Clinical trials: CYP1A2 Polymorphism
CYP1A2 Polymorphism, Caffeine and Resistance Training
Caffeine, CYPA12 and Resistance Training
Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance.
- Trial name
- NCT06610123
- Testing
- Caffeine and Resistance training
- Where
- Spain
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Polymorphism, Genetic, Depression
CYP1A2, ABCB1, CYP2C9 and Plasma Concentration of Agomelatine in Adult Patients With Depression
1. The plasma concentrations of agomelatine and its two metabolites are simultaneously determined by High performance liquid chromatography-tandem mass spectrometry; 2.
- Conditions
- Polymorphism, Genetic, Depression, CYP1A2 Polymorphism, CYP2C9 Polymorphism
- Trial name
- NCT06120543
- Volunteers
- 50 people
- Sponsor
- Affiliated Hospital of Nantong University
CYP1A2 Polymorphism, Caffeine and Resistance Exercise
Caffeine, CYPA12 and Resistance Exercise
Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance.
- Trial name
- NCT06610110
- Testing
- Caffeine
- Where
- 2 sites in Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alberto Pérez-López
Chronic Obstructive Pulmonary Disease
Association Study Between CYP1A2 Gene Polymorphisms and Metabolism of Theophylline
The aim of this study is to determine whether common CYP1A2 gene polymorphisms effect metabolism of theophylline in Han and Uygur Patients with chronic obstructive pulmonary disease patients.
- Trial name
- NCT03015090
- Testing
- Theophylline
- Where
- China
- Volunteers
- 110 people
- Sponsor
- XiaoGuang Zou
Chronic Obstructive Pulmonary Disease
Association Between CytochromeP4501A2 and CytochromeP4502E1 Gene Polymorphisms and Metabolism of Theophylline
The aim of this study is to determine whether common CYP1A2 and CYP2E1 gene polymorphisms effect metabolism of theophylline in chronic obstructive pulmonary disease patients.
- Trial name
- NCT02001935
- Testing
- theophylline
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Zhujiang Hospital
Schizophrenia
Clozapine Plasma Levels and the Relationship to the Genetic Polymorphism in Shizophrenic Patients
Approximately 30-60% of all schizophrenia patients who fail to respond to typical antipsychotics may respond to Clozapine. Clozapine has long been considered the "gold standard" within the atypical neuroleptic spectrum, backed by…
- Trial name
- NCT01663077
- Testing
- Clozapine
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Tirat Carmel Mental Health Center
Pharmacokinetic Study in Healthy Volunteers
Kinetics of Yohimbine in Humans to Explore Sex and CYP2D6 Genotype Interactions
This study investigates the pharmacokinetics of yohimbine in women and men aged 18 to 40 years to explore sex-specific differences in CYP2D6-dependent drug metabolism.
- Trial name
- YOKI-1 (NCT06939608)
- Testing
- Yohimbine, ¹³C₃-caffeine
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
CYP1A2 Polymorphism
Personalized Nutrition Caffeine Intake in Healthy Adults.
Personalized nutrition is one of the most up to date trends in human nutrition and gains much interest of general public and scientists as well.
- Trial name
- NCT04122053
- Testing
- Intervention group with genotype information, Control group without genotype information
- Where
- Poland
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences
CYP1A2 Polymorphism, CYP2C19 Polymorphism
Clinical and Genetic Influencing Factors on Clozapine Pharmacokinetics
Clozapine (Clz), an atypical antipsychotic, is the reference medication for patients with treatment-resistant schizophrenia. Due to the high inter-individual variability of its pharmacokinetics and its narrow therapeutic index, a…
- Conditions
- CYP1A2 Polymorphism, CYP2C19 Polymorphism, Clozapine, Schizophrenia
- Trial name
- NCT04240496
- Testing
- Determination of plasma concentration of clozapine/ Genotyping
- Where
- Tunisia
- Volunteers
- 51 people
- Sponsor
- University of Monastir