Clinical trials: CRC
Colorectal Cancer
Elucidation of the Mechanisms and Effects of Certain Anesthetic Interventions on Digestive Cancer Patients Subjected to Surgery
Digestive cancers (liver, colonic, pancreatic) have a high incidence and high mortality, their population prevalence is also increasing.
- Trial name
- NCT04162535
- Testing
- Lidocaine 1% Injectable Solution, Blood extraction, Sevoflurane
- Where
- Romania
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Colorectal Cancer, Colorectal Neoplasms
The Impact of Choice on Colorectal Cancer Screening
In May of 2021, the United States Preventive Service Task Force (USPSTF) updated their colorectal cancer (CRC) screening guidelines by recommending screening at an earlier age for average-risk adults starting at the age of 45…
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Health Screening
- Trial name
- CRC45+ (NCT05275530)
- Testing
- Active FIT Choice, Active Colonoscopy Choice, Active Dual Choice
- Where
- 2 sites in United States
- Volunteers
- 20,509 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Colonic Polyp, Colorectal Cancer
Inception, Validation and Clinical Utility of a Score to Assess the Completeness of Caecal Visualisation
CCIS is a novel score, created specifically to evaluate the completeness of caecal visualized. It can be applied to a single or multiple images.
- Trial name
- NCT05854277
- Testing
- educational video
- Where
- Belgium
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Brain Cancer, Breast Cancer
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types.
- Conditions
- Brain Cancer, Breast Cancer, Bladder Cancer, Cervical Cancer
- Trial name
- CAMPERR (NCT05366881)
- Where
- 17 sites in United States
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Adela, Inc
Colorectal Cancer, Healthy
Computerized Feedback in Colonoscopy
In a cluster-randomized study compare if feedback from two computerized feedback systems doing a colonoscopy (CoPS and CoRS) can improve the adenoma detection rate and decrease patient discomfort.
- Trial name
- NCT04862793
- Testing
- Colonoscopy Progression Score (CoPS), Colonoscopy Retraction Score (CoRS)
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Copenhagen Academy for Medical Education and Simulation
Colorectal Cancer
Clinical Validation of ColonAiQ (a Blood-based Assay Targeting ctDNA Methylation) for Colorectal Cancer Detection
The DNA methylation targets in preoperative plasma samples of the subjects will be detected by the multi-gene methylation test (ColonAiQ), and the test accuracy will be evaluated by compared with the clinical diagnosis evidence.
- Trial name
- NCT06347887
- Testing
- ColonAiQ test and Colonoscopy
- Where
- 7 sites in China
- Volunteers
- 1,965 people, healthy volunteers welcome
- Sponsor
- Singlera Genomics Inc.
Colorectal Cancer
REINFORCEMENT ANASTOMOSIS WITH Modified Cyanacrylate IN Patients Undergoing to Oncologic Colorectal Surgery With Colorectal Anastomosis
In colorectal surgery about 30% of postoperative mortality is attributed to anastomotic leak, whit an incidence range between 1.8% and 15.9%.
- Trial name
- ANASTOSEAL (NCT03380858)
- Testing
- colectomy
- Where
- Italy
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute, Naples
Colorectal Cancer
Early Diagnosis and Recurrence Monitoring of Colorectal Cancer
Colorectal cancer (CRC) has an insidious onset and its survival rate is closely related to clinical stage. While the 5-year survival rate of stage I patients exceeds 90%, it drops to 14% in stage IV.
- Trial name
- NCT06991452
- Testing
- Liquid biopsy
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Colon Cancer, Rectal Cancer
Assessing Effect of Withdrawal Time on Adenoma Detection Rate for Screening Colonoscopy
The investigators' null hypothesis is that a withdrawal time of 9 to 10 minutes is non-inferior to a withdrawal time of 12 minutes or greater.
- Conditions
- Colon Cancer, Rectal Cancer, Colorectal Cancer
- Trial name
- NCT05018325
- Testing
- Colonoscopy with 6 minute withdrawal, Colonoscopy 9 minute withdrawal, Colonoscopy 12 minute withdrawal
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Colon Cancer, Rectal Cancer
GI SPORE Colon Biosample Protocol
The investigators are creating a data and specimen repository to study causes , early detection, prevention and treatment of colon and rectal cancer.
