Clinical trials: Caesarean Delivery
Pain Levels
Dural Puncture Epidural Versus Epidural Anesthesia for Cesarean Delivery
This study will compare two anesthetics techniques called Dural Puncture Epidural (DPE) and Standard Epidural as to which of the two can provide faster and potentially better at providing pain relief for cesarean sections.
- Trial name
- NCT03915574
- Testing
- 25G Dural Puncture Epidural, Standard Epidural
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- University of Arkansas
Cervical Ripening, Labor, Induced
Safety/Efficacy Study Comparing the Misoprostol Vaginal Insert to Cervidil for Cervical Ripening and Induction of Labor
The purpose of this study is to determine whether the misoprostol vaginal insert (50 mcg and 100 mcg) can safely and effectively speed time to vaginal delivery compared to Cervidil (R) in women who need to have cervical ripneing…
- Trial name
- NCT00308711
- Testing
- Misoprostol vaginal insert 100 mcg, Misoprostol vaginal insert 50 mcg, Dinoprostone vaginal insert (Cervidil)
- Where
- 52 sites in United States, Canada
- Volunteers
- 1,308 people
- Sponsor
- Ferring Pharmaceuticals
Postoperative Nausea
How Pregnant Women and Their Babies Metabolize Ondansetron Compared to a Group of Non-pregnant Women
This is called "Aim 1" of the investigators' NIH grant. Ondansetron (Zofran) is a safe and effective drug used in pregnant women to prevent nausea but the investigators do not know what effect pregnancy may have on the metabolism…
- Trial name
- Zofran_PK (NCT01801475)
- Testing
- Ondansetron
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Surgical Wound
A Clinical Trial of Subcuticular Staples Versus Subcuticular Suture for Cesarean Section Skin Closure
Currently, the way doctors close the skin during cesarean section is different between surgeons and there is little evidence to support the use of one kind of closure over the other.
- Trial name
- NCT01753518
- Testing
- Subcuticular suture, Subcuticular staple
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Margaret L. Dow, M.D.
Prolonged Second Stage of Labor
Trial of IV NTG for CD After Second Stage Arrest for the Prevention of Uterine Extension
Randomized controlled clinical trial of IV nitroglycerin at cesarean delivery for second stage arrest of descent to prevent or uterine extension at the hysterectomy site.
- Trial name
- NITRO (NCT02265965)
- Testing
- intravenous nitroglycerin
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Contraception
Opportunistic Salpingectomy for Permanent Sterilization at the Time of Cesarean Delivery
The purpose of this study is to compare the safety of performing a bilateral tubal ligation vs. bilateral salpingectomy, two procedures performed for permanent sterilization, at the time of cesarean delivery.
- Trial name
- NCT03135431
- Testing
- Bilateral Salpingectomy, Bilateral Tubal Ligation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Complications; Cesarean Section, Surgical Wound Infection
Subcuticular Suture for Cesarean Skin Incision Closure
A comparison of the type of suture used for cesarean skin incision approximation and the subsequent rate of wound complications has not been widely studied.
- Trial name
- NCT02459093
- Testing
- poliglecaprone 25 suture, polyglactin 910 suture
- Where
- 2 sites in United States
- Volunteers
- 550 people
- Sponsor
- Montefiore Medical Center
Endometritis, Wound Infection
Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection
The Cesarean Section Optimal Antibiotic Prophylaxis (C/SOAP) study is a large pragmatic multi-center randomized clinical trial designed to evaluate the comparative effectiveness and safety of azithromycin-based extended-spectrum…
- Conditions
- Endometritis, Wound Infection, Abscess, Surgical Site Infection
- Trial name
- C/SOAP (NCT01235546)
- Testing
- Azithromycin and standard of care
- Where
- 9 sites in United States
- Volunteers
- 2,013 people
- Sponsor
- Alan Tita
Endometritis
The Pharmacokinetics of Azithromycin Prophylaxis for Cesarean Delivery
PKAZ is a single institution study designed to evaluate the optimal dosing parameters for azithromycin for pre-surgical cesarean prophylaxis.
- Trial name
- PKAZ (NCT01464840)
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Hypotension
Spinal Anesthesia Induced Hypotension During Cesarean Section
The purpose of this study is to compare two methods for preventing low blood pressure associated with spinal anesthesia during Cesarean sections.
- Trial name
- NCT00846651
- Testing
- Colloid administration, Crystalloid administration, phenylephrine infusion
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Milton S. Hershey Medical Center
Intrauterine Device Expulsion
Copper Intrauterine Device (IUD) Insertion at Cesarean Delivery
The purpose of this study is to determine the expulsion rates of copper Intrauterine Devices (IUDs) placed at time of Cesarean Delivery.
