Clinical trials: CUP
Brain and Central Nervous System Tumors, Carcinoma of Unknown Primary
Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia, Lymphoma, or Solid Tumors
RATIONALE: Drugs used in chemotherapy, such as topotecan, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Brain and Central Nervous System Tumors, Carcinoma of Unknown Primary, Leukemia, Lymphoma
- Trial name
- NCT00112619
- Testing
- topotecan hydrochloride
- Where
- 11 sites in United States
- Volunteers
- 19 people
- Sponsor
- Pediatric Brain Tumor Consortium
Hip Dislocation
The 10-year Follow-up of the Delta-TT Trial.
This 10-year follow-up study aims to further investigate long-term migration patterns of the uncemented Delta-TT cup and H-MAX S stem, comparing outcomes between ceramic and polyethylene liners.
- Trial name
- RSA-10 (NCT06864897)
- Testing
- Total hip prothesis, Total hip prosthesis
- Where
- Netherlands
- Volunteers
- 51 people
- Sponsor
- JointResearch
Head and Neck Carcinoma, Head and Neck Carcinoma of Unknown Primary
Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT Study
This clinical trial studies how well intensity modulated proton therapy (IMPT) or intensity modulated X-ray (radiation) therapy (IMRT) works after surgery in treating patients with head and neck cancer.
- Conditions
- Head and Neck Carcinoma, Head and Neck Carcinoma of Unknown Primary, Hypopharyngeal Carcinoma, Laryngeal Carcinoma
- Trial name
- NCT05075980
- Testing
- Cisplatin, Intensity-Modulated Proton Therapy, Quality-of-Life Assessment
- Where
- 9 sites in United States
- Volunteers
- 174 people
- Sponsor
- Mayo Clinic
Total Hip Arthroplasty (THA)
Mpact 3D Metal Monolit Study
Total hip arthroplasty (THA) is one of the most common operations performed in orthopaedics to improve a patient's quality of life.
- Trial name
- NCT06748885
- Testing
- Mpact 3D Metal Monolith
- Where
- 3 sites in France
- Volunteers
- 88 people
- Sponsor
- Medacta International SA
Hip Arthritis, Hip Disease
MDR - PMCF Study for RingLoc Bipolar Acetabular Cup and Endo II Femoral Heads
The objective of this retrospective enrollment/prospective follow-up consecutive series PMCF study is to collect data confirming safety, performance, and clinical benefits of the RingLoc Bipolar Acetabular Cup and the Endo II…
- Conditions
- Hip Arthritis, Hip Disease, Hip Fractures, Hip Injuries
- Trial name
- NCT05199870
- Testing
- RingLoc Bipolar Acetabular Cup, Endo II Femoral Head
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Zimmer Biomet
Avascular Necrosis, Osteoarthritis
PMCF Study on the Safety and Performance of the Alloclassic Variall Cup Ceramic Bearing System in Total Hip Arthroplasty
The study is a multicenter, prospective, non-randomized, non-controlled consecutive cohort post-market clinical follow-up study.
- Conditions
- Avascular Necrosis, Osteoarthritis, Inflammatory Arthritis, Posttraumatic Arthritis
- Trial name
- NCT03672370
- Where
- 2 sites in Austria
- Volunteers
- 100 people
- Sponsor
- Zimmer Biomet
Arthroplasty Complications
Osteolysis Development Around Uncemented Cups With or Without Screw Holes
In order to investigate the role of acetabular cup screw holes for the transport of osteolysis-inducing particles in a total hip arthroplasty articulation, the investigators compare the amount of bone loss around acetabular cups…
- Trial name
- NCT03692351
- Testing
- Uncemented acetabular cup with screw holes, Uncemented acetabular cup without screw holes
- Volunteers
- 95 people
- Sponsor
- Sahlgrenska University Hospital
Prosthesis Loosening
Investigating Proximal Migration in Trabecular Metal Cups Used In Acetabular Revision Surgery
This study is intended to compare the proximal migration of the tantalum design (TM) with a cemented cup used in conjunction with bone allografting in cases with major bone loss.
- Trial name
- NCT02237482
- Testing
- Trilogy cup, Trabecular metal cup (TM), ZCA cup
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Sahlgrenska University Hospital
Osteoarthritis, Osteonecrosis
E-Type - Early Wear of Polyethylene Liners Used in DMC
This is a single-centre, randomized, double-blinded controlled non-inferiority trial that will be conducted at the Orthopaedic Department at Uppsala University Hospital, Uppsala.
- Conditions
- Osteoarthritis, Osteonecrosis, Dysplasia; Hip
- Trial name
- E-type (NCT07863557)
- Testing
- Total Hip Arthroplasty
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Uppsala University
Total Hip Arthroplasty
Post Market Clinical Follow-Up of Plasmafit® Cup
Twelve months follow-up of implant survival and clinical and radiological follow-up of Plasmafit® Cup.
