Clinical trials: COPD Exacerbation (AECOPD)
Copd, COPD Exacerbation
Change in Breathing Pattern on Non-invasive Ventilation of COPD Patients Under Home Mechanical Ventilation
Acute exacerbation of COPD (AECOPD) worsen prognosis and quality of life of COPD patients. Telemonitoring could be a useful tool for early identification of AECOPD. Parameters that have to be monitored are not well defined.
- Trial name
- NCT03018470
- Testing
- Analysis of data from NIV built-in software
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Rouen
Chronic Obstructive Pulmonary Disease
Short Compared With Standard Duration of Antibiotic Treatment for AECOPD
Chronic obstructive pulmonary disease (COPD) is one of the most common diseases in the world. Acute exacerbation of COPD (AECOPD) refers to an exaggeration of the symptoms of the disease.
- Trial name
- AECOPD (NCT03698682)
- Testing
- Levofloxacin 500mg
- Where
- Tunisia
- Volunteers
- 310 people
- Sponsor
- University of Monastir
Chronic Obstructive Pulmonary Disease
PIFR-based Inhalation Therapy in Patients Recovering From AECOPD
This study is designed to determine whether the optimized inhalation therapy based on peak inspiratory flow rates (PIFR) measured against the simulated resistance can reduce the rate of treatment failure in patients recovering…
- Trial name
- NCT04000958
- Testing
- PIRF measured by InCheck DIAL, Regular treament
- Where
- China
- Volunteers
- 460 people
- Sponsor
- Shanghai Zhongshan Hospital
Chronic Obstructive Pulmonary Disease, COPD
Do Blood Tests Help to Decide Which Patients With Flares of Chronic Obstructive Pulmonary Disease (COPD) Need Antibiotics and Steroids?
The goal of this clinical trial is to see if the use of two simple blood tests: C reactive protein and eosinophils, can reduce the use of steroids and antibiotics in patients with flares of chronic obstructive pulmonary disease…
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD, Exacerbation of COPD, AECOPD
- Trial name
- Bidex (NCT06929767)
- Testing
- biomarker-guided decision making, GOLD recommendations
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Ottawa Hospital Research Institute
Chronic Obstructive Pulmonary Disease
A Study of the Inflammatory Pathways Associated With Chronic Obstructive Pulmonary Disease Exacerbations
The purpose of this study is to observe how the inflammatory pathways differ in subjects with chronic obstructive pulmonary disease (COPD) during an acute exacerbation of COPD (AECOPD).
- Trial name
- NCT01337661
- Where
- Ireland
- Volunteers
- 26 people
- Sponsor
- MedImmune LLC
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
High-Intensity vs Low-Intensity NPPV in Patients With an AECOPD: The HAPPEN Trial
To determine whether high-intensity NPPV, compared with low-intensity NPPV, could reduce the need for endotracheal intubation during hospitalization in patients with an AECOPD and hypercapnia.
- Trial name
- NCT02985918
- Testing
- High-intensity NPPV, Low-intensity NPPV
- Where
- 31 sites in China
- Volunteers
- 300 people
- Sponsor
- Beijing Chao Yang Hospital
Chronic Obstructive Pulmonary Disease
Short Antibiotic Treatment Versus Duration Guided by Markers of Inflammation in the Treatment of AECOPD
Chronic obstructive pulmonary disease (COPD) is one of the most common diseases in the world. In a recent study, we showed that administration of levofloxacin is superior to placebo in the treatment of decompensation of COPD; it…
- Trial name
- AECOPD (NCT02067780)
- Testing
- Levofloxacin 500mg
- Where
- Tunisia
- Volunteers
- 310 people
- Sponsor
- University of Monastir
COPD Exacerbation, COPD
COPD in the Time of COVID-19
This cross-sectional observational study will collect information about changes in exacerbation frequency and behaviour amongst a clinical cohort of severe or complex COPD clinic patients.
- Trial name
- NCT04407598
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- University of Leicester
Angina, Acute Bronchiolitis
Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care
Antimicrobial resistance (AMR), considered one of the greatest global threats by the WHO, justifies the development of initiatives to promote appropriate antibiotic use-especially in primary care, where most antibiotics in France…
- Conditions
- Angina, Acute Bronchiolitis, Acute Bronchitis, COPD Exacerbation (AECOPD)
- Trial name
- GRASP (NCT07359287)
- Testing
- Antibiotic prescribing according to guidelines
- Where
- France
- Volunteers
- 4,500 people
- Sponsor
- University Hospital, Caen
Chronic Obstructive Pulmonary Disease
ECCO2R as an Adjunct to NIV in AECOPD
Chronic obstructive pulmonary disease (COPD) is one of the UKs commonest chronic diseases and is responsible for a significant number of acute hospital admissions.
