Clinical trials: Caloric Restriction
Osteoarthritis, Knee, Hypertension
The Clinical Impact of Diet on Medical Conditions Treated Within Bundled Payment Models: a Pilot Study
Diet interventions (e.g., low-energy diets) are recommended as a treatment for obesity, obese patients with osteoarthritis, hypertension (HTN), and type 2 diabetes (T2D).
- Conditions
- Osteoarthritis, Knee, Hypertension, Type 2 Diabetes, Obesity
- Trial name
- NCT05735873
- Testing
- Low-energy diet
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Glucocorticoid Effect
The Role of Glucocorticoids to Maintain Energy Homeostasis During Starvation (Gluco-Starve)
In a randomized, cross-over study, 20 healthy volunteers will receive a block and replace therapy that mimics physiological GC rhythm (metyrapone plus hydrocortisone) or placebo.
- Trial name
- NCT05919992
- Testing
- Metyrapone 250 mg Oral Tablets, Hydrocortisone 19.9mg s.c., pulsatile with a flow rate of 10μl/s
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Eleonora Seelig
Obesity
The Addition of Probiotic Consumption to a Nutritional Intervention and Caloric Restriction on Body Weight and Composition in Overweight Participants
Limited interventional human studies suggest that probiotic supplementation may be a beneficial strategy for promoting weight loss when added to a nutritional intervention via their effects on lipid absorption and metabolic…
- Trial name
- NCT02962583
- Testing
- Weight loss, Probiotic Formula
- Where
- Canada
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Laval University
Aging
Long-term Caloric Restriction and Cellular Aging Markers
The purpose of this study is to see whether people who have restricted the number of calories they eat for a long period of time, compared to normal-eating and obese people, have markers of cellular aging that look younger.
- Trial name
- CRONA (NCT01256840)
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Low-Calorie Diet, Diet, High-Protein
The Effect of Diet Counseling for Low Calorie-High Protein on the Body Composition, Inflammation Marker, and Oxidative Stress Marker in Obese People With Weight Cycling
The world prevalence of obesity in adult population in 2014 was nearly 13% while in Indonesia, it has reached 32.9% in the same year. Obesity is an established risk factors for cardiovascular diseases.
- Conditions
- Low-Calorie Diet, Diet, High-Protein, Obesity; Pituitary, Weight Cycling
- Trial name
- NCT03374150
- Testing
- diet counseling
- Where
- 2 sites in Indonesia
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Gastrointestinal Hormones
Impact of Macronutrient Composition of Energy-restricted Diet and Exercise on Body Composition and Appetite Hormones.
The main aim of this study is to investigate the effect of energy-restricted low and high-carbohydrate diet combined with exercise training on appetite regulatory hormones, subjective appetite and energy intake in overweight and…
- Trial name
- NCT06022315
- Testing
- caloric restrction high carbohydrate low fat diet with exercise training program, caloric restrction high fat low carbohydrate diet with exercise training program
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Obesity
The Effect of a Short-term Very Low Calorie Diet on Heart Rate Variability in Obese Individuals
The purpose of this study is to determine whether short-term adherence to a very low calorie diet is effective in improving heart rate variability in obese individuals.
- Trial name
- NCT02070770
- Testing
- Very low calorie diet, Standard weight loss diet
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- King's College London
Obesity
Effect of Specific Diet and Physical Activity on Weight and/or Fat Loss
The main purpose of this study is to assess metabolic effects (decreased amount of body fat content, insulin sensitivity and lipid profile improvement) of weight loss intervention based on specific life style counseling (low…
- Trial name
- NCT02325804
- Testing
- Lifestyle Counseling
- Where
- Slovakia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Metabolically Unhealty Obese, Dyslipidemia
Effect of a Low-Calorie MCT-Rich Traditional Minangkabau Diet on Obese Individuals
This study aims to investigate the effect of a low-calorie diet rich in medium-chain triglycerides (MCTs) based on traditional Minangkabau foods on metabolic biomarkers in individuals with obesity.
- Conditions
- Metabolically Unhealty Obese, Dyslipidemia, Diabetes (DM), Resistance, Insulin
- Trial name
- NCT07423884
- Testing
- Low-Calorie Diet Rich in Medium-Chain Triglycerides (MCTs) Based on Traditional Minangkabau Foods
- Where
- Indonesia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Andalas University
Microgravity, Caloric Restriction
BRAHMS: Bed Rest And HypoMetabolism Study
The goal of this single arm, interventional monocentric clinical trial is to investigate the physiological effects of a combination of head-down bedrest and caloric restriction on the human body.
- Trial name
- BRAHMS (NCT07499167)
- Testing
- head down bedrest and caloric restriction
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Men, Life Style
Dietary Effects on Weight Loss and Lipid Profile in Sedentary Men
Negative-calorie diet is among the popular dieting guides for weight loss; however, there is still little knowledge about this method.
