Clinical trials: CPAP Ventilation
Sleep Apnea, Obesity
The Effects of Treating Obese and Lean Patients With Sleep Apnea
The investigators' overall goal is to compare the effect of CPAP treatment on intermediate cardiovascular risk measures in obese versus lean patients with obstructive sleep apnea (OSA).
- Trial name
- PISA (NCT01578031)
- Testing
- Positive Airway Pressure During Sleep (ResMed S9 Elite), Usual Care
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Obstructive Apnea
Comparison of a Demand Oxygen Delivery
Conducting a randomized control trial of oxygen in children with Down syndrome to treat moderate to severe obstructive sleep apnea.
- Trial name
- DOSA (NCT06609694)
- Testing
- Portable oxygen concentrator Inogen G5 model
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Obstructive Sleep Apnea, Hypoxemia
Mechanisms of Endothelial Cell Dysfunction in Sleep Apnea
Sleep apnea is a common sleep disorder characterized by temporary stops in breathing during sleep and has been associated with the development of cardiovascular disease.
- Trial name
- NCT00859950
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Hypoxemia, Altitude Hypoxia
Effects of Continuous Positive Airway Pressure on Peripheral Oxygen Saturation, Work of Breathing, and Exercise Tolerance at Altitude
Dyspnea and exercise intolerance are well known to travelers who have experienced time at high elevations, greater than 2500 meters (8200 feet).
- Trial name
- NCT05971290
- Testing
- Continuous positive airway pressure, Ambient air
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Ventilation Therapy; Complications
Ultrasound Measurements of Basilica Vein Diameter at Room Air Breathing and at Positive Pressure on Healthy Volunteers
Peripherally Inserted Central Catheters (PICC) and midline placement requires the catheter size to be one third of the venous diameter, or less.
- Trial name
- PEEPVEIN-2021 (NCT05201755)
- Testing
- CPAP
- Where
- Italy
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Preeclampsia
Prevalence Study of Sleep Apnea in Women With Preeclampsia
Hypothesis: The prevalence of sleep apnea is greater in pregnant women with preeclampsia than in pregnant women without preeclampsia.The presence of sleep apnea will be associated with poor blood pressure control, worsening blood…
- Trial name
- NCT00259688
- Testing
- CPAP therapy for subjects diagnosed with sleep apnea
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Sleep Apnea, Ventricular Arrythmias
Sleep Apnea-hypopnea Syndrome (SAHS) and Ventricular Arrhythmias
Hypothesis: The CPAP treatment diminishes the effect of ventricular arrhythmias in patients with ischemic heart disease or dilated myocardiopathy, systolic ventricular disfunction and sleep apnea-hypopnea syndrome…
- Conditions
- Sleep Apnea, Ventricular Arrythmias, Systolic Left Ventricle Dysfunction
- Trial name
- SAHS-ICD (NCT00765713)
- Testing
- Nasal continuous positive airway pressure
- Where
- 3 sites in Spain
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario La Paz
Dysphagia, OSA
Obstructive Sleep Apnea (OSA), Oral Frailty, Dysphagia, Continuous Positive Airway Pressure (CPAP)
The purpose of this study is to evaluate the effects of the CPAP treatment on oral frailty and dysphagia among OSA patients.
- Conditions
- Dysphagia, OSA, CPAP
- Trial name
- NCT05977296
- Testing
- CPAP
- Where
- Taiwan
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Obstructive Sleep Apnea of Adult
Impact of Intermittent Hypoxia on the Function of the Phagocytes
Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis are included as well as healthy controls without OSA.
- Trial name
- NCT03618719
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Obstructive Sleep Apnea
Revised Algorithm for Next Generation DeVilbiss Healthcare AutoAdjust Continuous Positive Airway Pressure (CPAP)
The purpose of this protocol is to improve the current FDA-approved continuous positive pressure auto-titration algorithm, including treatment precision, residual disease detection characteristics and phenotyping with the…
- Trial name
- NCT01797705
- Testing
- DeVilbiss AutoAdjust CPAP with revised algorithm
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- DeVilbiss Healthcare LLC
OSA - Obstructive Sleep Apnea
Evaluation of a Wearable PAP Device in a Tethered Configuration for the Treatment of Obstructive Sleep Apnoea.
