Clinical trials: COPD With Hyperinflation
Copd, Heart Failure
Effect of Dual Bronchodilation With Umeclidinium/Vilanterol on Patients With COPD, Hyperinflation and Heart Failure
Double-blind, randomized, two-period crossover, placebo-controlled, single-center study, to determine the effect of umeclidinium/vilanterol 55/22 μg compared with placebo on the increase in left systolic chamber function during…
- Trial name
- CHHEF (NCT04522596)
- Testing
- Umeclidinium/vilanterol
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Luis Puente Maestu
Pulmonary Disease, Chronic Obstructive
Mechanisms of Dyspnea Relief During Exercise in COPD Patients Following Treatment With Tiotropium (Spiriva)
To explore the mechanisms of dyspnea relief during exercise in patients with COPD following treatment with tiotropium bromide (Spiriva)
- Trial name
- NCT00274027
- Testing
- tiotropium bromide
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Boehringer Ingelheim
Chronic Obstructive Pulmonary Disease, COPD
The HERO-study: Effects of Roflumilast in Patients With COPD (Chronic Obstructive Pulmonary Disease) (BY217/M2-121)
The purpose of this trial is to study the effects of roflumilast on lung function parameters indicative of hyperinflation in patients with COPD.
- Trial name
- NCT00108823
- Testing
- Roflumilast
- Where
- 16 sites in United States, Canada and 5 more
- Volunteers
- 550 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease (COPD)
Phase IV O2 Consumption Study in COPD Patients.
A Phase IV study evaluating changes in oxygen consumption and cardiac function in Subjects with Chronic obstructive pulmonary disease (COPD) with resting hyperinflation after administration of Symbicort pMDI 160/4.5 μg.
- Trial name
- NCT02533505
- Testing
- Budesonide 160 mcg and formoterol fumarate dihydrate 4.5 mcg Inhalation aerosol
- Where
- 5 sites in United States
- Volunteers
- 51 people
- Sponsor
- AstraZeneca
Pulmonary Disease, Chronic Obstructive
Effects of Tiotropium on Breathing Capacity and Exercise Limitation in Early Stages of Chronic Obstructive Pulmonary Disease
Optimal clinical management in early stages of COPD is not established. Tiotropium has been shown to improve exercise tolerance during (CWR) cycle ergometry with GOLD stage II to IV COPD, improvements in constant speed treadmill…
- Trial name
- NCT01072396
- Testing
- Tiotropium
- Where
- 15 sites in United States, Canada
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Chronic Obstructive Pulmonary Disease
CHF5993 and CHF1535 pMDI on Lung Hyperinflation and Exercise Endurance Time in Subjects With COPD
Double Blind, Multinational, Multicentre, Randomised, Placebo-Controlled, 3-Way Cross-Over Study To Evaluate The Effect Of A Triple Combination Of Beclometasone Dipropionate And Formoterol Fumarate Plus Glycopyrronium (CHF5993)…
- Trial name
- TRIFORCE (NCT05097014)
- Testing
- CHF5993, CHF1535
- Where
- Germany
- Volunteers
- 106 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
COPD, Hyperinflation
Effect of Elastic Chest Compression on Functional Exercise Capacity and Respiratory Performance in Patients With COPD
The goal of this clinical trial is to investigate the effects of elastic chest compression on functional exercise capacity and respiratory performance of patients with COPD.
- Trial name
- NCT06519474
- Testing
- Theraband chest compression
- Where
- Taiwan
- Volunteers
- 17 people
- Sponsor
- National Taiwan University Hospital
Pulmonary Disease, Chronic Obstructive
The Effect of BEVESPI AEROSPHERE ® Therapy on Exercise Tolerance in COPD
The objective of the study is to determine if a dual inhaled bronchodilator (Glycopyrrolate/Formoterol) is effective in increasing exercise time relative to placebo in patients with Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT03081156
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- William Stringer, md
COPD With Hyperinflation, Diaphragmatic Weakness
Upright MRI in Lung Disease
The diaphragm is the main muscle assisting breathing. This study aims to assess the use of MRI in patients with diaphragmatic weakness and patients with Chronic Obstructive Pulmonary Disease (COPD) who have hyperinflation.
- Trial name
- NCT03531775
- Testing
- Upright MRI
- Where
- 2 sites in United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Pulmonary Disease, Chronic Obstructive
Comparing the Efficacy of Tiotropium + Olodaterol Fixed Dose Combination (FDC) Over Tiotropium in Improvement of Lung Hyperinflation, Exercise Capacity and Physical Activity in Japanese COPD Patients
This is a multi-centre, randomised, double-blinded, active-controlled, 2-way cross over trial to assess the effects of once daily administration of orally inhaled tiotropium + olodaterol FDC or tiotropium (both delivered by the…
- Trial name
- NCT02629965
- Testing
- tiotropium, olodaterol
- Where
- 43 sites in Japan
- Volunteers
- 184 people
- Sponsor
- Boehringer Ingelheim
Chronic Obstructive Pulmonary Disease, Hyperinflation
A Study to Investigate the Effect of Budesonide/Glycopyrronium/Formoterol Fumarate Metered Dose Inhaler (BGF MDI) Compared With Placebo MDI on Heart and Lung Function in Participants With Chronic Obstructive Pulmonary Disease (COPD) and Hyperinflation
The purpose of the study is to evaluate the effect of BGF MDI compared with placebo MDI on cardiac and lung function when administered in participants diagnosed with COPD and hyperinflation.