- Trial name
- NCT02019849
- Testing
- Plasmafit® Total Hip Arthroplasty
- Where
- 2 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Aesculap AG
Osteoarthritis, Hip
HXLPE Vs CPE Cups Under 50 Years
This randomized controlled trial evaluated the long-term wear of cemented highly cross-linked polyethylene (HXLPE) versus conventional polyethylene (CPE) acetabular cups in patients under 50 years undergoing primary total hip…
- Trial name
- NCT06706193
- Testing
- Total hip arthroplasty using CPE, Total hip arthroplasty using HXLPE
- Volunteers
- 59 people
- Sponsor
- Radboud University Medical Center
Cancer of Unknown Primary
[18F]F-FAPI PET-CT to Identify Carcinoma of Unknown Primary Origin
The investigators will determine the proportion of CUP patients in whom the primary tumor can be identified by [18F]F-FAPI PET-CT.
- Trial name
- FAPI for CUP (NCT06644716)
- Testing
- [18F]F-FAPI PET-CT
- Where
- 6 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- Erasmus Medical Center
Cancer-Associated Anorexia, Head and Neck Squamous Cell Carcinoma
Olanzapine for Managing Anorexia in Head and Neck Cancer Patients Undergoing Chemoradiation, MACRO Trial
This phase II trial compares the effect of adding olanzapine to standard of care symptom management for nausea to standard of care alone in managing an abnormal loss of the appetite for food (anorexia) in patients treated with…
- Conditions
- Cancer-Associated Anorexia, Head and Neck Squamous Cell Carcinoma, Neck Squamous Cell Carcinoma of Unknown Primary
- Trial name
- NCT06995508
- Testing
- Best Practice, Olanzapine, Questionnaire Administration
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Roswell Park Cancer Institute
Caffeine, Balance; Distorted
The Effect of Turkish Coffee on Postural Control and Hand-eye Coordination in Young Adults
Although the effects of different doses of caffeine on balance have been evaluated in various studies, the effects of low doses of caffeine ingested with Turkish coffee on postural control and hand-eye coordination remain…
- Conditions
- Caffeine, Balance; Distorted, Coordination and Balance Disturbances
- Trial name
- NCT06561113
- Testing
- Caffeine intake
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Neoplasms, Unknown Primary
Gemcitabine/Irinotecan/ZD1839 vs Paclitaxel/Carboplatin/Etoposide/ZD1839 in Carcinoma of Unknown Primary Site
In this randomized trial, we will investigate the activity and toxicity of two active regimens, gemcitabine/irinotecan and paclitaxel/carboplatin/Etoposide (both followed by ZD1839) in the first-line treatment of patients with…
- Trial name
- NCT00193596
- Testing
- Etoposide, Gemcitabine, Irinotecan
- Where
- 31 sites in United States
- Volunteers
- 198 people
- Sponsor
- SCRI Development Innovations, LLC
Osteoarthritis, Arthritis
A Multi-centre, Prospective Surveillance to Assess Mid-term Performance of the Mpact Cup
This is a multi-centre, prospective post marketing surveillance study to assess mid-term performance of the Mpact cup in subjects requiring primary total hip arthroplasty.
- Conditions
- Osteoarthritis, Arthritis, Avascular Necrosis, Fracture of the Femoral Neck or Head
- Trial name
- NCT02196818
- Testing
- Mpact Acetabular Shell
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Medacta International SA
Breast Cancer Diagnosis, Breast Cancer Prevention
Contrast Enhanced Mammography in the Evaluation of Cancer of Unknown Primary Syndrome
This study aims to evaluate the role of Contrast-Enhanced Mammography (CEM) in identifying the primary tumor site in patients presenting with Cancer of Unknown Primary (CUP) syndrome.
- Trial name
- CEM_CUP_syndr (NCT06843096)
- Testing
- Contrast-Enhanced Mammography (CEM)
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Graziella di Grezia
Hip Osteoarthritis
The Influence of "Operating Table Position Simulating Radiographs" on Acetabular Cup Angle During Primary Total Hip Replacement
Goal of the research 1. To check the viability of "Operating Table Position Simulating Radiographs", while positioned on the contralateral side. 2.
- Trial name
- NCT00789048
- Testing
- radiograph
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Aseptic Loosening, Arthroplasty Complications
Total Hip Arthoplastry Revision by Dual-mobility Acetabular Cup Cemented in a Metal Reinforcement
Total hip arthroplasty (THA) requires bone reconstruction in case of severe acetabular injury, with risk of dislocation, especially postoperatively.
- Trial name
- PTH (NCT03680443)
- Testing
- assembly in THA revision
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Unknown Primary Cancer
Review of Molecular Profiling-Real Time Polymerase Chain Reaction (Rt-Pcr) in Unknown Primary Cancer
This will be a retrospective review of 30 patients with unknown primary cancer who have had commercially available RT-PCR assays performed on biopsied tumors, in order to determine if the assay results are consistent with…
- Trial name
- NCT00876408
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- SCRI Development Innovations, LLC