Clinical trials: COVID, Coronavirus
COVID-19
Crowdsourcing an Open COVID-19 Imaging Repository for AI Research
The objectives of this project are to (1) assemble a crowdsourced, de-identified radiographic repository; and (2) train and validate existing COVID-NET deep learning diagnostic models.
- Trial name
- NCT05384912
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Long Covid19
Long-term Effects of SARS-CoV-2 on the Central Nervous System and One-year Follow-up of "Long COVID-19" Patients
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the seventh coronavirus known to infect humans, and causing coronavirus disease 2019 (COVID-19). .
- Trial name
- NCT05492292
- Testing
- Perfusion brain scintigraphy imaging
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Brugmann University Hospital
Long COVID, Post-Acute COVID-19
Post-Covid Condition Cohort: Evolution of Symptomatology, Patient Profile and Associated Prognostic Factors
The aim of our cohort is to collect prospectively, in a standardized and exhaustive manner, the health data of patients referred to the CAPCoV, our holistic referal post covid clinics for post-covid condition in order to be able…
- Conditions
- Long COVID, Post-Acute COVID-19, Post-Acute COVID19 Syndrome
- Trial name
- SYNPOCov (NCT05610436)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Central Hospital, Nancy, France
Coronavirus
Convalescent Plasma to Limit Coronavirus Associated Complications
Researchers are trying to assess the treatment potential and safety of anti-SARS-CoV-2 convalescent plasma in patients with acute respiratory symptoms with confirmed COVID-19.
- Trial name
- NCT04325672
- Testing
- Convalescent Plasma
- Sponsor
- Mayo Clinic
COVID-19
Antimicrobial Resistance During the SARS-CoV-2 (COVID-19) Pandemic
Assess the incidence and rates of resistant pathogens prior to and during the COVID-19 pandemic.
- Trial name
- NCT06334731
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Methodist Health System
Covid19, Measles Vaccine
Do Childhood Measles and DTaP Vaccination Decrease the Mortality Rate Caused by COVID-19 in OECD Countries?
Mortality rates caused by SARS CoV-2 differ between countries and this difference might be explained by several reasons. Childhood vaccination rate is thought to be one of them.
- Conditions
- Covid19, Measles Vaccine, Mortality
- Trial name
- NCT04468802
- Testing
- Case fatality rate
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
COVID, ARDS
PROne Positioning in coVID-19 Oxygeno-dependent Patients in Spontaneous Ventilation (PROVID Study)
The COVID epidemics is responsible for a huge number of death following COVID acute respiratory failure. First instance treatment includes oxygenotherapy up to 15L/min in spontaneous ventilation.
- Trial name
- PROVID (NCT04366856)
- Testing
- 1: Prone positioning, 2: No instruction regarding positioning
- Where
- France
- Volunteers
- 446 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Covid19
Efficacy of Sofosbuvir Plus Ledipasvir in Egyptian Patients With COVID-19 Compared to Standard Treatment
Currently there is no known effective therapy or vaccine for treatment of SARS-CoV-2, highlighting urgency around identifying effective therapies.
- Trial name
- NCT04530422
- Testing
- Sofosbuvir plus Ledipasvir
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Almaza Military Fever Hospital
COVID-19
Evaluation of Ganovo （Danoprevir ） Combined With Ritonavir in the Treatment of SARS-CoV-2 Infection
Evaluation of the efficacy and safety of Ganovo combined with ritonavir for patients infected with SARS-CoV-2.
- Trial name
- NCT04291729
- Testing
- Ganovo+ritonavir+/-Interferon nebulization
- Where
- China
- Volunteers
- 11 people
- Sponsor
- The Ninth Hospital of Nanchang
COVID 19, Patients Hospitalized
Evaluation of the Efficacy and Safety of Treatments for Patients Hospitalized for COVID-19 Infection Without Signs of Acute Respiratory Failure, in Tunisia
Evaluation of the efficacy and safety of Treatments for Patients Hospitalized for COVID-19 Infection without signs of acute respiratory failure, in Tunisia Multicentric Randomized Comparative Study
- Trial name
- THINC (NCT04528927)
- Testing
- HCQ, Azithromycin, Doxycycline
- Where
- Tunisia
- Sponsor
- Abderrahmane Mami Hospital
COVID-19
Longitudinal Energy Expenditure and Metabolic Effects in Patients With COVID-19 (LEEP-COVID)
This current proposal evaluates the Longitudinal Energy Expenditure and Metabolic Effects in Patients with COVID-19 (LEEP-COVID) to understand, guide and optimize our metabolic and nutritional care of these high risk patients.
