Clinical trials: Caffeine-Related Disorders
Caffeine, Placebo - Control
Effects of Caffeine Ingestion on Morning Cognitive and 4-km Time Trial Performance in Males
Athletes often compete in the morning when they are biologically weaker; normally in competition heats or quarterfinals to qualify for the finals scheduled in the evening.
- Conditions
- Caffeine, Placebo - Control, No Pill
- Trial name
- NCT07469852
- Testing
- Caffeine (300 mg), No Pill
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Common Cold
Effects of a Common Cold Treatment on Cognitive Function
A reduction in alertness and lower levels of performance are commonly associated with the common cold. Paracetamol has been shown to be more effective than placebo in treating symptoms associated with upper respiratory tract…
- Trial name
- NCT01466348
- Testing
- Paracetamol and Caffeine, Paracetamol
- Where
- United Kingdom
- Volunteers
- 72 people
- Sponsor
- GlaxoSmithKline
Syncope, Vasovagal
The Effect of CPC on Aborting Tilt Induced Syncope in Patients With a History of Vasovagal Syncope or Near Syncope
Syncope is defined as transient loss of consciousness associated with inability to maintain postural tone with rapid and spontaneous recovery.
- Trial name
- NCT04972123
- Testing
- CPC - Capsaicin, Phenylephrine, Caffeine, Tilt Table Test
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- University of Wisconsin, Madison
Laparoscopic Cholecystectomy
Effect of Caffeine on Time to Anesthetic Emergence After Laparoscopic Cholecystectomy : Randomized-controlled Trial
A faster emergence from general anesthesia has a double medico-economic impact by reducing the risks of complications and optimizing the performance of surgical units.
- Trial name
- NCT05079880
- Testing
- 300 mg of caffeine citrate infusion
- Where
- Tunisia
- Volunteers
- 60 people
- Sponsor
- Tunis University
Pain, Postoperative, Tooth Diseases
Efficacy and Safety of Ibuprofen and Caffeine in Dental Pain
The primary objective of this study is to compare the efficacy of a combination product containing ibuprofen 400 mg and caffeine 100 mg versus either ingredient alone as well as placebo for the treatment of post-surgical dental…
- Trial name
- NCT01929031
- Testing
- ibuprofen + caffeine, ibuprofen, caffeine
- Where
- United States
- Volunteers
- 562 people
- Sponsor
- Boehringer Ingelheim
Fat Metabolism, Caffeine
Caffeine Strategies and Fat Oxidation
The goal of this clinical trial is to learn if different forms of caffeine ingestion can influence fat oxidation during submaximal cycling exercise.
- Conditions
- Fat Metabolism, Caffeine, Cycling, Exercise
- Trial name
- NCT07402902
- Testing
- Caffeine (Guinama Anhydrous Powder), Caffeine (Nescafé Classic Coffee), Caffeine (Kafewake Gum)
- Where
- Spain
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
Healthy
Hand Reaction Speed and Manual Dexterity & Caffeine Dependence
This study aims to evaluate the effects of caffeine dependence on hand reaction time and fine motor skills in university students.
- Trial name
- NCT07032454
- Testing
- High Caffeine Consumption, Low Caffeine Consumption
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people
- Sponsor
- Saglik Bilimleri Universitesi
Healthy
Study to Evaluate the Effect of Multiple Doses of BIRT 2584 XX Tablets on the Pharmacokinetic Parameters of Warfarin, Omeprazole, Caffeine, and Dextromethorphan in Healthy Male Volunteers
The study aimed to investigate the effect of BIRT 2584 XX and its metabolite BI 610100 on the Pharmacokinetics (PK) of five probe substrates for cytochrome P450 isozymes.
- Trial name
- NCT02256813
- Testing
- BIRT 2584 XX, Warfarin sodium, Omeprazole
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Caffeine, Pain, Joint
Pain Management After Shoulder Arthroplasty
Pain control is a critical after many surgical procedures. It is well known that orthopaedic surgeries are among the most painful procedures, with total joint arthroplasty being a clear example of this situation.
- Trial name
- NCT04872270
- Testing
- Total Shoulder Arthroplasty, Caffeine Pill, Percocet 10Mg-325Mg Tablet
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
CYP1A2 Polymorphism
Personalized Nutrition Caffeine Intake in Healthy Adults.
Personalized nutrition is one of the most up to date trends in human nutrition and gains much interest of general public and scientists as well.
- Trial name
- NCT04122053
- Testing
- Intervention group with genotype information, Control group without genotype information
- Where
- Poland
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences
Coronary Artery Disease
Effects of Espresso on Platelet Aggregability in Patients with Coronary Artery Disease
Discovered thousands of years ago, coffee is among the most consumed beverages in the world. The relationship between coffee and cardiovascular risk, more specifically coronary artery disease, is controversial.
