Clinical trials: Cancer, Gastrointestinal
Metastatic Biliary Tract Carcinoma, Metastatic Colorectal Carcinoma
Liposomal Irinotecan, Fluorouracil, Leucovorin Calcium, and Rucaparib in Treating Patients With Metastatic Pancreatic, Colorectal, Gastroesophageal, or Biliary Cancer
This phase I/II trial studies the side effects and best dose of liposomal irinotecan and rucaparib when given together with fluorouracil and leucovorin calcium and to see how well they work in treating patients with pancreatic…
- Conditions
- Metastatic Biliary Tract Carcinoma, Metastatic Colorectal Carcinoma, Metastatic Gastroesophageal Junction Adenocarcinoma, Metastatic Malignant Digestive System Neoplasm
- Trial name
- NCT03337087
- Testing
- Fluorouracil, Irinotecan Sucrosofate, Laboratory Biomarker Analysis
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- Academic and Community Cancer Research United
General Anesthesia Gastrointestinal Cancer Surgery
The Safety and Effectiveness of NEPA in Preventing Postoperative Nausea and Vomiting After General Anesthesia Gastrointestinal Cancer Surgery: A Single-Center Retrospective Study
The rapid progress of multiple antiemetic regimens ensures that patients can receive full dose chemotherapy, however, there are still a large number of unmet clinical needs in patient evaluation and treatment.
- Trial name
- NCT06417567
- Testing
- NEPA
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Rectal Neoplasms, Rectum Cancer
SGM-101 in Colorectal Brain Metastases.
This study assesses the feasibility of SGM-101, a fluorochrome-labeled anti-carcinoembryonic antigen monoclonal antibody, for intraoperative near-infrared fluorescence imaging of colorectal brain metastases by injecting SGM-101…
- Conditions
- Rectal Neoplasms, Rectum Cancer, Colorectal Neoplasms, Brain Metastases
- Trial name
- SGM-CBM (NCT04755920)
- Testing
- SGM-101
- Where
- 2 sites in Netherlands
- Volunteers
- 10 people
- Sponsor
- Leiden University Medical Center
Gastrointestinal Cancers, Gastrointestinal Cancer Metastatic
Electronic Patient Reported Outcomes in Patients With Gastrointestinal Cancers
This is a randomized trial of patients with gastrointestinal (GI) cancers treated at University of California, San Francisco (UCSF) who are starting a new line of systemic therapy to evaluate the feasibility of electronic patient…
- Trial name
- NCT05359042
- Testing
- Electronic Patient Reported Outcomes platform, Health Related Quality of Life Surveys
- Sponsor
- University of California, San Francisco
Advanced Gastrointestinal Cancer
89Zr-AMG211 PET Imaging Study
AMG 211 is a bispecific single-chain antibody construct of the bispecific T-cell engager (BiTE®) class that targets human carcinoembryonic antigen (CEA, CD66e) on (tumor) cells and cluster of differentiation 3 (CD3) positive…
- Trial name
- NCT02760199
- Testing
- 89Zr-AMG211, 89-ZrAMG211 PET
- Where
- 2 sites in Netherlands
- Volunteers
- 9 people
- Sponsor
- University Medical Center Groningen
Colorectal Adenoma, Colorectal Cancer
PRevention Using EPA Against coloREctal Cancer
This research study is evaluating the effect of AMR101 as a possible chemopreventive agent to reduce risk of colorectal cancer in individuals with a history of colorectal adenoma.
- Conditions
- Colorectal Adenoma, Colorectal Cancer, Endoscopic Surgery, Eicosapentaenoic Acid
- Trial name
- PREPARE (NCT04216251)
- Testing
- AMR101
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Massachusetts General Hospital
Esophageal Neoplasms, Stomach Neoplasms
Early Detection of Esophageal Cancer
Esophageal cancer is a common malignancy with a very poor prognosis. The principal reason for its poor prognosis is that most tumors are asymptomatic and go undetected until they have spread beyond the esophageal wall and are…
- Conditions
- Esophageal Neoplasms, Stomach Neoplasms, Endoscopy, Gastrointestinal, Digestive System Endoscopic Surgical Procedures
- Trial name
- NCT00341523
- Where
- China
- Volunteers
- 6,864 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer
Phase I/II Study of KRN330 Plus Irinotecan in Patients With Metastatic Colorectal Cancer
The primary objective of the Phase II portion of this study is to assess the efficacy of KRN330 in combination with irinotecan after first-line or adjuvant FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin)/CapOx (capecitabine…
- Trial name
- NCT00838578
- Testing
- KRN330, Irinotecan
- Where
- 12 sites in United States
- Volunteers
- 65 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Liver Cancer, Pancreas Cancer
PRIORITY-CONNECT 2 Pilot Trial
The provision of preoperative interventions (prehabilitation: including exercise, nutrition, and psychological treatment) have been reported to reduce postoperative complications by as much as 50% and reduce hospital stay by up…
- Conditions
- Liver Cancer, Pancreas Cancer, Oesophageal Cancer, Gastric Cancer
- Trial name
- NCT06212700
- Testing
- Preoperative Exercise, Postoperative Exercise, Preoperative Nutrition
- Where
- 2 sites in Australia
- Volunteers
- 20 people
- Sponsor
- Surgical Outcomes Research Centre (SOuRCe)
Lung Cancer, Gastrointestinal Cancer
NextSteps Intervention for Advanced Cancer Patients and Caregivers
This study seeks to test the efficacy of a psychosocial intervention to empower advanced cancer patients and their caregivers and improve their quality of life (QOL).
