Clinical trials: Caffeine-Related Disorders
Healthy Adults
Ketone Production With Acute Caffeine Intake
Evaluate the effect of a caffeine supplement on the stimulation of lipolysis and the production of ketones in healthy adults (N=10).
- Trial name
- NCT02694601
- Testing
- Control, Caffeine low dose, Caffeine high dose
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Caffine, Placebo - Control
Effects of Caffeine Ingestion on Morning Cognitive and Muscle Strength Measures in Males
Tournament scheduling and environmental factors often require athletes to compete in the morning. Equally due to time constraints, athletes may choose to train in the morning.
- Conditions
- Caffine, Placebo - Control, No Pill
- Trial name
- NCT07466628
- Testing
- No Pill
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Drowsiness, Sleep Deprivation
TESTING AN MTM THEORY-BASED INTERVENTION ON REDUCING DROWSY DRIVING BEHAVIOR, "STAY AWAKE, STAY ALIVE ©," AMONG COLLEGE STUDENTS
The goal of this randomized controlled educational study is to learn whether a structured, theory-based program can help reduce drowsy driving among college students (18 years and older) in Nevada.
- Conditions
- Drowsiness, Sleep Deprivation, Fatigue
- Trial name
- NCT07434921
- Testing
- MTM Theory based intervention, Standard AAA Knowledge based
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Spinal Cord Injuries
Effects of Caffeine and Intermittent Hypoxia on Leg Function in Human Spinal Cord Injury
Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote meaningful functional recovery in persons with…
- Trial name
- NCT02323698
- Testing
- Caffeine, AIH
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Healthy
Variation in the Impact of Coffee on the Metabolic Rate
The purpose of this study is to explore variation in the impact of coffee on metabolic rate. The investigators plan to recruit healthy participants, half male and half female.
- Trial name
- NCT06432504
- Testing
- Caffeine content
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Cardiovascular System
Effects of Caffeine on Cerebral Blood Flow
The goal of this clinical trial is to evaluate in clinically healthy young people if: after caffeine ingestion, there are variations in blood velocity of the middle cerebral arteries (VMCA), this variation is dependent on the…
- Trial name
- NCT05866848
- Testing
- Anhydrous caffeine (45mg), Anhydrous caffeine (120mg)
- Where
- Portugal
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Escola Superior de Tecnologia da Saúde de Coimbra
Obesity
"Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat
This study compares four treatments to see which one causes the most weight loss, fat loss, loss of abdominal fat and improvement in blood tests like cholesterol.
- Trial name
- NCT00377975
- Testing
- Ephedrine, Pioglitazone, Caffeine
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Caffeine, Insufficient Sleep
Consequences of Caffeine Intake in Sleep Restricted Teenagers
The goal of this clinical trial is to systematically investigate two prominent factors in teenagers' daily life: Caffeine and sleep restriction (SR) and their combined influence on sleep, cognition, and behavior in healthy…
- Trial name
- NCT05790161
- Testing
- Caffeine
- Where
- Switzerland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Psychiatric Hospital of the University of Basel
Caffeine Dependence
A Long-term Safety and Efficacy of EnXtra (E-AG-01) in Healthy Adults
The present study has been proposed to investigate the long-term safety and efficacy of EnXtra in healthy adults habituated to caffeine.
- Trial name
- NCT03731286
- Testing
- Alpinia Galanga, Microcellulose crystalline
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Exercise Performance, Metabolism
Effects of a Caffeine- and Protein-Containing Coffee Beverage on Metabolism and Muscular Performance
The purpose of this randomized, double-blind, crossover study is to investigate the effects of Bang® Keto Coffee on resting and post-exercise metabolism and muscular performance during lower body resistance exercise.
