Clinical trials: CVC
Nonalcoholic Steatohepatitis
AURORA: A Study for the Efficacy and Safety of Cenicriviroc (CVC) for the Treatment of Liver Fibrosis in Adults With Nonalcoholic Steatohepatitis (NASH)
The AURORA study will be conducted to confirm the efficacy and safety of cenicriviroc (CVC) for the treatment of liver fibrosis in adult participants with NASH.
- Trial name
- AURORA (NCT03028740)
- Testing
- Cenicriviroc
- Where
- 346 sites in United States, Australia and 26 more
- Volunteers
- 1,778 people
- Sponsor
- Tobira Therapeutics, Inc.
Dysbiosis, Catheter-Related Infections
Cutaneous Microbiota Evolution in ICU Patients With CVC (ICMc)
Intensive Care Unit (ICU) patients are exposed to catheter-related infections with an important morbidity. Catheter colonization is constant but infection is not. Cutaneous dysbiosis could be the missing link.
- Trial name
- ICMc (NCT06095076)
- Testing
- Skin swabbing, Data collection
- Where
- French Guiana
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Cayenne
Central Venous Catheter
Use of the Skin Glue in the Placement of Central Venous Catheters Port a Catch
The use of glue as a device in the implantation of central venous catheters has recently been introduced into European clinical practice, initially with the aim of blocking bleeding at the point of exit of the PICCs, but at the…
- Trial name
- Port glue cvc (NCT03801811)
- Testing
- Study of the efficacy of using skin glue in the application of Port a cath
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Parma
Implementation Science, Behavior and Behavior Mechanisms
Deimplementing CXR After CVC (DRAUP) in the ICU
This study proposes adapting and testing an innovative, behavioral theory-driven deimplementation program called DRAUP in two intensive care units for proof of concept and support that the program can help providers and hospital…
- Trial name
- NCT06146348
- Testing
- adapted DRAUP strategy bundle
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Washington University School of Medicine
Cancer, Central Venous Catheterization
Study of Sodium Bicarbonate in Restoring Blocked Catheters
This is a study looking at the use of sodium bicarbonate to restore the flow of blocked central line devices in patients with blood cancers.
- Trial name
- NCT03348826
- Testing
- Sodium Bicarbonate 8.4% Solution for Injection, Alteplase Injectable Solution
- Where
- Canada
- Sponsor
- University Health Network, Toronto
Childhood Cancer, Aplastic Anemia
Trial of Two Central Venous Catheter (CVC) Flushing Schemes in Pediatric Hematology and Oncology Patients
The purpose of this study is to determine whether flushing Central Venous Catheters (CVCs) with Normal saline once per week is not inferior to flushing with 10U/ml heparin 3 times per week, in preventing CVC occlusions.
- Conditions
- Childhood Cancer, Aplastic Anemia, Metabolic Disorders
- Trial name
- NCT01343680
- Testing
- Heparin, Normal saline
- Where
- 2 sites in Canada
- Volunteers
- 2 people
- Sponsor
- Alberta Children's Hospital
Central Venous Catheterization, Exposure to X-Rays
Agitated Saline Versus CXR Confirmation of Central Venous Lines
Central venous lines insertion are common procedures these days. CVL placed under USG guidance have high success rates and low complications even in developing country settings.
- Trial name
- NCT03442790
- Testing
- Agitated Saline Method, chest x-ray
- Volunteers
- 260 people
- Sponsor
- Nepal Mediciti Hospital
Bacterial Infections
Safety and Efficacy Study of Angiotech Central Venous Catheter to Prevent Bacterial Catheter Colonization
The main purpose of this study is to determine if the Angiotech central venous catheter (CVC) is equal in effectiveness to a CVC coated with chlorhexidine and silver sulfadiazine in preventing bacterial catheter colonization.
- Trial name
- NCT00288418
- Testing
- Central Venous Catheter
- Where
- 21 sites in United States
- Volunteers
- 960 people
- Sponsor
- Angiotech Pharmaceuticals
Pulmonary Arterial Hypertension
Withdrawal of Prostacyclin Pathway Therapy in Patients With Pulmonary Arterial Hypertension Receiving Sotatercept (WATERLOO)
Pulmonary arterial hypertension (PAH) is a rare lung disease that leads to elevated blood pressure in the lungs and strain on the right side of the heart.
- Trial name
- WATERLOO (NCT07700303)
- Testing
- Discontinuation of parenteral prostacyclins analogues or selexipag
- Where
- Canada
- Volunteers
- 78 people
- Sponsor
- University of Alberta
Central Venous Cather Position
Assessing Validity of M-Mode Time-to-Turbulence "T2T" Echo Use to Confirm CVC Tip Position
Using an ultrasound echocardiography , we will measure the time to turbulance "T2T" from injecting saline into the central venous catheter CVC to the appeareance of turbulance on the screen using an MMode.
- Trial name
- NCT03058445
- Testing
- Echocardiography, CVC
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- South Tyneside and Sunderland NHS Foundation Trust
ADHD
Mindfulness Based Cognitive Training in Children and Adolescents With ADHD
Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders, with a pooled worldwide prevalence of 7.2% among children.