- Trial name
- NCT04885439
- Testing
- NextSteps
- Where
- United States
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Cancer Colon, Gastrointestinal Disease
Time Longitudinal Study of the Microbiome in Colorectal Cancer Subjects
Researchers are trying to determine whether certain microbiome cause cancer or whether they are part of the microbiome in the gut due to the presence of cancer.
- Trial name
- NCT03951792
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Mayo Clinic
Colon Cancer, Ovarian Cancer
Exercise Intervention Prior to CRS-HIPEC: Feasibility & Impact
Our objective is to initiate an exercise program for patients with advanced GI or Gyn cancer, as prehabilitation prior to surgery.
- Conditions
- Colon Cancer, Ovarian Cancer, GI Cancer, Gynecologic Cancer
- Trial name
- NCT04731441
- Testing
- Home-based Exercise Program Prior to CRS-HIPEC, Exercise Education
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Milton S. Hershey Medical Center
Esophageal Neoplasms, Head and Neck Neoplasms
Evaluate the Efficacy of Adding Intraluminal Brachytherapy After CCRT for Local-regional Thoracic Esophageal Cancer.
The purpose of this study is to observe the safety and effectiveness of the add-on of intraluminal brachytherapy with BRAXX esophageal brachytherapy applicator after definitive CCRT in patients with thoracic esophageal cancer.
- Conditions
- Esophageal Neoplasms, Head and Neck Neoplasms, Gastrointestinal Neoplasms, Digestive System Diseases
- Trial name
- NCT06365866
- Testing
- "BRAXX" Esophageal Brachytherapy Applicator., Add-on of intraluminal brachytherapy
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Upper Gastrointestinal Cancer
Real-World Use of Adjuvant Nivolumab in Patients With Upper Gastrointestinal Cancer in Canada
The purpose of this observational study is to describe the patient, disease and treatment characteristics of eligible participants with upper gastrointestinal cancer treated with adjuvant nivolumab.
- Trial name
- NCT06361563
- Testing
- Nivolumab
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- Bristol-Myers Squibb
Upper Gastrointestinal Cancer
Real-World Use of Nivolumab for the Treatment of Patients With Metastatic Upper Gastrointestinal Cancer in Canada
The purpose of this observational study is to describe the demographics, and disease characteristics of participants with metastatic upper gastrointestinal cancer, along with the treatment characteristics of these patients when…
- Trial name
- NCT06361576
- Testing
- Nivolumab
- Where
- Canada
- Volunteers
- 700 people
- Sponsor
- Bristol-Myers Squibb
Gastric Cancer, Gastrointestinal Cancer
Comparison of Outcomes of Multiple Platforms for Assisted Robotic - Gastrectomy
The object of this exploratory clinical trial is to evaluate intra and post-operative complications in a population that underwent Robotic Gastrectomy, with multiple platforms: DaVinci; Hugo; Versius.
- Conditions
- Gastric Cancer, Gastrointestinal Cancer, Neoplasms, Gastric Diffuse Adenocarcinoma
- Trial name
- NCT06362070
- Testing
- DaVinci® Surgical System, Hugo™ RAS System, Versius® Robotic Surgery System
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Liver Metastases, Liver Metastasis Colon Cancer
DNX-2440 for Resectable Colorectal Liver Metastasis
The purpose of this study is to test an experimental oncolytic adenovirus called DNX-2440 in patients with resectable multifocal (≥ 2 lesions) liver metastasis, who are scheduled to have curative-intent liver resection surgery.
- Conditions
- Liver Metastases, Liver Metastasis Colon Cancer, Colorectal Cancer, Breast Cancer
- Trial name
- NCT04714983
- Testing
- DNX-2440
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- DNAtrix, Inc.
Gastrointestinal Neoplasms
Remote Real-Time Guidance System in Home Care of Patients With PICC or PORT
Clinical treatment of digestive tract tumor patients often need chemotherapy before and after operation, most chemotherapy drugs will cause harm to patients, prone to leakage, leading to tissue necrosis.
- Trial name
- RRTGS (NCT05106244)
- Testing
- Real-Time Guidance of Home Care for Patients with PICC or PORT
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Advanced Gastrointestinal Cancers
Lymphocyte Enhancement in Gastroenteric Oncology
LEGO is single center double-blind randomized trial aimed at testing the efficacy of an essential ammino acid (EAA) supplementation in improving the absolute count of peripheral lymphocytes and the tolerance to chemotherapy in…
- Trial name
- NCT06343272
- Testing
- EAA supplementation
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Colonic Polyp, Gastrointestinal Neoplasms
Clinical Study on Continuous Suture of Endoscopic Mucosal Defects
The use of clips to completely clip mucosal defects after ESD/EMR can reduce postoperative adverse events, but the rate of incomplete mucosal defects closure is high.
- Trial name
- NCT05190042
- Testing
- Cotinuous suture, Clips
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences