Clinical trials: CV Risk
Type 2 Diabetes Mellitus
Efficacy and Safety of Alogliptin vs. Acarbose in Chinese Type 2 Diabetes Mellitus (T2DM) Patients With High CV Risk or CHD Treated With Aspirin and Inadequately Controlled With Metformin Monotherapy or Drug Naive
Primary Objectives: To assess efficacy in terms of change from baseline in Hemoglobin A1c (HbA1c) at the end of study between the two drugs.
- Trial name
- ACADEMIC (NCT03794336)
- Testing
- Alogliptin, Acarbose, Metformin
- Where
- China
- Volunteers
- 1,293 people
- Sponsor
- Sanofi
Secondary Prevention, CHD
National Tunisian Clinical Registry on CardioVascular Secondary Prevention Clinical
A non-interventional, national longitudinal multicenter study of CV secondary prevention in Tunisia
- Conditions
- Secondary Prevention, CHD, CV Risk
- Trial name
- NATURE STOP-CH (NCT07034274)
- Where
- Tunisia
- Volunteers
- 7,284 people
- Sponsor
- Dacima Consulting
Cardiovascular Disease, Chronic Kidney Disease Patients
A Study Using L5 as a Risk Factor of Cardiovascular (CV) Disease in Chronic Renal and Dialytic Patients
The purpose of this study is to determine whether L5, one of the Low Density Lipoproteins, is an effective predicting factor for cardiovascular disease in chronic renal and hemodialytic patients.
- Conditions
- Cardiovascular Disease, Chronic Kidney Disease Patients, Hemodialytic Patients, High LDL Level
- Trial name
- L5 (NCT01236820)
- Where
- Taiwan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Cardiovascular (CV) Risk, Healthy Eating Index
Pulses: Optimizing Pulse Consumption for Cardiometabolic Health
This randomized clinical trial aims to evaluate the effects of consuming two different doses of pulses (1.5 cups/week or 3 cups/week) in individuals with baseline intake below 1.5 cups/week, compared to a control group receiving…
- Conditions
- Cardiovascular (CV) Risk, Healthy Eating Index, HbA1c, Lipid Profile
- Trial name
- NCT06861153
- Testing
- Pulses 1.5 cups Group, Pulses 3 cups Group, My Plate Group (Control)
- Where
- 2 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Rheumatoid Arthritis (RA, Oxidative Stress
Oxidative Stress and Cardiovascular Risk in Patients With Rheumatoid Arthritis
The pathogenic process underlying atherosclerosis resembles a chronic inflammatory response in which oxidative stress is involved.
- Conditions
- Rheumatoid Arthritis (RA, Oxidative Stress, Cardiovascular (CV) Risk
- Trial name
- PIFIISC23/07 (NCT07760662)
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- University of La Laguna
Cardiovascular Disease
Better Adherence to Therapeutic Lifestyle Change Efforts Trial
The purpose of this study is to determine whether knowledge of abnormal results from a noninvasive test for detection of subclinical atherosclerosis (carotid intima media thickness [CIMT]), in addition to knowledge of…
- Trial name
- BATTLE (NCT00458874)
- Testing
- CIMT results
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Endothelial Function, Aerobic Exercise
VascuFit: Exercise and Vascular Aging
Exercise is a cornerstone of health care helping to improve and maintain a good organ functionality, including vascular function, in health and disease.
- Conditions
- Endothelial Function, Aerobic Exercise, Middle-aged Adults Sedentary, Elevated CV-risk)
- Trial name
- VascuFit (NCT05235958)
- Testing
- non-linear periodized exercise (NLPE), Exercise counselling
- Where
- Switzerland
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Karsten Königstein
Kidney Transplant, Cardiovascular (CV) Risk
Multimorbidity and Cardiovascular Risk Factors After Renal Transplant
Who can participate? Any adults over the age of 18 who have received a kidney transplant at the research centre are eligible for recruitment within the first month after transplant What does the study involve? The study involves…
- Conditions
- Kidney Transplant, Cardiovascular (CV) Risk, Multimorbidity
- Trial name
- MCaRT (NCT07205692)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Blood Pressure Monitoring, Ambulatory, Cardiovascular (CV) Risk
Work-Related Frustration and Higher Cardiovascular Risk Blood Pressure Profiles
Background: Mental health is a national priority in France, especially in the workplace. The impact of poor quality of life at work on mental health has been demonstrated.
- Conditions
- Blood Pressure Monitoring, Ambulatory, Cardiovascular (CV) Risk, Quality of Life at Work, Hypertension
- Trial name
- TRACA (NCT07740434)
- Where
- 3 sites in France
- Volunteers
- 316 people, healthy volunteers welcome
- Sponsor
- University of Burgundy
Cardiovascular Disease
An Observational Study of Burden of Upper GI-Symptoms in CV Risk Patients
The purpose of this study is to investigate the burden of upper gastrointestinal symptoms in patients with cardiovascular disease taking low dose aspirin
- Trial name
- NCT00681759
- Where
- 3 sites in United States, Canada and 1 more
- Volunteers
- 1,836 people
- Sponsor
- AstraZeneca
Cardiovascular (CV) Risk, Heart Attack Patients
Health Behaviour and Readiness to Change After Myocardial Infarction: A Cross-sectional Survey
This study investigates health behaviour and readiness for lifestyle change in patients who recently had a heart attack (myocardical infarction) treated with stenting (PTCA).
