Clinical trials: COVID-19 Pneumonia
COVID-19
Non Invasive Positive Pressure Ventilation to Minimize Aerosolization for COVID 19
Patients presenting to the emergency department, or needing hospitalization, for a variety of medical conditions often require non-invasive ventilation (breathing support).
- Trial name
- NCT04344925
- Testing
- Aerosol-reducing Mask, Standard Mask
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Coronavirus, Covid19
Impact of Aerosol Box Use on Healthcare Provider Contamination
Aerosol Generating Medical Procedures (AGMP) are procedures that have the potential to create tiny particles suspended in the air. These particles can contain germs such as viruses.
- Conditions
- Coronavirus, Covid19, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT04880668
- Testing
- Aerosol Box (Splashguard)
- Where
- 4 sites in United States, Canada
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- KidSIM Simulation Program
Covid19, Environmental Exposure
Study on Kidney Disease and EnviromenTal Chemical
1. Purpose: To confirm the changes in lifestyle due to differences in perceptions of infectious disease risk after the COVID-19 pandemic, decrease in exposure levels of environmentally hazardous chemicals and changes in…
- Conditions
- Covid19, Environmental Exposure, Chronic Kidney Diseases
- Trial name
- NCT04679168
- Where
- South Korea
- Volunteers
- 310 people
- Sponsor
- Seoul National University Hospital
Post COVID-19 Syndrome, Rehabilitation
Implementation of Rehabilitation Program for Post COVID-19
Many people who have suffered from the effects of this disease might now be at risk of long-term impairment and disability. The extent of this impairment and disability is yet unknown, but it is clear from early research that…
- Trial name
- NCT04694768
- Testing
- Rehabilitation
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
COVID-19 (Healthy Volunteers)
Safety, Reactogenicity, and Immunogenicity Study of Heterologous Booster Vaccination of a SARS-CoV-2 Recombinant Protein Nanoparticle Vaccine (GBP510)
This is randomized, placebo-controlled, observer-blinded, multi-center study to assess safety, reactogenicity and immunogenicity of booster vaccination of a SARS-CoV-2 recombinant protein nanoparticle vaccine (GBP510) adjuvanted…
- Trial name
- NCT05175950
- Testing
- SARS-CoV-2 Recombinant Protein Nanoparticle Vaccine (GBP510) (RBD of SARS-CoV-2 25ug / dose) Adjuvanted with AS03, Normal saline
- Where
- 9 sites in South Korea
- Volunteers
- 770 people, healthy volunteers welcome
- Sponsor
- Korea University Guro Hospital
Kidney Transplant, Pancreatic Transplat
SARS-CoV2 (COVID-19) Seroepidemiological Transplanted Subjects (Kidney, Kidney-pancreas, Pancreas, Langerhans Islets)
Evaluate SARS-CoV2 infection and the degree of immunity possibly developed in transplanted population using the Luciferase Immuno Precipitation System (LIPS) test.
- Conditions
- Kidney Transplant, Pancreatic Transplat, Pancreatic Islets Langerhans
- Trial name
- NCT04487197
- Testing
- blood sample for seroepidemiological investigation
- Where
- Italy
- Volunteers
- 282 people
- Sponsor
- Antonio Secchi
Covid19, Thrombotic Microangiopathies
Ravulizumab and COVID-19
Ultomiris (Ravulizumab), is a monoclonal antibody that specifically targets terminal complement products and is proposed for the treatment of COVID-19 induced microvasculature injury and endothelial damage leading to thrombotic…
- Conditions
- Covid19, Thrombotic Microangiopathies, Acute Kidney Injury
- Trial name
- NCT04570397
- Testing
- Ravulizumab
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Brigham and Women's Hospital
Depression
Assessment of Stress, Depression and Anxiety in Healthcare Caring for Patients With COVID-19
Medical personnel working in the Intensive Care Unit will be examined by means of tests. Their aim is to check how work-related stress in a potentially lethal threat affects the occurrence of depression, stress, anxiety and sleep…
- Trial name
- NCT04631497
- Testing
- test
- Where
- Poland
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
COVID-19
Trial to Evaluate Efficacy and Safety of Nitazoxanide in the Treatment of Mild or Moderate COVID-19
Trial to Evaluate Efficacy and Safety of Nitazoxanide in the Treatment of Mild or Moderate COVID-19
- Trial name
- NCT04486313
- Testing
- Nitazoxanide, Vitamin Super B-Complex
- Where
- 2 sites in United States
- Volunteers
- 935 people
- Sponsor
- Romark Laboratories L.C.
COVID-19 Drug Treatment
Ivermectin Effect on SARS-CoV-2 Replication in Patients With COVID-19
In the context of COVID-19 pandemic, a report on ivermectin suppression of SARS-CoV-2 viral replication in cell cultures has been published, and the use of this medication seems to be potentially useful for the therapy.