- Trial name
- NCT02243267
- Testing
- sample collection
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Colorectal Disorders, Regional Anesthesia Morbidity
Transversus Abdominis Plane Blocks With and Without Dexamethasone
Dexamethasone will be used as an adjunct to local anesthetics (bupivacaine) to prolong the duration of laparoscopically-placed transversus-abdominis plane blocks in elective colorectal resection.
- Conditions
- Colorectal Disorders, Regional Anesthesia Morbidity, Analgesia, Local Anesthetic Complication
- Trial name
- TAP-DEX (NCT05432934)
- Testing
- Dexamethasone
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Breast Cancer, Cervical Cancer
A Telephone-Based Prevention Care Manager in Increasing Screening Rates for Breast Cancer, Cervical Cancer, and Colorectal Cancer in Minority and Low-Income Women
RATIONALE: Studying the barriers that prevent minority and low-income women from undergoing cancer screening, and offering encouragement to them over the telephone, may help improve cancer screening rates.
- Conditions
- Breast Cancer, Cervical Cancer, Colorectal Cancer
- Trial name
- NCT00376909
- Testing
- educational intervention, study of socioeconomic and demographic variables
- Where
- 2 sites in United States
- Volunteers
- 2,729 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Colorectal Cancer
Folate-Depleted Diet Compared With Folate-Supplemented Diet in Preventing Colorectal Cancer in Patients at High Risk for Colorectal Cancer
RATIONALE: Chemoprevention therapy is the use of certain agents to try to prevent the development of cancer. The use of folic acid may be effective in preventing colorectal cancer.
- Trial name
- NCT00096330
- Testing
- dietary intervention, folic acid
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Colorectal Cancer
Promoting CRC Screening in an Urban Minority Population
The purpose of this study (Healthy Colon Project II) is to evaluate different educational approaches for increasing rates of colorectal cancer (CRC) screening in a hard-to-reach urban minority population with health insurance.
- Trial name
- NCT02392143
- Testing
- Printed Education Material, Academic Detailing, Academic Detailing+Telephone Education
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- Teachers College, Columbia University
Colorectal Cancer Screening
Large-Scale Implementation of a Decision Aid About Colorectal Cancer Screening
The goal of the project is to improve shared decision making and increase uptake of colorectal cancer (CRC) screening by facilitating the implementation of a decision aid about CRC and screening options in two healthcare systems…
- Trial name
- IDecide (NCT06597955)
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Indiana University
Breast Carcinoma, Colorectal Carcinoma
Assessment of Current Biomarker Testing Practices for Common Solid Cancers in Precision Oncology in the Community Setting
This trial assesses current biomarker testing practices for common solid cancers in precision oncology in the community setting.
- Conditions
- Breast Carcinoma, Colorectal Carcinoma, Community Practice, Lung Carcinoma
- Trial name
- NCT03804255
- Testing
- Survey Administration
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- ECOG-ACRIN Cancer Research Group
Colorectal Cancer
A Comparison of Methods to Detect Polyps During Colonoscopy
Colorectal cancer (CRC) is the third most common cancer and second leading cause of cancer deaths in western countries. Colonoscopy is a preferred colorectal screening modality since it has both diagnostic and therapeutic…
- Trial name
- NCT01025960
- Testing
- Standard Inspection Colonoscopy, Dual Inspection Colonoscopy
- Where
- United States
- Volunteers
- 768 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Colorectal Cancer
Colon Cancer Prevention Study
The goal of this research study is to design messages which can help people learn more about how to prevent colon cancer. Eligible participants will be asked to review a series of short cancer prevention messages and share their…
- Trial name
- NCT00924690
- Testing
- Behavioral Messages, Generic Messages
- Where
- United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Cancer Colorectal
Evaluation of Letters Promoting Colorectal Cancer Testing
In this evaluation, 4 different versions of letters are being sent with mailers promoting colorectal cancer screening with an at-home test.
- Trial name
- NCT04548765
- Testing
- Letter, Loss Frame and Fear Appeals, Transparency
- Where
- United States
- Volunteers
- 14,644 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Colorectal Cancer, Colorectal Neoplasms
Early Onset Colorectal Cancer Detection
Colorectal cancer (CRC) once predominantly affected older individuals, but in recent years has witnessed a progressive increase in incidence among young adults.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Adenocarcinoma, Colorectal Cancer Stage I
- Trial name
- ENCODE (NCT06342401)
- Testing
- ENCODE
- Where
- 13 sites in United States, Italy and 2 more
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center