- Trial name
- NCT04350073
- Testing
- Q-NRG Metobolic Cart Device, MuscleSound Ultrasound, Multifrequency Bioimpedance Spectroscopy
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Duke University
Covid19
Phase 1 Study to Assess Safety, Tolerability, PD, PK, Immunogenicity of IV NTR-441 Solution in Healthy Volunteers and COVID-19 Patients
This first-in-human clinical study is a Phase 1a/ 1b, randomized, double-blind, placebo-controlled study to assess the safety, tolerability, and PK/PD of NTR-441 in healthy subjects and patients with COVID-19 after single…
- Trial name
- NCT04941183
- Testing
- NTR-441
- Where
- 4 sites in Austria, Ukraine
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Neutrolis
Pneumonia Caused by Human Coronavirus
Clinical Progressive Characteristics and Treatment Effects of 2019-novel Coronavirus
Objects: The purpose of this study was to observe the characteristics of morbidity, disease progression and therapeutic effects of 2019-novel coronavirus pneumonia patients with different clinical types.
- Trial name
- 2019-nCoV (NCT04292327)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Fujian Provincial Hospital
COVID-19
A Phase 1b Trial to Evaluate the Safety and Immunogenicity of a SARS-CoV-2 mRNA Chimera Vaccine Against COVID-19
This is a phase 1b, randomized, double-blind, positive control trial in healthy adults, intended to evaluate the safety and immunogenicity profile of RQ3013 in healthy adults primed with a two-dose inactivated vaccine 6-9 months…
- Trial name
- NCT05396573
- Testing
- RQ3013, Comirnaty
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Walvax Biotechnology Co., Ltd.
COVID-19, Influenza
Study on Combined Vaccination With SARS-CoV-2 Inactivated Vaccine and Quadrivalent Influenza Vaccine
This study is an open-label, single-center, randomized phase IV clinical trial of the SARS-CoV-2 inactivated vaccine manufactured by Sinovac Research \& Development Co., Ltd.
- Trial name
- NCT04801888
- Testing
- Two doses of inactivated SARS-CoV-2 vaccine at the schedule of day 0,28 and one dose Quadrivalent Influenza Vaccine on day 0 or day 28., Two doses of inactivated SARS-CoV-2 vaccine at the schedule of day 0,28 and one dose Quadrivalent Influenza Vaccine on day 14.
- Where
- China
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Sinovac Research and Development Co., Ltd.
Covid19
Face Masks to Reduce COVID-19 in Bangladesh
The primary goal of the village-level intervention is to assess whether mask-wearing reduces community-level COVID-19 seroconversion. The individual experiment assess whether masks protect against COVID-19 seroconversion.
- Trial name
- NCT04630054
- Testing
- Face mask, Face mask awareness
- Where
- Bangladesh
- Volunteers
- 350,000 people, healthy volunteers welcome
- Sponsor
- Yale University
Covid19
Antiseptic Mouth Rinses to Reduce Salivary Viral Load in COVID-19 Patients
As no curative treatment for SARS-CoV-2 is currently available, most public health measures to contain the pandemic are based on preventing the spread of the pathogen.
- Trial name
- BUCOSARS (NCT04707742)
- Testing
- Betadine© bucal 100 mg/ml, Oximen® 3%, Clorhexidine Dental PHB©
- Where
- Spain
- Volunteers
- 160 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
SARS-CoV-2 Infection
Phase II/III Study of the AVX/COVID-12 Vaccine Against COVID-19 Applied as a Booster.
This is a phase II/III parallel, double-blind, active-controlled, non-inferiority study to evaluate immunogenicity and safety of a booster immunization scheme of a single intramuscular dose of the recombinant vaccine against…
- Trial name
- NCT05710783
- Testing
- AVX-COVID/12, ChAdOx-1-S[recombinant]
- Where
- 14 sites in Mexico
- Volunteers
- 4,065 people, healthy volunteers welcome
- Sponsor
- Laboratorio Avi-Mex, S.A. de C.V.
Covid19
COVID-19 Soliris Expanded Access Protocol
This protocol provides participants with COVID-19 access to Soliris.
- Trial name
- NCT04802083
- Testing
- Eculizumab
- Sponsor
- Alexion Pharmaceuticals, Inc.
Long COVID Syndrome
Characteristics of Long COVID-19 Syndrome
Characterization of patients with long COVID syndrome including symptoms, medical history and persistent organ damage.
- Trial name
- NCT04793269
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Christian Clarenbach
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