- Trial name
- NCT02086084
- Testing
- NIV, ECCO2R
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Chronic Obstructive Pulmonary Disease
Comparative Effects of Different Noninvasive Ventilation Mode on Neural Respiratory Drive in Recovering AECOPD Patients
Background: The efficiency of Neural respiratory drive (NRD)expressed by a ratio of ventilation to the diaphragm electromyogram (EMGdi) decreases in patients with COPD .Improving the neural respiratory drive efficiency of COPD…
- Trial name
- NCT01782768
- Testing
- noninvasive positive pressure ventilation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Chronic Obstructive Pulmonary Disease
Supine Daoyin in the Treatment of AECOPD
The purpose of this study was to evaluate the clinical efficacy and safety of supine daoyin in the treatment of AECOPD.
- Trial name
- NCT04913961
- Testing
- Supine Daoyin, western medicine conventional therapy
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Obstructive Pulmonary Disease, Exacerbation Copd
AECOPD and Nutritional Supplementation in COPD
Better understanding of the duration needed to overcome metabolic disturbances in patients experiencing exacerbation. Also, the explore role of nutritional intervention in the treatment program of stable COPD patients and in…
- Trial name
- NCT06801964
- Testing
- Stable isotope infusion, Protein and Fish Oil, Protein and Olive Oil
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
COPD Exacerbation
HFNC vs Nasal Cannula in Mild Chronic Obstructive Pulmonary Disease Exacerbation
For AECOPD patients, only 8% patients ventilated by noninvasive and invasive positive pressure ventilation. Nasal cannula is the most common pattern of oxygen therapy in mild AECOPD.
- Trial name
- NCT03003559
- Testing
- High flow nasal cannula
- Where
- China
- Volunteers
- 328 people
- Sponsor
- China-Japan Friendship Hospital
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Impact of HI-NPPV Vs LI-NPPV on Tolerance Among AECOPD Patients
To determine whether high-intensity NPPV, compared with low-intensity NPPV, could have an effect on the subjective tolerance in patients with an AECOPD and hypercapnia.
- Trial name
- NCT06692023
- Testing
- High-intensity NPPV, Low-intensity NPPV
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Chao Yang Hospital
Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of COPD
Remote Monitoring of COPD Patients Experiencing an Acute Exacerbation Through Health Evaluations Using Wearable Mobile Technology
Chronic obstructive pulmonary disease (COPD) causes about 3 million deaths annually and significantly burdens healthcare systems, costing the EU 38.6 billion euros, largely due to frequent hospitalizations triggered by acute…
- Trial name
- COPD-BREATHE (NCT06890767)
- Testing
- Wearable mobile device, CAT Questionnaire, DHRQ Questionnaire
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- David Ruttens
Safety of NHF in Acute Hypercapnic AECOPD
NHF in Acute Hypercapnic Acute Exacerbation of COPD
Patients with AECOPD and NIV failure and in absence will be treated with NHF device. Inclusion criteria are pH < 7,38 and pCO2 > 45 mm Hg. Patients were treated if pH >7,38 or refusal of therapy.
- Trial name
- NCT03523481
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- Jens Bräunlich, MD
Pulmonary Disease, Chronic Obstructive
Magnesium Sulfate to Prevent Hospitalisation of Acute Exacerbations of Chronic Obstructive Pulmonary Disease
The purpose of this study is to assess whether administration of a bolus dose of MgSO4 (magnesium sulfate) plus standard therapy is superior to standard therapy alone for the management of Acute Exacerbations of Chronic Pulmonary…
- Trial name
- NCT02498496
- Testing
- Magnesium Sulfate
- Sponsor
- Hôpital de Verdun
COPD, COPD Exacerbation Acute
Relationship Between Plasma Metabolome and the Efficacy of Systemic Glucocorticoid in AECOPD
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) significantly increases the mortality of the patients with COPD. Guidelines have recommended systemic glucocorticoid as regular treatment.
- Trial name
- NCT04710849
- Testing
- Serum metabolic markers
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Comparing Hydrocortisone and Prednisolone for Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)
The goal of this cluster randomized controlled trial is to determine the optimal treatment for Acute Exacerbation of Chronic Obstructive Pulmonary Disease.
- Trial name
- NCT06892210
- Testing
- Methylprednisolone (drug), Hydrocortisone
- Where
- 14 sites in Denmark
- Volunteers
- 2,000 people
- Sponsor
- Copenhagen Respiratory Research