Clinical trials: Calorie Restriction
Time Restricted Eating, Obesity
Time-restricted Eating Versus Daily Continuous Calorie Restriction on Body Weight and Colorectal Cancer Risk Markers
Approximately 42% of American adults are obese, and this condition is strongly related to the development of colorectal cancer. Innovative lifestyle strategies to treat obesity and reduce colorectal cancer risk are critically…
- Conditions
- Time Restricted Eating, Obesity, Weight Loss, Colorectal Cancer
- Trial name
- NCT05114798
- Testing
- Time restricted eating, Calorie Restriction
- Where
- United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Obesity, Type 2 Diabetes Mellitus
Changes in Insulin Sensitivity After Weight Loss
This study is designed to compare the changes in insulin sensitivity as well as gastrointestinal hormone levels in diabetic and non-diabetic obese individuals who are undergoing weight loss procedures.
- Conditions
- Obesity, Type 2 Diabetes Mellitus, Insulin Resistance
- Trial name
- NCT00627484
- Testing
- Gastric bypass, Gastric banding, Sleeve gastrectomy
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Columbia University
Inflammation
Effects of a Short Term Caloric Restriction on T Cell Activation in Fat
Overweight and obesity are major problems and their complications such as cardiovascular disease and type 2 diabetes mellitus pose great burdens on healthcare systems.
- Trial name
- NCT02473835
- Testing
- Calorie restriction, Activity monitoring, Diet monitoring
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Bath
Obesity, Menopause
Calorie Restriction With Leucine Supplementation
The purpose of this study is to determine whether consuming additional leucine during calorie restriction induced weight loss has beneficial or harmful effects on multi-organ (liver, muscle, adipose tissue) insulin sensitivity…
- Conditions
- Obesity, Menopause, Osteoporosis, Sarcopenia
- Trial name
- NCT01757340
- Testing
- Weight loss with normal protein and leucine intake, Weight loss with protein/leucine supplementation
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Calorie Restriction
The CALERIE™ Legacy Study
The purpose of the CALERIE Legacy Study is to follow up on the health and wellness of participants from phase 2 of the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trial, which was…
- Trial name
- NCT05651620
- Where
- 3 sites in United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Tufts University
Obesity, Menopause
Calorie Restriction, Protein Supplementation and Metabolic Health
The purpose of this study is to determine whether consuming additional protein during calorie restriction induced weight loss has beneficial or harmful effects on multi-organ (liver, muscle, adipose tissue) insulin sensitivity…
- Conditions
- Obesity, Menopause, Osteoporosis, Sarcopenia
- Trial name
- CRPS (NCT01538836)
- Testing
- Weight loss with normal protein intake, Weight loss with protein supplementation
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Obesity, Severe Obesity
Energy Expenditure From ECAL Indirect Calorimeter in a Multicomponent Weight Management Service
Whether greater weight loss is as a result of a smaller reduction in energy expenditure with caloric restriction is not known. Resting energy expenditure and 24-hour energy expenditure vary substantially between individuals.
- Conditions
- Obesity, Severe Obesity, Sleep Apnoea
- Trial name
- ECAL (NCT03638895)
- Testing
- ECAL Indirect Calorimeter, Diet, exercise & behaviour modification therapy
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Overweight and Obese Women
Impact of Beta-glucan Supplementation During Calorie and Carbohydrate-restricted Diet on Body Weight and Body Fat Loss, Appetite, and Gastrointestinal Appetite Hormones.
This study will investigate whether beta-glucan supplementation, when added to an energy and carbohydrate-restricted diet, facilitates body weight and body fat loss, and leads to less detrimental changes in subjective appetite…
- Trial name
- NCT07299942
- Testing
- Beta-glucan addition to a restricted calorie of meal replacements and carbohydrate diet.
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Liver Fat, Fertility Disorders
Effect of Lifestyle Intervention on Mobilization of Fat Storage and Iron Deposition in Obesity
The goal of this clinical trial is to learn if calorie-restricted balanced diet could uniquely influence various fat storage pools and iron deposition and explore the relationships between fat or iron deposition loss in specific…
- Conditions
- Liver Fat, Fertility Disorders, Life Style, Healthy, Glucose Metabolism Disorders (Including Diabetes Mellitus)
- Trial name
- NCT06441409
- Testing
- Lifestyle intervention
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Healthy Volunteers
Can Fish Oil and Phytochemical Supplements Mimic Anti-Aging Effects of Calorie Restriction?
The purpose of this study is to determine if a combination of 10 nutritional supplements provide health benefits that are consistent with protection against age-related disease.
