Clinical trials: CVC
Hematological Malignancies, Bacteremia
Concentrated Citrate Locking to Reduce the Incidence of CVC-related Complications in Hematological Patients
Patients with a hematological malignancy who are undergoing intensive chemotherapy need a central venous catheter (CVC)during their treatment. CVCs are locked with heparin when they are not used.
- Conditions
- Hematological Malignancies, Bacteremia, Thrombosis
- Trial name
- NCT01820962
- Testing
- heparin, concentrated citrate
- Where
- 2 sites in Netherlands
- Volunteers
- 212 people
- Sponsor
- Maastricht University Medical Center
Catheter-Associated Infections, Catheter-Related Infections
Safety and Effectiveness of Novel Nitroglycerin Based Catheter Lock Solution
The objective of this Phase I/II pilot study is to evaluate the safety and effectiveness of a non- antibiotic chelator based lock solution that contains nitroglycerin in combination with sodium citrate and ethanol (NiCE lock…
- Trial name
- NCT02577718
- Testing
- Nitroglycerin-citrate-ethanol (NiCE)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Novel Anti-Infective Technologies, LLC
Central Line Associated Blood Stream Infections (CLABSI)
Comparing The Safety And Efficacy Of DEFENCATH® In Reducing Central-Line Bloodstream Infections (CLABSIs) In Adults And Adolescent Participants Receiving Total Parenteral Nutrition Through A Central Venous Catheter (CVC)
This is a Phase 3, randomized, double-blind, controlled, adaptive, 2-arm, multicenter study to demonstrate the efficacy and safety of DefenCath in adult and adolescent participants receiving home Total Parenteral Nutrition (TPN)…
- Trial name
- NCT06822426
- Testing
- (taurolidine and heparin) catheter lock solution, Heparin
- Where
- 24 sites in United States, Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- CorMedix Therapeutics
Healthy
Pharmacokinetic and Safety Study of Cenicriviroc and Pioglitazone, When Dosed Alone or in Combination
A single center, open-label, fixed sequence study to evaluate the pharmacokinetics (PK) of Cenicriviroc (CVC) administered with and without Pioglitazone (PGZ), and to evaluate the PK of PGZ administered with and without CVC.
- Trial name
- NCT02342067
- Testing
- Cenicriviroc, Pioglitazone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tobira Therapeutics, Inc.
Non-alcoholic Steatohepatitis (NASH)
Study of Safety, Tolerability, and Efficacy of a Combination Treatment of LJN452 and CVC in Adult Patients With NASH and Liver Fibrosis
The purpose of this study was to assess the safety, tolerability, and efficacy of a combination treatment of tropifexor (LJN452) and cenicriviroc (CVC) in adult patients with nonalcoholic steatohepatitis (NASH) and liver fibrosis.
- Trial name
- TANDEM (NCT03517540)
- Testing
- Tropifexor (LJN452), Cenicriviroc (CVC)
- Where
- 65 sites in United States, Argentina and 15 more
- Volunteers
- 193 people
- Sponsor
- Novartis Pharmaceuticals
Nosocomial Infections
ED Residents MBP During CVC Placement: Sim Lab Based Training
1. Baseline performance in maximal barrier precaution technique of Emergency Medicine (EM) residents, certified in CVC placement, is poor 2.
- Trial name
- EM CVC MBP (NCT00791583)
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Central Venous Catheterization, Ultrasonography
Bilateral Internal Jugular Veins Ultrasound Scanning Prior to CVC Placement
Central venous catheter placement is a common procedure in the intensive care unit and is a required skill for all residents working in the critical care setting.
- Conditions
- Central Venous Catheterization, Ultrasonography, Critical Care
- Trial name
- BIUS (NCT02741453)
- Testing
- Standard Practice, Bilateral IJ Ultrasound Scanning
- Where
- United States
- Volunteers
- 278 people
- Sponsor
- Vanderbilt University Medical Center
Catheterization, Central Venous
Can Ultrasound be Used to Verify CVC Position and to Exclude Pneumothorax?
The purpose of this study is to determine if emergency room physicians can use bedside ultrasound to quickly determine the proper placement of a central venous catheter and to evaluate for complications such as a punctured lung.
- Trial name
- NCT00388375
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Christiana Care Health Services
HIV-1 Infection
Efficacy, Safety, and Tolerability of Cenicriviroc (CVC) in Combination With Truvada or Sustiva Plus Truvada in HIV 1-infected, Antiretroviral Treatment-naïve, Adult Patients Infected With Only CCR5-tropic Virus
This is a randomized, double-blind, double-dummy, 48-week, comparative study. Approximately 150 HIV-infected, treatment-naïve patients with CCR5-tropic virus will be stratified by HIV-1 RNA: ≥100,000 copies/mL versus <100,000…
- Trial name
- NCT01338883
- Testing
- Cenicriviroc 100 mg, Cenicriviroc 200 mg + Truvada, Sustiva + Truvada
- Where
- 48 sites in United States, Puerto Rico
- Volunteers
- 143 people
- Sponsor
- Tobira Therapeutics, Inc.
