Clinical trials: COVID19 ARDS
Covid19, ARDS
Noninvasive Ventilation in Moderate-to-severe COVID-19-associated Acute Respiratory Distress-syndrome
Non-invasive ventilation can allow to avoid intubation and improve outcomes in moderate-to-severe COVID-19-associated acute respiratory distress-syndrome (ARDS).
- Trial name
- COVID-NIV (NCT04667923)
- Testing
- Respiratory monitoring, Respiratory muscles ultrasound, Electro impedance tomography
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
ARDS, Human, COVID-19
London's Exogenous Surfactant Study for COVID19
The research team is investigating administering exogenous surfactant in COVID-19 patients with ARDS. The overall goal is to improve the outcome (mortality) of mechanically ventilated COVID-19 patients.
- Trial name
- LESSCOVID (NCT04375735)
- Testing
- Bovine Lipid Extract Surfactant
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
COVID-19, ARDS
Long-term Impact of COVID-19 Among COVID-19 Patients With Acute Respiratory Distress Syndrome in Brazil
The present multicenter prospective observational study aims to assess the long-term effects of COVID-19 on patients with Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- NCT05225194
- Testing
- COVID-19, ARDS
- Volunteers
- 318 people
- Sponsor
- Hospital Moinhos de Vento
Respiratory Distress Syndrome, Mechanical Ventilation
Mechanical Ventilation Strategy for Coronavirus Disease 2019 (COVID-19)
This is a prospective, randomized, single-center, open-label controlled trial, designed to compare the efficacy of two ventilation strategies (Low Tidal Volume and positive end-expiratory pressure (PEEP) based on the Acute…
- Conditions
- Respiratory Distress Syndrome, Mechanical Ventilation, SARS (Severe Acute Respiratory Syndrome)
- Trial name
- COVEN (NCT04497454)
- Testing
- EIT-Group, ARDSNet
- Where
- Brazil
- Volunteers
- 128 people
- Sponsor
- University of Sao Paulo General Hospital
Hypoxemic Respiratory Failure, Oxygen Toxicity
Handling Oxygenation Targets in COVID-19
Patients with COVID-19 and hypoxaemic respiratory failure and admitted to the intensive care unit (ICU) are treated with supplementary oxygen as a standard. However, quality of quantity evidence regarding this practise is low.
- Trial name
- HOT-COVID (NCT04425031)
- Testing
- Low oxygenation target, High oxygenation target
- Where
- 10 sites in Denmark, Norway and 1 more
- Volunteers
- 726 people
- Sponsor
- Aalborg University Hospital
Acute Respiratory Distress Syndrome, COVID-19
Polyvalent Immunoglobulin in COVID-19 Related ARds
As of 30/03/2020, 715600 people have been infected with COVID-19 worldwide and 35500 people died, essentially due to respiratory distress syndrome (ARDS) complicated in 25% of the with acute renal failure.
- Trial name
- ICAR (NCT04350580)
- Testing
- Human immunoglobulin
- Where
- 42 sites in France
- Volunteers
- 146 people
- Sponsor
- Centre Hospitalier St Anne
COVID19 ARDS
Mild Hypothermia for COVID-19 ARDS
Some patients with COVID have abnormally high carbon dioxide and low oxygen levels despite being on the ventilator. The hypothesis of the study is that the application of mild hypothermia to patients with COVID will decrease…
- Trial name
- NCT04570462
- Testing
- Hypothermia Via Cooling Machine- Arctic Sun 5000
- Where
- United States
- Sponsor
- Northwell Health
ARDS Due to Severe Acute Respiratory Syndrome Coronavirus 2
PEEP Setting in COVID19-related ARDS
The best way to titrate positive end-expiratory pressure (PEEP) in patients suffering from acute respiratory distress syndrome is still matter of debate.
- Trial name
- NCT05115526
- Testing
- PEEP setting
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Central Hospital, Nancy, France
COVID-19 Pneumonia, Covid19
A Randomized Controlled Trial to Investigate The Role of Adjuvant Inhalable Sodium Bicarbonate Solution 8.4% in Treatment of COVID-19
The aim of the study is to investigate the role of SB 8.4% as adjuvant therapy in the treatment of COVID- 19 patients proved to be RT-PCR positive (mild, moderate and severe).
- Conditions
- COVID-19 Pneumonia, Covid19, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT05035524
- Testing
- Sodium Bicarbonate Solution
- Where
- Egypt
- Volunteers
- 340 people
- Sponsor
- Mansoura University
Pneumonia, Viral
Characterization of Persistent Pulmonary Abnormalities Following COVID-19 Pneumonia
Severe Acute Respiratory Syndrome (SARS) SARS-CoV-2, name of the Coronavirus Group of international Committee on taxonomy of viruses, is an emerging virus from the family of coronaviridae, responsible for the COVID-19 pandemic.
- Trial name
- PULCO-19 (NCT04422613)
- Testing
- pulmonary anomalies 4 months after documented COVID-19 pneumonia
- Where
- France
- Volunteers
- 73 people
- Sponsor
- University Hospital, Toulouse
COVID-19
Sargramostim in Patients With Acute Hypoxic Respiratory Failure Due to COVID-19 (SARPAC)
Phase IV study to evaluate the effectiveness of additional inhaled sargramostim (GM-CSF) versus standard of care on blood oxygenation in patients with COVID-19 coronavirus infection and acute hypoxic respiratory failure.