- Trial name
- NCT01752868
- Testing
- Supplement
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Obesity, Metabolic Syndrome
Effect of Resvida, a Comparison With Calorie Restriction Regimen
The purpose of this study is to compare the effects of the antioxidant "resveratrol" to a diet intervention (Calorie Restriction) to determine how each of them affects the following: gene expression profile, cholesterol (lipids)…
- Conditions
- Obesity, Metabolic Syndrome, Diabetes, Aging
- Trial name
- Resvida (NCT00823381)
- Testing
- resveratrol, Calorie Restriction
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Alertness, Fatigue, Mood, and Performance, Calorie Restriction and Light Intervention
Fatigue in Long-Haul Operations
The purpose of the present study is to test novel countermeasures to reduce fatigue among airline pilots during long-haul flight operations.
- Trial name
- LHops26 (NCT07761611)
- Testing
- Caloric restriction, Light exposure
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- National Aeronautics and Space Administration (NASA)
Obesity
Effect of a 4-week Alternate Day Intermittent Energy Restriction Intervention vs Reduced
This pilot study is an active control randomized controlled trial with a sample size of 30 that will consist of 2 groups, to evaluate the effects of a one-month alternate day intermittent energy restriction (AltER) intervention…
- Trial name
- AltER2022 (NCT05213520)
- Testing
- Alternate Day Intermittent Energy Restriction, Reduced Calorie Diet
- Where
- 2 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Non-Alcoholic Fatty Liver Disease
Effectiveness and Adherence of Modified Alternate-day Calorie Restriction (MACR) in Non-Alcoholic Fatty Liver Disease
There is no effective therapy for non-alcoholic fatty liver disease (NAFLD), although intensive calorie restriction is typically recommended but dietary adherence is an issue.
- Trial name
- NCT03791203
- Testing
- Calorie restriction (MACR)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Gastrointestinal Hormones
Impact of Macronutrient Composition of Energy-restricted Diet and Exercise on Body Composition and Appetite Hormones.
The main aim of this study is to investigate the effect of energy-restricted low and high-carbohydrate diet combined with exercise training on appetite regulatory hormones, subjective appetite and energy intake in overweight and…
- Trial name
- NCT06022315
- Testing
- caloric restrction high carbohydrate low fat diet with exercise training program, caloric restrction high fat low carbohydrate diet with exercise training program
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Metabolic Syndrome, Meniscus; Degeneration
Metabolic Syndrome and Degenerate Meniscus Tears
The aim is to determine the outcomes of calorie-restricted diet and exercise intervention; libitum diet and waiting list control; early arthroscopic partial meniscectomy(APM) or delayed APM effect on MetS patients with Degenerate…
- Trial name
- NCT04837456
- Testing
- Calorie restricted diet and exercise intervention, libitum diet and waiting list control group, Early arthroscopic partial menisectomy group
- Where
- China
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- The First People's Hospital of Jingzhou
Obesity, Body Fat
Effects of Lipoic Acid and Eicosapentaenoic Acid (EPA) in Human Obesity
The aim of the study is to analyze the effects of Lipoic acid and/or EPA supplementation on weight loss, lipid profile, insulin resistance, oxidative and inflammation parameters, metabolomic profile as well as on adipose tissue…
- Conditions
- Obesity, Body Fat, Insulin Resistance
- Trial name
- OBEPALIP (NCT01138774)
- Testing
- Double blind dietary intervention with EPA and lipoic acid
- Where
- Spain
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Aging
CALERIE (Tufts) - Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy
This study is one of three CALERIE trials that test the hypothesis that a reduced calorie, nutritionally sound diet increases the length of life and prevents some age-related chronic diseases such as cancer, diabetes, and…
- Trial name
- NCT00099099
- Testing
- Caloric Restriction (CR)
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Obesity, Diet Modification
Efficacy of Balanced Nutrition Meal Replacement Along With a Caloric Restriction on Body Weight Control
The present study was designed to evaluate the impact of a nutritionally balanced conventional meal replacement diet with caloric restriction (intervention for 8 weeks) in Taiwanese obese subjects.
- Conditions
- Obesity, Diet Modification, Nutrient; Excess
- Trial name
- nutrition (NCT03642925)
- Testing
- Meal replacement diet
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chung Shan Medical University
Mild Cognitive Impairment, Metabolic Syndrome
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation
The study explores whether selective memory complaints (SMC), mild cognitive impairment (MCI) and the comorbidity of Metabolic Syndrome symptomatic of peripheral and cerebral hypo-metabolism with corresponding epigenetic shifts…
- Trial name
- NCT03319173
- Testing
- Dietary intervention
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Bristlecone Health, Inc.