Clinical trials: Calcinosis
Inflammation
Effect of Selenium Intervention on Inflammation in Older Adults
Serum levels of inflammatory mediators increase with age and are strongly associated with the most common and the most devastating health conditions found in older adults including frailty, chronic disease, disability and…
- Trial name
- NCT01289925
- Testing
- Selenium
- Where
- United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Coronary Artery Calcification
A Novel Ferumoxytol-enhanced Cardiac Magnetic Resonance for the Detection of Calcified Coronary Arteries
This study is a single-center, prospective, controlled, diagnostic study. The study will be consecutive and is expected to enroll 100 patients with CCTA confirmed coronary calcified lesions.
- Trial name
- NCT07400406
- Testing
- Superparamagnetic Iron Oxide Nanoparticles
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Renal Disease
Vitamin K2 Supplementation and Vascular Calcification
Vascular calcification is the leading cause of death in patients with end stage renal disease (ESRD) in hemodialysis. The protein matrix Gla vitamin K dependent (MGP) is a potent inhibitor of the vascular calcification.
- Trial name
- NCT04539418
- Testing
- Vitamin K 2
- Volunteers
- 59 people
- Sponsor
- Catholic University of Salta
Aortic Stenosis, Calcific
Accuracy of Using 2D Transesophageal Echocardiography Compared to Balloon Sizing in Determining Valve Size During Transcatheter Aortic Valve Implantation
The method of transcatheter aortic valve implantation (TAVI) introduced in 2002 by Alain Cribier et al. has offered new prospects for patients with severe aortic stenosis and multiple comorbidities, who are at high operative…
- Trial name
- NCT04242225
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Heterozigous Familial Hypercholesterolemia
Evaluation of Chylomicrons Metabolism in Sub-Clinical Atherosclerosis in Patients Whit Heterozigous Familial Hypercholesterolemia (FH) Treated With Statin Plus Ezetimibe
Study Title: Evaluation of chylomicrons metabolism in sub-clinical atherosclerosis in patients whit Heterozigous Familial Hypercholesterolemia (FH) treated with statin plus ezetimibe.
- Trial name
- NCT00475826
- Testing
- Statins and Ezetimibe
- Where
- Brazil
- Sponsor
- University of Sao Paulo
Cardiovascular Diseases
Vitamin K1 to Slow Progression of Vascular Calcification in HD Patients
Patients on hemodialysis (HD) exhibit an immensely increased cardiovascular mortality associated with extensive vascular calcification (VC).
- Trial name
- VitaVasK (NCT01742273)
- Testing
- Vitamin K1
- Where
- 13 sites in Belgium, Germany and 1 more
- Volunteers
- 63 people
- Sponsor
- RWTH Aachen University
Coronary Calcification, Vascular Calcification
Intravenous Sodium Thiosulfate on Coronary Calcification in Patients on Hemodialysis
The present study will examine the treatment effect of sodium thiosulfate on coronary calcification in patients on hemodialysis.
- Trial name
- NCT00720772
- Testing
- 25% intravenous (IV) sodium thiosulfate
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Ramathibodi Hospital
ATP-Binding Cassette Subfamily C Member 6 Deficiency, Pseudoxanthoma Elasticum
Evaluation of Safety, Tolerability, and Efficacy of INZ-701 in Adults With ABCC6 Deficiency Causing PXE
The purpose of this study is to assess the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics PD) of multiple ascending doses of INZ-701, an ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) recombinant…
- Conditions
- ATP-Binding Cassette Subfamily C Member 6 Deficiency, Pseudoxanthoma Elasticum, Generalized Arterial Calcification of Infancy
- Trial name
- NCT05030831
- Testing
- INZ-701
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 10 people
- Sponsor
- Inozyme Pharma
Neurocysticercosis
Treatment of Peri-calcification Edema in Neurocysticercosis (NCC)
Three-arm open, randomized comparative study of acetazolamide, dexamethasone, or no additional treatment to evaluate decrease in peri-calcification edema in neurocysticercosis
- Trial name
- NCT02945527
- Testing
- Acetazolamide, Dexamethasone
- Where
- Peru
- Volunteers
- 4 people
- Sponsor
- Universidad Peruana Cayetano Heredia
Coronary Artery Calcification
Melatonin and Coronary Artery Calcification
The investigators planned to research the association between plasma melatonin and coronary artery calcification in a Chinese population.
- Trial name
- NCT03967366
- Where
- China
- Volunteers
- 574 people
- Sponsor
- Chinese PLA General Hospital
Aortic Valve Calcification, Aortic Stenosis
Prevalence and Significance of Mutations in Genes Encoding NaPi-co-transporters in the Development of CAVD
Mutations in the SLC34A2 gene, that encodes the sodium phosphate co-transporter (NaPi-IIb), cause defect cell-uptake of phosphate, which leads to formation of calcium-phosphate concretions in the lungs as seen in Pulmonary…
- Trial name
- NCT02516800
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- University of Aarhus
Symptomatic Aortic Stenosis, Severe Aortic Valve Stenosis
DurAVR™ THV System: EMBARK Study
A prospective, non-randomized, single-arm, single-center, first-in-human study designed to evaluate the safety and feasibility of the DurAVR™ THV System in the treatment of subjects with symptomatic severe aortic stenosis.
