Clinical trials: Caffeine-Related Disorders
Supplementation, Sports Nutrition
Caffeine Kinetics and CrossFit®-Specific Performance
The study aims at assessing the relation between caffeine (CAF) and paraxanthine (PAX) kinetics after acute ingestion of caffeine (3 mg/kg body mass) in the form or mono- or multi-ingredient preparations and CrossFit®-specific…
- Conditions
- Supplementation, Sports Nutrition, Ergogenic Support, Discipline-specific Performance
- Trial name
- NCT05516212
- Testing
- CAFMONO supplementation, CAFMIPS_1 supplementation, CAFMIPS_2 supplementation
- Where
- Poland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Healthy Volunteers
Testing Potential Synergistic Effects of Albuterol and Caffeine on Metabolic Rate
The purpose of this study is to define a ratio of Caffeine and albuterol that gives a synergistic increase in metabolic rate.
- Trial name
- CALM (NCT02135965)
- Testing
- 2mg of Albuterol, 4mg of Albuterol, 100mg of Caffeine
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Drug Drug Interaction (DDI)
Drug-Drug Interaction (DDI) Study for TD-9855
This study is designed to assess the effect of fluvoxamine, itraconazole and smoking on the PK disposition of multiple doses TD-9855 in healthy male subjects.
- Trial name
- NCT03432793
- Testing
- TD-9855, Fluvoxamine, Itraconazole
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
Alzheimer Disease
Drug Interaction Study With a Potential Alzheimer's Disease Compound
The purpose of this study is to determine whether BMS-708163 will effect the pharmacokinetics of the commonly prescribed medicines midazolam, warfarin, caffeine,omeprazole and dextromethorphan
- Trial name
- NCT00726726
- Testing
- Interacting drugs - Cooperstown Cocktail (midazolam, warfarin, (+ vitamin K), caffeine, omeprazole and dextromethorphan), BMS-708163, BMS-708163 + Cooperstown Cocktail
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Hydrocortisone
Association Between Cortisol, Cortisone, Cotinine, Nicotine, Caffeine, Melatonin Levels in Hair, Serum, Urine, Saliva and Chronic Stress
The investigators aim to investigate the association between hair, serum, urine and saliva to measure cortisol, cortisone, cotinine, nicotine, melatonin and caffeine.
- Trial name
- NCT02403921
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Caffeine, Hypoxia
Caffeine and Hypoxia During Exercise in Males and Females
Several high-altitude destinations recommend their visitors to avoid caffeine, theoretically due to the associated diuresis which could contribute to acute mountain sickness.
- Trial name
- HypoCaff (NCT05764018)
- Testing
- Caffeine, Hypoxia, Normoxia
- Where
- Slovenia
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Jozef Stefan Institute
Caffeine, Flavonoids
Effects of a Cocoa Shot on the Human Brain
The Hershey Company is interested in investigating the effects of various chocolate beverages on brain physiology and cognitive function.
- Trial name
- NCT01924481
- Testing
- High Caffeine, Low caffeine, High theobromine
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Glaucoma, Primary Open Angle
Caffeine Consumption in Glaucoma Patients and Healthy Subjects
Caffeine is the most widely consumed drinking nutrient in the world. Caffeine effects various organs and the vascular system. It decreases ocular blood flow due to vasoconstriction.
- Trial name
- NCT03675412
- Testing
- Caffeine tablet
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Exercise
A Study to See if an Energy Drink With Caffeine and Green Tea Increases Fat Burning When Exercising
The goal of this study is to evaluate the influence of consuming a drink containing a combination of caffeine and green tea extracts on fat oxidation responses at rest, during and after a period of endurance type exercise.
- Trial name
- NCT07434752
- Testing
- Active (Green tea and caffeine)
- Where
- Australia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- RDC Clinical Pty Ltd
Focus: to Compare a Commercially Available Energy Drink, B Vitamins, Caffeine Alone, and Placebo for Effectiveness on Perceived Energy Level and Wakefulness
Efficacy of Energy Shots and Caffeine for Energy and Wakefulness Levels
The line of "5-hour Energy"® products are available over-the-counter as energy supplements. The appeal of these products involves ease of use, low caloric value, and the absence of sugar to prevent a "crash" later in the day.
- Trial name
- NCT01755299
- Testing
- Regular "5-hour Energy", Decaf "5-hour Energy", Compounded concentrated caffeine liquid
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- ProMedica Health System
Solid Tumors
Drug-drug Interaction Study of Tivantinib (ARQ 197) With Omeprazole, S-warfarin, Caffeine, Midazolam, and Digoxin in Cancer Subjects
The purpose of this study is to determine the effects of tivantinib on the pharmacokinetics of omeprazole, s-warfarin, caffein, midazolam, or digoxin in patients with cancer.
