Clinical trials: Caffeine-Related Disorders
Pain, Postoperative
Caffeine and Neurologic Recovery Following Surgery and General Anesthesia
The ongoing opioid epidemic is a public health crisis, and surgical patients are particularly vulnerable to opioid-dependency and related risks. Emerging data suggest that caffeine may reduce pain after surgery.
- Trial name
- NCT03577730
- Testing
- Caffeine Citrate, Dextrose Water
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- University of Michigan
Kidney Injury, Pre-Term
Improving Preterm Kidney Outcomes With Caffeine
This study is being done to see if additional caffeine citrate (20 milligrams per kilogram IV bolus) helps babies with low kidney oxygenation already being treated with caffeine citrate (20 milligrams per kilogram IV bolus on day…
- Trial name
- NCT07262060
- Testing
- Caffeine citrate
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- University of Wisconsin, Madison
Coffee, Anthocyanins
Short-term Effects of Caffeine and a Multi-ingredient Pre-workout on Exercise Performance
The investigators are conducting a study to see how a commercial pre-workout supplement, coffee, and water affect how well people perform. The study is conducted across four visits.
- Conditions
- Coffee, Anthocyanins, Exercise Performance
- Trial name
- NCT07024940
- Testing
- Ethiopian Coffee, Supplement
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Panic Disorder
Genetic Causes of Panic Disorder
This study will try to identify genes that increase the risk of developing panic disorder-an anxiety disorder characterized by recurrent unexpected panic attacks-and that contribute to the abnormalities associated with it.
- Trial name
- NCT00083265
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- National Institute of Mental Health (NIMH)
Caffeine
5 vs 10-Minute Chewing of Caffeinated Gum: Plasma Caffeine Pharmacokinetics
The goal of this study is to understand how chewing duration affects how quickly caffeine from caffeinated chewing gum appears in the blood and how long higher caffeine levels are maintained.
- Trial name
- NCT07386899
- Testing
- Caffeine 300 MG
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ege University
Muscle Hypotrophy, Exercise Performance
Resistance Training Adaptations and Caffeine Intake
This parallel-group, randomized, double-blind, placebo-controlled trial investigates the effects of three different caffeine supplementation strategies on resistance training-induced adaptations in 120 caffeine-naive, inactive…
- Conditions
- Muscle Hypotrophy, Exercise Performance, Muscle Strength, Adaptation
- Trial name
- NCT07410195
- Testing
- Caffeine (Constant Daily Dose), Caffeine (Escalating Dose), Caffeine (Training Days Only)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Cancer, Pain
Efficacy of Caffeine Injection as an Adjuvant to Opioid Therapy in Cancer Pain
Pain is a most common symptom and it has a high impact on quality of life in cancer patients. Many cancer patients have received opioid therapy, but also many of them have suffered from side effects of opioids.
- Trial name
- NCT00879775
- Testing
- Caffeine, Normal saline
- Where
- 2 sites in South Korea
- Volunteers
- 41 people
- Sponsor
- Korea Research Foundation
High Myopia, Choroid
Effect of Caffeine on Ocular Circulation in High Myopes
To investigate the effect of caffeine on ocular circulation by using Optical Coherence Tomography and Optical Coherence Tomography Angiography.