- Trial name
- NCT04316832
- Testing
- Mindfulness based cognitive training, Control exercise
- Where
- Romania
- Volunteers
- 70 people
- Sponsor
- Babes-Bolyai University
Other Female Genital, Cancer
Scheduled Triple-lumen Central Venous Catheter Exchange: A Prospective Controlled Randomized Study
CVC Pros and Cons of scheduled Triple-lumen Central Venous Catheter Exchange: A Prospective Controlled Randomized Study
- Trial name
- NCT00250809
- Testing
- Placement of a central venous catheter
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of New Mexico
AIDS Dementia Complex, HIV-1-Associated Cognitive Motor Complex
Effect of Cenicriviroc on HIV Neurocognitive Impairment
The study hypothesis is that cenicriviroc will improve cognition in HIV infected individuals with cognitive impairment. The investigators will study the effect of cenicriviroc on cognition in 24 subjects over a 24 week period.
- Conditions
- AIDS Dementia Complex, HIV-1-Associated Cognitive Motor Complex, Human Immunodeficiency Virus
- Trial name
- NCT02128828
- Testing
- cenicriviroc
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Hawaii
Healthy
Pharmacokinetic and Safety Study of Cenicriviroc and HMG-CoA Reductase Inhibitors, Caffeine and Digoxin
This is a Phase 1, Open-Label, 3-Period, Single-sequence, Drug-drug Interaction Study in Healthy Subjects to Assess the Effect of Cenicriviroc on the Pharmacokinetics (PK) of HMG-CoA Reductase Inhibitors [Rosuvastatin (ROS)…
- Trial name
- NCT02685462
- Testing
- Rosuvastatin, Atorvastatin, Simvastatin
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Tobira Therapeutics, Inc.
Central Venous Catheter Thrombosis
Thrombotic Complications After Central Venous Catheterization
Rationale: Complications related to central venous catheterization are mechanical, infectious or thrombotic in origin. Potential complications of catheter-related thrombosis are not insubstantial and include pulmonary embolism…
- Trial name
- TARZAN (NCT04302376)
- Testing
- Cather-related thrombosis ultrasonography
- Where
- Netherlands
- Volunteers
- 173 people
- Sponsor
- Amsterdam UMC, location VUmc
Bloodstream Infection
Antimicrobial Catheter Securement Dressings for the Prevention of Cvc-related Bloodstream Infections in Cancer Patients
In neutropenic cancer patients, catheter-related bloodstream infections may cause severe infections and even death. To assess the prophylactic effect of a chlorhexidine coated catheter securement dressing on the incidence of…
- Trial name
- COAT (NCT01544686)
- Testing
- 3M™ Tegaderm™ CHG IV and 3M™ Tegaderm™ Advanced IV
- Where
- 5 sites in Germany
- Volunteers
- 630 people
- Sponsor
- University of Cologne
Cancer Patients, Central Venous Catheter Thrombosis
Central Venous Catheter (CVC) Associated Deep Vein Thrombosis (DVT) in Cancer Patients
Cancer patients with Central Venous Catheter (CVC) Associated Deep Vein Thrombosis (DVT) will be treated with Low Molecular Weight Heparin (LMWH) and apixaban. Study duration is 12 weeks.
- Conditions
- Cancer Patients, Central Venous Catheter Thrombosis, Upper Extremity Thrombosis
- Trial name
- NCT03100071
- Testing
- Apixaban
- Where
- 2 sites in Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Michael Kovacs
Catheter-Related Infections, Central Venous Catheters
Advanced Dressings for CVC Infection Prevention in PICU
Randomised, single-blind clinical trial comparing chlorhexidine gluconate-impregnated transparent dressings versus conventional transparent dressings in the prevention of central venous catheter-related bloodstream infections…
- Conditions
- Catheter-Related Infections, Central Venous Catheters, Bloodstream Infection, Pediatric Intensive Care Units
- Trial name
- NCT07175116
- Testing
- 3M™ Tegaderm™ Antimicrobial Transparent Dressing (chlorhexidine gluconate-impregnated), Conventional transparent polyurethane dressing
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- University of Seville
Catheter Dysfunction
Management of the Lack of Blood Return on a Central Venous Catheter (CVC) Before Chemotherapy
Compare two methods of managing the lack of CVC blood return : opacification using contrast media injection or radio-clinical method with a simple chest X-ray followed by a rapid infusion of physiological serum
- Trial name
- CATAREV-B (NCT05100355)
- Testing
- Physiological serum injection, Contrast agent injection
- Where
- 9 sites in France
- Volunteers
- 92 people
- Sponsor
- Institut Cancerologie de l'Ouest
Catheter Related Infection
Catheter Early Withdrawal or Maintenance in Sepsis or Septic Shock
Central venous catheter(CVC)-related infection is an inherent complication of this device that should be treated promptly. However, there are doubts about the need for the immediate withdrawal of CVC while there is still no…
- Trial name
- NCT01947751
- Testing
- CVC exchange, CVC maintenance
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Hospital Nossa Senhora da Conceicao