- Trial name
- NCT04381884
- Testing
- IVERMECTIN (IVER P®) arm will receive IVM 600 µg / kg once daily plus standard care. CONTROL arm will receive standard care.
- Where
- 3 sites in Argentina
- Volunteers
- 45 people
- Sponsor
- Laboratorio Elea Phoenix S.A.
COVID-19
Low-dose Lenalidomide for Non-severe COVID-19 Treatment Trial
Double-blind randomized controlled clinical trial (RCT) of low-dose lenalidomide in the treatment of elderly patients (> 60 years of age) with mild to moderate clinical signs of COVID-19 disease from the Hospital Universitario of…
- Trial name
- GETAFE (NCT04361643)
- Testing
- Lenalidomide as a 5 mg capsule PO daily, days 1, 3, and 5.
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Hospital Universitario Getafe
Covid19, SARS (Severe Acute Respiratory Syndrome)
A Phase 3 Randomized Double Blind Efficacy and Safety Study of Oral Polio Vaccine and NA-831 for Covid-19
In this randomized double blind Phase 3 clinical trial we will study the efficacy and safety of oral polio vaccine with and without NA-831 versus placebo.
- Conditions
- Covid19, SARS (Severe Acute Respiratory Syndrome), SARS-CoV Infection, SARS-CoV-2
- Trial name
- OPV-NA831 (NCT04540185)
- Testing
- Biological: oral polio vaccine, NA-831, Combination of oral polio vaccine and NA-831
- Where
- 10 sites in United States, New Zealand
- Volunteers
- 3,600 people, healthy volunteers welcome
- Sponsor
- Biomed Industries, Inc.
Occupational Health
Influence of the COVId-19 Pandemic on STRESS of Occupational Health Workers
Coronavirus has caused containment of more than half of the world's population and a major and rapid reorganization of clinical and support services.
- Trial name
- COVISTRESSWork (NCT04619576)
- Testing
- Occupational health workers
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
SARS-CoV2 Infection, Ventilator Associated Pneumonia
Ventilation Associated Pneumonia and Covid-19
In December 2019, a new pandemic emerged, the COVID-19 disease caused by a SARS-Cov-2 virus. One of the most common symptoms of COVID-19 is mainly respiratory failure and patients requires assistance by mechanical ventilation.
- Conditions
- SARS-CoV2 Infection, Ventilator Associated Pneumonia, Ards, COVID-19
- Trial name
- ECOLCOVID (NCT05089968)
- Where
- France
- Volunteers
- 268 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Corona Virus Infection, Pneumonia
COVID-19 Specific T Cell Derived Exosomes (CSTC-Exo)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused mass mortality in the last 3 months that necessitates urgent development of new therapeutical agents.
- Trial name
- NCT04389385
- Testing
- COVID-19 Specific T Cell derived exosomes (CSTC-Exo)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Activities, Mental Health Issue
Effects of the COVID-19 Health Emergency on Biopsychosocial Health
There is a critical need to determine the impact of the COVID-19 emergency on the comprehensive well-being of people as they are living through the emergency and sequelae of the emergency period.
- Conditions
- Activities, Mental Health Issue, Life Style
- Trial name
- NCT04409535
- Testing
- WHOQOL-BREF survey
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
EGD, Covid19
Aerosol Particle From EGD in Patients With and Without Head Box in COVID-19 Era
According to preexisting data, it has revealed the fundamental role that aerosols play in the transmission of the COVID-19 virus.
- Conditions
- EGD, Covid19, Aerosol Disease, Head Box
- Trial name
- NCT04981535
- Testing
- Head box during upper gastrointestinal endoscopy
- Where
- Thailand
- Volunteers
- 190 people
- Sponsor
- King Chulalongkorn Memorial Hospital
COVID-19
Echocardiographic Manifestation in Patients With Omicron Variant of COVID-19
The cardiovascular scenario associated with omicron, the new variant of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19), remains unclear.
- Trial name
- NCT05379543
- Testing
- Echocardiography
- Where
- China
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
COVID-19
Phase Ⅰ Clinical Trial of a Candidate COVID-19 Vaccine
In this trial, a single-arm, open-label study design will be used to evaluate the safety and tolerability after vaccination with escalating doses of the investigational vaccine (Recombinant COVID-19 Vaccine (chimpanzee adenovirus…
- Trial name
- NCT05706324
- Testing
- Recombinant COVID-19 Vaccine (chimpanzee adenovirus vector) for Inhalation
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wuhan BravoVax Co., Ltd.
COVID-19, Vaccine Adverse Reaction
Adverse Events Report of Inactivated COVID-19 Vaccine
Numerous vaccination studies are conducted to protect against COVID-19 infection, and preclinical and clinical studies are still ongoing worldwide.
- Trial name
- NCT05026879
- Testing
- Inactivated COVID-19 vaccine (CoronaVac)
- Where
- Turkey (Türkiye)
- Volunteers
- 4,040 people, healthy volunteers welcome
- Sponsor
- Bozyaka Training and Research Hospital
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