- Trial name
- NCT01439802
- Testing
- Copper IUD placement at time Cesarean Delivery (Copper T 380A)
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Obstetric Labor Complications, Cesarean Section
Evaluation of a Quality Improvement Project on Impacted Fetal Head at Cesarean Section
This study is an evaluation of a Quality Improvement (QI) project addressing delivery of the impacted fetal head being conducted at Regions Hospital.
- Trial name
- NCT03387189
- Testing
- Quality Improvement Project
- Where
- United States
- Volunteers
- 409 people
- Sponsor
- HealthPartners Institute
Pregnant Women, Pain
Hyperbaric Bupivacaine Versus Hyperbaric Prilocaine 2% for Cesarean Section Under Spinal Anesthesia
Over the past 15 years, cesarean delivery is most commonly performed under spinal anesthesia using hyperbaric bupivacaine which provides an adequate sensory and motor block.
- Conditions
- Pregnant Women, Pain, Hypotension
- Trial name
- NCT02973048
- Testing
- Hyperbaric bupivacaine, Hyperbaric prilocaine
- Where
- 2 sites in Belgium
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Postoperative Pain
Intrathecal Morphine for Cesarean Delivery
This is a randomized double blinded non-inferiority study comparing the duration of pain relief when patients receive one of three doses of spinal morphine.
- Trial name
- NCT05069012
- Testing
- Morphine Sulfate
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Beth Israel Deaconess Medical Center
Bladder Injury, Complications; Cesarean Section
Cystoinflation to Prevent Bladder Injury in Obstetrics and Gynaecology Surgery
Part1:The healthy pregnant women with previous operative deliveries admitted for elective C-section will be counselled and conditioned informed consent will be taken to be included in either study group if dense pelvic adhesions…
- Conditions
- Bladder Injury, Complications; Cesarean Section, Adhesions Pelvic
- Trial name
- NCT04302545
- Testing
- Cystoinflation
- Where
- Pakistan
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- Shazia Saaqib
Cesarean Section
Ripening Interventions: Prostaglandins vs EASI Catheter
The primary aim of this randomized clinical trial is to compare the effect of misoprostol vs extra amniotic saline infusion via a catheter (EASI) for cervical ripening on the proportion of patients delivered by cesarean section…
- Trial name
- RIPE (NCT00383942)
- Testing
- Misoprostol, Catheter
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Loyola University
Cesarean Section
Chloroprocaine Lavage to Improve Outcomes Related to Operative Cesarean Delivery
The long term objective is to show that intraperitoneal chloroprocaine can be used an alternative option to avoid general anesthesia during cesarean delivery, to alleviate mother's discomfort from surgical pain, reduce…
- Trial name
- CLOR-PRO (NCT03760718)
- Testing
- Preservative free 1% Chloroprocaine, Preservative free 2% Chloroprocaine, Preservative free 3% Chloroprocaine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Oregon Health and Science University
Pregnancy, Cesarean Section
Gastric Volumes by US in Term Parturients Undergoing CS With and Without Metoclopramide
Our objective is to compare gastric volumes (mL) between women who receive metoclopramide versus placebo prior to scheduled cesarean delivery in appropriately fasted patients.
- Conditions
- Pregnancy, Cesarean Section, Aspiration
- Trial name
- NCT05033041
- Testing
- Study drug metoclopramide
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Northwestern University
Uterine Scar, Cesarean Section Complications
Single or Double-layer Uterine Closure Techniques
There are different surgical techniques of uterine closure during cesarean. A growing data has suggested that the closure technique has an effect on uterine scar healing.
- Conditions
- Uterine Scar, Cesarean Section Complications, Cesarean Section; Dehiscence
- Trial name
- NCT03629028
- Testing
- Residual myometrium thickness, Niche Presence, Adjacent myometrium thickness
- Where
- Turkey (Türkiye)
- Volunteers
- 282 people, healthy volunteers welcome
- Sponsor
- Safak Baran Yilmaz
Hypertrophic Skin Condition of Anterior Abdomen
Negative Pressure Wound Therapy-PICO: Cosmesis in Repeat C-Sections
There are millions of births each year with 32% of women undergoing cesarean sections (C-sections), which results in skin scarring. Repeat C-sections increased by 178% from 1979-2010.
- Trial name
- NCT05266053
- Testing
- PICO 7 dressing, Standard wound dressing
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Indiana University