Clinical trials: COVID-19; Immunity
Covid19
Micronutrient Status Involved in Immunity in Elderly Patients With COVID-19
During the ongoing COVID-19 pandemic, age was clearly the major factor of mortality. Increasing age was strongly associated with this risk, with the upper 80 years age group having more than 12-fold increased risk compared with…
- Trial name
- MicroCovAging (NCT04877509)
- Testing
- Selenium, Zinc and Copper, Vitamin A, D, E plasma concentrations during patient hospitalization
- Where
- France
- Volunteers
- 229 people
- Sponsor
- Hospices Civils de Lyon
Covid19, COVID-19 Vaccines
Immune Response to Anti COVID-19 Vaccine in Immunocompromised Patients: a Cohort Study
Despite COVID-19 pandemic having started more than one year ago, there are still limited treatment options for these patients, and over 145 million cases and 3 millions deaths have ensued worldwide.
- Trial name
- NCT04888793
- Testing
- Serologic immune response evaluation
- Where
- Chile
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Healthy Adult Volunteers
Efficacy and Safety of Heterologous and Homologous COVID-19 Vaccination
The investigators conduct a prospective analysis to compare homologous and heterologous adenovirus vector ChAdOx1-nCov-19 (Astra-Zeneca) or SARS-CoV-2 messenger RNA-1273 (Moderna) vaccine inoculation.
- Trial name
- NCT05074368
- Testing
- ChAdOx1-nCov-19 (Astra-Zeneca), SARS-CoV-2 messenger RNA-1273 (Moderna) vaccine
- Where
- Taiwan
- Volunteers
- 499 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
SARS-CoV-2
Polio Vaccine (IPV) for SARS-CoV-2 and Prevention of Coronavirus Disease (COVID-19)
A total of 300 healthy volunteers between the ages of 18 and 80 with no previous history of COVID-19 will be entered into the study and will receive IPV by injection on Day 1.
- Trial name
- NCT04639375
- Testing
- Vaccinated with polio vaccine (IPV)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- E-MO Biology Inc
Sepsis Syndrome
Use of a Live Attenuated Vaccine as an Immune-based Preventive Against COVID-19-associated Sepsis
The objective of this randomized clinical trial is to test whether administration of live attenuated MMR vaccine (measles mumps rubella; Merck) to eligible adults at highest risk for contracting COVID-19 (healthcare workers…
- Trial name
- NCT04475081
- Testing
- MMR vaccine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
SARS-CoV-2, COVID-19
Characterizing SARS-CoV-2-specific Immunity in Individuals Who Have Recovered From COVID-19
The purpose of this study is to learn more about infection with and recovery from the virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- Trial name
- NCT04403880
- Testing
- Sample collection
- Where
- 53 sites in United States, Malawi and 4 more
- Volunteers
- 760 people, healthy volunteers welcome
- Sponsor
- HIV Vaccine Trials Network
Covid19, Cancer
A Study on the Immune-response to COVID-19 Vaccination in Cancer Patients - the IOSI-COVID-19-001 Study
This is a single centre prospective observational study to assess the immune response to SARS-CoV-2 vaccines in cancer patients receiving active treatment or in follow-up at the IOSI and in non-cancer patients (age and gender…
- Trial name
- NCT04800146
- Testing
- Blood sample
- Where
- Switzerland
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Ilaria Colombo
HIV Infections, Covid19
Safety and Immune Response of COVID-19 Vaccination in Patients With HIV Infection
On 11 February 2020, the International Committee for the Classification of Viruses named the disease caused by SAＲS-CoV-2 infection in humans as the new coronavirus pneumonia (coronavirus disease 2019, COVID-19).
- Trial name
- NCT05043129
- Testing
- Biological/Vaccine: SARS-COV-2 VACCINE
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Covid19
Vaccination Against COVID-19 in Pregnant and Lactating Women in Belgium
This study will investigate whether pregnant and lactating women can develop similar protective immunity as non-pregnant women against Coronavirus Infectious Disease 2019 (COVID-19) upon vaccination, without safety issues.
