Clinical trials: CYP2D6 Polymorphism
Genotype Guided(HNF4a), Healthy Subjects
STUDY The Effect of HNF-4A G60D Variant on the In VIVO CYP2D6 Activity By Tolterodine Pharmacokinetic Study
This study was to investigate the pharmacokinetics of tolterodine, substrate of CYP2D6 in healthy subject in relation to the presence of HNF-4A G60D variant.
- Trial name
- HNF4a (NCT01181505)
- Testing
- Tolterodine
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Inje University
Drug Metabolism, Poor, CYP2D6-RELATED
Pharmacogenetic Factors and Side Effects of Metoclopramide and Diphenhydramine
Pharmacokinetic of Metoclopramide (MCP) in correlation to polymorphisms of CYP2D6 and Dopamine-D2-Receptor. Pharmacokinetic of Diphenhydramine (DPH) in correlation to polymorphisms of CYP2D6
- Trial name
- MalD (NCT01289938)
- Testing
- Diphenhydramine, Metoclopramide
- Where
- Germany
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Matthias Schwab
Anovulation, Disorder Due Cytochrome P450 CYP2D6 Variant
Influence of Pharmacogenetic Factors, Paroxetine and Clarithromycin on Pharmacokinetics of Clomiphene
Aim of the study is the clinical validation of the metabolism and the pharmakokinetic of Clomifen in correlation to CYP2D6 and inhibition of CYP3A4.
- Conditions
- Anovulation, Disorder Due Cytochrome P450 CYP2D6 Variant, Cytochrome P450 CYP3A Enzyme Deficiency
- Trial name
- NCT01289756
- Testing
- Clomiphene, clomiphene and paroxetine, clomiphene and clarithromycin
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Robert Bosch Gesellschaft für Medizinische Forschung mbH (RBMF)
Breast Cancer
Role of Cytochrome P450 2D6 (CYP2D6) *4 Polymorphism,in Malignant Breast Diseases
The aim of our study is to investigate the potential role of the CYP2D6*4 polymorphism in breast cancer and furthermore to assess the role of oxidative stress, antioxidant capacity and ferretin in pathogenesis of breast cancer in…
- Trial name
- NCT00539422
- Testing
- pcr and serum markers for breast cancer
- Where
- Egypt
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mansoura University
Malaria, Vivax Malaria
Biomarkers of P. Vivax Relapse
Plasmodium vivax malaria is difficult to manage because even after taking medicine that kills the infection in the blood, it can continue to hide quietly in the liver, later re-emerging into the blood and causing another episode…
- Conditions
- Malaria, Vivax Malaria, Relapse, CYP2D6 Polymorphism
- Trial name
- NCT04228315
- Testing
- Primaquine
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Armed Forces Research Institute of Medical Sciences, Thailand
Healthy
Impact of Genetic Polymorphism on Drug-Drug Interactions Involving CYP2D6
CYP2D6 is characterized by a huge variability in the general population, mainly because of genetic polymorphism and drug-drug interactions (DDIs). CYP2D6 genotype is known to have an impact on the extent of DDIs.
- Trial name
- NCT03054220
- Testing
- Dextromethorphan 5 MG, Tramadol 10 mg, Duloxetine 60mg
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Jules Desmeules
Depression
A Genotype Stratification Study for Pharmacokinetics and Pharmacodynamics of Amitriptyline in Healthy Male Subjects
A total of 24 healthy Korean male subjects will receive a single oral dose of amitriptyline, 25 mg. Subjects will be enrolled in this study based on their cytochrome P450 2D6 and cytochrome P450 2C19 genotypes, and serial blood…
- Trial name
- NCT02519400
- Testing
- Amitriptyline
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Healthy
Cytochrome P450 2D6 Genotype on the Clinical Effect of Carvedilol
A Clinical Study to Evaluate the Effect of Cytochrome P450 2D6 polymorphism on Pharmacokinetics/Pharmacodynamics After Multiple Administration of Carvedilol
- Trial name
- NCT02286934
- Testing
- Carvedilol, Isoproterenol Sensitivity Test
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Cytochrome P450 2D6 Ultra-rapid Metabolism
CYP2D6 Screening for Adverse Drug Reactions to Codeine in Breast Milk
The purpose of this study is to determine if non-invasive salivary genetic screening of breastfeeding mothers taking codeine will allow for the successful identification of mother-infant pairs susceptible to adverse events and to…
- Trial name
- NCT01050400
- Testing
- Cytochrome P450 2D6 (CYP2D6) genetic screening.
- Where
- Canada
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Kidney Diseases
Chinese Herb Nephropathy Epidemiology and Association With CYP2D6, CYP2C19, PXR, or MDR1 Polymorphism
1. Chinese herb nephropathy (CHN), a kind of kidney failure caused by Chinese herbs, may be related to the a component called aristolochic acid (AA). 2.
- Trial name
- NCT01503645
- Where
- 2 sites in Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
CYP2D6 Polymorphism
Effects of Retinoids on CYP2D6 Activity During Pregnancy
Prospective drug interaction study during pregnancy.
- Trial name
- NCT03117660
- Testing
- Vitamin A
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Washington
Late Onset Alzheimer Disease
Response to Donepezil, Drug Plasma Concentration and the CYP2D6 and APOE Genetic Polymorphisms
Pharmacological treatment of AD is currently based on cholinesterase inhibitors (ChEI) and memantine, which have been shown to lead to modest, although effective, clinical benefits.
- Trial name
- NCT03349320
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Pharmacokinetic Study in Healthy Volunteers
Kinetics of Yohimbine in Humans to Explore Sex and CYP2D6 Genotype Interactions
This study investigates the pharmacokinetics of yohimbine in women and men aged 18 to 40 years to explore sex-specific differences in CYP2D6-dependent drug metabolism.
- Trial name
- YOKI-1 (NCT06939608)
- Testing
- Yohimbine, ¹³C₃-caffeine
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Metabolism, Interaction
-Methylenedioxymethamphetamine (MDMA, Ecstasy) Induced Changes in Drug Metabolism: Gender and Genetic Polymorphisms
The purpose of this study are: 1. to evaluate the involvement of CYP2D6, CYP3A4 and CYP1A2 (through dextromethorphan and caffeine challenges), and catechol-O-methyltransferase (COMT)in MDMA metabolism 2.
- Trial name
- NCT01447472
- Testing
- MDMA
- Where
- Spain
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Pharmacokinetic Study in Healthy Volunteers
Evaluation of Solanidine as an Exogenous Biomarker to Phenotype CYP2D6 Activity in Humans
This study investigates the evaluation of solanidine as an exogenous biomarker to phenotype CYP2D6-activity in humans. Participants will be classified by their CYP2D6 genotype into poor metabolizers (PM), low intermediate…
- Trial name
- SOLA-1 (NCT07817030)
- Testing
- Yohimbine, Consumption of a defined potato-rich meal
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald