Clinical trials: Calcitonin
Rib Fractures, Pain
Analgesic Effect of Intranasal Calcitonin on Patients With Fractured Ribs
This study, which will be conducted at the emergency room of the Sacré-Cœur hospital, requires the recruitment of 60 subjects and involves some telephone follow-up.
- Trial name
- NCT00444808
- Testing
- Intranasal calcitonin
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Université de Montréal
Migraine Disorders, Chronic Migraine
Biochemical Profiling of Migraine Patients
Aim of the study was to assess a potential dysfunction of the endocannabidiome system (eCBome) in migraine patients. Migraine patients who will undergo preventive therapy with monoclonal antibodies directed against the calcitonin…
- Conditions
- Migraine Disorders, Chronic Migraine, Episodic Migraine
- Trial name
- SPHERA_WP1_1 (NCT06549270)
- Testing
- MAbs
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Headache, Migraine
Correlation of Calcitonin Gene-Related Peptide (CGRP) Levels in Saliva With the Evolution of an Attack of Migraine
To assess CGRP levels in saliva through the evolution of migraine.
- Trial name
- NCT00772473
- Testing
- subjects personal triptan
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Clinvest
Migraine, Episodic Migraine
Study of Two Digital Therapeutics for the Prevention of Episodic Migraine Receiving CGRP Therapy (ReMMiD-C)
Randomized study of two digital therapeutics for the prevention of episodic migraine in patients currently receiving Calcitonin Gene-Related Peptide (CGRP) Inhibitor Therapy
- Conditions
- Migraine, Episodic Migraine, Headache, Headache, Migraine
- Trial name
- NCT06004388
- Testing
- Click Digital Therapeutic
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Click Therapeutics, Inc.
Chronic Migraine Headache, Psychologic Adaptation
Psychological Support for Chronic Migraine Patients Treated With Anti-CGRP (Anti-Calcitonin Gene-Related Peptide ) Monoclonal Antibodies
Chronic migraine is a disabling neurological condition that can significantly affect quality of life, emotional well-being, social participation, and daily functioning.
- Trial name
- MIG-PSY-CGRP (NCT07877493)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Central Hospital, Nancy, France
Migraine
CGRP-induced Migraine Attacks in Patients Who Have Tried Anti-CGRP Monoclonal Antibody Treatment
The investigators aim to investigate the incidence of migraine attacks after calcitonin gene-related peptide (CGRP) infusion in patients who have tried anti-CGRP monoclonal antibody treatment for the prevention of migraine.
- Trial name
- NCT03481400
- Testing
- Calcitonin Gene-Related Peptide
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Danish Headache Center
Oral Squamous Cell Carcinoma (OSCC), Oropharyngeal Squamous Cell Carcinoma (OPSCC)
Rimegepant-Sensitized Neoadjuvant Chemoimmunotherapy for Oral or Oropharyngeal Squamous Cell Carcinoma
This study will evaluate whether adding rimegepant to standard neoadjuvant chemoimmunotherapy can improve treatment response in patients with primary or recurrent oral or oropharyngeal squamous cell carcinoma who are planned to…
- Trial name
- NCT07812467
- Testing
- Rimegepant, Tislelizumab, Nab-paclitaxel
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Shanghai Zhongshan Hospital
Migraine, Headache
The Role of CGRPand Nociceptin in Migraine
The release of the neuropeptide calcitonin gene-related peptide (CGRP) is thought to play a causative role in migraine. Nociceptin immunoreactivity and ORL-1 mRNA have been detected in human trigeminal ganglia where it was…
- Trial name
- NCT00155129
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Thyroid Cancer, Medullary
177Lu-PP-F11N in Combination With Sacubitril for Receptor Targeted Therapy and Imaging of Metastatic Thyroid Cancer
The purpose of this study is to determine the use of 177Lu-PP-F11N for imaging and therapy of patients with advanced medullary thyroid carcinoma (MTC). 177Lu-PP-F11N is a gastrin analogon, binding to cholecystokinin-2 receptors.
- Trial name
- NCT03647657
- Testing
- 177Lu-PP-F11N, Sacuitril
- Where
- Switzerland
- Volunteers
- 8 people
- Sponsor
- University Hospital, Basel, Switzerland
Head and Neck Cancer
Plasma Calcitonin Gene-Related Peptide (CGRP) Levels in Patients With Head and Neck Malignancies Undergoing Radiotherapy
This prospective study investigates the dynamic changes in plasma calcitonin gene-related peptide (CGRP) levels during radiotherapy and their association with radiotherapy-related pain in patients with head and neck malignancies.
- Trial name
- NCT07029373
- Where
- China
- Volunteers
- 23 people
- Sponsor
- West China Hospital
Familial Hemiplegic Migraine, Migraine With Aura
Calcitonin Gene-related Peptide in Familial Hemiplegic Migraine (FHM) and Migraine With Aura (MA)
The aim of the present study is to explore the importance of migraine phenotype on the headache/migraine responses after CGRP in FHM-patients, MA-patients and healthy volunteers.
