Clinical trials: COPD Exacerbation (AECOPD)
Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Chronic Obstructive Pulmonary Disease (COPD)
Red Blood Cell and Platelet Indices for Predicting Outcomes in Acute Exacerbations of COPD
The purpose of this study is to evaluate if standard, easily accessible blood tests can help doctors predict the severity and outcomes of sudden flare-ups in patients with Chronic Obstructive Pulmonary Disease (COPD).
- Conditions
- Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Chronic Obstructive Pulmonary Disease (COPD), AECOPD
- Trial name
- NCT07693127
- Volunteers
- 50 people
- Sponsor
- Assiut University
Obstructive Chronic Bronchitis With Acute Exacerbation
STI Combined to Valsalva Maneuver for the Diagnosis of Left Ventricular Dysfunction in COPD Exacerbations
The aim of this investigation was to assess the value of Systolic Time Intervals (STIs) as a method of detecting Left Ventricular Dysfunction (LVD) in patients admitted to the emergency department for cute exacerbations of…
- Trial name
- STICOPD (NCT02481908)
- Testing
- STI measurements at baseline and under Valsalva maneuver
- Where
- Tunisia
- Volunteers
- 189 people
- Sponsor
- University of Monastir
Chronic Obstructive Pulmonary Disease
The Doses of Systemic Steroid in Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)
It is well established that steroid use is a benefit in the treatment of chronic obstructive pulmonary disease (COPD) with acute exacerbation (AE). But it is still debated about the regimen and dosage of steroid use.
- Trial name
- NCT01215825
- Where
- Taiwan
- Volunteers
- 164 people
- Sponsor
- Far Eastern Memorial Hospital
COPD, AECOPD
The CANadian EXAcerbation of COPD Trial
The natural history of Chronic Obstructive Pulmonary Disease (COPD) is marked by acute, episodic attacks known as exacerbations of COPD.
- Trial name
- CAN-EXACT (NCT07850648)
- Where
- Canada
- Volunteers
- 125 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
COPD, COPD Exacerbation (AECOPD)
COPD Flare-Up Clinic After Severe Exacerbations
This prospective randomized controlled trial evaluates whether a specialized "COPD flare-up clinic service" improves outcomes in patients following an acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
- Trial name
- FLARE-COPD (NCT07629869)
- Testing
- Follow-up in a flare-up clinic
- Where
- Israel
- Volunteers
- 240 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
COPD Exacerbation
Feasibility, Safety and Efficacy of Nebulized Long-Acting Bronchodilators (Formoterol and Revefenacin) vs. Short-Acting Bronchodilators (Albuterol and Ipratropium) in Hospitalized Patients With AECOPD
The purpose of this study is to assess the feasibility, safety and efficacy of a combination of nebulized Formoterol and Revefenacin among patients hospitalized for AECOPD compared with standard-of-care therapy with nebulized…
- Trial name
- NCT04655170
- Testing
- Revefenacin (YUPELRI) & Formoterol (Perforomist), Albuterol Inhalation Aerosol (short-acting beta-agonists) & Ipratropium Aerosol (short-acting anticholinergic)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Tennessee Graduate School of Medicine
Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Microbiome
Prospective Cohort Study of Molecular Mechanism of Lower Respiratory Tract Microbes in Patients With AECOPD
How to reduce the rapid decline of lung function in patients with AECOPD is a clinically urgent problem to be solved. Studies have suggested that there is a bacterial flora imbalance in the lower respiratory tract of COPD…
- Trial name
- REASON (NCT04259736)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Huashan Hospital
Pulmonary Disease, Chronic Obstructive, Infections, Bacterial
Observational Study Of An Electronic Questionnaire In Patients With Chronic Obstructive Pulmonary Disease (COPD)
The aim of the study is to develop a new patient-reported outcome (PRO) questionnaire measuring the impact of an acute exacerbation on daily lives of patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00259909
- Testing
- GSK questionnaire, St. George's Respiratory Questionnaire, Acute Short Form 12 version 2
- Where
- 123 sites in United States, Germany and 1 more
- Volunteers
- 259 people
- Sponsor
- GlaxoSmithKline
COPD, Emphysema or COPD
Steroid Resistance During COPD Exacerbations With Respiratory Failure
Chronic obstructive pulmonary disease (COPD) is a lung disease caused by cigarette smoke that affects millions of people. In the United States, COPD is the 3rd leading cause of death making it one of our most important public…
- Conditions
- COPD, Emphysema or COPD, COPD Exacerbation, COPD Exacerbation Acute
- Trial name
- NCT03680495
- Testing
- Methylprednisolone
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Colorado, Denver
Procalcitonin, Chronic Obstructive Pulmonary Disease
A Trial of Procalcitonin in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Current antibiotic prescription for patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is generally based on the Anthonisen criteria in The Global Initiative for Chronic Obstructive Pulmonary…
- Trial name
- NCT04682899
- Testing
- procalcitonin-guided antibiotic therapy, guideline-guided antibiotic therapy
- Volunteers
- 500 people
- Sponsor
- Capital Medical University
Acute Heart Failure, COPD Exacerbation
Use of PARniv for Early Diagnosis of LVF in AECOPD
Left ventricular failure (LVF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This association is frequently underestimated with regard to the difficulty of clinical diagnosis .
- Trial name
- NCT05189119
- Testing
- non invasive ventilation
- Where
- Tunisia
- Volunteers
- 80 people
- Sponsor
- University of Monastir
COPD Exacerbation, Dyspnea
Palliation of Dyspnea With Mouth Piece Ventilation in AECOPD
An uncontrolled feasibility study on using mouth piece ventilation in palliation of dyspnea in subjects with acute exacerbation of COPD without acute hypercapnic respiratory failure.
- Trial name
- NCT03025425
- Testing
- Trilogy 100 ® (Philips Respironics)
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Tampere University Hospital
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The Effect of EDP on Diaphragmatic Function and Neural Respiratory Drive in Patient With AECOPD
Chronic Obstructive Pulmonary Disease (COPD) is a common respiratory disease characterized by airflow limitation that is progressive and not fully reversible.
- Trial name
- NCT03083418
- Testing
- control group, EDP
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhujiang Hospital
Acute Exacerbation Chronic Obstructive Pulmonary Disease
Intravenous Alpha-1 Antitrypsin for Hospitalized Patients With COPD Exacerbations (AECOPD Study)
Intravenous augmentation therapy with purified preparations of AAT (Alpha1-antitrypsin) derived from human plasma is a well consolidated specific therapeutic option to treat the severe deficient state of AAT.
- Trial name
- NCT07125664
- Testing
- alpha1-proteinase inhibitor, produced from the plasma of human donors (Prolastin 1000 mg, powder and solvent for solution for infusion)
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
COPD Exacerbation
Physiotherapy in Hypoxic AECOPD Patients
Hypoxia is considered a key player in many of the comorbidities that characterize COPD, such as pulmonary hypertension, skeletal muscle dysfunction, and systemic inflammation.
- Trial name
- NCT04295655
- Testing
- Global Exercise intervention, Functional Electrostimulation Group, Standard treatment
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Universidad de Granada