- Trial name
- HerzAktiv (NCT07785921)
- Where
- Germany
- Volunteers
- 143 people
- Sponsor
- Kliniken Essen-Mitte
Cardiovascular Risk
C2 -CORVUS Cholesterol-Control (C2) Controlled Targets for High Vascular Risk Patients Using Effective Statins (CORVUS)
To demonstrate a higher percent rate of achieved target lipid goals among patients at high cardiovascular risk using more potent lipid-lowering treatment options including high-potency statins and combination therapies.
- Trial name
- C2 -CORVUS (NCT00921752)
- Where
- 26 sites in Hungary
- Volunteers
- 1,500 people
- Sponsor
- AstraZeneca
Cardiovascular (CV) Risk
Lions Hearts: A Community Approach to Multigenerational Cardiovascular Disease Risk
This pilot study evaluates the feasibility, acceptability, and preliminary effectiveness of Lion Hearts, a community-based, family-centered physical activity intervention designed to improve cardiovascular health among…
- Trial name
- NCT07147387
- Testing
- Lion Hearts Family-Based Physical Activity Program
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Penn State University
Coronary Artery Disease
Family Atherosclerosis Counseling and Testing Project
Family history of early atherosclerotic disease in a first-degree relative [(FDR) sibling, parent or child] is an important risk factor for coronary artery and/or vascular disease.
- Trial name
- NCT00387595
- Sponsor
- University of British Columbia
Type 2 Diabetes, Cardiovascular Complication
Study on the Predictive Value of High-sensitivity Cardiac Troponin I, N-terminal Pro-B-natriuretic Peptide, and Soluble Suppression of Tumorigenesis-2 for Mortality and the Development of Cardiovascular Events in Patients With Type 2 Diabetes (Diabetes-CV)
The Diabetes-CV study is an observational study designed to assess the prognostic value of serum cardiac damage markers high-sensitivity cardiac troponin I (hs-cTnI), N-terminal pro-B-natriuretic peptide (NT-proBNP), and soluble…
- Trial name
- Diabetes-CV (NCT06902857)
- Where
- Italy
- Volunteers
- 964 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Hypercholesterolemia, Atherosclerotic Cardiovascular Diseases
Evaluation of Long-Term Safety and Tolerability of ETC-1002 in High-Risk Patients With Hyperlipidemia and High CV Risk (CLEAR Harmony)
The purpose of this study is to see if ETC-1002 (bempedoic acid) is safe and well-tolerated versus placebo in patients with high cardiovascular risk and elevated LDL cholesterol that is not adequately controlled by their current…
- Trial name
- NCT02666664
- Testing
- ETC-1002
- Where
- 104 sites in United States, Canada and 4 more
- Volunteers
- 2,230 people
- Sponsor
- Esperion Therapeutics, Inc.
Nicotine, Mental Health
The SCAPIS-Snus Study
Historically, snus use in Sweden was very stable, primarily used by about 20% of men and only 4-5% of women. However, the recent introduction of "white snus" (nicotine pouches) has dramatically changed this landscape.
- Conditions
- Nicotine, Mental Health, Cardiovascular (CV) Risk, Metabolic Abnormalities
- Trial name
- SUCCESS (NCT07573319)
- Where
- 5 sites in Sweden
- Volunteers
- 30,154 people
- Sponsor
- Karolinska Institutet
Primary Health Care, Telemedicine
Proactive Telemedicine to Improve Healthcare Access and Prevention in Rural Primary Care (PTM)
The study evaluates whether Proactive Telemedicine (PTM) can improve healthcare access for individuals who have not contacted their primary care team for at least one year, compared with face-to-face visits.
- Conditions
- Primary Health Care, Telemedicine, Face to Face Consultation, Health Care Access
- Trial name
- PTM (NCT07299201)
- Testing
- Telemedicine Brief Behavioural Lifestyle Intervention, Face to face Brief Behavioural Lifestyle Intervention
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Aerobic Exercise, Rhumatoid Arthisis
Effects of an Aerobic Exercise Program on Cardiovascular Risk in Patients With Chronic Kidney Disease or Rheumatoid Arthritis
The goal of this clinical trial is to determine whether an aerobic exercise program can reduce cardiovascular risk in patients with systemic inflammation, such as those with rheumatoid arthritis and chronic kidney disease.
- Conditions
- Aerobic Exercise, Rhumatoid Arthisis, Chronic Kidney Disease, Cardiovascular (CV) Risk
- Trial name
- PARCA (NCT07469540)
- Testing
- Aerobic exercise program, Therapeutic education
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Jérôme Bouchan
Rheumatoid Arthritis, Cardiovascular Disease
Lipids, Inflammation, and CV Risk in RA
The objective of this study was to examine the relationship between inflammation, lipids, and cardiovascular risk in rheumatoid arthritis.
- Trial name
- LiiRA (NCT02714881)
- Testing
- Certolizumab
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Brigham and Women's Hospital