Vascular Access Complication
Vascular Access in Hematological Patients - PICC Versus CVC
The use of peripherally inserted central catheters (PICCs) represents a major advance for hematological patients, enabling the effective delivery of chemotherapy and/or blood products particularly for prolonged infusions or in…
- Trial name
- NCT02405728
- Testing
- Centrally inserted central catheters (CICCs), Peripherally inserted central catheters (PICCs)
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Federico II University
Critical Illness
The Effects of Anti-infective Central Venous Catheter on Catheter-related Infection in Critically Patients
The purpose of this study is to investigate the effect of anti-infective central venous catheter(Certofix®Protect) on reducing catheter-related bloodstream infection in critically ill patients in China, and the relationship…
- Trial name
- NCT02645682
- Testing
- anti-infection CVC, normal CVC
- Where
- 2 sites in China
- Volunteers
- 1,818 people
- Sponsor
- West China Hospital
Ultrasound for Diagnosis of CVC Position in Children
Feasibility Study of CVC Diagnosis Via Ultrasound in Children
After the placement of a central venous catheter in children, a routine chest X-ray will be performed in order to examine the correct position of the catheter.
- Trial name
- CVC (NCT02178423)
- Testing
- Ultrasound for diagnosis of CVC position in children
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Vienna
Nurse Education
The Effect of Virtual Simulation Games on Nursing Students' Knowledge, Skills, Confidence and Satisfaction in CVC Care
This study aims to evaluate the effect of virtual simulation games on developing nursing students' knowledge, skills, confidence, and satisfaction levels regarding central venous catheter care and management.
- Trial name
- CVC (NCT07378384)
- Testing
- Virtual Simulation Game-Based Education, Standard Nursing Education
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Zeynep Kandemir özsoy
HIV-infection/AIDS
Study of Dolutegravir (DTG) on PK of Cenicriviroc (CVC), and CVC on PK of DTG & on a Single Dose of Midazolam
To evaluate the PK, safety and tolerability of Cenicriviroc (CVC) administered with and without Dolutegravir (DTG) and CVC with and without a single dose of Midazolam in healthy subjects.
- Trial name
- NCT01827540
- Testing
- Cenicriviroc, Dolutegravir, Midazolam
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tobira Therapeutics, Inc.
Infection
Antimicrobial Catheter Lock Solution for the Treatment of Central Line Associated Bloodstream Infection (CLABSI)
A CVC is a sterile flexible tube that allows a drug to flow from a bottle or bag directly into a patient's bloodstream. CVCs may cause infections when bacteria gets into the catheter and enters the bloodstream.
- Trial name
- NCT01539343
- Testing
- Antimicrobial Solution
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- M.D. Anderson Cancer Center
Liver Insufficiency
Phase 1 Study of Multiple-Dose Pharmacokinetics of Cenicriviroc in Subjects With Mild and Moderate Hepatic Impairment
To determine whether CVC exposures are altered in subjects with impaired hepatic function, compared to subjects with normal hepatic function.
- Trial name
- NCT02120547
- Testing
- Cenicriviroc in mild liver impaired, Cenicriviroc in moderate liver impaired
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Tobira Therapeutics, Inc.
HIV Infection
Investigation of The Effect of Cenicriviroc (CVC) Plus FTC/TDF on Cardiovascular Disease Risk Factors
This is a single-site substudy, "Investigation of the Effect of Cenicriviroc (CVC) plus Emtricitabine/Tenofovir (FTC/TDF) on Atherosclerosis Risk Factors", open to all patients enrolled in the primary study, "A Phase 2b…
- Trial name
- NCT01474954
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of California, San Francisco
Chronic Renal Insufficiency
Intensive Versus Standard Hemodialysis CVC Dysfunction Protocol
Central venous catheters (CVCs) are used for vascular access by approximately 56% of our 380 hemodialysis (HD) patients at the Capital Health Renal Program.
- Trial name
- NCT02474810
- Testing
- Alteplase
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Nova Scotia Health Authority
Children in the Pediatric Intensive Care Unit or General Pediatric Care Unit Requiring a Central Venous Catheter
Study of the Use of Coated Venous Catheters in the Critically Ill Child
This study should help determine to determine whether or not the use of an antibiotic coated catheter will significantly reduce the number of central line related bloodstream infections in children requiring a CVC.
- Trial name
- NCT00202813
- Testing
- Cook Spectrum Pediatric Central Venous Catheter Anti-microbial Impregnated Polyurethane and Arrow Pediatric Central Venous Catheter
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Corewell Health West
Success Rate for Subclavian or Femoral Vein Catetherisation
Ultrasound Guidance Versus Anatomical Landmarks for CVC Catheterisation:
anatomical landmarks on the body surface were used to insert central vein catheter. However, ultrasound technique is emerging as a new technique for vein catheterisation.
- Trial name
- NCT03207932
- Testing
- Central vein catheterisation
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Pisa