- Conditions
- Symptomatic Aortic Stenosis, Severe Aortic Valve Stenosis, Aortic Valve Calcification
- Trial name
- NCT05182307
- Testing
- DurAVR™ THV System
- Where
- Georgia
- Volunteers
- 150 people
- Sponsor
- Anteris Technologies Ltd.
Moderate to Severe Calcified Coronary Artery Stenosis
Clinical Trial of T-wave™ Coronary Lithotripsy Catheter System
A prospective, multi-center, single-group target value method was used in this study. According to the inclusion criteria stipulated in this trial protocol, > 3 medical device clinical trial institutions with the record of the…
- Trial name
- NCT05552131
- Testing
- T-wave coronary lithotripsy catheter system
- Volunteers
- 190 people
- Sponsor
- Suzhou Zhonghui Medical Technology Co., Ltd.
Hemodialysis, Anuria
Hemodialysis Frequency and the Calcification Propensity of Serum
The aim of this clinical research project is to test the hypothesis that daily dialysis has favorable effects on the calcification propensity of human serum, when determined by the investigators' newly developed in vitro serum…
- Trial name
- Intensified HD (NCT01975025)
- Testing
- Short daily dialysis for 2 weeks
- Where
- Switzerland
- Volunteers
- 17 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Coronary Artery Disease
IVUS-guided DES Implantation in Coronary Calcification
Coronary calcified lesion is associated with a poor clinical outcome. Intravascular ultrasound (IVUS) provides anatomic information in detail about reference vessel dimensions and lesion characteristics including severity of…
- Trial name
- ULTIMATE IV (NCT05800002)
- Testing
- Intravascular ultrasound, Angiography
- Where
- China
- Volunteers
- 864 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Coronary Artery Disease, Severe Coronary Artery Disease
Lithotripsy Versus Balloon Angioplasty for Optimal Treatment of CAlcified Lesions With and Without Optical Coherence Tomography evaluatION
Severely calcified coronary artery disease means that calcium has built up in the blood vessels that supply the heart. This makes coronary procedures more difficult and increases the risk of complications during and after…
- Conditions
- Coronary Artery Disease, Severe Coronary Artery Disease, Coronary Artery Calcification
- Trial name
- LOCATION (NCT07388030)
- Testing
- IVL Pretreatment + OCT-Guided Stent Implantation, IVL Pretreatment + Angiography-Guided Stent Implantation, Balloon Angioplasty (BA) Pretreatment + OCT-Guided Stent Implantation
- Where
- China
- Volunteers
- 3,060 people
- Sponsor
- Shanghai Bluesail Boyuan Medical Technology Co., Ltd.
Systemic Sclerosis (SSc), Calcinosis Cutis
Quantification of Calcinosis Cutis Disease Burden Using Computed Tomography Images
The main purpose of this study is to develop sensitive radiographic measurement techniques that can be used as outcome measures along with patient-reported outcome instruments in clinical trials of calcinosis cutis treatments…
- Trial name
- NCT07228429
- Testing
- Sodium Thiosulfate (STS), Sodium Thiosulfate Injection
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Yale University
Peripheral Artery Disease, End Stage Renal Disease on Dialysis
A Cross-Sectional Study to Assess Walking Performance in Subjects With Peripheral Artery and End Stage Kidney Disease
A cross-sectional, non-interventional study to assess walking performance, vascular function, and lower limb calcification in subjects with peripheral artery disease and end-stage kidney disease (PAD-ESKD) receiving hemodialysis.
- Trial name
- NCT04487301
- Where
- 7 sites in United States
- Volunteers
- 36 people
- Sponsor
- Sanifit Therapeutics S. A.
Renal Transplant, Atherosclerosis
Arterial Stiffness and Calcifications in Incident Renal Transplant Recipients
The purpose of this study is to determine the: Natural history of calcification posttransplantation Natural history of BMC following renal transplantation Reverse correlation between calcification score and aortic calcifications…
- Conditions
- Renal Transplant, Atherosclerosis, Arterial Stiffness
- Trial name
- ASCIT (NCT00547040)
- Testing
- no intervention
- Where
- Belgium
- Volunteers
- 304 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Idiopathic Infantile Hypercalcemia - Mild Form
The Antibiotic Rifampin to Reduce High Levels of Blood and Urine Calcium in IIH
Idiopathic infantile hypercalcemia(IIH) is a rare,genetic disorder of mineral metabolism. Biallelic loss of functions mutations of CYP24A1, the gene encoding the 24-hydroxylase enzyme that represents the principal pathway for…
- Trial name
- NCT03384121
- Testing
- Rifampin 150 mg, 300 mg capsules and 25 mg/mL oral suspension
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- The Hospital for Sick Children