- Trial name
- NCT04180787
- Testing
- Beverage Consumption
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Caffeine, Affect
Evaluating the Role of Expectations in Response to Caffeine Consumption: An RCT
The purpose of this project is to examine the effect of expectancy on mood and alertness after consumption of caffeine "treatment" or placebo "control" pill, given that participants know their probability for receiving the…
- Conditions
- Caffeine, Affect, Cognitive Ability, General, Mood
- Trial name
- NCT02461693
- Testing
- Caffeine
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Caffeine
Effects of Caffeine on EEG Theta/Beta Ratio and Cognitive Control
Cognitive control driven by the prefrontal cortex (PFC) of the brain is thought to be important for goal-directed control over stimulus-driven processes.
- Trial name
- NCT02940808
- Testing
- Caffeine (200mg)
- Where
- Netherlands
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Caffeine, Hypoxia
Caffeine and Hypoxia During Exercise in Males and Females
Several high-altitude destinations recommend their visitors to avoid caffeine, theoretically due to the associated diuresis which could contribute to acute mountain sickness.
- Trial name
- HypoCaff (NCT05764018)
- Testing
- Caffeine, Hypoxia, Normoxia
- Where
- Slovenia
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Jozef Stefan Institute
Esports, Caffeine
Effects of Caffeine, L-Theanine, and Diaphragmatic Breathing on Esports Players' Performance
The purpose of this study is to investigate whether caffeine, L-theanine (a natural amino acid found in tea), and diaphragmatic breathing exercises can help improve the game performance of esports players.
- Conditions
- Esports, Caffeine, L-theanine
- Trial name
- CLD Esports St (NCT06621797)
- Testing
- Intervention 1: Dietary Supplement - Caffeine Supplement, Intervention 2: Dietary Supplement - Caffeine + L-Theanine Supplement, Intervention 3: Dietary Supplement - Caffeine Supplement + Diaphragmatic Breathing Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Caffeine
5 vs 10-Minute Chewing of Caffeinated Gum: Plasma Caffeine Pharmacokinetics
The goal of this study is to understand how chewing duration affects how quickly caffeine from caffeinated chewing gum appears in the blood and how long higher caffeine levels are maintained.
- Trial name
- NCT07386899
- Testing
- Caffeine 300 MG
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ege University
Hypertension, Healthy
Effect of Oral Caffeine and L-Citrulline Supplementation on Arterial Function in Healthy Males
Caffeine is an exceedingly popular and consumed pharmacological agent. Although caffeine is primarily consumed from coffee and tea beverages, it is also available in other forms such as sodas, energy drinks, tablets and capsules.
- Trial name
- NCT02214290
- Testing
- Caffeine, L-citrulline
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Florida State University
Endotoxemia
A Possible Therapeutic Role for Adenosine During Inflammation
The adenosine receptor is known for its anti-inflammatory actions and could therefore be a potential target in the treatment of sepsis and septic shock.
- Trial name
- NCT00513110
- Testing
- AMPD1 polymorphism, Caffeine infusion
- Where
- Netherlands
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Adenosine Metabolism
The Effect of Rosuvastatin on Adenosine Metabolism
The aim of this study is to show whether rosuvastatin influences adenosine metabolism. Therefore we will determine whether rosuvasatin increases dipyridamole-induced vasodilation by increased adenosine receptor stimulation.
- Trial name
- NCT00554138
- Testing
- rosuvastatin
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Liver Functions, Bioequivalence
Coffee Bioequivalence Trial
The goal of this clinical trial is to test if coffee consumed as a tablet is biologically equivalent to that consumed traditionally as a drink.
- Conditions
- Liver Functions, Bioequivalence, Cardiovascular Risk, Cardiometabolic Risk Markers
- Trial name
- NCT06758531
- Testing
- Instant coffee given as a drink, Coffee given in a tablet form
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Reading
Caffeine, Exercise Performance
Energy Drink Effects on Performance, Mood, and Cardiovascular Outcomes
Energy drinks are widely promoted to increase energy, enhance mental alertness, and improve physical performance. ccording to the National Center for Complementary and Integrative Health (NCCIH) at NIH [1], next to multivitamins…
- Conditions
- Caffeine, Exercise Performance, Energy Drink, Cardiovascular Safety
- Trial name
- NCT05559372
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Nathaniel Jenkins