Clinical trials: Cachexia; Cancer
PDAC, Pancreas Adenocarcinoma (MSI-H)
Targeted Nutritional Intervention (HMB, Arginine, Glutamine) in Patients With Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is frequently associated with cancer cachexia, a condition characterized by progressive loss of skeletal muscle mass and strength driven by systemic inflammation.
- Trial name
- NUTRI-MYO (NCT07883161)
- Testing
- HMB / L-Arginine / L-Glutamine oral nutritional mixture, Standard Dietary Counseling
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Anorexia, Cachexia
Docetaxel With or Without Infliximab in Treating Weight Loss, Loss of Appetite, and Fatigue in Patients With Unresectable Non-Small Cell Lung Cancer (Infliximab Treatment Discontinued Effective 10/05/05)
RATIONALE: Drugs used in chemotherapy, such as docetaxel, work in different ways to stop tumor cells from dividing so they stop growing or die. Infliximab may improve cancer-related weight loss, lack of appetite, and fatigue.
- Conditions
- Anorexia, Cachexia, Fatigue, Lung Cancer
- Trial name
- NCT00040885
- Testing
- infliximab, docetaxel
- Where
- 188 sites in United States
- Volunteers
- 67 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Cancer-related Cachexia
Pilot Study of APD209 in Cancer Cachexia
Primary Objective: To assess the efficacy of APD209 in adult patients with active cachexia associated with advanced malignancy and not caused by simple starvation.
- Trial name
- NCT00895726
- Testing
- APD209
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- Acacia Pharma Ltd
Cancer, Psychosocial Functioning
Body Composition and Psychosocial Factors in ICI-Treated Cancer Patients
Evaluation of the effects of body composition, psychosocial factors, and drug-related problems on clinical progression (such as toxicity, treatment response, and quality of life) in cancer patients treated with immune checkpoint…
- Conditions
- Cancer, Psychosocial Functioning, Treatment Side Effects, Cachexia
- Trial name
- NCT07130981
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Hacettepe University
Cachexia; Cancer; Sarcopenia
The Role of the Muscle-nervous System Interface in Cancer Cachexia
Sarcopenia is an important component of cachexia associated with cancer, and their high incidence in cancer patients emphasizes the need for a better understanding of its mechanisms, which can result in better therapeutic…
- Trial name
- NUMANCAN (NCT03477721)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Roma La Sapienza
Non-small Cell Lung Cancer (NSCLC), Cachexia
A Study to Learn About the Study Medicine Called Ponsegromab in Adults With Lung Cancer-Associated Significant Body Weight Loss
Study to investigate the effect of ponsegromab on skeletal muscle mass and physical function in adult participants with non-small cell lung cancer associated cachexia.
- Trial name
- NCT07663630
- Testing
- ponsegromab
- Where
- 7 sites in United States, China
- Volunteers
- 80 people
- Sponsor
- Pfizer
Cachexia; Cancer
The Effect of Colon Cancer on Muscle Gene Expression, Body Composition, Muscle Function, and Muscle Metabolism
Rationale: Cancer cachexia is a complex metabolic syndrome characterized by clinically relevant loss of muscle mass with or without loss of fat mass.
- Trial name
- COMUNEX (NCT03789136)
- Testing
- Not applicable, observational study
- Where
- Netherlands
- Volunteers
- 55 people
- Sponsor
- Wageningen University
Pancreatic Cancer, Cachexia; Cancer; Sarcopenia
Spatial Multi-omics and Intelligent Early Warning of Pancreatic Cancer Cachexia
The goal of this observational study is to explore the spatial multi-omics mechanism of cachexia in pancreatic cancer and construct a high-precision multimodal intelligent early warning model for its early diagnosis in…
- Trial name
- NCT07670286
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Peking Union Medical College Hospital
Esophageal Adenocarcinoma
Chemotherapy in the Context of Esophageal and Gastroesophageal Junction Cancer Cachexia
Cachexia is a syndrome frequently associated with digestive cancers and more particularly with esophageal and gastroesophageal adenocarcinoma.
- Trial name
- CHIFMEOE (NCT05954117)
- Testing
- Adipose tissue biopsies
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Breast Cancer, Cancer Cachexia
Cachexia and Gut Microbiota in Patients With Breast Cancer Receiving Home Care
This study aims to evaluate the possible association between cancer cachexia and Gut Microbiota (GM) in patients with Breast Cancer (BC) cared at home.
- Trial name
- GM_ANT (NCT07653698)
- Testing
- Probiotic Mixture
- Volunteers
- 140 people
- Sponsor
- Fondazione ANT Franco Pannuti ETS
Cachexia, Depression
Computerized Questionnaires in Assessing Symptoms, Pain, Depression, and Physical Function in Patients With Metastatic and/or Advanced Locoregional Cancer
RATIONALE: A computer-based system for assessing symptoms may be effective for patients with metastatic or advanced cancer. PURPOSE: This clinical trial is studying how well computerized questionnaires work in assessing symptoms…
- Conditions
- Cachexia, Depression, Pain, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00972634
- Testing
- computer-assisted intervention, questionnaire administration, assessment of therapy complications
- Where
- Norway
- Volunteers
- 1,051 people
- Sponsor
- Norwegian University of Science and Technology
Cancer, Cachexia
Neurobehavioural and Cognitive Changes in Cancer Cachexia (CANCOG)
The goal of this observational study is to to look for changes within the brain, and changes in body-to-brain signals in people with cancer and people who do not have cancer. The main questions it aims to answer are: 1.
- Conditions
- Cancer, Cachexia, Cachexia-Anorexia Syndrome, Appetite Loss
- Trial name
- CANCOG (NCT06112964)
- Testing
- MRI/ Functional MRI, Self-reported questionnaires, Computer based tasks
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Breast Cancer Female, Gynecologic Cancer
Cachexia in Gynecological Cancer and the Preventive Role of Weight Training
The study aim was to compare the effectiveness of combined training (CT; aerobic + resistance exercises) and high-intensity interval body weight training (HIITBW) on body composition, metabolic and inflammatory profile, physical…
- Conditions
- Breast Cancer Female, Gynecologic Cancer, Menopause, Physical Activity
- Trial name
- NCT03200639
- Testing
- Combined training, High intensity interval training with body weight
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Triangulo Mineiro
Oncology Patients Receiving Chemotherapy, Cachexia-Anorexia Syndrome
Olanzapine in the Prevention and Treatment of Anorexia-Cachexia Syndrome in Patients Receiving Neoadjuvant/Preoperative Chemotherapy
The goal of this clinical trial is to learn if olanzapine works to prevent and treat anorexia-cachexia syndrome and appetite loss in cancer patients.
- Conditions
- Oncology Patients Receiving Chemotherapy, Cachexia-Anorexia Syndrome, Oncology
- Trial name
- NCT07633236
- Testing
- OLANZapine 2.5 MG
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Blokhin's Russian Cancer Research Center
Cancer Cachexia, Omega 3
Effects of Dietary Supplementation With omega3-fatty Acids (Fish Oil) and Progressive Resistance Training on Skeletal Muscle Status in Gynaecological, Gastrointestinal and Urological Cancer Patients
Cancer cachexia is a common and prognostically relevant complication of advanced malignancies, characterized by systemic inflammation, increased catabolism, and reduced nutritional intake, leading to a progressive loss of…
- Conditions
- Cancer Cachexia, Omega 3, Resistance Training, Cancer
- Trial name
- SUPPORT (NCT07643558)
- Testing
- Omega 3 FA (Fish Oil), Training
- Where
- Germany
- Volunteers
- 288 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Gynecologic Cancer, Cachexia
WB-EMS and Individualized Nutritional Support in Gynecological Cancer Patients
This study evaluates the effects of a 12-week whole-body electromyostimulation (WB-EMS) training combined with individualized nutritional support on body composition, muscle strength and function, quality of life, fatigue and…
- Trial name
- NCT03570242
- Testing
- Whole-Body Electromyostimulation (WB-EMS)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
NSCLC, Fatigue
Safety, Efficacy and Pharmacokinetics of ALD518 in Patients With Non-Small Cell Lung Cancer-related Fatigue and Cachexia
The purpose of this study is to asses the safety and efficacy of ALD518 in patients with Non-Small Cell Lung Cancer-Related Fatigue and cachexia (weight-loss).
- Conditions
- NSCLC, Fatigue, Cachexia
- Trial name
- NCT00866970
- Testing
- ALD518, Infusion of 0.9% Saline without ALD518
- Where
- 43 sites in Australia, Canada and 7 more
- Volunteers
- 124 people
- Sponsor
- CSL Behring
Cachexia, Weight Loss
The Effects of a 12 Week Home-based Exercise Intervention on Physical Performance in Patients With Cancers of the Gastrointestinal Tract With Pre- Cachexia or Cachexia
The main purpose of this research study is to determine if exercise improve or worsen cachexia.
- Conditions
- Cachexia, Weight Loss, Gastrointestinal Cancer
- Trial name
- NCT04802486
- Testing
- EXCAP©®
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Rochester
Epithelial Ovarian Cancer
Vitamin D and Pre Cachexia and Cancer Cachexia in Epithelial Ovarian Cancer
Several ex vivo, in vitro, and observational studies on various type of cancer shown positive effect of vitamin D. Vitamin D has widely known as immunomodulator property in various diseases.
- Trial name
- VitD (NCT04864431)
- Testing
- Vitamin D
- Where
- 3 sites in Indonesia
- Volunteers
- 54 people
- Sponsor
- Universitas Indonesia
Autologous Hematopoietic Stem Cell Transplant
Muscle Stimulation for Physical Function During Stem Cell Transplant
Some blood, bone marrow, and lymphatic (hematologic) cancers such as Hodgkin/Non-Hodgkin lymphomas, chronic lymphocytic leukemia, and multiple myeloma, are over-represented in Veterans due to exposures including Agent Orange and…
- Trial name
- NCT04364256
- Testing
- RS-4i Plus Sequential Stimulator (RS Medical, Vancouver, WA)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- VA Office of Research and Development