05783544
- Testing
- Interleukin-1B, Interleukin-4, Interleukin-6
- Where
- Uzbekistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan
COPD Exacerbation Acute
A Study to Evaluate the Efficacy and Safety of Sitafloxacin in Adult Subjects With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable disease, that causes obstructed airflow from the lungs that causes persistent obstructive airflow limitation.
- Trial name
- NCT05400369
- Testing
- Sitafloxacin, Moxifloxacin Hydrochloride
- Where
- 18 sites in China
- Volunteers
- 140 people
- Sponsor
- Daiichi Sankyo
COPD, Physical Activity
Transcutaneous Electrical Nerve Stimulation During Exercise in Patients With COPD
Early pulmonary rehabilitation is recommended after an episode of severe exacerbation of chronic obstructive pulmonary disease (COPD). However, its implementation is challenging particularly as regard exercise training.
- Conditions
- COPD, Physical Activity, Rehabilitation, TEN
- Trial name
- proTENS (NCT03548870)
- Testing
- CWRT with low frequency transcutaneous electrical nerve stimulation
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Groupe Hospitalier du Havre
COPD Exacerbation
Efficacy of Nebulized Long-Acting Bronchodilators (Formoterol and Revefenacin) vs. Short-Acting Bronchodilators (Albuterol and Ipratropium) in Patients Presenting to the Emergency Department With Acute Exacerbation of COPD (ECOPD)
The primary aim is to determine whether nebulized Formoterol twice daily plus Revefenacin once daily is non-inferior to standard-of-care nebulized Albuterol and Ipratropium therapy four times daily in relieving dyspnea among…
- Trial name
- NCT07721922
- Testing
- Revefenacin, formoterol fumarate, Albuterol sulfate
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- University of Tennessee Graduate School of Medicine
Pharyngitis, Acute Tonsillitis
Clinical Trial for the Assessment of Delayed Antibiotic Treatment Strategies
The general hypothesis is that delayed antibiotic treatment strategies present similar effectiveness, when compared with non-prescription of antibiotics or the prescription of antibiotics, in the non-complicated acute respiratory…
- Conditions
- Pharyngitis, Acute Tonsillitis, Rhinosinusitis, Acute Bronchitis
- Trial name
- PDA (NCT01363531)
- Testing
- Antibiotic prescription strategies
- Where
- Spain
- Volunteers
- 405 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Chronic Obstructive Pulmonary Disease, Respiratory Failure
NHF vs NIV in Patients With Acute Exacerbation of COPD
Although non-invasive ventilation (NIV) usage has increased significantly over time in COPD exacerbation, a great percentage of patients (~30%) present contraindications to NIV or cannot tolerate it.
- Conditions
- Chronic Obstructive Pulmonary Disease, Respiratory Failure, Acute Exacerbation Copd
- Trial name
- NCT03466385
- Testing
- Nasal High Flow, Non-Invasive Ventilation
- Where
- 3 sites in Greece
- Volunteers
- 498 people
- Sponsor
- Evangelismos Hospital
Chronic Obstructive Lung Disease, Acute Exacerbation of COPD
Are Comorbidities Related to Frequent Severe Exacerbations of AECOPD
INTRODUCTION: Relationship between comorbidities and COPD is two-sided. While the number of comorbidities increasing, the frequency of acute exacerbations of COPD (AECOPD) is increasing, too.
- Conditions
- Chronic Obstructive Lung Disease, Acute Exacerbation of COPD, Comorbidities and Coexisting Conditions
- Trial name
- NCT05504993
- Testing
- Frequency of AECOPD
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people
- Sponsor
- Ankara University
Chronic Obstructive Pulmonary Disease, Diastolic Dysfunction
Diastolic Dysfunction and Pauci-inflammatory Acute Exacerbations of COPD
This is a prospective study to determine the relationships between pauci-inflammatory exacerbations and diastolic dysfunction, and their implications in hospitalized patients with acute exacerbations of COPD.
- Trial name
- NCT03110614
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- University of Alabama at Birmingham
Chronic Obstructive Pulmonary Disease, Anxiety
Anxiety and Depression in Patients Hospitalizes for an Acute Exacerbation of COPD
This study will try to elucidate wheter the impact of a psychiatric intervention in patients hospitalized because an acute exacerbation of COPD and anxiety/depression and reconsulting at 1 and 6 month after discharge.
- Conditions
- Chronic Obstructive Pulmonary Disease, Anxiety, Depression
- Trial name
- ADPHA-EPOC (NCT01520376)
- Testing
- Counselling
- Where
- Spain
- Volunteers
- 169 people
- Sponsor
- Nestor Soler Porcar, MD, PhD
Chronic Obstructive Pulmonary Disease
Analysis of the Dynamics of the Lung Microbiota During Acute Exacerbation of COPD Requiring Admission to Intensive Care Unit
This study aims to investigate the correlation between pulmonary microbiota dynamics (including bacteria, fungi and viruses) and COPD exacerbation for COPD patients admitted to ICU
- Trial name
- ADMiRE (NCT03641235)
- Testing
- Sputum collection
- Where
- France
- Volunteers
- 29 people
- Sponsor
- University Hospital, Bordeaux
Chronic Obstructive Pulmonary Disease (COPD)
Clinical Evaluation of SenseGuard™ to Detect Respiratory Changes, During Home Monitoring of Subjects With High Risk of AECOPD.
This is an observational, open labeled study. The study aims to evaluate the capability of SenseGuard™ (SG) non-invasive wearable device, to detect, post-hoc, early respiratory changes due to exacerbation by daily monitoring of…
- Trial name
- NCT05119374
- Testing
- SenseGuard Investigational Device
- Where
- 6 sites in Israel
- Volunteers
- 57 people
- Sponsor
- NanoVation
Acute Decompensated Heart Failure, COPD Exacerbation
Use of ΔIVC for Early Diagnosis of AHF in AECOPD
Acute Heart failure (AHF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This association is frequently underestimated with regard to the difficulty of clinical diagnosis.
- Trial name
- NCT05327374
- Testing
- calculation of the inferior vena cava collapsibility index
- Where
- 3 sites in Tunisia
- Volunteers
- 401 people
- Sponsor
- University of Monastir
COPD Exacerbation Acute
Comparison of Bronchodilator Treatment Practices in Group E COPD Patients
COPD is a heterogeneous condition caused by airway (bronchitis/bronchiolitis) or alveolar (emphysema) abnormality, changes with chronic respiratory changes (dyspnea, dyspnoea, phlegm).
- Trial name
- NCT06178068
- Testing
- Comparison of bronchodilator effectiveness of nebulizer therapy devices
- Volunteers
- 39 people
- Sponsor
- Ataturk University
COPD Exacerbation
Effect of High Flow Nasal During Exercise in COPD Patients
Early pulmonary rehabilitation is recommended after an episode of severe exacerbation of chronic obstructive pulmonary disease (COPD). However, its implementation is challenging particularly as regard exercise training.
- Trial name
- AiRehab (NCT03058081)
- Testing
- High Flow nasal cannula
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Groupe Hospitalier du Havre
Chronic Obstructive Pulmonary Disease
N-acetylcysteine (NAC) for the Treatment of Acute Exacerbation of COPD
Patients with Chronic obstructive pulmonary disease (COPD) experience gradually deteriorating lung function, which may be complicated by acute exacerbations.
- Trial name
- NCT05706402
- Testing
- N-acetylcysteine
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- Queen Mary Hospital, Hong Kong