- Trial name
- NCT04827251
- Testing
- Coffee
- Where
- Brazil
- Volunteers
- 29 people
- Sponsor
- University of Sao Paulo
Neurobehavioral Manifestations, Drug Related Sleep Disturbance
Acute and Residual Effects of Caffeinated Beer
The aim of this study is to develop information about the acute and residual effects of a new product being targeted to young adults.
- Conditions
- Neurobehavioral Manifestations, Drug Related Sleep Disturbance, Alcohol Intoxication
- Trial name
- NCT00515294
- Testing
- Caffeinated Alcoholic Beer, Non-Caffeinated Alcoholic Beer, Caffeinated Non-Alcoholic Beer
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Boston University
Nutrition, Pediatric Obesity
Metabolic and Genetic Impacts of Energy Drinks in Youth
Caffeine containing energy drinks (CCED) are beverages that typically contain mixtures of simple sugars, caffeine and may contain vitamin, mineral and/or herbal preparations.
- Conditions
- Nutrition, Pediatric Obesity, Pediatric, Caffeine
- Trial name
- NCT03512496
- Testing
- Acute energy drink - Caffein, Acute energy drink - Decaf
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Calgary
Esports, Caffeine
Effects of Caffeine, L-Theanine, and Diaphragmatic Breathing on Esports Players' Performance
The purpose of this study is to investigate whether caffeine, L-theanine (a natural amino acid found in tea), and diaphragmatic breathing exercises can help improve the game performance of esports players.
- Conditions
- Esports, Caffeine, L-theanine
- Trial name
- CLD Esports St (NCT06621797)
- Testing
- Intervention 1: Dietary Supplement - Caffeine Supplement, Intervention 2: Dietary Supplement - Caffeine + L-Theanine Supplement, Intervention 3: Dietary Supplement - Caffeine Supplement + Diaphragmatic Breathing Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Parkinson's Disease
Caffeine for Motor Manifestations of Parkinson's Disease
Numerous epidemiological studies have linked lifelong use of caffeine to a lower risk of Parkinson's disease (PD) - prospective studies have estimated that non-coffee drinkers have an approximately 1.7-2.5 fold increased risk of…
- Trial name
- NCT01190735
- Testing
- Caffeine alkaloid
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- Ron Postuma
Premature Infant Disease, Apnea of Prematurity
Caffeine Citrate in Preterm Infants at Risk of Apnea in Zambia
The goal of this clinical trial is to learn if caffeine citrate prevents apneic events that result in sick visits in moderately preterm infants after discharge from the hospital.
- Conditions
- Premature Infant Disease, Apnea of Prematurity, Development, Infant
- Trial name
- NCT06518603
- Testing
- Caffeine citrate 20mg/kg/day
- Where
- Zambia
- Volunteers
- 340 people
- Sponsor
- University of Alabama at Birmingham
RSV Infection, Drug Drug Interaction
A Study to Evaluate the Drug-Drug Interaction of EDP-323 With Midazolam, Caffeine, and Rosuvastatin in Healthy Participants
The primary aim of this study is to assess the effect of EDP-323 on the pharmacokinetics and safety of midazolam, caffeine, and rosuvastatin in healthy adult participants.
- Trial name
- NCT06917508
- Testing
- EDP-323, Midazolam, Caffeine
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Enanta Pharmaceuticals, Inc
Sleep Deprivation, Performance
Impact of Sleep Deprivation and Caffeine in Medical Professionals
While the negative impact of sleep deprivation on cognitive processing and the partial reversal of this phenomenon by caffeine are well known, the types of cognitive processing previously studied have been limited to simple…
- Trial name
- NCT04273841
- Testing
- Military Energy Gum
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Institute of Research (WRAIR)
Caffeine
Early Versus Routine Caffeine Administration in Extremely Preterm Neonates
Premature infants are at risk of having pauses in breathing, or apneas, due to their immaturity. Premature infants are routinely given caffeine, a respiratory stimulant, on the first day of life to prevent apneas.
- Trial name
- EARLYCAFFEINE (NCT01783561)
- Testing
- Caffeine
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Sharp HealthCare
Hypoxic-Ischemic Encephalopathy
Dose Optimization of Caffeine for HIE
This is a phase Ib, open-label, dose-validating and safety study of caffeine in neonates with hypoxic-ischemic encephalopathy (HIE) undergoing therapeutic hypothermia.
- Trial name
- NCT06448780
- Testing
- Caffeine citrate 20 mg/kg, Caffeine citrate 30 mg/kg
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- University of North Carolina, Chapel Hill