Clinical trials: COVID19 ARDS
COVID-19, SARS-CoV-2 Virus
SARS-CoV-2/COVID-19 Study of Next Generation Non-Invasive Passive Detection Technologies (Level42)
The goal of this observational study is to evaluate new non-invasive passive surveillance technologies, Level 42 AI imPulse™ Una and TOR devices for the detection of COVID-19, Flu, and/or RSV in asymptomatic and symptomatic…
- Conditions
- COVID-19, SARS-CoV-2 Virus, COVID-19 Pneumonia, Respiratory Infection
- Trial name
- PassiveDetec (NCT05765396)
- Testing
- imPulse™ Systems (Una and TOR) infrasound-to-ultrasound e-stethoscope
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Geneva Foundation
Covid19, ARDS, Human
MSC-based Therapy in COVID-19-associated Acute Respiratory Distress Syndrome
Considering the potential of mesenchymal stromal cells (MSCs) in the treatment of lung injuries by COVID-19, this pilot clinical trial evaluates the safety and potential efficacy of the cell therapy, administered intravenously…
- Trial name
- NCT04525378
- Testing
- Mesenchymal stromal cell-based therapy
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- D'Or Institute for Research and Education
SARS-CoV Infection
VERU-111 in the Treatment of SARS-Cov-2 Infection by Assessing Its Effect on the Proportion of Patients Who Die on Study
To demonstrate the efficacy of VERU-111 in the treatment of SARS-Cov-2 Infection by assessing its effect on the proportion of patients who die on study (prior to Day 60).
- Trial name
- VERU-111 (NCT04842747)
- Testing
- VERU-111
- Where
- 58 sites in United States, Argentina and 4 more
- Volunteers
- 204 people
- Sponsor
- Veru Inc.
COVID-19 Pneumonia, Superinfection
The Diagnosis of Superinfections in Mechanically Ventilated Covid-19 Patients
Patients with severe Coronavirus Disease 2019 (Covid-19) pneumonia depending on mechanical ventilation are at risk of superinfections, especially infections of respiratory tract.
- Conditions
- COVID-19 Pneumonia, Superinfection, ARDS, Human
- Trial name
- SUPER-BAL (NCT05148975)
- Testing
- Bronchoalveolar lavage fluid diagnostics
- Where
- 2 sites in Czechia
- Volunteers
- 150 people
- Sponsor
- Brno University Hospital
Severe Acute Respiratory Syndrome (SARS) Pneumonia, COVID-19 Pneumonia
GM-CSF Inhalation to Prevent ARDS in COVID-19 Pneumonia
To assess the safety and tolerability of inhaled molgramostim nebuliser solution in patients with COVID-19 pneumonia.
- Trial name
- GI-COVID (NCT04569877)
- Testing
- Molgramostim nebuliser solution
- Where
- 9 sites in Germany
- Volunteers
- 63 people
- Sponsor
- University of Giessen
COVID, SARS-CoV-2
European/Euro-ELSO Survey on Adult and Neonatal/ Pediatric COVID-19 Patients in ECMO
In the last 10 years, severe acute respiratory infection (SARI) was responsible of multiple outbreaks putting a strain on the public health worldwide.
- Conditions
- COVID, SARS-CoV-2, ARDS, Human, Refractory Hypoxemia
- Trial name
- EuroECMO-COVID (NCT04366921)
- Where
- 97 sites in Austria, Belgium and 17 more
- Volunteers
- 150 people
- Sponsor
- Maastricht University Medical Center
Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19
CORONA (COvid pRONe hypoxemiA): Prone Positioning for Hypoxemic COVID-19 Patients With Do-not-intubate Goals
The purpose of this trial is to determine whether Prone Positioning (PP) improves outcomes for non-intubated hospitalized patients with hypoxemic respiratory failure due to COVID-19, who are not candidates for mechanical…
- Conditions
- Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19, Acute Respiratory Distress Syndrome, ARDS
- Trial name
- CORONA (NCT04402879)
- Testing
- Prone Positioning (PP)
- Where
- 4 sites in Canada
- Volunteers
- 596 people
- Sponsor
- University of Calgary
Sars-CoV2
COVID-19 Respiratory Distress and Antithrombotic Drugs in Subject's Habits
Current management of VID-19 consists of oxygen support without specific treatment. Hospitalization may suddenly require delayed resuscitation.
- Trial name
- CRASH (NCT04412473)
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Strasbourg, France
Covid19, Ultrasound
Lung Ultrasound in COVID-19 Patients
To assess the prognostic performance of an early global LUS score with respect to the mortality in ICU and duration of ventilation.
- Conditions
- Covid19, Ultrasound, ARDS
- Trial name
- LUS-COVID (NCT04487769)
- Where
- Netherlands
- Volunteers
- 137 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
COVID-19 Acute Respiratory Distress Syndrome, Viral Disease
Registry for Hemoperfusion of Covid-19 ICU Patients
The ongoing COVID-19 pandemic caused high hospitalization and mortality rates especially in critically ill patients. Unfortunately, there is no present study with a large number of patients that would offer us clear answers on…
- Conditions
- COVID-19 Acute Respiratory Distress Syndrome, Viral Disease, Critical Illness, Multi Organ Failure
- Trial name
- HERICC (NCT05470907)
- Testing
- Hemoperfusion
- Where
- Croatia
- Volunteers
- 1,050 people
- Sponsor
- Croatian Society for Organ Support
Acute Respiratory Distress Syndrome, Coronavirus Infection
Vadadustat for the Prevention and Treatment of Acute Respiratory Distress Syndrome (ARDS) in Hospitalized Patients With Coronavirus Disease 2019 (COVID-19)
The purpose of this study is to evaluate the efficacy of vadadustat for the prevention and treatment of acute respiratory distress syndrome (ARDS) in hospitalized patients with Coronavirus Disease 2019 (COVID-19).
