Clinical trials: CRC
Colorectal Cancer
Efficacy and Tolerability of Suprep With and Without Simethicone for Routine Colonoscopy for Colorectal Cancer Screening
The purpose of this study is to investigate Suprep bowel preparation, with and without the anti-gas medication simethicone, in terms of efficacy and patient tolerability in the preparation of patients undergoing routine…
- Trial name
- NCT02523911
- Testing
- Simethicone, sodium sulfate/potassium sulfate/magnesium sulfate solution
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- MercyOne Des Moines Medical Center
Colorectal Cancer Prevention
Colorectal Cancer Prevention Research Study: Eat Right, Screen Right
The Eat Right, Screen Right Extension program aims to help adult learners manage nutrition risks and screening options for colorectal cancer prevention.
- Trial name
- NCT07393906
- Testing
- Web-based module
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Florida
Colonic Polyps, Esophageal Diseases
Confocal Probe-based Endoscopic Imaging, Colorectal Cancer, Gastrointestinal (GI) Pathologies
The recently developed endoscopic Confocal probe microscopy system allows imaging of surface epithelium during ongoing endoscopy (upper and lower) with the potential of immediate diagnosis of various GI pre-malignant and…
- Trial name
- ASGE-FNDT-1 (NCT00874263)
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Wild-type KRAS,NRAS and BRAF V600E Metastatic Colorectal Cancer
Continuing Cetuximab Plus Chemotherapy After First Progression in Wild-type KRAS, NRAS and BRAF V600E Metastatic Colorectal Cancer
The aim of this study was to evaluate the efficacy and safety of continuing cetuximab combined with chemotherapy after first-line progression in wild-type KRAS,NRAS and BRAF colorectal cancer.
- Trial name
- NCT04718038
- Testing
- Cetuximab combind mFOLFOX6/FOLFIRI
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Henan Cancer Hospital
Colorectal Neoplasms
Message Framing and Colorectal Cancer Screening
The main purpose of this study is to promote colorectal cancer (CRC) screening among individuals who have never been screened, with these individuals being members of a panel who participant in online studies.
- Trial name
- CRC (NCT02483832)
- Testing
- Educational materials
- Where
- United States
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Duke University
Colorectal Cancer
Screening for Colorectal Cancer With FOBT, Virtual Colonoscopy and Optical Colonoscopy. A Randomized Clinical Trial in the Florence District
RATIONALE: Computed tomographic colonography (CTC) has proven to be accurate in detecting colorectal neoplasms and may be a primary test in colorectal cancer screening.
- Trial name
- SAVE (NCT01651624)
- Testing
- Invitation to screening
- Where
- Italy
- Volunteers
- 16,087 people, healthy volunteers welcome
- Sponsor
- Cancer Prevention and Research Institute, Italy
Malignant Neoplasm of Large Intestine
Effectiveness of Direct-to-Patient Outreach on Colorectal Cancer Screening Within a Low Income and Diverse Population
The purpose of this study is to determine if the direct mailing of fecal occult blood testing (FOBT) kits to patients who are due for colorectal cancer screening is an effective way to improve colorectal cancer screening rates…
- Trial name
- NCT01385579
- Testing
- Care manager outreach
- Where
- United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Prevention of Colorectal Cancer
Colon Cancer Prevention Using Selenium
Selenium's ability to prevent colorectal cancer (CRC) has been suspected for nearly 30 years, but has never been directly studied in humans.
- Trial name
- NCT01211561
- Testing
- Selenium, selenomethionine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Breast Cancer, Colorectal Cancer
Detection of Cancer in Breath Samples by Trained Detection Dogs
The goal of this study is to show that trained detection dogs can identify breast, lung, prostate or colorectal cancer by sniffing masks containing breath samples.
- Conditions
- Breast Cancer, Colorectal Cancer, PROSTATE CANCER, Lung Cancer
- Trial name
- NCT06255041
- Where
- 2 sites in Israel
- Volunteers
- 1,386 people, healthy volunteers welcome
- Sponsor
- SpotitEarly
Colorectal Cancer (CRC), Advanced Adenomas (AA)
Collection of Samples USOPTIVAL Study
A prospective multi-center observational study. The study will enroll eligible subjects from the United States to optimize the biomarker panel and evaluate the performance of a cfDNA marker panel selected by the Sponsor for CRC…
- Trial name
- NCT04792684
- Testing
- Optimization of Plasma Circulating Free-DNA (cfDNA) Marker Panel
- Where
- 16 sites in United States
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- Universal Diagnostics
Colorectal Neoplasms, Aberrant DNA Methylation
Diagnostic Potential of Hypermethylated DNA in Colorectal Cancer
Colorectal cancer (CRC) is one of the most common forms of cancer and the second leading cause of cancer-related deaths in the western world.