- Conditions
- Men, Life Style, Lipid Metabolism Disorders, Obesity
- Trial name
- NCT03082794
- Testing
- NCD, LCD
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- P.L.Shupik National Medical Academy of Post-Graduate Education
Obesity, Overweight
Comparing of Long Bout and Short Bouts of Similar Volume of Walking in Obese on Weight Loss During a Weight Loss Program
The purpose of this present study is to determine if a daily walking program of 50 continuous minutes (long bout) or two 25-minute bouts (short bouts) in similar volume on body weight, abdominal fat mass deposition and…
- Trial name
- NCT02387827
- Testing
- Diet+ short term versus long -term physical activity
- Where
- Iran
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Novindiet Clinic
Metabolic Syndrome, Meniscus; Degeneration
Metabolic Syndrome and Degenerate Meniscus Tears
The aim is to determine the outcomes of calorie-restricted diet and exercise intervention; libitum diet and waiting list control; early arthroscopic partial meniscectomy(APM) or delayed APM effect on MetS patients with Degenerate…
- Trial name
- NCT04837456
- Testing
- Calorie restricted diet and exercise intervention, libitum diet and waiting list control group, Early arthroscopic partial menisectomy group
- Where
- China
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- The First People's Hospital of Jingzhou
Weight Loss
Intermittent Fasting, Caloric Restriction and Body Composition in Obese Men and Women
This study systematically quantified the effects of intermittent fasting and caloric restriction (IFCR) on total and regional (abdominal) body composition (lean mass and fat mass), blood lipids, toxins, oxidative stress…
- Trial name
- NCT02525419
- Testing
- Weight Loss Phase, HP-IF, HH
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Skidmore College
Obesity
Protect - The Impact of a High Protein Diet on Preservation of Muscle Mass
The present study is designed to investigate whether a high protein diet will preserve muscle mass during caloric restriction in older adults.
- Trial name
- NCT01915030
- Testing
- High protein diet, standard protein diet
- Where
- Netherlands
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Diabetes Mellitus, Type 2, Obesity
Microbiome and Health Indicators in People With Obesity, Prediabetes and Type 2 Diabetes Undergoing a Lifestyle Intervention
The incidence of type 2 diabetes worldwide is growing rapidly, being one of the fastest growing global health emergencies of the 21st century according to the International Diabetes Federation.
- Conditions
- Diabetes Mellitus, Type 2, Obesity, PreDiabetes
- Trial name
- MicrobiAr (NCT05372445)
- Testing
- Non-intensive intervention, Intensive intervention
- Where
- Argentina
- Volunteers
- 468 people, healthy volunteers welcome
- Sponsor
- National Council of Scientific and Technical Research, Argentina
Overweight
Caloric Restriction and Body Weight in Adults
The purpose of this study is to determine the role of 1. dietary calcium in fecal fat loss and the association between lactose maldigestion, dietary calcium level and source, and weight loss induced by caloric restriction. 2.
- Trial name
- NCT00808275
- Testing
- Dietary calcium
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
BRCA Mutation, PALB2 Gene Mutation
Low Dose TamOxifen and LifestylE Changes for bReast cANcer prevenTion
Circulating levels of Sex Hormone Binding Globulin (SHBG) are significantly associated with a decreased risk of breast cancer. The main aim of this clinical trial is to verify whether Low Dose Tamoxifen (LDT) increases…
- Conditions
- BRCA Mutation, PALB2 Gene Mutation, Ductal Carcinoma in Situ, Lobular Carcinoma in Situ
- Trial name
- TOLERANT (NCT06033092)
- Testing
- Tamoxifen 10 mg Tablet, Intermittent caloric restriction, Step counter Device
- Where
- 4 sites in Italy
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- European Institute of Oncology
Obesity, Diet Modification
Efficacy of Balanced Nutrition Meal Replacement Along With a Caloric Restriction on Body Weight Control
The present study was designed to evaluate the impact of a nutritionally balanced conventional meal replacement diet with caloric restriction (intervention for 8 weeks) in Taiwanese obese subjects.
- Conditions
- Obesity, Diet Modification, Nutrient; Excess
- Trial name
- nutrition (NCT03642925)
- Testing
- Meal replacement diet
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chung Shan Medical University
Muscle Wasting, Protein Intake
Effects of Ketones on Muscle Wasting During Caloric Restriction in Lean Females
Because of these anabolic properties of ketone bodies and the fact that ketone bodies prevent muscle protein breakdown for gluconeogenesis during energetic stress, ketone bodies can be a promising strategy to prevent or treat…
- Conditions
- Muscle Wasting, Protein Intake, Ketosis, Caloric Restriction
- Trial name
- NCT04744142
- Testing
- Ketone supplementation, Increased protein intake
- Where
- Belgium
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- KU Leuven