- Trial name
- NCT04478071
- Testing
- vadadustat
- Where
- United States
- Volunteers
- 448 people
- Sponsor
- The University of Texas Health Science Center, Houston
Acute Respiratory Distress Syndrome, Inflammation
Dexmedetomidine to Improve Outcomes of ARDS in Critical Care COVID-19 Patients
A continuous infusion of Dexmedetomidine (DEX) will be administered to 80 patients admitted to Critical Care because of signs of Respiratory Insufficiency requiring non-invasive ventilation.
- Conditions
- Acute Respiratory Distress Syndrome, Inflammation, Dexmedetomidine, Cytokine Storm
- Trial name
- COVID-DEX (NCT04358627)
- Testing
- Dexmedetomidine Injectable Product
- Volunteers
- 80 people
- Sponsor
- Hospital Clinic of Barcelona
COVID-19, Acute Respiratory Distress Syndrome
DEXamethasone EARLY Administration in Hospitalized Patients With Covid-19 Pneumonia
The aim of this study is to evaluate the efficacy of dexamethasone in hospitalized adults with COVID-19 pneumonia who do not require supplementary oxygen on admission, but have high risk of developing acute respiratory distress…
- Conditions
- COVID-19, Acute Respiratory Distress Syndrome, Pneumonia, Viral
- Trial name
- EARLYDEXCoV2 (NCT04836780)
- Testing
- Dexamethasone
- Where
- 3 sites in Spain
- Volunteers
- 126 people
- Sponsor
- Hospital Universitario Infanta Leonor
COVID-19 Acute Respiratory Distress Syndrome
Safety and Efficacy of Inhaled XW001 For Hospitalized COVID-19 Patients Requiring Oxygen Therapy
This is a multiregional, randomized, double-blind, placebo-controlled Phase 2 study in patients with confirmed symptomatic COVID-19, designed to evaluate the safety, tolerability, efficacy, and PK of XW001 (IL-29 analog)…
- Trial name
- NCT05083117
- Testing
- XW001
- Where
- 2 sites in Argentina, Peru
- Sponsor
- Sciwind Biosciences APAC CO Pty. Ltd.
Severe COVID-19
Corticosteroids in Severe COVID-19 (ASAP-ESICM/ESAIC Study)
Brief Summary: Administration of systemic corticosteroids for patients with severe forms of severe acute respiratory syndrome in coronavirus-2 (SARS-CoV-2) infection are recommended by several guidelines.
- Trial name
- ASAPESICMESAIC (NCT04866082)
- Testing
- questionnaire
- Where
- Czechia
- Volunteers
- 466 people, healthy volunteers welcome
- Sponsor
- Brno University Hospital
COVID-19, Cytokine Storm
CORONA: A Study Using DeltaRex-G Gene Therapy for Symptomatic COVID-19
COVID-19 is an infectious disease caused by severe acute respiratory syndrome coronavirus 2. COVID-19 causes life threatening complications known as Cytokine Release Syndrome or Cytokine Storm and Acute Respiratory Distress…
- Conditions
- COVID-19, Cytokine Storm, Acute Respiratory Distress Syndrome
- Trial name
- CORONA (NCT04378244)
- Testing
- DeltaRex-G
- Sponsor
- Aveni Foundation
COVID-19, ARDS, Human
Curosurf® in Adult Acute Respiratory Distress Syndrome Due to COVID-19
Surfactant replacement therapy (SRT) improves oxygenation and survival in NRDS and some infant ARDS. SRT was tried in adult ARDS with conflicting results.
- Trial name
- Caards-1 (NCT04384731)
- Testing
- poractant alfa
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Dr Christophe LENCLUD
COVID-19, ARDS
Respiratory and Hemodynamic Changes Induced in Mechanically Ventilated Patients for COVID-19
In the present context, it seems necessary to try to describe as precisely as possible the physiological alterations due to COVID-19.
- Conditions
- COVID-19, ARDS, Sars-CoV2
- Trial name
- PHYSIO-COVID (NCT04347928)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Lille
Covid19, ARDS
Long-Term Functional, Quality-of-Life, Neuropsychological and Cognitive Outcomes in COVID-19 Critical Illness Survivors
The corona virus disease 2019 (COVID-19), suddenly incepted in December 2019 in Wuhan, China, leading to one of the greatest health care emergencies of the last century.
- Conditions
- Covid19, ARDS, Critical Illness, Neurocognitive Dysfunction
- Trial name
- LUNGTERMcov (NCT04881266)
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University of Zurich
COVID-19 Acute Respiratory Distress Syndrome
Telerehabilitation Program and Detraining in Patients With Post-COVID-19 Sequelae
The primary objective of this study is to evaluate the effects of a 15-week home telerehabilitation program and a detraining period on cardiorespiratory fitness and muscular efficiency in patients with post-COVID-19 sequelae…
- Trial name
- NCT05866224
- Testing
- Telerehabilitation program
- Where
- Spain
- Volunteers
- 130 people
- Sponsor
- Campus docent Sant Joan de Déu-Universitat de Barcelona