- Trial name
- NCT02928120
- Where
- Denmark
- Volunteers
- 658 people, healthy volunteers welcome
- Sponsor
- Ole Thorlacius-Ussing, MD, DMSc, Professor of Surgery
Colorectal Cancer, Adenomatous Colorectal Polyps
Selenium for Prevention of Adenomatous Colorectal Polyps
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. Selenium may be effective in preventing the recurrence of adenomatous colorectal polyps.
- Conditions
- Colorectal Cancer, Adenomatous Colorectal Polyps, Precancerous Condition
- Trial name
- NCT00078897
- Testing
- Selenium
- Where
- 7 sites in United States
- Volunteers
- 1,621 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Colorectal Cancer
Efficacy of Vitamin D in Colorectal Cancer Chemoprevention
Vitamin D's ability to prevent colorectal cancer (CRC) has been suspected for nearly 30 years, but has never been directly studied in humans.
- Trial name
- NCT01574027
- Testing
- Vitamin D3 (cholecalciferol)
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Colorectal Cancer
Computerized and Mailed Reminders in Increasing the Rate of Colorectal Cancer Screening in Adults With an Average Risk for Colorectal Cancer
RATIONALE: Screening may help doctors find colorectal cancer sooner, when it may be easier to treat. Computerized and mailed reminders may help increase the rate of colorectal cancer screening in adults with an average risk for…
- Trial name
- NCT00355004
- Testing
- counseling intervention, fecal occult blood test, screening colonoscopy
- Where
- 3 sites in United States
- Volunteers
- 21,860 people, healthy volunteers welcome
- Sponsor
- Harvard Medical School (HMS and HSDM)
Colorectal Carcinoma
Improving Colonoscopy Surveillance for Patients With High Risk Colon Polyps
This clinical trial tests a multilevel intervention at the clinic, provider and patient levels, to improve colonoscopy surveillance in patients with high risk colon polyps.
- Trial name
- NCT06376565
- Testing
- Best Practice, Communication Intervention, Interview
- Where
- United States
- Volunteers
- 1,680 people, healthy volunteers welcome
- Sponsor
- Jonsson Comprehensive Cancer Center
Colorectal Cancer, Colorectal Adenoma
Adenoma Detection Rate in Artificial Intelligence-assisted Colonoscopy
The goal of this quasi randomized multicenter controlled clinical trial (RCT) is to investigate whether a combined real time computer-aided polyp detection (CADe) and computer-aided polyp characterization (CADx) system (GI…
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Colorectal Neoplasms
- Trial name
- NCT05740137
- Testing
- AI-assisted colonoscopy
- Where
- 4 sites in Denmark
- Volunteers
- 795 people, healthy volunteers welcome
- Sponsor
- Ismail Gögenur
Colorectal Cancer
A Prospective Cohort Study on Colorectal Cancer Screening in Community Population
This study will validate the real world results of polygene methylation detection in colorectal cancer in a large prospective community cohort.
- Trial name
- NCT05485077
- Where
- China
- Volunteers
- 18,000 people, healthy volunteers welcome
- Sponsor
- Singlera Genomics Inc.
Colorectal Cancer, Precancerous Condition
S0000D: Effect of Vitamin E and/or Selenium on Colorectal Polyps in Men Enrolled on SELECT Trial SWOG-S0000
RATIONALE: Studying tissue samples in the laboratory from participants receiving treatment on the Selenium and Vitamin E Cancer Prevention Trial (SELECT) SWOG-S0000 may help doctors predict a participant's response to treatment…
- Trial name
- ACP (NCT00706121)
- Testing
- Vitamin E, Selenium
- Where
- United States
- Volunteers
- 8,094 people, healthy volunteers welcome
- Sponsor
- SWOG Cancer Research Network
Cardiovascular Diseases, Cardiotoxicity
Cancer Treatment Related Cardiovascular Toxicity: Comprehensive Myocardial and Vascular Phenotyping
Observational prospective cohort study designed to assess the mechanisms of fluoropyrimidine induced cardiovascular toxicity.
- Conditions
- Cardiovascular Diseases, Cardiotoxicity, Fluorouracil Adverse Reaction, Malignancy
- Trial name
- PC-TOX (NCT06048458)
- Testing
- Cardiovascular magnetic resonance with stress perfusion, CT coronary angiography, Retinal OCT angiography
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University College, London
Colorectal Neoplasms
A Multicenter, Clinical Study of FOLFOXIRI With Bevacizumab As First-line Therapy in Patients With mCRC
The purpose of this study to assess efficacy and tolerability of combination therapy FOLFOXIRI with Bevacizumab (BV) as a first-line therapy in patients with metastatic colorectal cancer.
- Trial name
- QUATTRO (NCT02246049)
- Testing
- Bevacizumab, 5-fluorouracil, Irinotecan hydrochloride
- Where
- Japan
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- EPS Corporation