- Conditions
- Familial Hemiplegic Migraine, Migraine With Aura, Healthy
- Trial name
- CGRP-2008 (NCT00687947)
- Testing
- CGRP
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Health Postmenopausal Women
Drug Interaction of SMC021 With Concomitant Antacid (Calcium Carbonate/Magnesium Hydroxide).
This study will assess the effect of concomitant antacid on the pharmacokinetics and pharmacodynamics of SMC021
- Trial name
- NCT00421590
- Testing
- SMC021
- Where
- Denmark
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Novartis
Hypophosphatemia
FGF-23 Suppressibility by Calcitonin
Introduction: Based on our experience with calcitonin as an FGF-23 suppressive agent in a patient with an FGF-23 producing tumor we hypothesize that calcitonin may be a physiologically important regulator of FGF-23 production and…
- Trial name
- NCT00688077
- Testing
- Calcitonin
- Where
- Netherlands
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Rijnstate Hospital
Thyroid Cancer, Medullary, Neuroendocrine Tumor of the Lung Grade 1 and 2
177Lu-PP-F11N for Receptor Targeted Therapy and Imaging of Metastatic Thyroid Cancer.
The purpose of this study is to determine the use of 177Lu-PP-F11N for imaging and therapy of patients with advanced medullary thyroid carcinoma (MTC). 177Lu-PP-F11N is a gastrin analogon, binding to cholecystokinin-2 receptors.
- Conditions
- Thyroid Cancer, Medullary, Neuroendocrine Tumor of the Lung Grade 1 and 2, Neuroendocrine Tumor of the Thymus Grade 1 and 2, Neuroendocrine Tumor GEP Grade 1-3
- Trial name
- Lumed (NCT02088645)
- Testing
- 177Lu-PP-F11N
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University Hospital, Basel, Switzerland
Migraine, Headache
Long-term Atogepant in Real-world Practice
This prospective multicentre observational study aims to evaluate the long-term effectiveness, safety, tolerability, and treatment persistence of atogepant for migraine prevention in routine clinical practice.
- Conditions
- Migraine, Headache, Headache (Migraine), Migraine Disease
- Trial name
- GEMA PROJECT (NCT07699549)
- Testing
- Atogepant 60 mg, Headache diary, Patient-reported outcome measures
- Where
- Spain
- Volunteers
- 513 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
CGRP Expression in Human Periodontal Ligament
Calcitonin Gene-related Peptide Expression in Human Periodontal Ligament
The purpose of this study was to quantify the effect of moderate and severe orthodontic forces on Calcitonin gene-related peptide expression in the healthy human periodontal ligament.
- Trial name
- NCT04881786
- Testing
- Orthodontic forces
- Where
- Colombia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Institucion Universitaria Colegios de Colombia
Acute Mountain Sickness
Calcitonin Gene-related Peptide Antibody in Acute Mountain Sickness
Acute mountain sickness (AMS) is a common condition that can occur when healthy people travel quickly to high altitude. Typical symptoms include headache, nausea, tiredness, dizziness, and poor sleep.
- Trial name
- NCT07653516
- Testing
- Fremanezumab 225 Mg/1.5 mL Subcutaneous Solution
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Migraine Disorders, Chronic Migraine
Searching for Novel Biological Phenotypes in Migraine Patients Resistant to Treatments
The investigators aim to define the neurofunctional phenotype of migraine patients who did not respond to at least 3 preventive treatments, including monoclonal antibodies (mAbs) targeting calcitonin gene-related peptide (CGRP)…
- Conditions
- Migraine Disorders, Chronic Migraine, Episodic Migraine
- Trial name
- SPHERA_WP1_2 (NCT06562413)
- Testing
- MAbs
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Obese Adults
A Phase 1 Study of VK3019 in Overweight and Obese Adults Without Comorbidities
This is a Phase 1, randomized, double-blind, placebo-controlled single ascending dose (SAD) study to evaluate the safety, tolerability, pharmacodynamics and pharmacokinetics of VK3019 in overweight and obese adults without…
- Trial name
- NCT07846033
- Testing
- SC VK3019
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Viking Therapeutics, Inc.
Migraine
Positron Emission Tomography (PET) Study of Brain Calcitonin Gene-Related Peptide (CGRP) Receptor Occupancy After Telcagepant Administration (MK-0974-067)
The purpose of this study is to determine the receptor occupancy (RO) associated with telcagepant (MK-0974) administration based on displacement of [11C]MK-4232 from the CGRP receptors in the brain using PET.
- Trial name
- NCT01315847
- Testing
- telcagepant, [11C]MK-4232
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC