Clinical trials: Cachexia; Cancer
Cancer Cachexia
Placebo Controlled, Randomized Safety and Efficacy Study of RC-1291 in Cancer Anorexia/Cachexia
Activation of Ghrelin receptors have been demonstrated to stimulate appetite. RC-1291 HCl, by virtue of its ghrelin like activity and Growth Hormone releasing effects may have a dual role in the reversal of cancer induced…
- Trial name
- NCT00378131
- Testing
- RC-1291
- Where
- 17 sites in United States
- Volunteers
- 51 people
- Sponsor
- Helsinn Therapeutics (U.S.), Inc
Pancreatic Neoplasms, Pancreatic Cancer
Evaluating Weight Stability of Pancreatic Cancer Cachexia Patients
Eligible patients will have a diagnosis of both pancreatic adenocarcinoma and cachexia defined as greater than 5% unintentional weight loss within 6 months prior to screening visit.
- Conditions
- Pancreatic Neoplasms, Pancreatic Cancer, Cachexia, Weight Loss
- Trial name
- PanCax (NCT02400398)
- Testing
- Tube feeding
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Andrew Hendifar, MD
Non Small Cell Lung Cancer, Pancreatic Cancer
A Study of JMT203 in Patients With Cancer Cachexia
A Phase Ia/II, Multicenter Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of JMT203 in Patients with Cancer Cachexia
- Conditions
- Non Small Cell Lung Cancer, Pancreatic Cancer, Cancer Cachexia, Colorectal Cancer Cachexia
- Trial name
- NCT06868849
- Testing
- JMT203 Injection
- Where
- China
- Volunteers
- 307 people
- Sponsor
- Shanghai JMT-Bio Inc.
Neoplasms Pancreatic, Cachexia; Cancer
The Effect of Cannabis in Pancreatic Cancer
Cannabinoids are known to increase appetite, but THC components have psychogenic properties too. CBD is the main component in the plant, and have only minimal psychogenic effects.
- Conditions
- Neoplasms Pancreatic, Cachexia; Cancer, Cannabis, Appetite Loss
- Trial name
- NCT03245658
- Testing
- THC and CBD Mixture
- Where
- Denmark
- Sponsor
- Jens Rikardt Andersen
Cancer
Role of Serum Albumin and Total Protein in Survival of Cancer Cachectic Patients
Serum albumin can indicate the onset of cancer cachexia, provide information about a patient's nutritional status, and serve as a biomarker for the prognosis of patients with cancer cachexia.
- Trial name
- NCT05103059
- Testing
- BMI
- Volunteers
- 100 people
- Sponsor
- Assiut University
Fasting, Feeding, Time Restricted
Anabolic Effects of Intraoperative Feeding in Reconstruction Surgery
Perioperative fasting remains a common clinical practice in surgical patients to prevent the development of postoperative anesthesia- and surgical-related complications.
- Conditions
- Fasting, Feeding, Time Restricted, Stress-related Problem, Head and Neck Neoplasms
- Trial name
- NCT04266015
- Testing
- Enteral nutrition formula
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- E-DA Hospital
Cancer, Hypogonadism
Prevalence of Hypogonadism in Male Cancer Patients
Cancer and its complications are common problems. In most cases, this condition has a profound impact on survival and quality of life (QoL).
- Trial name
- NCT00472940
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Cachexia-Anorexia Syndrome
Feasibility Study for Repurposing RET Inhibitors
The purpose of this study is to assess the effects of selpercatinib on cachexia and anorexia in patients diagnosed with NSCLC, colorectal cancer, or pancreatic cancer.
- Trial name
- FEATHER (NCT07146893)
- Testing
- Selpercatinib, Strength Assessment
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Oklahoma
Cachexia
A Dose Escalation Study of AV-380 in Cancer Patients With Cachexia
This open label ascending dose study is designed to evaluate the safety, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of AV-380 in cancer patients with Cachexia.
- Trial name
- NCT05865535
- Testing
- AV-380
- Where
- 12 sites in United States
- Volunteers
- 30 people
- Sponsor
- AVEO Pharmaceuticals, Inc.
Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma
LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia
This study evaluates cancer-related weight and muscle mass loss, symptoms, and physical function (cachexia) in patients undergoing treatment for colorectal, lung, or pancreatic cancer that cannot be removed by surgery…
- Conditions
- Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma, Advanced Pancreatic Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8
- Trial name
- LOTUS (NCT06073431)
- Testing
- Biospecimen Collection, Computed Tomography, Electronic Health Record Review
- Where
- 225 sites in United States
- Volunteers
- 800 people
- Sponsor
- University of Rochester
Muscle Wasting, Non-Small Cell Lung Cancer
Effect of GTx-024 on Muscle Wasting in Patients With Non-Small Cell Lung Cancer (NSCLC) on First Line Platinum
The purpose of this study is to determine if the investigational drug GTx-024 can help patients with non small cell lung cancer increase physical function and maintain or gain muscle.
- Trial name
- NCT01355497
- Testing
- GTx-024
- Where
- 30 sites in United States
- Volunteers
- 330 people
- Sponsor
- GTx
Gastric Cancer, Gastric Adenocarcinoma
MalnutritiOn Assessment With biOelectrical impedaNce Analysis in gastRic Cancer patIentS Undergoing Multimodal trEatment
The aim of this single-arm prospective, multicenter, cross-sectional study is to evaluate the nutritional status and body composition on tumor regression grade with bioelectrical impedance analysis in gastric cancer patients…
- Conditions
- Gastric Cancer, Gastric Adenocarcinoma, Malnutrition, Cachexia
- Trial name
- MOONRISE (NCT05723718)
- Testing
- Observational Survey
- Where
- Poland
- Volunteers
- 125 people
- Sponsor
- Medical University of Lublin
Toxicity Due to Chemotherapy, Cancer Cachexia
Chemotherapy-related Toxicity, Nutritional Status and Quality of Life
Determine whether nutritional support with high protein ONS in adult oncologic patients in the first step of cancer cachexia - asymptomatic precachexia, influence on the toxicity of systemic therapy.
- Conditions
- Toxicity Due to Chemotherapy, Cancer Cachexia, Metastatic Colorectal Cancer, Quality of Life
- Trial name
- NCT02848807
- Testing
- NUTRIDRINK Compact Protein
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- University Clinical Centre, Gdansk
Cancer Cachexia
A Prospective, Randomized, Controlled, Multicenter Study of Kanglaite Injection for the Treatment of Cancer Cachexia
The purpose of the study is to explore the efficacy and safety of Kanglaite Injection in the treatment of patients with late-stage cancer cachexia.
- Trial name
- NCT02553187
- Testing
- Kanglaite Injection
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Zhejiang Kanglaite Pharmaceutical Co.Ltd
Cancer Cachexia (CC), Cancer Cachexia
To Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of GB18 Injection in Healthy Participants
This study is a first-in-human, randomized, double-blind, placebo-controlled, dose-escalation trial in healthy adult participants to evaluate the safety, tolerability, PK, PD, and immunogenicity of GB18.
- Conditions
- Cancer Cachexia (CC), Cancer Cachexia, Cancer Cachexia Syndrome
- Trial name
- NCT07237464
- Testing
- GB18 injection
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Shenzhen Kexing Pharmaceutical Co., Ltd.
Cachexia; Cancer, Muscle Wasting
Muscle Wasting in Children and Adolescents With Cancer
The series of the 3-year study aims to explore parents' experience of caring for a child's weight change among parents of children and adolescents with cancer, examine the associations and trends among muscle wasting and…
- Conditions
- Cachexia; Cancer, Muscle Wasting, Child Development, Adolescent Development
- Trial name
- NCT04353063
- Testing
- Multidisciplinary care with a personalized care
- Where
- Taiwan
- Volunteers
- 440 people
- Sponsor
- National Taiwan University Hospital
Colorectal Cancer, Cancer Cachexia
Structural Characteristics of Trunk and Limb Muscles in Cachectic Colorectal Cancer Patients
Until now, cancer is still associated with high morbidity and mortality, and is therefore a big issue for the public health. Colorectal cancer is the second leading cause of cancer death in developed countries.
- Trial name
- CTLm-CCP (NCT06780423)
- Testing
- Minimal invasive fine needle muscle biopsies
- Where
- 2 sites in Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Cachexia
The Impact of Oligo-Fucoidan in Cancer Cachexia and Sarcopenia
Fucoidan also ameliorates tumour and chemotherapy-induced muscle atrophy and -related cachectic symptoms in vivo and in vitro. To evaluate the effect of fucoidan in cancer cachexia or sarcopenia in cancer patients.
- Trial name
- OFCS (NCT05623852)
- Testing
- fucoidan
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Medical University WanFang Hospital
Cachexia; Cancer, Weight Loss
Evaluating the Combined Intervention of Nutritional Supplementation (Remune) and Exercise in Patients With Cancer Cachexia
The main purpose of this research study is to determine if the use of a nutritional supplement and exercise improve or worsen cachexia.
- Conditions
- Cachexia; Cancer, Weight Loss, Lung Cancer, Gastrointestinal Cancer
- Trial name
- NCT04131426
- Testing
- Remune, EXCAP©®
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Rochester
Adherence, Gastrointestinal Cancer
Adherence to Exercise and Dietary Intervention in Cancer Patients
Intervention programs in cancer patients have been proposed with the aim of improving outcome. Bearing in mind that compliance is a limiting factor to the benefit provided from exercise and diet, assessing adherence to these…
- Trial name
- CEDI (NCT05237921)
- Testing
- Combined Exercise and Dietary Intervention (CEDI), Standard Care
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Hospital Beatriz Ângelo