Clinical trials: Caloric Restriction, open to volunteers
Obesity & Overweight
Safety and Tolerability of a Nutritional Formula Designed to Aid in Maintenance of Muscle During Periods of Caloric Restriction in Adults
Muscle loss during caloric restriction is a significant concern for metabolic health and physical function, yet there is limited evidence on interventions that simultaneously target multiple contributing pathways.
- Trial name
- Redefine (NCT07447843)
- Testing
- Redefine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Nature's Sunshine Products, Inc.
Overweight and Obesity
Chronic Effect of Fasting
The aim of the study is to determine if time-restricted feeding (TRF) is an effective dietary strategy to weight loss after 8 weeks intervention. TRF will be compared with an intervention without restriction in time for feeding.
- Trial name
- NCT03574103
- Testing
- Caloric restriction only, Caloric restriction plus TRF morning, Caloric restriction plus TRF night
- Where
- 2 sites in Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Type 2 Diabetes Mellitus (T2DM), Semaglutide
The Impact of Semaglutide Compared to Energy Restriction on Type 2 Diabetes
To evaluate the effects of subcutaneous injection of semaglutide for 12 weeks on patients with type 2 diabetes mellitus (T2DM), compared with concurrent energy-restricted management, on glycemic control, weight loss, inflammatory…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Semaglutide, Caloric Restriction
- Trial name
- NCT07272343
- Testing
- semaglutide, caloric restriction
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Obesity (BMI Equal to or >30), Postmenopausal Symptoms
Time-Restricted Eating and Personalized Energy-Restricted Diet in Obese Postmenopausal Women
This clinical study aims to compare the effects of time-restricted eating and a personalized energy-restricted diet on anthropometric measurements, body composition, biochemical parameters, blood pressure, handgrip strength…
- Conditions
- Obesity (BMI Equal to or >30), Postmenopausal Symptoms, Sleep Quality
- Trial name
- NCT07874399
- Testing
- Time-Restricted Eating, Personalized Energy-Restricted Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gazi University
Metabolic Syndrome
The Effectiveness of Intermittent Fasting, Caloric Restriction and Physical Activity On Metabolic Syndrome
Metabolic syndrome (MetS) is a global health issue defined by a cluster of risk factors-abdominal obesity, elevated blood pressure, high fasting blood sugar, high triglycerides, and low HDL cholesterol-that together significantly…
- Trial name
- NCT07181655
- Testing
- Modified Intermittent Fasting
- Where
- Malaysia
- Volunteers
- 140 people
- Sponsor
- Universiti Putra Malaysia
Overweight, Obesity
A Research Study to See How NNC0487-0111 Affects the Body's Energy Use After a Weight Loss in Adults Living With Overweight or Obesity, Compared to a Low-calorie Diet or Placebo
The purpose of this clinical study is to evaluate how NNC0487-0111 affects the amount of energy the body uses in people living with obesity or overweight following weight loss.
- Trial name
- NCT07757087
- Testing
- NNC0487-0111, LED
- Where
- 2 sites in Denmark, Netherlands
- Volunteers
- 120 people
- Sponsor
- Novo Nordisk A/S
Obesity Type 2 Diabetes Mellitus
Fecal Microbiota Transplantation (FMT) Combined With Calorie-Restricted Diet and Semaglutide in Patients With Obesity and Type 2 Diabetes
Investigation of the efficacy of fecal microbiota transplantation added to calorie-restricted diet and semaglutide versus calorie-restricted diet and semaglutide alone for weight loss and metabolic improvement in patients with…
- Trial name
- NCT07599046
- Testing
- Fecal microbiota transplantation (FMT), Semaglutide (1 Mg Dose), Calorie-restricted diet
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Eighth Affiliated Hospital, Sun Yat-sen University
Diabetes Mellitus Type 2 in Obese
Normalized Glucose Levels in Type 2 Diabetes With Carbohydrate or Caloric Restriction
This is a randomized controlled trial to determine whether a low-carbohydrate (LC) diet can lead to normalized blood glucose levels in patients with short duration of type 2 diabetes (T2D).