- Trial name
- NCT01517399
- Testing
- tivantinib, omeprazole, s-warfarin
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Daiichi Sankyo
Diabetes Mellitus, Type 2
Experimental Studies of the Effects of Caffeine on Glucose Regulation
This project contains experimental studies of the effects of the drug caffeine on glucose regulation in adults who have Type 2 diabetes.
- Trial name
- NCT00432887
- Testing
- caffeine administration
- Volunteers
- 150 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Exercise Performance, Metabolism
Effects of a Caffeine- and Protein-Containing Coffee Beverage on Metabolism and Muscular Performance
The purpose of this randomized, double-blind, crossover study is to investigate the effects of Bang® Keto Coffee on resting and post-exercise metabolism and muscular performance during lower body resistance exercise.
- Trial name
- NCT04180787
- Testing
- Beverage Consumption
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Energy Expenditure, Cognition
A Randomized Study to Examine the Ability of a Caffeine-Based Energy Drink to Impact Energy Expenditure, Fat Oxidation, Reaction Time, and Other Perceptual Indicators
The purpose of this study is to evaluate the changes in energy expenditure, fat oxidation, reaction time, and perceptual indicators of energy and focus after acute ingestion of a caffeine-based energy drink.
- Conditions
- Energy Expenditure, Cognition, Reaction Time
- Trial name
- ASH (NCT05998096)
- Testing
- Caffeine-Based Energy Drink
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Acute Intermittent Porphyria (AIP), Acute Hepatic Porphyria (AHP)
A Study to Investigate the Interaction Between Givosiran and a 5-probe Drug Cocktail in Patients With Acute Intermittent Porphyria (AIP)
The purpose of this study is to evaluate the effect of givosiran on the pharmacokinetics of the 5-probe cocktail of midazolam, caffeine, losartan, omeprazole, and dextromethorphan, and their metabolites, in asymptomatic patients…
- Conditions
- Acute Intermittent Porphyria (AIP), Acute Hepatic Porphyria (AHP), Porphyria, Acute Intermittent, Acute Porphyria
- Trial name
- NCT03505853
- Testing
- Givosiran, 5-probe cocktail
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Alnylam Pharmaceuticals
Mental Fatigue
The Effect of a Caffeine Blend on Reaction Time, Mental Performance and Focus in Athletic Males
This is a cross-over design study in which subjects arrived to the lab and were assigned a supplement to ingest. Prior to ingestion subjects completed baseline reaction time testing along with a questionnaire.
- Trial name
- NCT03019523
- Testing
- Caffeine Blend, Sugar Pill
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Mary Hardin-Baylor
Wrinkle, Spot Pigmented
Skin Rejuvenation With Topical Extract and Other Nutraceuticals
Hemp extract has been shown in several pre-clinical and clinical studies to have anti-aging effects on the skin through anti-oxidant and anti-inflammatory effects, in addition resveratrol, thyme and caffeine have been shown to…
- Conditions
- Wrinkle, Spot Pigmented, Lines Skin
- Trial name
- NCT05734703
- Testing
- Nutraceutical Topical
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Medical Life Care Planners, LLC
Caffeine, Insufficient Sleep
Consequences of Caffeine Intake in Sleep Restricted Teenagers
The goal of this clinical trial is to systematically investigate two prominent factors in teenagers' daily life: Caffeine and sleep restriction (SR) and their combined influence on sleep, cognition, and behavior in healthy…
- Trial name
- NCT05790161
- Testing
- Caffeine
- Where
- Switzerland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Psychiatric Hospital of the University of Basel
Athletes
The Acute Effects of Combined Caffeine and Sodium Bicarbonate Consumption on Isometric Mid-thigh Pull
The aim of this study was to investigate the effects of isolated and combined caffeine and sodium bicarbonate consumption on acute isometric mid-thigh pull (IMTP) strength, and verify whether they are cumulative, neutral or…
- Trial name
- NCT05883046
- Testing
- Performance-Enhancing Substances, Baseline (Control)
- Where
- Turkey (Türkiye)
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Bozok University
Eating Behavior, Obesity
Caffein Consumption and Response Inhibition
With the abundance of energy-dense foods that are designed for ease of consumption in the current environment, it is of importance to better understand the factors that may undermine the control of energy intake at healthy…
- Trial name
- NCT01815203
- Testing
- Caffeine
- Where
- Sweden
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Uppsala University