- Trial name
- NCT03294967
- Testing
- Caffeine, Vitamin E
- Where
- Hong Kong
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Healthy
The Effect of Coffee on Energy Expenditure and Caffeine Metabolism
Obesity is a risk factor for chronic diseases, and improving energy expenditure is a way to prevent and treat obesity. The purpose of this project is to explore the relationship between the effect of coffee on energy expenditure…
- Trial name
- NCT06712511
- Testing
- Caffeine content
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Caffeine, Exercise Performance
Energy Drink Effects on Performance, Mood, and Cardiovascular Outcomes
Energy drinks are widely promoted to increase energy, enhance mental alertness, and improve physical performance. ccording to the National Center for Complementary and Integrative Health (NCCIH) at NIH [1], next to multivitamins…
- Conditions
- Caffeine, Exercise Performance, Energy Drink, Cardiovascular Safety
- Trial name
- NCT05559372
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Nathaniel Jenkins
Healthy Adult Male
Effects of Caffeine on Agility in Amateur Soccer Players
This randomized, double-blind, placebo-controlled crossover clinical trial aims to investigate the acute effects of caffeine supplementation on motor and perceptual-cognitive components of agility performance in male amateur…
- Trial name
- NCT07844122
- Testing
- Caffeine 300 MG
- Where
- Slovakia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Comenius University
Healthy Adult Male
Acute Effects of Caffeine on Repeated Sprint Performance and Energy Distribution
The goal of this study is to learn if low-dose caffeinated coffee improves repeated sprint performance and affects energy system contributions in combat sports athletes.
- Trial name
- NCT07596511
- Testing
- Cycling Repeated Sprint Test (6 × 10 s), Breath-by-Breath VO₂ Monitoring - COSMED K5, Capillary Blood Lactate Sampling (non-invasive)
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Trabzon University
Caffeine
Genetic Determinants of Cardiovascular Response to Coffee Drinking
Cardiovascular and neuropsychologic effects of coffee are still debated. The precise mechanism underlying the actions of caffeine on the cardiovascular and neuropsychologic systems is incompletely understood and a considerable…
- Trial name
- NCT01330680
- Testing
- Coffee, Decaffeinated coffee
- Where
- Italy
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Healthy
To Determine Blood Concentrations of Ibuprofen and Caffeine in a Tablet Against Ibuprofen Alone From Another Tablet
The objective of the trial is to compare to combination of 400 mg ibuprofen and 100 mg caffeine against 400 mg ibuprofen alone under fed conditions
- Trial name
- NCT02629354
- Testing
- Ibuprofen, Caffeine
- Where
- South Africa
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Caffeine
The Effects of Caffeine on Heart Rate and Heart Rate Variability
In previous research we have shown that an acute caffeine dose of 5 mg/kg body mass reduces heart rate at rest and during low intensity exercise, with the effect dissipating as exercise intensity increases.
- Trial name
- NCT05521386
- Testing
- Caffeine
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- St Mary's University College
Panic Disorder, Healthy
Effects of Caffeine on Anxiety, Emotional Processing, Approach-avoidance Behavior, and Interoception in Panic Disorder
The current study is a placebo-controlled, double-blind, randomized controlled study using a cross-over design, including participants with Panic disorder and healthy controls.
- Trial name
- NCT05261594
- Testing
- Caffeine
- Where
- Sweden
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Caffeine
Caffeine Supplementation, Resistance Training and Blood Antioxidant Status
The purpose of this study is to verify the effect of acute caffeine intake on resistance training volume and blood antioxidant status, in a randomised, double-blind, placebo-controlled crossover trial.
- Trial name
- NCT05230303
- Testing
- Caffeine supplementation
- Where
- Poland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
Pediatric Obesity, Diet, Food, and Nutrition
Reducing Sugar-sweetened Beverage Consumption Among Children
Lowering sugar-sweetened beverage (SSB) consumption is a central component of lifestyle behavior change aimed at preventing and managing obesity, yet effective reduction of SSB intakes has been met with many challenges.
- Trial name
- NCT04025060
- Testing
- Commercially-available caffeine-free soda, Carbonated water, Regular soda
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- George Washington University
Osteoporosis
Determining the Risk Factors Such as Smoking, Alcohol, and Caffeine and Their Association With Osteoporosis in Men
The goals of this project are to establish a new cohort of male veterans and describe associations between potential risk factors and baseline bone mineral density (BMD) as well as rates of BMD loss.
- Trial name
- NCT00011323
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- US Department of Veterans Affairs
CYP1A2 Polymorphism, Caffeine and Resistance Training
Caffeine, CYPA12 and Resistance Training
Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance.
- Trial name
- NCT06610123
- Testing
- Caffeine and Resistance training
- Where
- Spain
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Alcala