- Trial name
- CarborCal (NCT05801614)
- Testing
- Low carb diet
- Where
- Sweden
- Volunteers
- 286 people
- Sponsor
- Region Stockholm
Metabolically Unhealty Obese, Dyslipidemia
Effect of a Low-Calorie MCT-Rich Traditional Minangkabau Diet on Obese Individuals
This study aims to investigate the effect of a low-calorie diet rich in medium-chain triglycerides (MCTs) based on traditional Minangkabau foods on metabolic biomarkers in individuals with obesity.
- Conditions
- Metabolically Unhealty Obese, Dyslipidemia, Diabetes (DM), Resistance, Insulin
- Trial name
- NCT07423884
- Testing
- Low-Calorie Diet Rich in Medium-Chain Triglycerides (MCTs) Based on Traditional Minangkabau Foods
- Where
- Indonesia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Andalas University
Down Syndrome
Aerobic Exercise With and Without Low Calorie Diet on Adiposity and BMI of Down Syndrome
Down syndrome (DS) is caused by trisomy 21, or the presence of an extra copy of chromosome 21. A calibrated weight scale is used to measure participants' weight accurately.
- Trial name
- NCT06943170
- Testing
- Aerobic Exercise and Low Calorie Diet
- Where
- Pakistan
- Volunteers
- 22 people
- Sponsor
- Riphah International University
Surgical Complications
To Evaluate If Preoperative 7 Days Low Calorie Diet Reduces Postoperative Morbidity in Liver Surgery
The rationale for this study is to evaluate whether a standardized, preoperative, short-term Low Calorie Diet (LCD) reduces intraoperative bleeding and postoperative morbidity in liver surgery.
- Trial name
- LowCaLi (NCT07801716)
- Testing
- Low calorie meal replacement plan
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Region Skane
Insulin Resistance, NAFLD
Reversal of Lipid-Induced Insulin Resistance
The purpose of this study is to examine whether weight reduction decreases intramyocellular (IMCL) and hepatic lipid content, and improves insulin sensitivity of muscle and fat tissue in people who are insulin resistant and have…
- Trial name
- NCT02193295
- Testing
- Caloric Restriction
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Yale University
Pediatric Obesity, Type 2 Diabetes
Low EnerGy DiEt iN Adolescents With Obesity and Type 2 Diabetes: The LEGEND Study
This is a multicentre, single-arm, feasibility study in adolescents with T2DM and obesity to investigate the recruitment and retention rates to a study using Low Energy Diets(LED).
- Trial name
- LEGEND (NCT06572345)
- Testing
- Low-energy diet, Qualitive interview - LED participants, Qualitive interview - Participants declining LED
- Where
- United Kingdom
- Volunteers
- 73 people
- Sponsor
- Nottingham University Hospitals NHS Trust
NAFLD
Non-alcoholic Fatty Liver Disease in Low Birth Weight Individuals
The investigators will conduct a proof-of-principle 4-weeks low-calorie diet (LCD) intervention study in low birth weight (LBW) subjects and normal birth weight (NBW) controls with documented (MR scan) liver fat content equal to…
- Trial name
- NCT05842850
- Testing
- Caloric restriction intervention, No intervention
- Where
- 2 sites in Denmark
- Volunteers
- 8 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type2diabetes
The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction
Caloric restriction (and RYGB) improves insulin action and lowers fasting glucose, glucagon and EGP, without changes in postprandial EGP and glucagon concentrations.
- Trial name
- NCT05499702
- Testing
- Caloric Restriction, Hyperglycemic clamp
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Adrian Vella
Tumor Surgery
Caloric Restriction In Sarcoma Patients Treated With Pre-Operative RT
This study is being conducted to decrease the rate of surgical wound complications. The investigators are studying the effects that caloric restriction has on decreasing the rate of surgical wound complications.
- Trial name
- NCT02792270
- Testing
- Caloric Restriction Diet
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus Type 2
Effectiveness of Low-Calorie MIND-HK Diet and Very Low-Calorie Diet on Glycemic Control and Cardiovascular Outcomes in Adults With Type 2 Diabetes: A 12-Week Randomized Controlled Trial
The objective of this project is to assess the effectiveness of a low-calorie and very low-calorie Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND-HK) diet in improving glycemic control and cardiovascular…
- Trial name
- NCT07635121
- Testing
- Low-calorie MIND-HK diet, Very Low-calorie MIND-HK diet, Control group
- Volunteers
- 180 people
- Sponsor
- Hong Kong Metropolitan University