- Trial name
- PREGCOVAC (NCT05618548)
- Testing
- COVID-19 vaccine
- Where
- Belgium
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Zoster Varicella, Vaccination; Infection
The Influence of Trained Immunity in COVID-19 Vaccinated Individuals
The concept of trained immunity defines the long-term functional reprogramming of innate immune cells, which is evoked by exogenous or endogenous insults and leads to an altered response towards a second challenge after return to…
- Trial name
- NCT05705180
- Testing
- recombinant adjuvanted zoster vaccine
- Where
- Germany
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Wuerzburg University Hospital
SARS-CoV Infection, Covid19
Study of HEarT DiseAse and ImmuNiTy After COVID-19 in Ireland
SETANTA study will investigate the incidence of cardiac abnormalities as assessed by cardiac magnetic resonance imaging in unselected patients after acute SARS-CoV-2 infection and correlation with immunological response and…
- Conditions
- SARS-CoV Infection, Covid19, Cardiomyopathies
- Trial name
- SETANTA (NCT04823182)
- Testing
- Cardiovascular Magnetic Resonance Imaging
- Where
- Ireland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cardiovascular Research Institute Dublin
Covid19 Immunology
The COVID-19 PUI Reality Check (CPRC) Study
This study compares SARS-CoV-2 immune responses in high pretest probability swab negative hospitalized PUI patients vs. low pretest probability swab negative hospitalized APS (Asymptomatic Persons being Screened) patients to try…
- Trial name
- CPRC (NCT04474288)
- Testing
- SARS-CoV-2 antibody testing
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Bassett Healthcare
Covid19
Prevalence of Thrombosis in COVID-Patients
Examination of the prevalence of thrombosis in COVID-patients, especially in an out-patient setting. Assessment by duplex sonography. If thrombosis is detected, we will correlate it with immunity status.
- Trial name
- NCT04615026
- Testing
- duplex sonography
- Where
- Germany
- Volunteers
- 525 people
- Sponsor
- University Hospital Augsburg
Health Care Worker Patient Transmission, Receptor Site Alteration
Different Susceptibility to SARS CoV-2 Infection Among Health Care Workers Highly Exposed to COVID-19.
The primary objective of this study is to establish differences in susceptibility to SARS CoV-2 infection among health care workers (HCW) highly exposed to patients with COVID-19 diagnosis.
- Conditions
- Health Care Worker Patient Transmission, Receptor Site Alteration, Susceptibility, Disease, Immune Response
- Trial name
- CoVEX (NCT04402827)
- Testing
- Susceptibility to infection
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Asociacion para el Estudio de las Enfermedades Infecciosas
Cancer
COVID-19: Immune Response in Patients With Cancer Undergoing mRNA Vaccination Against SARS-CoV-2
This trial aims to measure the humoral and adaptive immune response in patients with cancer diagnosis undergoing mRNA vaccination against SARS-CoV-2 and assess its efficacy in preventing COVID-19.
- Trial name
- I-SPARC (NCT05075538)
- Testing
- Spikevax, Comirnaty, Spikevax bivalent Original/Omicron BA.1
- Where
- 2 sites in Belgium
- Volunteers
- 152 people
- Sponsor
- Jules Bordet Institute
COVID-19 Respiratory Infection, Pulmonary Tuberculoses
Effect of SARS-CoV-2 Disease on Immune Responses, Disease Severity and Treatment Outcomes in Pulmonary Tuberculosis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the Coronavirus disease (COVID-19). Tuberculosis (TB) is the foremost cause of infectious deaths globally.
- Trial name
- COVID-19-TB (NCT04930978)
- Where
- India
- Volunteers
- 250 people
- Sponsor
- Tuberculosis Research Centre, India
COVID 19
MURDOCK Cabarrus County COVID-19 Prevalence and Immunity (C3PI) Study
The objectives of this research is to: Assess perceptions, concerns, and practices related to the COVID-19 pandemic and mitigation strategies using the MURDOCK Study Community Registry and Biorepository population as a measure of…
- Trial name
- C3PI (NCT04424004)
- Testing
- COVID-19 PCR and serology testing
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Duke University
COVID-19
Evaluation of the Immune Response to SARS-CoV-2 Among Patients With Covid-19 in Costa Rica
Describe the immune response of patients affected by SARS-CoV-2, including an assessment of the types of antibodies elicited by the infection, specifc antibody titers for the different isotypes, evolution of the antibody response…
- Trial name
- RESPIRA (NCT04537338)
- Testing
- 1. Characterize the immune response after infection with SARS-CoV-2
- Volunteers
- 2,000 people
- Sponsor
- Agencia Costarricense de Investigaciones Biomedicas
Covid19, Breastfeeding
Gestational Immunity for Transfer
This is a study prospective cohort study at an urban academic centre, with two parts: 1. Health outcomes, and maternally transferred antibodies, in babies born to mothers who had antenatal COVID-19 and convalesced before…
- Conditions
- Covid19, Breastfeeding, Vaccine Exposure Via Breast Milk
- Trial name
- GIFT (NCT04802278)
- Testing
- COVID-19 vaccine
- Where
- Singapore
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Pathogen Infection Covid-19 Infection
Immunity and Safety of Covid-19 Synthetic Minigene Vaccine
In December 2019, viral pneumonia caused by a novel beta-coronavirus (Covid-19) broke out in Wuhan, China. Some patients rapidly progressed and suffered severe acute respiratory failure and died, making it imperative to develop a…
- Trial name
- NCT04276896
- Testing
- Injection and infusion of LV-SMENP-DC vaccine and antigen-specific CTLs
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute