Clinical trials: CORE
Clinical Trial, Acute Coronary Syndrome
Impact of Evolocumab as an Additional Lipid-lowering Therapy to Changes in Lipid Core Burden Index of Non-culprit Vulnerable Plaque in Patients Who Underwent Percutaneous Coronary Intervention for the Acute Coronary Syndrome
This study aimed to investigate the impact of intensive cholesterol-lowering therapy (including evolocumab), drug treatment for high-risk plaques (Vulnerable plaques) with a high probability of developing acute coronary syndrome.
- Trial name
- NCT04719221
- Testing
- Evolocumab, NIRS IVUS
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Korea University Anam Hospital
Sacroiliac Joint Dysfunction
Effects of Core Stabilization Exercises With and Without Dry Cupping in Patients With Sacroiliac Joint Dysfunction
The aim of this study is to compare the effects of core stabilization exercises with and without dry cupping on pain and disability in patients with sacroiliac joint dysfunction.
- Trial name
- NCT05404984
- Testing
- Dry cupping with core stabilization exercises, Core stabilization exercises
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- Riphah International University
Flatfoot, Flexible
The Effect of Foot Core Exercises or Foot Orthotics in Symptomatic Flexible Flatfoot
The overall goal of this study is to evaluate the effect of a foot strengthening program (focused on the intrinsic foot muscles) on ankle and foot joint kinematics and kinetics (rearfoot, midfoot, and forefoot) in patients with…
- Trial name
- NCT05840965
- Testing
- Foot muscle strengthening, Foot orthotics
- Where
- Belgium
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Rotator Cuff Injuries
Muscle Thickness, Trunk Proprioception, and Postural Stability in Rotator Cuff Pathology
The rotator cuff consists of the supraspinatus, infraspinatus, teres minor, and subscapularis muscles and their tendons, which surround and stabilize the shoulder joint.
- Trial name
- NCT07744165
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Adolescence Idiopathic Scoliosis
Machine Learning Prediction of Disease Progression in Adolescent Idiopathic Scoliosis
Background and Problem Overview Adolescent Idiopathic Scoliosis (AIS) is a progressive musculoskeletal disorder characterized by a three-dimensional deformation of the spine occurring during adolescence.
- Trial name
- NCT07556042
- Testing
- Core Stabilization Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul University
Total Hip Arthroplasty (THA)
Effects of Foot Core Exercises in Patients With Total Hip Arthroplasty
The goal of this clinical trial is to investigate the effects of foot core exercises on lower extremity muscle strength, viscoelastic properties, functional parameters, foot and ankle posture, balance, and the morphological…
- Trial name
- NCT07665801
- Testing
- Hip Rehabilitation Exercise Program, Foot-Core Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Hacettepe University
Solid Pancreatic Mass Lesions, Malignant Neoplasm of Pancreas
Comparison of a Novel 22-gauge Core Biopsy Needle
The goal of this clinical research study is to compare the performance of a newly available needle with reverse bevel design (called the EchoTip® Procore™ needle) with standard needles to see which needle gives better diagnostic…
- Trial name
- NCT01598194
- Testing
- Novel 22-gauge Core Biopsy Needle + Standard Biopsy Needle
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- M.D. Anderson Cancer Center
Sarcopenia, Muscle Weakness
Foot Core Exercise Program on Balance Control and Walking in Aged Sarcopenia
In modern society with an increasing aging population, recent literature has defined sarcopenia as a significant reduced mass and function of skeletal muscle with physical limitations due to aging.
- Conditions
- Sarcopenia, Muscle Weakness, Walking, Difficulty, Balance Control
- Trial name
- NCT05750888
- Testing
- integrated exercise therapy with 3D printing exerciser for training intrinsic foot muscles, regular exercises for the elderly
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Buddhist Tzu Chi General Hospital
AML, Childhood, Relapse/Recurrence
Safety and Efficacy of Avapritinib in Relapsed or Refractory Pediatric CBF-AML With KIT Mutation
The purpose of this study is to evaluate the efficacy and safety of avapritinib in relapsed or refractory pediatric core binding factor acute myeloid leukemia with KIT mutation.
- Conditions
- AML, Childhood, Relapse/Recurrence, Refractory AML, Core Binding Factor Acute Myeloid Leukemia
- Trial name
- NCT06316960
- Testing
- Avapritinib, Azacitidine Injection, Decitabine Injection
- Where
- 12 sites in China
- Volunteers
- 50 people
- Sponsor
- Children's Hospital of Soochow University
COVID-19 Respiratory Infection
Dynamics of Markers of Infection and Inflammation in Hospitalized Coronavirus Disease 2019 (COVID-19) Patients
Patients requiring admission to the hospital due to a moderate and severe COVID-19 infection may differ in their ability to respond to viral infection and to eliminate viral load.
- Trial name
- NCT04887623
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- University Hospital Hradec Kralove
Stroke; Paralysis
Effects of Core Strengthening and PNF Pattern on Balance and Plantar Pressure in Chronic Stroke
To compare the effects of core strengthening and PNF on standing balance and plantar pressure in chronic stroke patients
- Trial name
- PNF (NCT05436782)
- Testing
- core strengthening exercises, Routine physical therapy
- Where
- Pakistan
- Volunteers
- 73 people
- Sponsor
- University of Lahore
Hypothermia
Warmed Humidified Carbon Dioxide (CO2) for Open Surgery
Eighty adult patients undergoing open colon surgery will be randomized to either: 1. standard warming measures including heating sheets, warming of fluids, and insulation of limbs and head, or to 2.
- Trial name
- S2 (NCT00801424)
- Testing
- humidified warmed CO2
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska University Hospital
Hypertension, Low Back Pain
Effect of Home-exercise Programs Versus Supervised Core Stability Exercises on Hypertensive Patient With Low Back Pain
Thirty male and female hypertension patients with chronic mechanical non-specific low back pain were included in this randomized controlled study conducted at the Ababa Private Physical Therapy Center in Beni-Seuf, Egypt.
- Trial name
- NCT06387927
- Testing
- home exercise program, the core stability exercise
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ahram Canadian University
Acute Lymphoblastic Leukemia
Effects of Core Stabilization Exercises in Children With Acute Lymphoblastic Leukemia
The goal of this clinical trial is to investigate the effects of core stabilization exercises applied in addition to the conventional exercise program on physical function, functional muscle strength, functional exercise…
- Trial name
- NCT06794762
- Testing
- Conventional exercises, Core stabilization exercises in addition to conventional exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Karamanoğlu Mehmetbey University
Aviation, Heat Stress
Changes in Aviators' Body Core Temperature Measurements at F-35
The many complaints that have been expressed by the US aircrew of the F-35 regarding the heat stress in the cockpit raised an obvious concern that, as a result of such heat levels, the aviators' core body temperature may increase…
- Trial name
- NCT03234270
- Testing
- Core temperature measurements
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Israeli Air Force Aeromedical Center
Body Temperature Regulation
Non-invasive Sensor for Core Temperature Measurement
Soldiers are required to perform and maintain alertness in difficult environmental conditions. The sensor examined in this trail may indicate body core temperature elevation during exertion.
- Trial name
- Drager (NCT02017184)
- Testing
- Noninvasive core temperature thermistor
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
NSCLC (Non-small Cell Lung Cancer), Metastatic NSCLC - Non-Small Cell Lung Cancer
Observational Lung Trial to Collect Tissue to Train and Validate a Live Tumor Diagnostic Platform (ELEPHAS-01)
The primary objective of this study is to determine the ex-vivo prognostic accuracy of the Cybrid live tumor diagnostic platform using in-vivo RECIST 1.1 as the reference method.
- Trial name
- ELEPHAS-01 (NCT05478538)
- Testing
- Core Needle, Forceps, or Punch Biopsy
- Where
- 7 sites in United States
- Volunteers
- 200 people
- Sponsor
- Elephas
Physical Endurance
Isometric Core Muscle Endurance in Healthy Active and Non-active Working Age Populations
Objectives: The purpose of this study was to investigate a possible correlation between core muscle endurance and participants' age in healthy adult population.
- Trial name
- NCT04209335
- Testing
- isometric core muscle endurance testing
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hanna Holmberg
Lung Cancer, Lung; Node
Low-dose Computed Tomography-guided Core Needle Biopsy for Lung Nodules
Investigators aim to compare the diagnostic accuracy and radiation exposure between low-dose and standard-dose computed tomography-guided core needle biopsy for lung nodules.
- Trial name
- NCT04217655
- Testing
- Low-dose computed tomography, Standard-dose computed tomography
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xuzhou Central Hospital
Acute Ischemic Stroke, Large Infarct Core
Methylprednisolone Adjunctive to Endovascular Thrombectomy for Stroke
The efficacy and safety of methylprednisolone in acute ischemic stroke patients with large infarct cores (ASPECTS score < 6 or infarct volume ≥50 mL) due to anterior circulation large vessel occlusion have not been clearly…
- Trial name
- MIRACLE (NCT06360458)
- Testing
- Methylprednisolone sodium succinate
- Where
- 99 sites in China
- Volunteers
- 928 people
- Sponsor
- Wan-Jin Chen
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