- Trial name
- ORATOS (NCT07073950)
- Testing
- Budesonide/Glycopyrronium/Formoterol Fumarate, Metered dose inhaler
- Where
- 7 sites in Germany, United Kingdom
- Volunteers
- 56 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
Effects of Inhaled Corticosteroids in the Systemic Inflammation Induced by Exercise in Patients With COPD
Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary and systemic inflammation. The effect of inhaled corticosteroids (IC) on inflammation in COPD is controversial.
- Trial name
- NCT02209974
- Testing
- Fluticasone
- Where
- Spain
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Hospital Son Llatzer
COPD
Dynamic Hyperinflation and Tiotropium
We will detect dynamic hyperinflation (DH) in 40 COPD (chronic obstructive pulmonary disease) patients with moderately severe disease using metronome paced hyperventilation (MPH) with inspiratory capacity as the primary end…
- Trial name
- NCT00569270
- Where
- 2 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Gelb, Arthur F., M.D.
Chronic Obstructive Pulmonary Disease (COPD), Pulmonary Hyperinflation
Effect of Simeox® on Residual Volume in COPD Patients With Pulmonary Hyperinflation
Brief Summary People with severe chronic obstructive pulmonary disease (COPD) often have too much air trapped in their lungs (pulmonary hyperinflation). This makes it hard to breathe and reduces quality of life.
- Trial name
- SIMEO-RV COPD (NCT07665931)
- Testing
- Simeox
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- Azienda Socio Sanitaria Territoriale di Lodi
Emphysema
EASE Trial: Exhale Airway Stents for Emphysema
This is an international clinical research study evaluating the safety and effectiveness of a new procedure called airway bypass.
- Trial name
- EASE (NCT00391612)
- Testing
- Exhale® Drug-Eluting Stent
- Where
- 37 sites in United States, Australia and 8 more
- Volunteers
- 450 people
- Sponsor
- Broncus Technologies
Pulmonary Disease, Chronic Obstructive, Chronic Bronchitis
Add-on Effects of Tiotropium Over Formoterol in Exercise Tolerance on Chronic Obstructive Pulmonary Disease Patients
The primary objective is to comparatively evaluate the isolated effects of a long-acting beta2-adrenergic (formoterol fumarate 12µg b.i.d.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Chronic Bronchitis, Pulmonary Emphysema
- Trial name
- NCT00680056
- Testing
- Formoterol plus Tiotropium
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- Federal University of São Paulo
COPD, Emphysema
Tiotropium Induced Bronchodilation in Lung CT Scored Emphysema
To evaluate if tiotropium (Spiriva)induced bronchodilation of inspiratory capacity in patients with moderate to severe copd subjected to metronome paced hyperventilation induced dynamic hyperinflation is dependent upon the extent…
- Trial name
- NCT00570544
- Testing
- tiotropium
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Gelb, Arthur F., M.D.
Pulmonary Disease, Chronic Obstructive
Effect on Exercise Endurance and Lung Hyperinflation of Tiotropium + Olodaterol in COPD Patients.
The primary objective of this trial is to investigate the effect of 6 weeks treatment with tiotropium + olodaterol fixed dose combination inhalation solution on lung hyperinflation and exercise tolerance in patients with COPD.
- Trial name
- NCT01533935
- Testing
- Tiotropium + Olodaterol, Tiotropium, Olodaterol
- Where
- 33 sites in United States, Argentina and 6 more
- Volunteers
- 291 people
- Sponsor
- Boehringer Ingelheim
Emphysema, Pulmonary, Emphysema or COPD
An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema
This is a prospective, open-label, multi-center, single-arm study planned to enroll 200 subjects with heterogeneous emphysema and collateral ventilation (CV) in the target lobe.
- Trial name
- CONVERT_II (NCT06035120)
- Testing
- AeriSeal System
- Where
- 38 sites in United States, Australia and 8 more
- Volunteers
- 200 people
- Sponsor
- Pulmonx Corporation
Emphysema or COPD, Emphysema
A Multi Center Study Testing a New Implant for Adults With Severe Emphysema
A study taking place at multiple sites in the United States, Europe and Brazil to evaluate how well a new therapy for severe COPD/emphysema works, and how safe it is.
- Conditions
- Emphysema or COPD, Emphysema, COPD
- Trial name
- IAB-2 (NCT07119229)
- Testing
- Implantable Artificial Bronchus
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Pulmair Medical, Inc.