- Trial name
- SARPAC (NCT04326920)
- Testing
- Sargramostim, Control
- Where
- 4 sites in Belgium
- Volunteers
- 87 people
- Sponsor
- University Hospital, Ghent
Acute Respiratory Distress Syndrome
Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration (REALIST)
Acute Respiratory Distress Syndrome (ARDS) causes the lungs to fail due to the collection of fluid in the lungs (pulmonary oedema).
- Trial name
- REALIST (NCT03042143)
- Testing
- Human umbilical cord derived CD362 enriched MSCs
- Where
- United Kingdom
- Volunteers
- 129 people
- Sponsor
- Belfast Health and Social Care Trust
COVID-19, SARS-CoV2
Host Response Mediators in Coronavirus (COVID-19) Infection
The coronavirus (COVID-19) pandemic continues to grow exponentially. Angiotensin II levels are increased in human influenza and are associated with influenza viral load, disease progression and mortality.
- Trial name
- ARBS CORONA I (NCT04510623)
- Testing
- ARBs and/or ACE inhibitors, Usual Care
- Where
- 15 sites in Canada
- Volunteers
- 500 people
- Sponsor
- University of British Columbia
Acute Respiratory Distress
The ARCTIC Trial: Aerosolized Inhaled Adenosine Treatment in Patients With Acute Respiratory Distress Syndrome (ARDS) Caused by COVID-19
This is a phase II study to test adenosine efficacy for down-regulation of the overwhelming inflammation of COVID-19 in the lungs as reflected by clinical recovery of lung function; resolution of clinically relevant markers of…
- Trial name
- NCT04588441
- Testing
- Adenosine
- Sponsor
- University of Florida
COVID-19, Cytokine Release Syndrome
Therapeutic Plasma Exchange for Coronavirus Disease-2019 Triggered Cytokine Release Storm;
Background: investigators have seen recently from experience in Western countries with best health care systems that pandemics cannot be managed in hospitals.
- Trial name
- Plex (NCT04485169)
- Testing
- Therapeutic Plasma Exchange
- Where
- Pakistan
- Volunteers
- 280 people
- Sponsor
- UNICEF
ARDS, Human, COVID-19 Respiratory Infection
Respiratory Drive and Inspiratory Effort in COVID-19 Associated ARDS
Data comparing respiratory drive and effort in critically ill patients with acute respiratory distress syndrome associated to different severity of COVID-19 penumonia (CARDS) and to other risk factors are lacking.
- Conditions
- ARDS, Human, COVID-19 Respiratory Infection, COVID-19 Acute Respiratory Distress Syndrome, Respiratory Effort-Related Arousal
- Trial name
- NCT06224010
- Testing
- Respiratory drive and effort assessment
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- University of Turin, Italy
COVID, ARDS
PROne Positioning in coVID-19 Oxygeno-dependent Patients in Spontaneous Ventilation (PROVID Study)
The COVID epidemics is responsible for a huge number of death following COVID acute respiratory failure. First instance treatment includes oxygenotherapy up to 15L/min in spontaneous ventilation.
- Trial name
- PROVID (NCT04366856)
- Testing
- 1: Prone positioning, 2: No instruction regarding positioning
- Where
- France
- Volunteers
- 446 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Distress Syndrome Related to SARS-CoV-2
COronaVirus Induced Acute Respiratory Disease Syndrome During PREGnancy
Few data are available on the management of critically ill pregnant women with pneumonia related to SARS-CoV-2. In the absence of clear recommendations for the management of delivery, clinicians are faced with the risk of…
- Trial name
- COVADIS-PREG (NCT05193526)
- Testing
- No intervention
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
COVID-19 Acute Respiratory Distress Syndrome, COVID-19 Pneumonia
Effect of Prone Positioning on the Severity of COVID-19 Pneumonia and Acute Respiratory Distress Syndrome.
With this research, we are aiming at finding out the effectiveness of prone positioning in this region population affected by moderate pneumonia due to covid 19 infection so that the hospital staff and doctors may be encouraged…
- Conditions
- COVID-19 Acute Respiratory Distress Syndrome, COVID-19 Pneumonia, Prone Positioning
- Trial name
- COVID-19 (NCT05405335)
- Testing
- Prone Positioning Maneuver
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Ayub Medical College, Abbottabad
Intensive Care Units, ARDS, Human
Therapeutic Plasma Exchange to Alleviate Hyperinflammatory Condition During Severe Covid-19 Infections
Severe Covid-19 (Coronavirus Disease 2019) infections generate major but inappropriate production of cytokines and, in some cases, generate anti-IFN (Interferon) auto-antibodies, inducing acute respiratory distress syndrom…
- Conditions
- Intensive Care Units, ARDS, Human, Covid19
- Trial name
- CovidEP (NCT04751643)
- Testing
- Therapeutic plasma exchange : 3 sessions in 3 consecutive days (day 1 to day 3), Usual treatments in intensive care unit according to the current state of knowledge
- Where
- 8 sites in France
- Volunteers
- 21 people
- Sponsor
- Hospices Civils de Lyon