Each participant will wear a wearable PAP device, tethered to a released PAP device for up to 7 nights. Objectives include collecting and evaluating participants feedback on seal, comfort and usability of the wearable PAP device.
- Trial name
- NCT07420140
- Testing
- Positive Airway Pressure
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- ResMed
Sleep Apnea, Obstructive
Study of PROVIGIL ® (Modafinil) Treatment in Children and Adolescents With Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea Syndrome
The primary objectives of the study are to determine the effectiveness of PROVIGIL treatment, compared to placebo treatment, in children and adolescents with excessive sleepiness (ES) associated with obstructive sleep…
- Trial name
- NCT00107809
- Testing
- Modafinil
- Where
- 64 sites in United States, Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Cephalon
Infant, Newborn, Diseases, Intubation Complication
Noninvasive Positive Pressure Ventilation During Neonatal Nasal Intubation
The goal of this study is to perform a quality control assessment of our local intubation protocol in any newborn infant requiring endotracheal intubation in the delivery room or neonatal intensive care unit at the Department of…
- Trial name
- IntubAID (NCT06139809)
- Testing
- Intubation
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Obstructive Sleep Apnea
Simulated In-House Usability Study of Eclipse Continuous Positive Airway Pressure (CPAP) Device
The study is designed to assess the usability of a novel CPAP human interface compared to a traditional nasal mask. Human subjects will interact with two different CPAP interfaces including a traditional CPAP mask and the 2nd…
- Trial name
- NCT05570747
- Testing
- Usability
- Where
- 3 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Bleep, LLC
Sleep Apnea, Obstructive
The Changes of Patterns of Microarray in Patients With Obstructive Sleep Apnea
The aim of this study are (1) To genome-wide profile the gene expression patterns of peripheral blood mononuclear cell (PBMC) in patients with obstructive sleep apnea (OSA) (2) To profile the gene expression patterns change…
- Trial name
- NCT00498849
- Testing
- CPAP
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Sleep Apnea, Obstructive
Evaluation of a Health Dashboard Intervention to Improve Engagement With CPAP Therapy in PAP-Naïve Patients: Project Neo
This is a prospective, open-label study to evaluate the effectiveness of providing a dashboard with merged health metrics of CPAP (continuous positive airway pressure/ PAP) usage, self-reported sleepiness, blood pressure (BP) and…
- Trial name
- NCT04912635
- Testing
- Neo App
- Where
- Australia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- ResMed
Obstructive Sleep Apnea
Obstructive Sleep Apnea Treatment With CPAP With and Without the Use of Expiratory Pressure Relief Technology
Expiratory pressure relief (EPR) is a technology designed to improve patient comfort during continous positive airway pressure (CPAP) treatment for obstructive sleep apnea (OSA).
- Trial name
- OSAEPR (NCT05219591)
- Testing
- EPR
- Where
- Brazil
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
High Altitude Pulmonary Edema
Comparison of CPAP and Gamow Bag Ventilation to Treat HAPE
High altitude pulmonary edema (HAPE) is mostly treated with supplemental oxygen, nifedipine 30mg twice a day, rest, limiting cold exposure and descent (simulated or actual) Gamow Bag provides simulated descent and buy time for…
- Trial name
- CPAP (NCT04710953)
- Testing
- Continuous positive airway pressure machine
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- sultan mehmood kamran
Sleep Apnea Syndromes, Oxidative Stress
Efficacy of Continuous Positive Airway Pressure in Reducing Oxidative Stress in Individuals With Sleep Apnea
Sleep-disordered breathing (SDB) is a condition in which a person experiences frequent breathing pauses during sleep, also known as sleep apnea.
- Conditions
- Sleep Apnea Syndromes, Oxidative Stress, Cardiovascular Diseases
- Trial name
- SASS (NCT00607893)
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Hyperoxemia, Intensive Care Unit (ICU)
Hyperoxemia in the Intensive Care Unit(ICU)
In our study, to research the prevalence of hyperoxemia in adult patients treated in the intensive care unit (ICU) and its relationship with clinical outcomes.
- Conditions
- Hyperoxemia, Intensive Care Unit (ICU), CPAP, Invasive Mechanical Ventilation
- Trial name
- ICU (NCT07549763)
- Where
- Turkey (Türkiye)
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Trakya University